Ming Hu

发表

Xiao-Chai-Hu-Tang (XCHT) Intervening Irinotecan's Disposition: The Potential of XCHT in Alleviating Irinotecan-Induced Diarrhea.

S. Basu, Li Li, R. Ghose, 2019, Current cancer drug targets.

Insight into Tartrate Inhibition Patterns in vitro and in vivo Based on Cocrystal Structure with UDP-glucuronosyltransferase 2B15.

W. Xie, Lijun Zhu, M. Hu, 2019, Biochemical pharmacology.

Species and Gender Differences Affect the Metabolism of Emodin via Glucuronidation

Wei Liu, Jiajie Zhang, Zhongqiu Liu, 2010, The AAPS Journal.

Glucuronides Hydrolysis by Intestinal Microbial β-Glucuronidases (GUS) Is Affected by Sampling, Enzyme Preparation, Buffer pH, and Species

Dong Liang, Song Gao, M. Hu, 2021, Pharmaceutics.

Amino acid facilitates absorption of copper in the Caco-2 cell culture model.

Taijun Yin, Song Gao, M. Hu, 2014, Life sciences.

Potential of Herb-Drug / Herb Interactions between Substrates and Inhibitors of UGTs Derived from Herbal Medicines.

M. Hu, Zhongqiu Liu, Jinjun Wu, 2019, Pharmacological research.

Validation of IMP Dehydrogenase Inhibitors in a Mouse Model of Cryptosporidiosis

L. Hedstrom, V. Jala, B. Haribabu, 2013, Antimicrobial Agents and Chemotherapy.

Identification of the position of mono-O-glucuronide of flavones and flavonols by analyzing shift in online UV spectrum (lambdamax) generated from an online diode array detector.

R. Singh, M. Hu, Zhongqiu Liu, 2010, Journal of agricultural and food chemistry.

Validated LC-MS/MS method for the determination of 3-hydroxflavone and its glucuronide in blood and bioequivalent buffers: application to pharmacokinetic, absorption, and metabolism studies.

Taijun Yin, Song Gao, M. Hu, 2013, Journal of pharmaceutical and biomedical analysis.

In vivo pharmacokinetics of hesperidin are affected by treatment with glucosidase-like BglA protein isolated from yeasts.

Yong-mei Li, Xiao-Mian Li, M. Hu, 2008, Journal of agricultural and food chemistry.

Bioavailability challenges associated with development of anti-cancer phenolics.

Song Gao, M. Hu, Ming Hu, 2010, Mini reviews in medicinal chemistry.

Determination of pharmacokinetics of chrysin and its conjugates in wild-type FVB and Bcrp1 knockout mice using a validated LC-MS/MS method.

Taijun Yin, Song Gao, M. Hu, 2015, Journal of agricultural and food chemistry.

Disposition of Flavonoids via Enteric Recycling: Enzyme-Transporter Coupling Affects Metabolism of Biochanin A and Formononetin and Excretion of Their Phase II Conjugates

X. Jia, Huimin Lin, M. Hu, 2004, Journal of Pharmacology and Experimental Therapeutics.

Metabolism of Flavonoids via Enteric Recycling: Role of Intestinal Disposition

Huimin Lin, Jun Chen, Ming Hu, 2003, Journal of Pharmacology and Experimental Therapeutics.

Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice.

R. Singh, Song Gao, M. Hu, 2010, Journal of pharmaceutical and biomedical analysis.

Bioavailability and Pharmacokinetics of Dihydroartemisinin (DHA) and its Analogs—Mechanistic Studies on its ADME

U. Osonwa, M. Hu, Ming Hu, 2018, Current Pharmacology Reports.

Poor oral bioavailability of a promising anticancer agent andrographolide is due to extensive metabolism and efflux by P-glycoprotein.

Juan Zhou, Wei Liu, Zhongqiu Liu, 2011, Journal of pharmaceutical sciences.

First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics.

S. Basu, Shuxing Zhang, Baojian Wu, 2011, Journal of pharmaceutical sciences.

A novel strategy for screening bioavailable quality markers of traditional Chinese medicine by integrating intestinal absorption and network pharmacology: Application to Wu Ji Bai Feng Pill.

D. Yuan, Li Li, Taijun Yin, 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Development and validation of an UPLC-MS/MS method for the quantification of columbin in biological matrices: Applications to absorption, metabolism, and pharmacokinetic studies.

Taijun Yin, Song Gao, Rongjin Sun, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Use of Isoform-Specific UGT Metabolism to Determine and Describe Rates and Profiles of Glucuronidation of Wogonin and Oroxylin A by Human Liver and Intestinal Microsomes

Wei Liu, Qiong Zhou, M. Hu, 2010, Pharmaceutical Research.

Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveal both unique and shared positional preferences.

Juan Zhou, M. Hu, Zhongqiu Liu, 2012, Journal of agricultural and food chemistry.

The Pharmacokinetics of Raloxifene and Its Interaction with Apigenin in Rat

Jing Chen, X. Jia, M. Hu, 2010, Molecules.

