W. Müller

H. Möller, R. Ihl, S. Gauthier, 2019, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

δ‐Aminolevulinic acid: Influences on synaptic GABA receptor binding may explain CNS symptoms of porphyria

S. Snyder, W. Müller, S. Snyder, 1977, Annals of neurology.

beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic acid.

W. Schunack, W. Wenning, W. Müller, 1983, Journal of Medicinal Chemistry.

β‐carbolines as benzodiazepine receptor ligands II: Synthesis and benzodiazepine receptor affinity of β‐carboline‐3‐carboxylic acid amides

W. Schunack, W. Müller, K. P. Lippke, 1985 .

On the neuropharmacology of Harmane and other β-carbolines

H. Rommelspacher, W. Müller, H. Borbe, 1981, Pharmacology Biochemistry and Behavior.

Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels

N. Klugbauer, M. Nöldner, W. Müller, 2013, PloS one.

Hyperforin activates nonselective cation channels (NSCCs)

A. Singer, W. Müller, K. Treiber, 2005, British journal of pharmacology.

Platelet and lymphocyte free intracellular calcium in affective disorders

D. Riemann, W. E. Müller, H. Gann, 2005, European Archives of Psychiatry and Clinical Neuroscience.

Hans Förstl, W. Müller, A. Eckert, 2005, European Archives of Psychiatry and Clinical Neuroscience.

Preparative and analytical separation of the zopiclone enantiomers and determination of their affinity to the benzodiazepine receptor binding site.

G. Hempel, G. Blaschke, W. Müller, 1993, Chirality.

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

M. Jendrach, U. Brandt, A. Eckert, 2009, Neurobiology of Aging.

Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity.

U. Hafner, M. Rolli, C. Schäfer, 1997, Pharmacopsychiatry.

Flavonoids and the aging brain.

S. Schaffer, W. Müller, G. Eckert, 2005, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Binding of coumarin anticoagulants to human and bovine serum albumin. Circular dichroism studies.

N. Brown, W. Müller, 1978, Pharmacology.

Plant derived omega-3-fatty acids protect mitochondrial function in the brain.

M. Nöldner, M. Schubert-Zsilavecz, M. Wurglics, 2010, Pharmacological research.

The FASEB Journal • Research Communication Hyperforin—a key constituent of St. John’s wort specifically activates TRPC6 channels

M. Gollasch, K. Essin, C. Harteneck, 2022 .

Current St John's wort research from mode of action to clinical efficacy.

W. Müller, W. Müller, 2003, Pharmacological research.

Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase.

Oliver Werz, Dieter Steinhilber, O. Werz, 2002, Biochemical pharmacology.

Recent Advances in Nutritional Sciences Tocotrienols: Constitutional Effects in Aging and Disease 1

S. Schaffer, G. Eckert, W. Müller, 2005 .

Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract.

U. Hafner, M. Rolli, M. Wonnemann, 1998, Pharmacopsychiatry.

Understanding local Mediterranean diets: a multidisciplinary pharmacological and ethnobotanical approach.

Wieland Peschel, L. Sidossis, Y. Manios, 2005, Pharmacological research.

Specific TRPC6 Channel Activation, a Novel Approach to Stimulate Keratinocyte Differentiation*

Walter E. Müller, M. Gollasch, K. Essin, 2008, Journal of Biological Chemistry.

Local mediterranean food plants and nutraceuticals.

M. Heinrich, W. Müller, C. Galli, 2006 .

Antioxidant properties of Mediterranean food plant extracts: geographical differences.

S. Schaffer, W. Müller, G. Eckert, 2005, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

Better tolerability of St. John's wort extract WS 5570 compared to treatment with SSRIs: a reanalysis of data from controlled clinical trials in acute major depression

H. Möller, H. Volz, S. Kasper, 2010, International clinical psychopharmacology.

Effects of Hypericum Extract on the Expression of Serotonin Receptors

R. Rossol, W. Müller, 1994 .

Stabilization of Mitochondrial Membrane Potential and Improvement of Neuronal Energy Metabolism by Ginkgo Biloba Extract EGb 761

Anne Eckert, Susanne Hauptmann, A. Eckert, 2005, Annals of the New York Academy of Sciences.

Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial

H. Möller, H. Volz, S. Kasper, 2010, International clinical psychopharmacology.

From Mitochondrial Dysfunction to Amyloid Beta Formation: Novel Insights into the Pathogenesis of Alzheimer’s Disease

A. Reichert, K. Leuner, W. Müller, 2012, Molecular Neurobiology.

Neurotoxic Mechanisms Caused by the Alzheimer's Disease-linked Swedish Amyloid Precursor Protein Mutation

C. Haass, A. Eckert, U. Keil, 2003, Journal of Biological Chemistry.

The Benzodiazepine Receptor

W. Müller, 1981 .

Benzodiazepine antagonism by harmane and other β-carbolines in vitro and in vivo

H. Rommelspacher, W. Müller, H. Borbe, 1981 .

Inhibition of benzodiazepine receptor binding by several tryptophan ad indole derivatives.

W. Müller, A. E. Stillbauer, K. Fehske, 1981, Biochemical pharmacology.

Muscarinic cholinergic receptors on intact human lymphocytes properties and subclass characterization

W. Müller, H. Moises, B. Bering, 1987, Biological Psychiatry.

S. Leutner, W. Müller, A. Eckert, 2000, Neurobiology of Aging.

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation.

