S. Lefèbvre

发表

Solution Structure of Substrate-based Ligands When Bound to Hepatitis C Virus NS3 Protease Domain*

D. Lamarre, S. LaPlante, G. Kukolj, 1999, The Journal of Biological Chemistry.

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.

S. LaPlante, M. Bös, J. Gillard, 2004, Bioorganic & medicinal chemistry letters.

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors.

C. Maroun, S. Leit, M. Fournel, 2009, Bioorganic & medicinal chemistry letters.

Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy.

S. LaPlante, J. Gillard, A. Jakalian, 2004, Angewandte Chemie.

Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases.

M. Robert, A. Macleod, A. Vaisburg, 2008, Bioorganic & medicinal chemistry letters.

Binding Site Characterization and Resistance to a Class of Non-nucleoside Inhibitors of the Hepatitis C Virus NS5B Polymerase*

Louise Thauvette, Graham A. McGibbon, P. Beaulieu, 2005, Journal of Biological Chemistry.

Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.

D. Lamarre, S. LaPlante, P. Beaulieu, 2004, Nucleic acids research.

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

Sylvain Lefebvre, Daniel Delorme, A. Kalita, 2008, Molecular Cancer Therapeutics.

Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors.

Eric Therrien, M. Fournel, Zuomei Li, 2015, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of lysine derived sulfamides as histone deacetylase inhibitors.

Alain Ajamian, Sylvain Lefebvre, Alina Nicolescu, 2009, Bioorganic & medicinal chemistry letters.

Sulfamides as novel histone deacetylase inhibitors.

Alain Ajamian, Sylvain Lefebvre, Alina Nicolescu, 2009, Bioorganic & medicinal chemistry letters.

Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity.

O. Moradei, S. Leit, S. Fréchette, 2007, Journal of medicinal chemistry.

N-(3-fluoro-4-(2-arylthieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.

M. Robert, Nancy Z. Zhou, S. Raeppel, 2009, Bioorganic & medicinal chemistry letters.

N-(4-(6,7-Disubstituted-quinolin-4-yloxy)-3-fluorophenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides: a novel series of dual c-Met/VEGFR2 receptor tyrosine kinase inhibitors.

Sylvain Lefebvre, M. Robert, Nancy Z. Zhou, 2009, Bioorganic & medicinal chemistry letters.

MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

A. Kalita, M. Robert, A. Macleod, 2008, Molecular Cancer Therapeutics.