Enhancement of Oral Bioavailability of 20(S)-Ginsenoside Rh2 through Improved Understanding of Its Absorption and Efflux Mechanisms

Taijun Yin, Song Gao, M. Hu, 2011, Drug Metabolism and Disposition.

Oral Bioavailability Challenges of Natural Products Used in Cancer Chemoprevention

S. Basu, A. Deb, Song Gao, 2013 .

Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement Magnolia officinalis Extract for Prevention against Oral Carcinoma.

Li Li, R. Singh, Taijun Yin, 2020, Journal of agricultural and food chemistry.

Intestinal Absorption Mechanisms of Prenylated Flavonoids Present in the Heat-Processed Epimedium koreanum Nakai (Yin Yanghuo)

X. Jia, M. Hu, Yan Chen, 2008, Pharmaceutical Research.

Role of Intestinal Hydrolase in the Absorption of Prenylated Flavonoids Present in Yinyanghuo

X. Jia, M. Hu, Yan Chen, 2011, Molecules.

Development of a validated UPLC-MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies.

Menghua Liu, Jie Zhao, Lan Tang, 2017, Biomedical chromatography : BMC.

Temporal Interplay between Efflux Pumps and Target Mutations in Development of Antibiotic Resistance in Escherichia coli

V. Tam, Renu Singh, Michelle C. Swick, 2012, Antimicrobial Agents and Chemotherapy.

Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes.

R. Singh, M. Hu, Zhongqiu Liu, 2010, Molecular pharmaceutics.

Natural polyphenol disposition via coupled metabolic pathways

M. Hu, Zhongqiu Liu, Ming Hu, 2007, Expert opinion on drug metabolism & toxicology.

UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes

Liang Liu, Ying Wang, Zhongqiu Liu, 2015, Drug Metabolism and Disposition.

Uptake of Polymyxin B into Renal Cells

Ming Hu, Vincent H. Tam, V. Tam, 2014, Antimicrobial Agents and Chemotherapy.

In Vitro Assessment and Multicenter Cohort Study of Comparative Nephrotoxicity Rates Associated with Colistimethate versus Polymyxin B Therapy

V. Tam, Kady Phe, Taijun Yin, 2014, Antimicrobial Agents and Chemotherapy.

Characterization of Polymyxin B-Induced Nephrotoxicity: Implications for Dosing Regimen Design

Ming Hu, Vincent H. Tam, L. Truong, 2012, Antimicrobial Agents and Chemotherapy.

Sensitive and robust UPLC-MS/MS method to determine the gender-dependent pharmacokinetics in rats of emodin and its glucuronide.

Wei Liu, Song Gao, Zhongqiu Liu, 2011, Journal of pharmaceutical and biomedical analysis.

A Useful Microsoft Excel Add-in Program for Modeling Steady-state Enzyme Kinetics

Baojian Wu, Rol, Rol, 2012 .

Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt.

Li Li, Lijun Zhu, R. Ghose, 2020, Toxicology and applied pharmacology.

Reductive metabolism of oxymatrine is catalyzed by microsomal CYP3A4

Jian Shi, Lijun Zhu, M. Hu, 2015, Drug design, development and therapy.

Developing an activity and absorption-based quality control platform for Chinese traditional medicine: Application to Zeng-Sheng-Ping(Antitumor B).

Taijun Yin, Song Gao, M. You, 2015, Journal of ethnopharmacology.

Biopharmaceutical and pharmacokinetic characterization of matrine as determined by a sensitive and robust UPLC-MS/MS method.

Taijun Yin, Song Gao, M. You, 2010, Journal of pharmaceutical and biomedical analysis.

Carrier mediated transport of amino acids, small peptides, and their drug analogs

G. Amidon, P. Sinko, Ming Hu, 1987 .

CARRIER MEDIATED TRANSPORT OF AMINO ACIDS, THEIR DRUG ANALOGS*

G. Amidon, P. Sinko, Ming Hu, 1987 .

Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre‐exposure prophylaxis

R. L. Hood, A. Ballerini, A. Grattoni, 2018, Journal of controlled release : official journal of the Controlled Release Society.

Disposition of Flavonoids via Enteric Recycling: Structural Effects and Lack of Correlations between in Vitro and in Situ Metabolic Properties

V. Tam, X. Jia, M. Hu, 2006, Drug Metabolism and Disposition.

Glucuronidation: driving factors and their impact on glucuronide disposition

S. Basu, Jian Shi, R. Singh, 2017, Drug metabolism reviews.

The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells.

Wei Liu, Taijun Yin, Song Gao, 2013, Toxicology letters.

Mechanisms Responsible for Poor Oral Bioavailability of Paeoniflorin: Role of Intestinal Disposition and Interactions with Sinomenine

Liang Liu, Zhongqiu Liu, Ming Hu, 2006, Pharmaceutical Research.

Bioavailability challenges associated with development of saponins as therapeutic and chemopreventive agents.