R. Palmiter, A. Occhipinti, A. Reichert, 2012, Antioxidants & redox signaling.

Oligomeric and fibrillar species of β-amyloid (Aβ42) both impair mitochondrial function in P301L tau transgenic mice

M. Fändrich, J. Götz, U. Brandt, 2008, Journal of Molecular Medicine.

Soluble Beta-Amyloid Leads to Mitochondrial Defects in Amyloid Precursor Protein and Tau Transgenic Mice

J. Götz, W. Müller, F. Müller-Spahn, 2008, Neurodegenerative Diseases.

Mitochondrial dysfunction: the first domino in brain aging and Alzheimer's disease?

Reham M. Abdel-Kader, A. Eckert, S. Hauptmann, 2007, Antioxidants & redox signaling.

Enhanced ROS-generation in lymphocytes from Alzheimer's patients.

L. Frölich, K. Maurer, S. Leutner, 2005, Pharmacopsychiatry.

Proteomic and Functional Analyses Reveal a Mitochondrial Dysfunction in P301L Tau Transgenic Mice*

R. Ravid, P. Rizzu, J. Götz, 2005, Journal of Biological Chemistry.

ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain

S. Leutner, W. Müller, A. Eckert, 2001, Journal of Neural Transmission.

Parkinson Phenotype in Aged PINK1-Deficient Mice Is Accompanied by Progressive Mitochondrial Dysfunction in Absence of Neurodegeneration

R. Nussbaum, A. Reichert, A. Kurz, 2009, PloS one.

Increased Apoptotic Cell Death in Sporadic and Genetic Alzheimer's Disease

Anne Eckert, Walter E. Müller, A. Eckert, 2003, Annals of the New York Academy of Sciences.

Metabolism of Boswellic Acids in Vitro and in Vivo

M. Schubert-Zsilavecz, M. Karas, U. Bahr, 2008, Drug Metabolism and Disposition.

Characterization of an important drug binding area on human serum albumin including the high-affinity binding sites of warfarin and azapropazone.

W. Müller, K. Fehske, U. Wollert, 1982, Molecular pharmacology.

The location of drug binding sites in human serum albumin.

W. Müller, K. Fehske, U. Wollert, 1981, Biochemical pharmacology.

A highly reactive tyrosine residue as part of the indole and benzodiazepine binding site of human serum albumin.

K. Fehske, U. Wollert, W. Müller, 1979, Biochimica et biophysica acta.

The lone tryptophan residue of human serum albumin as part of the specific warfarin binding site. Binding of dicoumarol to the warfarin, indole and benzodiazepine binding sites.

W. Müller, K. Fehske, U. Wollert, 1979, Molecular pharmacology.

Triterpenes promote keratinocyte differentiation in vitro, ex vivo and in vivo: a role for the transient receptor potential canonical (subtype) 6.

D. Nashan, W. Müller, Stefan F Martin, 2010, The Journal of investigative dermatology.

Personality factors predisposing to depression correlate significantly negatively with M1-muscarinic and β-adrenergic receptor densities on blood cells

W. Müller, H. Moises, Birgit Beringe, 2004, European archives of psychiatry and neurological sciences.

The influence of carbamazepine on sleep-EEG and the clonidine test in healthy subjects: Results of a preliminary study

D. Riemann, F. Hohagen, M. Berger, 1994, Biological Psychiatry.

Cholinergic REM induction test: muscarinic supersensitivity underlies polysomnographic findings in both depression and schizophrenia.

M. Bohus, D. Riemann, F. Hohagen, 1994, Journal of Psychiatric Research.

Influence of the cholinesterase inhibitor galanthamine hydrobromide on normal sleep

J. Aldenhoff, D. Riemann, H. Gann, 1994, Psychiatry Research.

48-hour rapid cycling: results of psychopathometric, polysomnographic, PET imaging and neuro-endocrine longitudinal investigations in a single case.

D. Riemann, F. Hohagen, M. Berger, 1993, Journal of affective disorders.

The sleep structure of patients with anxiety disorders in comparison to that of healthy controls and depressive patients under baseline conditions and after cholinergic stimulation.

D. Riemann, F. Hohagen, M. Berger, 1992, Journal of affective disorders.

Introduction

W. Müller, 1991 .

Experimental Approaches for Testing the Cholinergic-Noradrenergic Imbalance Hypothesis of Affective Disorders

D. Riemann, M. Berger, P. Fleckenstein, 1990 .

Relation Between m-Cholinoceptor Density on Human Blood Cells and Psychological Predisposition Factors for Depression

H. Moises, B. Bering, W. Müller, 1989 .

Effects of subchronic administration of pyritinol on receptor deficits and phosphatidylinositol metabolism in the brain of the aged mouse

S. Cohen, H. Hartmann, W. Müller, 1993, Neuropharmacology.

Age-Associated Changes of Muscarinic Cholinergic and N -Methyl-D-Aspartate Receptors in the Mouse Brain: Partial Reconstitution by Phosphatidylserine Treatment

S. Cohen, H. Hartmann, T. Schubert, 1992 .

W. Müller, T. Schubert, L. Stoll, 1992, Neurobiology of Aging.

In vivo exposure to lead does not influence muscarinic receptors in the frontal cortex of the mouse brain.

S. Schulte, K. Friedberg, W. Müller, 1994, Toxicology.

Hyperforin - Antidepressant Activity by a Novel Mechanism of Action

W. Müller, M. Wonnemann, A. Singer, 2001, Pharmacopsychiatry.

Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis

Ling Li, G. Eckert, W. Wood, 2014, Journal of neurochemistry.

