Lubna Ghanem

发表

Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses.

J. Bukh, T. Scheel, Tanja B. Jensen, 2011, Gastroenterology.

Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle

J. Bukh, H. Krarup, Yi-Ping Li, 2016, Antimicrobial Agents and Chemotherapy.

Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1-7 and Escape Variants.

J. Bukh, T. Scheel, J. Gottwein, 2017, Gastroenterology.

HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape.

J. Bukh, K. Schønning, Qi Tang, 2019, Journal of hepatology.

Adapted J6/JFH1-Based Hepatitis C Virus Recombinants with Genotype-Specific NS4A Show Similar Efficacies against Lead Protease Inhibitors, Alpha Interferon, and a Putative NS4A Inhibitor

J. Bukh, N. Uzcátegui, H. Krarup, 2013, Antimicrobial Agents and Chemotherapy.

Combination Treatment with Hepatitis C Virus Protease and NS5A Inhibitors Is Effective against Recombinant Genotype 1a, 2a, and 3a Viruses

J. Bukh, T. Scheel, Yi-Ping Li, 2012, Antimicrobial Agents and Chemotherapy.

Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

J. Bukh, J. Pawlotsky, C. Sarrazin, 2019, Hepatology.

Development and Application of Hepatitis C Reporter Viruses with Genotype 1 to 7 Core-Nonstructural Protein 2 (NS2) Expressing Fluorescent Proteins or Luciferase in Modified JFH1 NS5A

J. Bukh, G. Leroux-Roels, P. Meuleman, 2011, Journal of Virology.

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization.

M. Fushimi, Dagmar Wachten, L. Levin, 2021, Molecular human reproduction.

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

C. Steegborn, R. Myers, L. Levin, 2022, Frontiers in Physiology.

Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates.

M. Fushimi, N. Liverton, S. Kargman, 2022, Journal of medicinal chemistry.

On-demand male contraception via acute inhibition of soluble adenylyl cyclase

C. Steegborn, D. Huggins, L. Levin, 2023, Nature Communications.

Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization

M. Fushimi, L. Levin, J. Buck, 2021, bioRxiv.

Capacitation induces changes in metabolic pathways supporting motility of epididymal and ejaculated sperm

J. Cross, L. Levin, J. Buck, 2023, Frontiers in Cell and Developmental Biology.