S. Basu, A. Deb, Song Gao, 2012, Current drug targets.

Metabolic profiles of Xiao Chai Hu Tang in mouse plasma, bile and urine by the UHPLC-ESI-Q-TOF/MS technique.

J. Chen, Shiming Du, Song Gao, 2019, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Mechanisms of Transport of Quinapril in Caco-2 Cell Monolayers: Comparison with Cephalexin

A. Dantzig, R. Stratford, Lijuan Liu, 2004, Pharmaceutical Research.

SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats

Jian Shi, Lijun Zhu, M. Hu, 2016, Drug Metabolism and Disposition.

Comparison of the Transport Characteristics of D- and L-Methionine in a Human Intestinal Epithelial Model (Caco-2) and in a Perfused Rat Intestinal Model

Yanping Zhu, Jiyue Chen, Hua Yang, 2004, Pharmaceutical Research.

Use of the Peptide Carrier System to Improve the Intestinal Absorption of L-α-Methyldopa: Carrier Kinetics, Intestinal Permeabilities, and In Vitro Hydrolysis of Dipeptidyl Derivatives of L-α-Methyldopa

G. Amidon, H. Mosberg, P. Subramanian, 2004, Pharmaceutical Research.

Simultaneous determinations of 17 marker compounds in Xiao-Chai-Hu-Tang by LC-MS/MS: Application to its pharmacokinetic studies in mice.

Li Li, Song Gao, M. Hu, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Challenges and Opportunities with Predicting In Vivo Phase II Metabolism via Glucuronidation From In Vitro Data

Yifan Tu, Shufan Ge, Ming Hu, 2016, Current Pharmacology Reports.

Transport-Glucuronidation Classification System and PBPK Modeling: New Approach To Predict the Impact of Transporters on Disposition of Glucuronides.

Taijun Yin, Song Gao, Yingjie Wei, 2017, Molecular pharmaceutics.

Age-and Region-Dependent Disposition of Raloxifene in Rats

Dong Liang, Song Gao, M. Hu, 2021, Pharmaceutical Research.

Development and validation of ultra-high-performance liquid chromatography-MS method for the determination of raloxifene and its phase II metabolites in plasma: Application to pharmacokinetic studies in rats.

Li Li, Dong Liang, Taijun Yin, 2020, Journal of separation science.

Disposition of naringenin via glucuronidation pathway is affected by compensating efflux transporters of hydrophilic glucuronides.

V. Tam, R. Singh, M. Hu, 2009, Molecular pharmaceutics.

Disposition of Flavonoids via Enteric Recycling: UDP-Glucuronosyltransferase (UGT) 1As Deficiency in Gunn Rats Is Compensated by Increases in UGT2Bs Activities

T. Daidoji, H. Yokota, Taijun Yin, 2009, Journal of Pharmacology and Experimental Therapeutics.

SPECIES- AND DISPOSITION MODEL-DEPENDENT METABOLISM OF RALOXIFENE IN GUT AND LIVER: ROLE OF UGT1A10

Huimin Lin, E. Jeong, Ming Hu, 2005, Drug Metabolism and Disposition.

Disposition Mechanisms of Raloxifene in the Human Intestinal Caco-2 Model

Huimin Lin, M. Hu, E. Jeong, 2004, Journal of Pharmacology and Experimental Therapeutics.

Understanding substrate selectivity of human UDP-glucuronosyltransferases through QSAR modeling and analysis of homologous enzymes

Baojian Wu, Dong Dong, R. Ako, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Regioselective Glucuronidation of Flavonols by Six Human UGT1A Isoforms

Baojian Wu, Beibei Xu, Ming Hu, 2011, Pharmaceutical Research.

Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones.

R. Singh, M. Hu, Zhongqiu Liu, 2009, Molecular pharmaceutics.

Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME.

Wei Zhu, Zhen Yang, K. Kulkarni, 2012, Anti-cancer agents in medicinal chemistry.

The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone.

Juan Zhou, Zhongqiu Liu, Lan Tang, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis

M. You, E. Szabo, R. Lubet, 2013, Molecular carcinogenesis.

Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA.

V. Tam, M. Hu, Xing Liu, 2007, Molecular pharmaceutics.

High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences

Lijun Zhu, M. Hu, Xiao-xiao Qi, 2017, Drug Metabolism and Disposition.

Kinetic characterization of secretory transport of a new ciprofloxacin derivative (CNV97100) across Caco-2 cell monolayers.

Ming Hu, Huimin Lin, Huimin Lin, 2002, Journal of pharmaceutical sciences.

Metabolism of Flavonoids via Enteric Recycling: Mechanistic Studies of Disposition of Apigenin in the Caco-2 Cell Culture Model

Huimin Lin, M. Hu, Jun Chen, 2003, Journal of Pharmacology and Experimental Therapeutics.

Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte‐based UPLC–MS/MS

L. Kwong, R. Dashwood, R. Singh, 2018, Journal of pharmaceutical and biomedical analysis.

UDP-Glucuronosyltransferase (UGT) 1A9-Overexpressing HeLa Cells Is an Appropriate Tool to Delineate the Kinetic Interplay between Breast Cancer Resistance Protein (BRCP) and UGT and to Rapidly Identify the Glucuronide Substrates of BCRP

Baojian Wu, Ming Hu, Wen Jiang, 2012, Drug Metabolism and Disposition.

Potential Beneficial Metabolic Interactions Between Tamoxifen and Isoflavones via Cytochrome P450-mediated Pathways in Female Rat Liver Microsomes

Z. Zhou, Joshua F. Alfaro, M. Hu, 2004, Pharmaceutical Research.

Role of Bacterial Translocation in the Progressive and Delayed Irinotecan Induced Diarrhea.

M. Overman, R. Ghose, Song Gao, 2018 .

Drug Metabolism in Gastrointestinal Tract

R. Singh, Ming Hu, 2011 .

Chapter 11 – Oral Absorption Basics: Pathways and Physicochemical and Biological Factors Affecting Absorption

Jian Shi, Zhongqiu Liu, Jinjun Wu, 2017 .

Oral Absorption Basics: Pathways, Physico-chemical and Biological Factors Affecting Absorption

Zhongqiu Liu, Stephen W. J. Wang, Ming Hu, 2009 .

A positive-negative switching LC-MS/MS method for quantification of fenoldopam and its phase II metabolites: Applications to a pharmacokinetic study in rats.

Dong Liang, Song Gao, M. Hu, 2021, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Characterization of oxygenated metabolites of ginsenoside Rg1 in plasma and urine of rat.

Liang Liu, Lee-Fong Yau, Jing-Rong Wang, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Characterization of oxygenated metabolites of ginsenoside Rb1 in plasma and urine of rat.

Liang Liu, Lee-Fong Yau, Jing-Rong Wang, 2015, Journal of agricultural and food chemistry.

Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer.

M. Hu, Zhongqiu Liu, Jinjun Wu, 2016, Pharmacological research.

Mutual interactions between flavonoids and enzymatic and transporter elements responsible for flavonoid disposition via phase II metabolic pathways.

M. Hu, Wen Jiang, Ming Hu, 2012, RSC advances.

Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications

Xiaoling Li, Ming Hu, 2011 .

Time-dependent expression of leukotriene B4 receptors in rat collagen-induced arthritis.

Yue Gao, M. Hu, Chunguang Han, 2007, Prostaglandins & other lipid mediators.

Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin.

Wei Liu, Zhongqiu Liu, Ling Ye, 2012, Toxicology and applied pharmacology.

Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling

Hongming Zheng, M. Hu, Zhongqiu Liu, 2016, Oncotarget.

Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells.

P. Hu, Liang Liu, Lee-Fong Yau, 2014, Journal of agricultural and food chemistry.

UGT1A1 dysfunction increases liver burden and aggravates hepatocyte damage caused by long-term bilirubin metabolism disorder.

Zhongqiu Liu, Zibo Li, Caiyan Wang, 2021, Biochemical pharmacology.

Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms.

M. Hu, Haiyan Xu, Stephen W. J. Wang, 2007, Molecular pharmaceutics.

Impact of diet on irinotecan toxicity in mice.

M. Ittmann, R. Ghose, Song Gao, 2018, Chemico-biological interactions.

Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity

B. Moorthy, R. Ghose, Song Gao, 2020, Expert opinion on drug metabolism & toxicology.

Development and validation of an UPLC-MS/MS method for the quantification of irinotecan, SN-38 and SN-38 glucuronide in plasma, urine, feces, liver and kidney: Application to a pharmacokinetic study of irinotecan in rats.

S. Basu, Taijun Yin, Song Gao, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

DISPOSITION OF FLAVONOIDS VIA RECYCLING: COMPARISON OF INTESTINAL VERSUS HEPATIC DISPOSITION

V. Tam, X. Jia, Huimin Lin, 2005, Drug Metabolism and Disposition.

Ginsenoside Rb1 directly scavenges hydroxyl radical and hypochlorous acid.

Jianming Lü, Q. Yao, Sarah M. Weakley, 2012, Current pharmaceutical design.

Inhibition of P-Glycoprotein Leads to Improved Oral Bioavailability of Compound K, an Anticancer Metabolite of Red Ginseng Extract Produced by Gut Microflora

Jing-Rong Wang, Taijun Yin, Song Gao, 2012, Drug Metabolism and Disposition.

Transport and Metabolic Characterization of Caco-2 Cells Expressing CYP3A4 and CYP3A4 Plus Oxidoreductase

Shiew-Mei Huang, K. Thummel, B. W. Penman, 1999, Pharmaceutical Research.

In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters

Jian Shi, Zhongqiu Liu, Jinjun Wu, 2016, The AAPS Journal.

Amino Acid Drug Transporters

M. Hu, Z. Qiu, Ming Hu, 2011 .

Liping Wang, Haojia Wang, Ying Wang, 2018, Biopharmaceutics & drug disposition.