Modulation of Pgp function by boswellic acids.

M. Schubert-Zsilavecz, M. Abdel-Tawab, C. Weber, 2006, Planta medica.

The Modification of the Lone Tryptophan Residue in Human Serum Albumin by 2-Hydroxy-5-nitrobenzyl Bromide

K. Fehske, U. Wollert, W. Müller, 1978, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

Mitochondrial dysfunction: cause and consequence of Alzheimer's disease.

G. Eckert, I. Denzer, Carola Stockburger, 2014, Progress in molecular biology and translational science.

Reduced TRPC Channel Expression in Psoriatic Keratinocytes Is Associated with Impaired Differentiation and Enhanced Proliferation

Wolf-Henning Boehncke, Walter E. Müller, C. Harteneck, 2011, PloS one.

Ginkgo biloba extract (EGb761) influences monoaminergic neurotransmission via inhibition of NE uptake, but not MAO activity after chronic treatment.

K. Leuner, C. Fehske, W. Müller, 2009, Pharmacological research.

Forum Review Mitochondrial Dysfunction: The First Domino in Brain Aging and Alzheimer's Disease?

Reham M. Abdel-Kader, A. Eckert, S. Hauptmann, 2007 .

Mitochondrial dysfunction in sporadic and genetic Alzheimer's disease

W. Müller, A. Eckert, S. Hauptmann, 2006, Experimental Gerontology.

Membrane disordering effects of beta-amyloid peptides.

G. Eckert, W. Wood, W. Müller, 2005, Sub-cellular biochemistry.

Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease.

Anne Eckert, Walter E. Müller, A. Eckert, 2003, Biochemical pharmacology.

Alzheimer's Disease-like Alterations in Peripheral Cells from Presenilin-1 Transgenic Mice

C. Luckhaus, S. Leutner, C. Czech, 2001, Neurobiology of Disease.

Simple 2,4-Diacylphloroglucinols as Classic Transient Receptor Potential-6 Activators—Identification of a Novel Pharmacophore

G. Schneider, M. Gollasch, C. Harteneck, 2010, Molecular Pharmacology.

Therapeutic concentrations of lithium and carbamazepine inhibit cGMP accumulation in human lymphocytes

T. Schubert, L. Stoll, W. Müller, 1991, Psychopharmacology.

Muscarinic cholinergic receptor binding in bovine retina

W. Müller, 1977, Neuroscience Letters.

In vitro and in vivo effects of lead on specific 3H-PN200-110 binding to dihydropyridine receptors in the frontal cortex of the mouse brain.

S. Schulte, K. Friedberg, W. Müller, 1995, Toxicology.

Effects of EGb 761® Ginkgo biloba Extract on Mitochondrial Function and Oxidative Stress

S. Leutner, A. Eckert, U. Keil, 2003, Pharmacopsychiatry.

Plant foods and brain aging: a critical appraisal.

S. Schaffer, W. Müller, G. Eckert, 2006, Forum of nutrition.

Amyloid beta-protein interactions with membranes and cholesterol: causes or casualties of Alzheimer's disease.

U. Igbavboa, W. Müller, G. Eckert, 2003, Biochimica et biophysica acta.

A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC–MS/MS

D. Volmer, W. G. Wood, W. Müller, 2010, Analytical and bioanalytical chemistry.

Peripheral Mitochondrial Dysfunction in Alzheimer’s Disease: Focus on Lymphocytes

D. Prvulovic, J. Pantel, E. Savaskan, 2012, Molecular Neurobiology.

Chronic Administration of Statins Alters Multiple Gene Expression Patterns in Mouse Cerebral Cortex

M. Schubert-Zsilavecz, M. Karas, W. G. Wood, 2005, Journal of Pharmacology and Experimental Therapeutics.

Isoprenoid quantitation in human brain tissue: a validated HPLC–fluorescence detection method for endogenous farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP)

D. Volmer, G. Eckert, Gero P. Hooff, 2008, Analytical and bioanalytical chemistry.

Cholesterol-A janus-faced molecule in the central nervous system

U. Igbavboa, G. Eckert, W. Wood, 2007 .

Neuropsychiatric Drugs Against COVID-19: What is the Clinical Evidence?

P. Riederer, J. Mueller, W. Müller, 2022, Pharmacopsychiatry.

Serotonin-selektive Antidepressiva(SSRI, DSA)

H. Möller, S. Kasper, R. Engel, 2002 .

Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer’s disease

K. Maurer, F. Müller-Spahn, A. Eckert, 2006, Journal of Neural Transmission.

Elevated Levels of Fragmented DNA Nucleosomes in Native and Activated Lymphocytes Indicate an Enhanced Sensitivity to Apoptosis in Sporadic Alzheimer’s Disease

M. Hennerici, R. Zerfass, W. Müller, 2001, Dementia and Geriatric Cognitive Disorders.

S. Leutner, W. Müller, A. Eckert, 2001, Journal of Neural Transmission.

S. Leutner, W. Müller, A. Eckert, 2001 .

Lymphocytes as cell model to study apoptosis in Alzheimer's disease: vulnerability to programmed cell death appears to be altered.

