A. Risinger

发表

2,3-Seco-2,3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens

G. Mohamed, S. Ibrahim, D. Youssef, 2015, Natural product research.

Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype

J. Beutler, Karthik Ramachandran, S. Mooberry, 2019, Breast Cancer Research and Treatment.

Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4.

Ryan S. Davis, S. Mooberry, Erin O'Brien, 2010, Journal of medicinal chemistry.

A Stereocontrolled Annulation of the Taccalonolide Epoxy Lactone onto the Molecular Framework of trans-Androsterone.

E. J. Sorensen, S. Mooberry, Xiao-Yang Chen, 2017, Organic letters.

Eribulin Mesylate: Mechanism of Action of a Unique Microtubule-Targeting Agent

A. L. Risinger, S. Mooberry, Nicholas F. Dybdal-Hargreaves, 2015, Clinical Cancer Research.

Microtubule-Targeting Drugs: More than Antimitotics.

A. L. Risinger, S. Mooberry, R. Kaul, 2019, Journal of natural products.

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

M. Steinmetz, K. Altmann, A. Prota, 2019, International journal of molecular sciences.

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

S. Matthew, D. Lucena‐Agell, A. Prota, 2021, Proceedings of the National Academy of Sciences.

Fluorescence spectral shape analysis for nucleotide identification

Charles J. Zeman, K. Schanze, Zhiliang Li, 2019, Proceedings of the National Academy of Sciences.

Mapping chromatin structure in vivo using DNA methyltransferases.

Archana Dhasarathy, Archana Dhasarathy, Scott A. Hoose, 2004, Methods.

Anacolosins A-F and Corymbulosins X and Y, Clerodane Diterpenes from Anacolosa clarkii Exhibiting Cytotoxicity toward Pediatric Cancer Cell Lines.

R. Cichewicz, S. Cai, T. Grkovic, 2019, Journal of natural products.

Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea.

D. Powell, R. Cichewicz, S. Cai, 2020, Journal of natural products.

Identification and biological activities of new taccalonolide microtubule stabilizers.

G. Helms, A. L. Risinger, S. Mooberry, 2011, Journal of medicinal chemistry.

Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants.

D. Powell, T. Anderson, R. Cichewicz, 2016, Journal of natural products.

Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential

R. Cichewicz, S. Cai, A. L. Risinger, 2021, Cancers.

Taccalonolide Microtubule Stabilizers.

Samantha S. Yee, L. Du, A. Risinger, 2020, Progress in the chemistry of organic natural products.

Taccalonolide microtubule stabilizers.

S. Mooberry, Jing Li, A. Risinger, 2014, Bioorganic & medicinal chemistry.

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.

J. Doench, Huiyun Liang, R. Cichewicz, 2020, Journal of natural products.

Altertoxin II, a Highly Effective and Specific Compound against Ewing Sarcoma

Andrew J. Robles, P. Houghton, R. Cichewicz, 2021, Cancers.

In Vivo Evaluation of (−)-Zampanolide Demonstrates Potent and Persistent Antitumor Efficacy When Targeted to the Tumor Site

Tyler A. Johnson, P. Crews, A. L. Risinger, 2022, Molecules.

α- and β-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells.

C. Levenson, A. L. Risinger, J. Bohmann, 2015, Journal of natural products.

Didemnaketals F and G, New Bioactive Spiroketals from a Red Sea Ascidian Didemnum Species

G. Mohamed, S. Ibrahim, D. Youssef, 2014, Marine drugs.

In Situ Ring Contraction and Transformation of the Rhizoxin Macrocycle through an Abiotic Pathway.

R. Cichewicz, A. L. Risinger, S. Mooberry, 2019, Journal of natural products.

Targeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural products.

L. Du, A. L. Risinger, A. Risinger, 2019, Natural product reports.

The bat flower: a source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions.

A. L. Risinger, S. Mooberry, D. Frantz, 2013, Journal of natural products.

One- and Two-Photon Activated Release of Oxaliplatin from a Pt(IV)-Functionalized Poly(phenylene ethynylene).

K. Schanze, Samantha S. Yee, H. Gobeze, 2022, ACS applied materials & interfaces.

Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel

A. L. Risinger, S. Mooberry, A. Risinger, 2011, Cell cycle.

The Microtubule Destabilizer Eribulin Synergizes with STING Agonists to Promote Antitumor Efficacy in Triple-Negative Breast Cancer Models

S. Mooberry, Leila Takahashi-Ruiz, Peter Y. W. Chan, 2022, Cancers.

Taccalonolides: Novel microtubule stabilizers with clinical potential.

A. L. Risinger, S. Mooberry, A. Risinger, 2010, Cancer letters.

Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.

E. Hamel, S. Mooberry, Sudhir Raghavan, 2010, Journal of medicinal chemistry.

Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA

Huiyun Liang, S. Mooberry, Leila Takahashi-Ruiz, 2021, Molecular Pharmacology.

Efficacy of a Covalent Microtubule Stabilizer in Taxane-Resistant Ovarian Cancer Models

Samantha S. Yee, A. Risinger, April L. Risinger, 2021, Molecules.

Microtubule dynamics as a target in oncology.