Bioavailability of Polyphenols and Flavonoids in the Era of Precision Medicine.

M. Hu, Zhongqiu Liu, Baojian Wu, 2017, Molecular pharmaceutics.

Mechanism of L-α-Methyldopa Transport Through a Monolayer of Polarized Human Intestinal Epithelial Cells (Caco-2)

Ming Hu, Ronald T. Borchardt, R. Borchardt, 1990, Pharmaceutical Research.

In Situ Single-Pass Perfused Rat Intestinal Model for Absorption and Metabolism

Huimin Lin, E. Jeong, Yan Liu, 2004 .

A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies.

V. Tam, Song Gao, D. Chow, 2013, The Journal of antimicrobial chemotherapy.

Pharmaceutical Applications of Cell Culture: An Overview

Ming Hu, Ronald T. Borchardt, Ismael J. Hidalgo, 1991 .

A Useful Microsoft Excel Add-in Program for Pharmacokinetic Analysis

Baojian Wu, Ming Hu, Baojian Wu, 2012 .

Commentary: bioavailability of flavonoids and polyphenols: call to arms.

Ming Hu, Ming Hu, 2007, Molecular pharmaceutics.

Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones.

F. Gonzalez, K. Krausz, M. Hu, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Validated LC-MS/MS method for the determination of maackiain and its sulfate and glucuronide in blood: application to pharmacokinetic and disposition studies.

Taijun Yin, Song Gao, M. Hu, 2011, Journal of pharmaceutical and biomedical analysis.

LC-MS/MS quantification of sulfotransferases is better than conventional immunogenic methods in determining human liver SULT activities: implication in precision medicine

Li-jun Zhu, Ying Wang, Zhongqiu Liu, 2017, Scientific Reports.

Profiles and Gender-Specifics of UDP-Glucuronosyltransferases and Sulfotransferases Expressions in the Major Metabolic Organs of Wild-Type and Efflux Transporter Knockout FVB Mice.

Ying Wang, Zhongqiu Liu, Jiamei Chen, 2017, Molecular pharmaceutics.

Absolute quantification of UGT1A1 in various tissues and cell lines using isotope label-free UPLC-MS/MS method determines its turnover number and correlates with its glucuronidation activities.

Taijun Yin, Song Gao, M. Hu, 2014, Journal of pharmaceutical and biomedical analysis.

A novel local recycling mechanism that enhances enteric bioavailability of flavonoids and prolongs their residence time in the gut.

Qiong Zhou, M. Hu, Zhongqiu Liu, 2012, Molecular pharmaceutics.

Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein

Taijun Yin, Song Gao, Wen Jiang, 2012, Drug Metabolism and Disposition.

Breast Cancer Resistance Protein (BCRP) and Sulfotransferases Contribute Significantly to the Disposition of Genistein in Mouse Intestine

M. Hu, Haiyan Xu, Stephen W. J. Wang, 2010, The AAPS Journal.

Variable isoflavone content of red clover products affects intestinal disposition of biochanin A, formononetin, genistein, and daidzein.

M. Hu, Yan Chen, Stephen W. J. Wang, 2008, Journal of alternative and complementary medicine.

Coupling of conjugating enzymes and efflux transporters: impact on bioavailability and drug interactions.

X. Jia, Jun Chen, E. Jeong, 2005, Current drug metabolism.

Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin Glucuronides

Ying Wang, Zhongqiu Liu, Jinjun Wu, 2017, Pharmaceutical Research.

An update on polyphenol disposition via coupled metabolic pathways

Liping Wang, M. Hu, Zhongqiu Liu, 2019, Expert opinion on drug metabolism & toxicology.

Pharmacokinetic Characterization and Bioavailability Barrier for the Key Active Components of Botanical Drug Antitumor B (ATB) in Mice for Chemoprevention of Oral Cancer.

Peiying Yang, R. Singh, Taijun Yin, 2021, Journal of natural products.

Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Determine the Disposition of Esculetin-7-O-Glucuronide and 4-Methylesculetin-7-O-Glucuronide

Guangkuo Luo, X. Ou, Yushan Xie, 2019, Drug Metabolism and Disposition.

Species‐ and gender‐dependent differences in the glucuronidation of a flavonoid glucoside and its aglycone determined using expressed UGT enzymes and microsomes

Liping Wang, Lijun Zhu, M. Hu, 2015, Biopharmaceutics & drug disposition.

A combined strategy of mass fragmentation, post-column cobalt complexation and shift in ultraviolet absorption spectra to determine the uridine 5'-diphospho-glucuronosyltransferase metabolism profiling of flavones after oral administration of a flavone mixture in rats.

Liping Wang, Lijun Zhu, M. Hu, 2015, Journal of chromatography. A.

Disposition of formononetin via enteric recycling: metabolism and excretion in mouse intestinal perfusion and Caco-2 cell models.