C. Cotman, M. Hennerici, R. Zerfass, 1998, Journal of neural transmission. Supplementum.

Increased T-cell Reactivity and Elevated Levels of CD8+ Memory T-cells in Alzheimer’s Disease-patients and T-cell Hyporeactivity in an Alzheimer’s Disease-mouse Model: Implications for Immunotherapy

L. Frölich, K. Maurer, W. Müller, 2007, NeuroMolecular Medicine.

A New Link to Mitochondrial Impairment in Tauopathies

A. Reichert, M. Jendrach, A. Eckert, 2012, Molecular Neurobiology.

Hypericum perforatum L (St John's wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex

J. Kehr, W. Müller, P. Weikop, 2004, British journal of pharmacology.

Characterization of a common binding site for basic drugs on human α2-acid glycoprotein (orosomucoid)

W. Müller, A. E. Stillbauer, W. Müller, 1983, Naunyn-Schmiedeberg's Archives of Pharmacology.

Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer’s disease brain

N. Cairns, S. Leutner, A. Eckert, 2004, Journal of Neural Transmission.

The Potent Free Radical Scavenger α‐Lipoic Acid Improves Cognition in Rodents

S. Stoll, A. Rostock, R. Bartsch, 1994 .

The potent free radical scavenger α-lipoic acid improves memory in aged mice: Putative relationship to NMDA receptor deficits

W. Müller, S. Cohen, S. Stoll, 1993, Pharmacology, Biochemistry and Behavior.

Effects of Antidepressants on the Brain/Plasma Distribution of Corticosterone

W. Müller, G. Eckert, C. Weber, 2006, Neuropsychopharmacology.

Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer’s APP mutation and sensitizes cells to staurosporine-induced cell death

C. Haass, W. Müller, A. Eckert, 2002, Journal of Molecular Neuroscience.

Impact of aging

L. Frölich, K. Maurer, S. Leutner, 2007, NeuroMolecular Medicine.

Sporadic, and Genetic Risk Factors on Vulnerability to Apoptosis in Alzheimer's Disease

L. Frölich, K. Maurer, S. Leutner, 2003 .

Enhancement of proteolytic processing of the beta-amyloid precursor protein by hyperforin.

B. Steiner, W. Müller, Bettina Froestl, 2003, Biochemical pharmacology.

Heterologously Expressed GLT-1 Associates in ̃200-nm Protein-Lipid Islands

W. Kühlbrandt, S. Raunser, W. Müller, 2006 .

Enhanced Neuroplasticity by the Metabolic Enhancer Piracetam Associated with Improved Mitochondrial Dynamics and Altered Permeability Transition Pore Function

K. Friedland, Carola Stockburger, D. Miano, 2016, Neural plasticity.

Grundlegende Aspekte zur Neurotransmission

P. Riederer, E. Kienzl, W. Müller, 1992 .

Anne Eckert, Konrad Maurer, Katharina Schindowski, 2002, Mechanisms of Ageing and Development.

Stereospecific3H-QNB binding to human erythrocyte membranes associated with muscarinic cholinergic receptors

W. Müller, B. Bering, W. Müller, 2005, Journal of Neural Transmission.

St. John's Wort and its Active Principles in Depression and Anxiety

W. Müller, W. Müller, 2005 .

Chronic Treatment of Syrian Hamsters With Low-Dose Selegiline Increases Life Span in Females But Not Males

B. Kränzlin, S. Stoll, U. Hafner, 1997, Neurobiology of Aging.

Statins: drugs for Alzheimer’s disease?

W. G. Wood, W. Müller, G. Eckert, 2005, Journal of Neural Transmission.

Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice

T. Bayer, C. Czech, L. Pradier, 2005, Neurobiology of Disease.

Stabilization of mitochondrial function by Ginkgo biloba extract (EGb 761).

A. Eckert, S. Hauptmann, I. Scherping, 2007, Pharmacological research.

Mitochondrial dysfunction induced by disease relevant AbetaPP and tau protein mutations.

A. Eckert, S. Hauptmann, I. Scherping, 2006, Journal of Alzheimer's disease : JAD.

Apoptosis of CD4+ T and natural killer cells in Alzheimer's disease.

L. Frölich, K. Maurer, S. Leutner, 2006, Pharmacopsychiatry.

Enhanced apoptosis, oxidative stress and mitochondrial dysfunction in lymphocytes as potential biomarkers for Alzheimer's disease.

J. Pantel, K. Maurer, A. Eckert, 2007, Journal of neural transmission. Supplementum.

Piracetam improves mitochondrial dysfunction following oxidative stress

W. Müller, A. Eckert, S. Hauptmann, 2006, British journal of pharmacology.

Piracetam: Novelty in a Unique Mode of Action

W. Müller, A. Eckert, G. Eckert, 1999, Pharmacopsychiatry.

Lipid Membranes and β-Amyloid: A Harmful Connection

G. Eckert, W. Wood, W. Müller, 2010 .

Lipid membranes and beta-amyloid: a harmful connection.

G. Eckert, W. Wood, W. Müller, 2010, Current protein & peptide science.

Aging sensitizes toward ROS formation and lipid peroxidation in PS1M146L transgenic mice.

