David C. McGowan

发表

Discovery of novel potent and selective dipeptide hepatitis C virus NS3/4A serine protease inhibitors.

B. Samuelsson, Lili Hu, Magnus Nilsson, 2008, Bioorganic & medicinal chemistry letters.

Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.

F. Pauwels, T. Jonckers, E. Arnoult, 2017, Journal of medicinal chemistry.

Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties.

J. Newcomb, Xin Huang, Steve Schneider, 2007, Bioorganic & medicinal chemistry letters.

Versatile Multicomponent Reaction Macrocycle Synthesis Using α-Isocyano-ω-carboxylic Acids.

A. Dömling, C. Neochoritis, K. Kurpiewska, 2015, Organic letters.

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.

M. Cummings, Lili Hu, F. Pauwels, 2009, Bioorganic & medicinal chemistry letters.

Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350.

Elizabeth Hamelink, L. Vrang, B. Samuelsson, 2008, Bioorganic & medicinal chemistry letters.

Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase.

Lili Hu, Maxwell D Cummings, M. Cummings, 2009, Journal of medicinal chemistry.

Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.

Xin Huang, David Powers, Daniela Metz, 2006, Journal of medicinal chemistry.

Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.

P. Gallant, A. Oliveira-dos-Santos, J. Newcomb, 2008, Journal of medicinal chemistry.

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

J. Deval, J. Symons, D. Misner, 2020, bioRxiv.

Latest Advances in Small Molecule TLR 7/8 Agonist Drug Research.

David C. McGowan, 2019, Current topics in medicinal chemistry.

Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists.

F. Pauwels, T. Jonckers, E. Arnoult, 2018, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of novel HCV replication inhibitors

F. Pauwels, P. Raboisson, K. Simmen, 2017, Molecular Diversity.

Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus.

J. Vlach, F. Pauwels, E. Arnoult, 2016, Journal of medicinal chemistry.

Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library

Peggy Geluykens, M. Van Loock, B. Devogelaere, 2017, Antiviral research.

Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.

M. Cummings, B. Devogelaere, Lili Hu, 2014, Journal of medicinal chemistry.

Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.

M. Cummings, B. Devogelaere, Lili Hu, 2012, Angewandte Chemie.

Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists.

V. Pande, F. Pauwels, T. Jonckers, 2018, Bioorganic & medicinal chemistry letters.

Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.

A. Cheng, J. Newcomb, Xin Huang, 2007, Bioorganic & medicinal chemistry letters.

Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors.

L. Vrang, B. Samuelsson, Lili Hu, 2008, Bioorganic & medicinal chemistry letters.

Finger-loop inhibitors of the HCV NS5b polymerase. Part 1: Discovery and optimization of novel 1,6- and 2,6-macrocyclic indole series.

M. Cummings, Lili Hu, O. Nyanguile, 2012, Bioorganic & medicinal chemistry letters.

Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.

P. Gallant, M. Morrison, D. Elbaum, 2006, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Novel Indoles Targeting the Influenza PB2 Cap Binding Region.

Christophe Buyck, J. Grimes, J. Keown, 2019, Journal of medicinal chemistry.

Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase.

David Powers, Paul Hughes, Richard Kendall, 2007, Journal of medicinal chemistry.

2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.

V. Pande, F. Pauwels, T. Jonckers, 2018, Journal of medicinal chemistry.

Finger loop inhibitors of the HCV NS5b polymerase. Part II. Optimization of tetracyclic indole-based macrocycle leading to the discovery of TMC647055.

M. Cummings, B. Devogelaere, Lili Hu, 2012, Bioorganic & medicinal chemistry letters.

Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.

M. Cummings, B. Devogelaere, Lili Hu, 2012, Angewandte Chemie.

Discovery and early development of TMC647055, a non-nucleoside inhibitor of the hepatitis C virus NS5B polymerase.

M. Cummings, B. Devogelaere, Lili Hu, 2014, Journal of medicinal chemistry.