F. Giles, A. L. Risinger, S. Mooberry, 2009, Cancer treatment reviews.

The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms.

G. Kruh, G. Helms, S. Mooberry, 2008, Cancer research.

Amino acids regulate the transcription, internal sorting, and intrinsic activity of the general amino acid permease (GAP1) in S. cerevisiae

A. L. Risinger, A. Risinger, April L. Risinger, 2007 .

Abstract 965: Eribulin promotes a distinct immunogenic gene expression signature as compared with paclitaxel

S. Mooberry, Charles S. Fermaintt, A. Risinger, 2020 .

Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.

D. Schriemer, A. L. Risinger, S. Mooberry, 2013, Cancer research.

Microtubules as a Target in Cancer Therapy

A. L. Risinger, S. Mooberry, A. Risinger, 2012 .

Taccalonolide Microtubule Stabilizers Generated Using Semisynthesis Define the Effects of Mono Acyloxy Moieties at C-7 or C-15 and Disubstitutions at C-7 and C-25.

R. Cichewicz, L. Du, S. Mooberry, 2018, Journal of natural products.

Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri.

G. Helms, S. Mooberry, D. Frantz, 2010, Journal of natural products.

A Potent HDAC Inhibitor, 1-Alaninechlamydocin, from a Tolypocladium sp. Induces G2/M Cell Cycle Arrest and Apoptosis in MIA PaCa-2 Cells

D. Powell, R. Cichewicz, L. Du, 2014, Journal of natural products.

Activity-dependent reversible inactivation of the general amino acid permease.

C. Kaiser, Chris A Kaiser, April L Risinger, 2006, Molecular biology of the cell.

Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner

S. Mooberry, R. Kaul, A. Risinger, 2019, British Journal of Cancer.

Different ubiquitin signals act at the Golgi and plasma membrane to direct GAP1 trafficking.

C. Kaiser, A. L. Risinger, A. Risinger, 2008, Molecular biology of the cell.

Targeting the tubulin C-terminal tail by charged small molecules.

M. Mori, Mingyan Yang, R. Hortigüela, 2022, Organic & biomolecular chemistry.

Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides

R. Cichewicz, B. Stevenson, B. Stamps, 2017, Proceedings of the National Academy of Sciences.

Penicilloitins A and B, new antimicrobial fatty acid esters from a marine endophytic Penicillium species

D. Youssef, S. Mooberry, J. Badr, 2016, Zeitschrift fur Naturforschung. C, Journal of biosciences.

Structure-activity relationships of retro-dihydrochalcones isolated from Tacca sp.

G. Kellogg, S. Mooberry, Chenxiao Da, 2013, Journal of natural products.

Leucinostatins from Ophiocordyceps spp. and Purpureocillium spp. Demonstrate Selective Antiproliferative Effects in Cells Representing the Luminal Androgen Receptor Subtype of Triple Negative Breast Cancer.

R. Cichewicz, S. Mooberry, Yun‐Seo Kil, 2020, Journal of natural products.

Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time.

S. Mooberry, Nicholas F. Dybdal-Hargreaves, A. Risinger, 2015, Anticancer research.

Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris.

Huiyun Liang, R. Cichewicz, T. Grkovic, 2020, Journal of natural products.

Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

Samantha S. Yee, L. Du, Karthik Ramachandran, 2020, Nature Communications.

Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin

A. L. Risinger, S. Mooberry, Nicholas F. Dybdal-Hargreaves, 2017, Oncotarget.

Re-evaluation of the Fijianolide/Laulimalide Chemotype Suggests an Alternate Mechanism of Action for C-15/C-20 Analogs

Tyler A. Johnson, P. Crews, A. L. Risinger, 2022, ACS omega.

The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability.

A. L. Risinger, S. Mooberry, M. Natarajan, 2011, Cancer letters.

Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers.

Lihong Hu, A. L. Risinger, S. Mooberry, 2011, Journal of the American Chemical Society.

Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design

G. Kellogg, S. Mooberry, Chenxiao Da, 2016, Molecular Pharmacology.

Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.

Andrew J. Robles, R. Cichewicz, L. Du, 2017, Journal of natural products.

Synthesis and Biological Evaluations of Electrophilic Steroids Inspired by the Taccalonolides.

Samantha S. Yee, H. Arman, A. L. Risinger, 2020, ACS medicinal chemistry letters.

Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers.

Samantha S. Yee, R. Cichewicz, L. Du, 2019, Journal of natural products.

Synthetic Reactions with Rare Taccalonolides Reveal the Value of C-22,23 Epoxidation for Microtubule Stabilizing Potency

S. Mooberry, Jiangnan Peng, Jing Li, 2014, Journal of medicinal chemistry.

Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency.

F. Gago, J. Díaz, F. Josa-Prado, 2023, European journal of medicinal chemistry.

Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

S. Mooberry, A. Gangjee, S. Choudhary, 2016, Molecules.

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

K. Berg, W. Clarke, Teresa S. Chavera, 2017, eLife.

Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents.

Taylor A. Gentile, E. Hamel, S. Mooberry, 2018, Bioorganic & medicinal chemistry.

Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development

Swati Banerjee, M. Bhat, S. Rogers, 2016, Journal of Cell Science.