W. Müller, F. Müller-Spahn, A. Eckert, 2006, Free radical biology & medicine.

Amyloid β-induced Changes in Nitric Oxide Production and Mitochondrial Activity Lead to Apoptosis*

C. Haass, J. Weyermann, C. Czech, 2004, Journal of Biological Chemistry.

Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations

S. Leutner, C. Czech, N. Touchet, 2000, Neuroscience Letters.

Mitochondrial Dysfunction: Common Final Pathway in Brain Aging and Alzheimer’s Disease—Therapeutic Aspects

A. Eckert, G. Eckert, K. Leuner, 2010, Molecular Neurobiology.

Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients

D. Volmer, W. G. Wood, U. Igbavboa, 2009, Neurobiology of Disease.

Editorial: Siegfried Hoyer’s concept of Alzheimer pathophysiology

L. Frölich, P. Riederer, W. Müller, 2015, Journal of Neural Transmission.

Chronic treatment with phosphatidylserine restores muscarinic cholinergic receptor deficits in the aged mouse brain

C. Gelbmann, W. Müller, 1992, Neurobiology of Aging.

Cholesterol-lowering drugs and Alzheimer's disease

Gunter P. Eckert, Walter E. Müller, G. Eckert, 2007 .

Effects of aging and β-amyloid on the properties of brain synaptic and mitochondrial membranes

W. G. Wood, W. Müller, G. Eckert, 2001, Journal of Neural Transmission.

Brain-membrane cholesterol in Alzheimer's disease.

G. Eckert, C. Kirsch, W. Müller, 2003, The journal of nutrition, health & aging.

Modulation of Cholesterol, Farnesylpyrophosphate, and Geranylgeranylpyrophosphate in Neuroblastoma SH-SY5Y-APP695 Cells: Impact on Amyloid Beta-Protein Production

W. G. Wood, W. Müller, G. Eckert, 2010, Molecular Neurobiology.

The interaction of beta-amyloid protein with cellular membranes stimulates its own production.

D. Kögel, U. Igbavboa, T. Deller, 2009, Biochimica et biophysica acta.

Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment

M. Nöldner, W. G. Wood, W. Müller, 2007, Neurobiology of Disease.

Alterations of intracellular calcium regulation during aging and Alzheimer's disease in nonneuronal cells.

Hans Förstl, W. Müller, A. Eckert, 1994, Life sciences.

β‐Amyloid protein enhances the mitogen‐induced calcium response in circulating human lymphocytes

W. Müller, A. Eckert, H. Hartmann, 1993, FEBS letters.

β-Amyloid Protein Amplifies Calcium Signaling in Central Neurons from the Adult Mouse

A. Eckert, H. Hartmann, W. Müller, 1993 .

Aging enhances the calcium sensitivity of central neurons of the mouse as an adaptive response to reduced free intracellular calcium

A. Eckert, H. Hartmann, W. Müller, 1993, Neuroscience Letters.

Brain cholesterol, statins and Alzheimer's Disease.

G. Eckert, C. Kirsch, A. Koudinov, 2003, Pharmacopsychiatry.

Apolipoprotein E genotype and alpha-tocopherol modulate amyloid precursor protein metabolism and cell cycle regulation.

A. Minihane, G. Rimbach, S. Schaffer, 2007, Molecular nutrition & food research.

Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity.

W. Müller, A. Eckert, H. Hartmann, 1994, Biochemical and biophysical research communications.

Is hypercholesterolemia a risk factor for alzheimer’s disease?

U. Igbavboa, G. Eckert, L. Johnson-Anuna, 2007, Molecular Neurobiology.

Liposome-incorporated DHA increases neuronal survival by enhancing non-amyloidogenic APP processing.

D. Kögel, G. Eckert, S. Hagl, 2011, Biochimica et biophysica acta.

Simvastatin protects neurons from cytotoxicity by up‐regulating Bcl‐2 mRNA and protein

W. G. Wood, U. Igbavboa, W. Müller, 2007 .

Presenilin 1 modifies lipid raft composition of neuronal membranes.

G. Eckert, W. Müller, 2009, Biochemical and biophysical research communications.

Effects of β-amyloid peptides on the fluidity of membranes from frontal and parietal lobes of human brain. High potencies of Aβ1-42 and Aβ1-43

N. Cairns, W. Gattaz, A. Maras, 1998 .

Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer's Disease.

W. Müller, K. Friedland, G. Eckert, 2018, Journal of Alzheimer's disease : JAD.

TRPC6 channel‐mediated neurite outgrowth in PC12 cells and hippocampal neurons involves activation of RAS/MEK/ERK, PI3K, and CAMKIV signaling

K. Leuner, G. Sillani, Anita M. Schuwald, 2013, Journal of neurochemistry.

Changes of intracellular calcium regulation in Alzheimer's disease and vascular dementia.

M. Hennerici, Hans Förstl, R. Zerfass, 1998, Journal of neural transmission. Supplementum.

Cholesterol asymmetry in synaptic plasma membranes

U. Igbavboa, G. Eckert, W. Gibson Wood, 2011, Journal of neurochemistry.

P.4.003 TRPC6 channel activation by hyperforin, the antidepressant active constituent of St. John's wort, induces neurite outgrowth

K. Leuner, J. Heiser, W. Müller, 2010, European Neuropsychopharmacology.

Hyperforin mediates neurite outgrowth via TRPC6 channels in PC12 cells

C. Harteneck, K. Leuner, W. Müller, 2007 .

Simvastatin Stimulates Production of the Antiapoptotic Protein Bcl-2 via Endothelin-1 and NFATc3 in SH-SY5Y Cells

W. G. Wood, U. Igbavboa, Grace Y Sun, 2010, Molecular Neurobiology.

A cell model for the initial phase of sporadic Alzheimer's disease.

Vicki A. M. Gold, K. Leuner, N. Kolesova, 2014, Journal of Alzheimer's disease : JAD.