X. Jia, E. Jeong, Ming Hu, 2005, Molecular pharmaceutics.

Protective Effects of Kojic Acid on the Periphery Blood and Survival of Beagle Dogs after Exposure to a Lethal Dose of Gamma Radiation

L. Du, Peng Li, Chao Liu, 2014, Radiation research.

Development and validation of a sensitive LC–MS/MS method for simultaneous determination of eight tyrosine kinase inhibitors and its application in mice pharmacokinetic studies

Yifan Tu, Taijun Yin, Song Gao, 2018, Journal of pharmaceutical and biomedical analysis.

Mutual regioselective inhibition of human UGT1A1-mediated glucuronidation of four flavonoids.

Song Gao, M. Hu, Baojian Wu, 2013, Molecular pharmaceutics.

Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis.

S. Basu, Baojian Wu, S. Meng, 2011, Current drug metabolism.

Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids.

R. Singh, M. Hu, Baojian Wu, 2011, Journal of agricultural and food chemistry.

Design and Synthesis of a Novel NIR Celecoxib-Based Fluorescent Probe for Cyclooxygenase-2 Targeted Bioimaging in Tumor Cells

Zuoxu Xie, Li Li, Taijun Yin, 2020, Molecules.

Highly variable contents of phenolics in St. John's Wort products affect their transport in the human intestinal Caco-2 cell model: pharmaceutical and biopharmaceutical rationale for product standardization.

Taijun Yin, Song Gao, Wen Jiang, 2010, Journal of agricultural and food chemistry.

Factors Influencing Oral Bioavailability of Thai Mango Seed Kernel Extract and Its Key Phenolic Principles

P. Pithayanukul, Taijun Yin, M. Hu, 2015, Molecules.

Inhibition of Human UGT1A1-Mediated Bilirubin Glucuronidation by Polyphenolic Acids Impact Safety of Popular Salvianolic Acid A/B-Containing Drugs and Herbal Products.

Weimin Cai, Xiaoming Xin, M. Hu, 2017, Molecular pharmaceutics.

Metabolic Disposition of Luteolin Is Mediated by the Interplay of UDP-Glucuronosyltransferases and Catechol-O-Methyltransferases in Rats

Liping Wang, Zhongqiu Liu, Linlin Lu, 2017, Drug Metabolism and Disposition.

Chronic Alcohol Consumption Increased Bile Acid Levels in Enterohepatic Circulation and Reduced Efficacy of Irinotecan.

M. Hu, Zhongqiu Liu, Lingzhi Gong, 2020, Alcohol and alcoholism.

Disposition of flavonoids via recycling: Direct biliary excretion of enterically or extrahepatically derived flavonoid glucuronides.

S. Basu, Taijun Yin, Song Gao, 2016, Molecular nutrition & food research.

Sulfation of selected mono‐hydroxyflavones by sulfotransferases in vitro: a species and gender comparison

Ming Hu, Lan Tang, Ling Ye, 2011, The Journal of pharmacy and pharmacology.

Functional and Molecular Characterization of Rat Intestinal Prolidase

Lixing Zheng, Ming Hu, Z. Cheng, 2003, Pediatric Research.

Disordered farnesoid X receptor signaling is associated with liver carcinogenesis in Abcb11‐deficient mice

Liping Wang, M. Hu, Zhongqiu Liu, 2021, The Journal of pathology.

A validated liquid chromatography-tandem mass spectrometry method for the determination of methyl gallate and pentagalloyl glucopyranose: application to pharmacokinetic studies.

P. Pithayanukul, Song Gao, M. Hu, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Use of Caco-2 Cell Monolayers to Study Drug Absorption and Metabolism

Huimin Lin, Jie Ling, Jun Chen, 2004 .

Tissue Distribution and Gender-Specific Protein Expression of Cytochrome P450 in five Mouse Genotypes with a Background of FVB

Lijun Zhu, M. Hu, Xiao-xiao Qi, 2018, Pharmaceutical Research.

In vitro glucuronidation of methyl gallate and pentagalloyl glucopyranose by liver microsomes.

P. Pithayanukul, Song Gao, M. Hu, 2016, Drug metabolism and pharmacokinetics.

Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo

Yifan Tu, Y. Rong, Taijun Yin, 2020, Archives of Toxicology.

Development of Caco-2 Cells Expressing High Levels of cDNA-Derived Cytochrome P4503A4

B. W. Penman, C. Crespi, Ming Hu, 1996, Pharmaceutical Research.

Disposition of Flavonoids for Personal Intake

Zhongqiu Liu, Jiamei Chen, Linlin Lu, 2017, Current Pharmacology Reports.

Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids

Liping Wang, Ying Wang, Zhongqiu Liu, 2015, The AAPS Journal.

Revolving door action of breast cancer resistance protein (BCRP) facilitates or controls the efflux of flavone glucuronides from UGT1A9-overexpressing HeLa cells.