Piracetam reverses hippocampal membrane alterations in Alzheimer's disease

N. Cairns, W. Müller, G. Eckert, 1999, Journal of Neural Transmission.

Effects of the standardized Ginkgo biloba extract EGb 761® on neuroplasticity

W. Müller, K. Leuner, J. Heiser, 2012, International Psychogeriatrics.

Membrane-disordering effects of β-amyloid peptides

W. Müller, G. Eckert, C. Kirsch, 2001 .

Neuropharmacology of the anxiolytic drug opipramol, a sigma site ligand.

W. Müller, C. Gentsch, B. Siebert, 2004, Pharmacopsychiatry.

Improvement of mitochondrial function and dynamics by the metabolic enhancer piracetam.

K. Leuner, K. Koch, Carola Stockburger, 2013, Biochemical Society transactions.

Improved Mitochondrial Function in Brain Aging and Alzheimer Disease – the New Mechanism of Action of the Old Metabolic Enhancer Piracetam

J. Orgogozo, G. Guidetti, K. Leuner, 2010, Front. Neurosci..

Effects of piracetam on membrane fluidity in the aged mouse, rat, and human brain.

W. Müller, K. Scheuer, S. Koch, 1997, Biochemical pharmacology.

Cholesterol modulates amyloid beta-peptide's membrane interactions.

W. G. Wood, W. Müller, G. Eckert, 2003, Pharmacopsychiatry.

Specific modulation of sigma binding sites by the anxiolytic drug opipramol

G. Holoubek, W. Müller, 2003, Journal of Neural Transmission.

Direct demonstration of the highly reactive tyrosine residue of human serum albumin located in fragment 299-585.

W. Müller, K. Fehske, U. Wollert, 1980, Archives of biochemistry and biophysics.

Non-Response to Antidepressants: Risk Factors and Therapeutic Possibilities

H. Möller, F. Holsboer, Werner Kissling, 1988, Pharmacopsychiatry.

No Abuse Potential of Silexan in Healthy Recreational Drug Users: A Randomized Controlled Trial

H. Möller, E. Seifritz, H. Volz, 2020, The international journal of neuropsychopharmacology.

Silexan in anxiety disorders: Clinical data and pharmacological background

H. Möller, H. Volz, S. Kasper, 2018, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

Lavender oil preparation Silexan is effective in generalized anxiety disorder--a randomized, double-blind comparison to placebo and paroxetine.

H. Möller, H. Volz, S. Kasper, 2014, The international journal of neuropsychopharmacology.

Stereospecific interaction of bicuculline with specific [3H]strychnine binding to rat spinal cord synaptosomal membranes

W. Müller, A. Goldinger, 1980, Neuroscience Letters.

Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells.

S. Schaffer, G. Eckert, W. Müller, 2010, Pharmacological research.

Determination of urinary 3-methoxy-4-hydroxyphenylethylene glycol and its conjugates by high-performance liquid chromatography with electrochemical and ultraviolet absorbance detection.

J. Filser, M. Fischer, W. Müller, 1989, Journal of chromatography.

The evaluation of 4-hydroxy-3-methoxyphenylglycol sulfate as a possible marker of central norepinephrine turnover. Studies in healthy volunteers and depressed patients.

W. Gattaz, J. Filser, W. Müller, 1988, Journal of psychiatric research.

1-Methyl-β-carboline (Harmane), a potent endogenous inhibitor of benzodiazepine receptor binding

H. Rommelspacher, H. Borbe, K. Fehske, 1980, Naunyn-Schmiedeberg's Archives of Pharmacology.

Benzodiazepine antagonism by harmane and other beta-carbolines in vitro and in vivo.

H. Rommelspacher, H. Borbe, K. Fehske, 1981, European journal of pharmacology.

β-Carboline binding indicates the presence of benzodiazepine receptor subclasses in the bovine central nervous system

H. Borbe, K. Fehske, U. Wollert, 1982, Naunyn-Schmiedeberg's Archives of Pharmacology.

Benzodiazepine receptor binding: the interactions of some non-benzodiazepine drugs with specific [3H] diazepam binding to rat brain synaptosomal membranes

U. Wollert, U. Schläfer, W. Müller, 1978, Naunyn-Schmiedeberg's Archives of Pharmacology.

Inhibition of GABA and benzodiazepine receptor binding by penicillins

Walter E. Müller, A. Antoniadis, Adam Antoniadis, 1980, Neuroscience Letters.

On the neuropharmacology of harmane and other beta-carbolines.

H. Rommelspacher, H. Borbe, K. Fehske, 1981, Pharmacology, biochemistry, and behavior.

Silexan does not cause withdrawal symptoms even when abruptly discontinued

H. Möller, H. Volz, S. Kasper, 2017, International journal of psychiatry in clinical practice.

Peripheral benzodiazepine binding sites on striated muscles of the rat: Properties and effect of denervation

W. Müller, H. Hopf, A. Ickstadt, 2005, Journal of Neural Transmission.

The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress‐induced apoptosis

D. Kögel, J. Prehn, C. Reimertz, 2003, Journal of neurochemistry.

Elevated vulnerability to oxidative stress‐induced cell death and activation of caspase‐3 by the Swedish amyloid precursor protein mutation

C. Haass, A. Eckert, B. Steiner, 2001, Journal of neuroscience research.

1H- and 13C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer’s disease

F. Zanella, U. Pilatus, G. Eckert, 2015, Journal of Neural Transmission.

Inhibition of glycine and GABA receptor binding by several opiate agonists and antagonists.

W E Müller, A Goldinger, U Wollert, 1981, General pharmacology.

Treatment duration (persistence) of basal insulin supported oral therapy (BOT) in Type-2 diabetic patients: comparison of insulin glargine with NPH insulin.

M. Schulz, R. Quinzler, F. Dippel, 2012, International journal of clinical pharmacology and therapeutics.

Lithium but not cholinergic ligands influence guanylate cyclase activity in intact human lymphocytes.

W. Müller, T. Schubert, W. Müller, 1990, Biochemical pharmacology.

The amyloid precursor protein potentiates CHOP induction and cell death in response to ER Ca2+ depletion

D. Kögel, J. Prehn, W. Müller, 2007, BMC Neuroscience.

Changes in prescribed medicines in older patients with multimorbidity and polypharmacy in general practice

C. Muth, F. Gerlach, A. Meid, 2018, BMC Family Practice.

Drug binding sites on human alpha-1-acid glycoprotein.

W. Müller, 1989, Progress in clinical and biological research.

The stereoselectivity of the 'single drug binding site' of human alpha 1-acid glycoprotein (orosomucoid).

F. Brunner, W. Müller, 1987, The Journal of pharmacy and pharmacology.

Specific decrease of high-affinity agonist states of alpha2-adrenoceptors in the aging mouse brain

W. Müller, C. Gelbmann, W. Müller, 2005, Journal of Neural Transmission / General Section JNT.

A Mitochondrial Role of SV2a Protein in Aging and Alzheimer's Disease: Studies with Levetiracetam.

Tabiwang N. Arrey, M. Karas, W. Müller, 2015, Journal of Alzheimer's disease : JAD.

Statins and neuroprotection

U. Igbavboa, G. Eckert, W. Wood, 2010, Annals of the New York Academy of Sciences.

Curcumin prevents mitochondrial dysfunction in the brain of the senescence-accelerated mouse-prone 8

G. Rimbach, J. Frank, R. Abdel-Kader, 2013, Neurochemistry International.

Specific [3H]strychnine binding associated with glycine receptors in bovine retina

W. Müller, H. Borbe, U. Wollert, 1981, Brain Research.

Effect of anxiolytic drug silexan on sleep – a narrative review

H. Volz, S. Kasper, M. Hatzinger, 2022, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

Neurotrophic Properties of Silexan, an Essential Oil from the Flowers of Lavender-Preclinical Evidence for Antidepressant-Like Properties

M. Nöldner, W. Müller, E. Koch, 2020, Pharmacopsychiatry.

Platelet 5-HT Uptake in Boys with Conduct Disorder

F. Poustka, K. Schmeck, C. Stadler, 2004, Neuropsychobiology.

St. Johns Wort (Hypericum), the Story Goes on

W. Müller, 1998 .

Liver slice uptake of intravenous and oral biliary contrast media.

A. E. Stillbauer, W. Müller, 1980, Archives internationales de pharmacodynamie et de therapie.

Treatment of Comorbid Anxiety and Depression with Escitalopram: Results of a Post-Marketing Surveillance Study

G. Laux, W. Müller, M. Friede, 2012, Pharmacopsychiatry.

Cholesterol Modulates the Membrane- Disordering Effects of Beta-Amyloid Peptides in the Hippocampus: Specific Changes in Alzheimer’s Disease

N. Cairns, W. Gattaz, A. Maras, 2000, Dementia and Geriatric Cognitive Disorders.

N-methyl-D-aspartate receptor density and membrane fluidity as possible determinants of the decline of passive avoidance performance in aging

R. Weigel, K. Scheuer, S. Stoll, 1995, Pharmacology Biochemistry and Behavior.

Stereospecific [3H]naloxone binding associated with opiate receptors in bovine retina.

W. Müller, H. Borbe, U. Wollert, 1982, Experimental eye research.

Disturbances of the neuronal calcium homeostasis in the aging nervous system.

W. Müller, A. Eckert, H. Hartmann, 1994, Life sciences.

Determination of hyperforin in mouse brain by high-performance liquid chromatography/tandem mass spectrometry.

M. Schubert-Zsilavecz, T. Dingermann, M. Karas, 2003, Analytical Chemistry.

Levoprotiline ((−)-oxaprotiline) effects on inositol phosphate generation in human peripheral lymphocytes

W. Müller, T. Schubert, W. Müller, 2005, Journal of Neural Transmission / General Section JNT.

Benzodiazepine hypnotics: Time course and potency of benzodiazepine receptor occupation after oral application

W. Müller, A. E. Stillbauer, W. Müller, 1983, Pharmacology Biochemistry and Behavior.

Elevated intracellular calcium levels after 5-HT2 receptor stimulation in platelets of depressed patients

D. Riemann, W. Müller, A. Eckert, 1993, Biological Psychiatry.

Elevated intracellular calcium levels after 5-HT2 receptor stimulation in platelets of patients with affective disorders

D. Riemann, H. Gann, A. Eckert, 1992, European Neuropsychopharmacology.

THE BENZODIAZEPINE RECEPTOR. A SUMMARY

W. Müller, W. Müller, 1982 .

The amplifying effect of beta-amyloid on cellular calcium signalling is reduced in Alzheimer's disease.