S. Basu, X. Jia, Taijun Yin, 2013, Molecular pharmaceutics.

Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model

Huimin Lin, M. Hu, Jun Chen, 2005, Cancer Chemotherapy and Pharmacology.

Pharmacokinetics and Renal Disposition of Polymyxin B in an Animal Model

V. Tam, Kamilia Abdelraouf, K. R. Ledesma, 2012, Antimicrobial Agents and Chemotherapy.

In Vitro Potency of Various Polymyxin B Components

V. Tam, K. R. Ledesma, Henry Cao, 2011, Antimicrobial Agents and Chemotherapy.

Quality, labeling accuracy, and cost comparison of purified soy isoflavonoid products.

M. Hu, Jun Chen, R. Chua, 2004, Journal of alternative and complementary medicine.

Effects of estrogen and estrus cycle on pharmacokinetics, absorption, and disposition of genistein in female Sprague-Dawley rats.

T. Niu, Zhen Yang, K. Kulkarni, 2012, Journal of agricultural and food chemistry.

[Molecular cloning, tissue distribution and expression in engineered cells of human orphan receptor GPR81].

Yue Gao, M. Hu, Yong-xue Liu, 2006, Sheng wu gong cheng xue bao = Chinese journal of biotechnology.

Magnolia extract is effective for the chemoprevention of oral cancer through its ability to inhibit mitochondrial respiration at complex I

M. You, K. Schmainda, S. Shin, 2020, Cell Communication and Signaling.

An UPLC-MS/MS method for quantifying tetrandrine and its metabolite berbamine in human blood: Application to a human pharmacokinetic study.

Meiling Zhu, Song Gao, Chenning Zhang, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS.

Ke Wang, Haiyan Xu, Zhonghua Zhao, 2009, Journal of pharmaceutical and biomedical analysis.

Development and validation of an LC-MS/MS method for the quantification of flavonoid glucuronides (wogonoside, baicalin, and apigenin-glucuronide) in the bile and blood samples: application to a portal vein infusion study.

Lei Zhou, Li Li, Yifan Tu, 2020, Analytical biochemistry.

Accurate Prediction of Glucuronidation of Structurally Diverse Phenolics by Human UGT1A9 Using Combined Experimental and In Silico Approaches

Shuxing Zhang, Baojian Wu, Ming Hu, 2012, Pharmaceutical Research.

A randomized, double-blind, placebo-controlled, single and multiple ascending dose Phase 1 study to determine the safety, pharmacokinetics and food and faecal microbiome effects of ibezapolstat administered orally to healthy subjects

K. Garey, M. Alam, M. Ducharme, 2020, The Journal of antimicrobial chemotherapy.

Development and validation of a highly sensitive UPLC-MS/MS method for simultaneous determination of aconitine, mesaconitine, hypaconitine, and five of their metabolites in rat blood and its application to a pharmacokinetics study of aconitine, mesaconitine, and hypaconitine

W. Liu, Song Gao, M. Hu, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

Bioactivity and Bioavailability of Ginsenosides are Dependent on the Glycosidase Activities of the A/J Mouse Intestinal Microbiome Defined by Pyrosequencing

R. Gibbs, J. Petrosino, Taijun Yin, 2013, Pharmaceutical Research.

Evaluation of 3,3',4'-trihydroxyflavone and 3,6,4'-trihydroxyflavone (4'-O-glucuronidation) as the in vitro functional markers for hepatic UGT1A1.

Shuxing Zhang, Baojian Wu, Ming Hu, 2011, Molecular pharmaceutics.

Quantitation of celecoxib and four of its metabolites in rat blood by UPLC-MS/MS clarifies their blood distribution patterns and provides more accurate pharmacokinetics profiles.

Song Gao, Yong Ma, Ming Hu, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Sulfotransferases and Breast Cancer Resistance Protein Determine the Disposition of Calycosin in Vitro and in Vivo.

Hongming Zheng, Lijun Zhu, M. Hu, 2017, Molecular pharmaceutics.

Determination of 7α-OH cholesterol by LC-MS/MS: Application in assessing the activity of CYP7A1 in cholestatic minipigs.

D. Burrin, Yifan Tu, Taijun Yin, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies.

J. Morrow, Shuxing Zhang, R. Singh, 2012, Molecular pharmaceutics.

Three-Dimensional Quantitative Structure-Activity Relationship Studies on UGT1A9-Mediated 3-O-Glucuronidation of Natural Flavonols Using a Pharmacophore-Based Comparative Molecular Field Analysis Model

J. Morrow, Shuxing Zhang, R. Singh, 2011, Journal of Pharmacology and Experimental Therapeutics.

[Absorption characteristics of ginsenoside Rb2 in Caco-2 cell monolayer].

Zhongqiu Liu, Jie Zhao, Cai-hua Yang, 2009, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.

Lispro Insulin: Adsorption and Stability in Selected Intravenous Devices

R. Campbell, M. Hu, J.C.C. Ung, 1999, The Diabetes educator.

Establishment and use of new MDCK II cells overexpressing both UGT1A1 and MRP2 to characterize flavonoid metabolism via the glucuronidation pathway.

Taijun Yin, Song Gao, Guangyi Yang, 2016, Molecular Nutrition & Food Research.

A New Strategy to Rapidly Evaluate Kinetics of Glucuronide Efflux by Breast Cancer Resistance Protein (BCRP/ABCG2)

Taijun Yin, Song Gao, Baojian Wu, 2012, Pharmaceutical Research.

Breast Cancer Resistance Protein-Mediated Efflux of Luteolin Glucuronides in HeLa Cells Overexpressing UDP-Glucuronosyltransferase 1A9

Zhongqiu Liu, Wen Jiang, Lan Tang, 2014, Pharmaceutical Research.

Quantitative prediction of glucuronidation in humans using the in vitro- in vivo extrapolation approach.

Shuxing Zhang, Baojian Wu, Dong Dong, 2013, Current topics in medicinal chemistry.

Acute changes in colonic PGE2 levels as a biomarker of efficacy after treatment of the Pirc (F344/NTac-Apc am1137) rat with celecoxib

Li Li, Taijun Yin, Song Gao, 2019, Inflammation Research.

Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats

V. Tam, R. Singh, Yifan Tu, 2021, eLife.

Simultaneous determination of tilianin and its metabolites in mice using ultra-high-performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study.

Liping Wang, Zhongqiu Liu, Qiang Li, 2018, Biomedical chromatography : BMC.

Typical Calibration Curve for Quantitation of Ginsenosides in Incubated Samples of NS-TG , NS-PPT , and NS-PPD

P. Hu, Liang Liu, Lee-Fong Yau, 2014 .

[Absorption and metabolism of flavonoids in Herba Epimedii via rat intestinal perfusion model].

X. Jia, Yan Chen, Xiaobin Tan, 2009, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.

Flavonoids Interference in Common Protein Assays: Effect of Position and Degree of Hydroxyl Substitution.

R. Singh, M. Hu, R. Lu, 2020, Analytical biochemistry.

Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling

M. Hu, Baojian Wu, Dong Dong, 2012, Drug metabolism reviews.

Mechanism and Kinetics of Transcellular Transport of a New β-Lactam Antibiotic Loracarbef Across an Intestinal Epithelial Membrane Model System (Caco-2)

A. Dantzig, Yanping Zhu, Jiyue Chen, 2004, Pharmaceutical Research.

Severely Impaired and Dysregulated Cytochrome P450 Expression and Activities in Hepatocellular Carcinoma: Implications for Personalized Treatment in Patients

Jian Shi, Ying Wang, Zhongqiu Liu, 2015, Molecular Cancer Therapeutics.

Response to Letter to the Editor on “Breast Cancer Resistance Protein (ABCG2) Determines Distribution of Genistein Phase II Metabolites: Reevaluation of the Roles of ABCG2 in the Disposition of Genistein”

Taijun Yin, Song Gao, M. Hu, 2012, Drug Metabolism and Disposition.

Significantly Decreased and More Variable Expression of Major CYPs and UGTs in Liver Microsomes Prepared from HBV-Positive Human Hepatocellular Carcinoma and Matched Pericarcinomatous Tissues Determined Using an Isotope Label-free UPLC-MS/MS Method

Jian Shi, Song Gao, Ying Wang, 2015, Pharmaceutical Research.

Metabolism of Phenolic Compounds in LPS-stimulated Raw264.7 Cells Can Impact Their Anti-inflammatory efficacy: Indication of Hesperetin.

Taijun Yin, Song Gao, Haoqing Chen, 2018, Journal of agricultural and food chemistry.

Gender-dependent differences in uridine 5'-diphospho-glucuronosyltransferase have implications in metabolism and clearance of xenobiotics

Wei Liu, K. Kulkarni, Ming Hu, 2013, Expert opinion on drug metabolism & toxicology.

Disposition of flavonoids impacts their efficacy and safety.

Rongjin Sun, Yong Ma, Min Zeng, 2015, Current drug metabolism.

Development and validation of an UPLC-MS/MS method for the quantification of ethoxzolamide in plasma and bioequivalent buffers: Applications to absorption, brain distribution, and pharmacokinetic studies

P. Dash, Jing Zhao, Taijun Yin, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Curcumin Affects Phase II Disposition of Resveratrol Through Inhibiting Efflux Transporters MRP2 and BCRP

Taijun Yin, Song Gao, Shufan Ge, 2016, Pharmaceutical Research.

High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences

Ying Wang, Zhongqiu Liu, Jiamei Chen, 2017, Drug Metabolism and Disposition.

SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats

Jian Shi, Ying Wang, Zhongqiu Liu, 2016, Drug Metabolism and Disposition.

Interplay of Efflux Transporters with Glucuronidation and Its Impact on Subcellular Aglycone and Glucuronide Disposition: A Case Study with Kaempferol.

Liping Wang, Hongming Zheng, W. Qu, 2018, Molecular pharmaceutics.