K. Beyreuther, H. Förstl, C. Czech, 1995, Neuroreport.

Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains

W. G. Wood, U. Igbavboa, W. Müller, 2003, Brain Research.

β-amyloid peptide decreases membrane fluidity

W. Müller, A. Eckert, K. Scheuer, 1995, Brain Research.

Pharmacological basis of the anxiolytic and antidepressant properties of Silexan®, an essential oil from the flowers of lavender

W. Müller, K. Friedland, G. Sillani, 2020, Neurochemistry International.

APOE Genotype and Alzheimer´s Disease

P. Lantos, I. McKeith, J. O'Brien, 2000, Dementia and Geriatric Cognitive Disorders.

Drug interactions with selegiline versus rasagiline

W. Jost, A. Storch, I. Csoti, 2012 .

Decreased exploratory activity and impaired passive avoidance behaviour in mice deficient for the α1b-adrenoceptor

J. Knauber, W. Müller, 2000, European Neuropsychopharmacology.

W. Müller, O. Pohl, S. Stoll, 1994, Life sciences.

Glutamatergic treatment strategies for age-related memory disorders.

W. Müller, K. Scheuer, S. Stoll, 1994, Life sciences.

Cholesterol: Coupling between membrane microenvironment and ABC transporter activity.

W. Müller, C. Franke, G. Eckert, 2007, Biochemical and biophysical research communications.

Ginkgo Biloba Extract (EGb 761) Independently Improves Changes in Passive Avoidance Learning and Brain Membrane Fluidity in the Aging Mouse

W. Müller, O. Pohl, K. Scheuer, 1996, Pharmacopsychiatry.

Elevated nitric oxide production mediates beta-amyloid-induced mitochondria failure.

F. Müller-Spahn, A. Eckert, U. Keil, 2004, Polish Journal of Pharmacology.

Brain aging: a risk factor of neurodegenerative disorders and a target for therapeutic intervention.

N. Pedigo, W. Müller, 1994, Life sciences.

Optical studies on interaction of biliary contrast agents with native and modified human serum albumin.

K. Fehske, W. Müller, 1981, Journal of pharmaceutical sciences.

Down-regulation of free intracellular calcium in dissociated brain cells of aged mice and rats.

A. Eckert, H. Hartmann, K. Velbinger, 1996, Life sciences.

Region-specific downregulation of free intracellular calcium in the aged rat brain

W. Müller, A. Eckert, H. Hartmann, 1996, Neurobiology of Aging.

Benzodiazepine receptor interactions may be involved in the neurotoxicity of various penicillin derivatives

W. Müller, A. Antoniadis, U. Wollert, 1980, Annals of neurology.

Pharmacology of the GABAergic/Benzodiazepine System

W. Müller, 1995 .

Enhanced vulnerability to apoptotic cell death in sporadic Alzheimer's disease

C. Cotman, M. Hennerici, R. Zerfass, 1998, Neuroreport.

Pharmacological and Nonpharmacological Approaches to the Treatment of Dementia

Hans Förstl, W. Müller, W. Müller, 2001 .

Interaction of piracetam with several neurotransmitter receptors in the central nervous system. Relative specificity for 3H-glutamate sites.

W. Müller, B. Bering, Müller We, 1985, Arzneimittel-Forschung.

Effects on transmitter uptake and their cellular and molecular basis

W. Müller, K. Treiber, 2005 .

Hyperforin modifies neuronal membrane properties in vivo

M. Schubert-Zsilavecz, M. Karas, D. Volmer, 2004, Neuroscience Letters.

The Effects of Extracts from St. John's Wort and Kava Kava on Brain Neurotransmitter Levels in the Mouse

G. Eckert, N. Serdarevic, N. Serdarevic, 2001, Pharmacopsychiatry.

Effects of hyperforin on the fluidity of brain membranes.

G. Eckert, W. Müller, 2001, Pharmacopsychiatry.

Chronic treatment with choline or scopolamine indicates the presence of muscarinic cholinergic receptor plasticity in the frontal cortex of young but not of aged mice

W. Müller, H. Pilch, W. Müller, 2005, Journal of Neural Transmission.

Treatment of Comorbid Anxiety and Depression with Escitalopram : Results of a PostMarketing Surveillance

W. Müller, M. Friede, G. Laux, 2012 .

Decreased β-amyloid sensitivity in Alzheimer's disease

Hans Förstl, A. Eckert, H. Hartmann, 1993, The Lancet.

Hypochlorous acid scavenging properties of local mediterranean plant foods

R. Llorach, D. Rivera, F. Visioli, 2004, Lipids.

beta-Amyloid peptide decreases membrane fluidity.

W. Müller, A. Eckert, K. Scheuer, 1995, Brain research.

Abstracts Second Congress of the European Society for Clinical Neuropharmacology

K. Jellinger, L. Iversen, K. Lesch, 1995, Journal of Neural Transmission / General Section JNT.

Regulation of the brain isoprenoids farnesyl- and geranylgeranyl-pyrophosphate is altered in male Alzheimer patients

D. Volmer, U. Igbavboa, G. Eckert, 2009 .

In vitro down-regulation predicts agonist efficacy at central muscarinic cholinergic receptors.

L. Stoll, W. Müller, 1991, Biochemical pharmacology.

Cortical NMDA receptor properties and membrane fluidity are altered in Alzheimer's disease.

N. Cairns, Hans Förstl, W. Gattaz, 1996, Dementia.

Lymphocytes and neutrophils as peripheral models to study the effect of beta-amyloid on cellular calcium signalling in Alzheimer's disease.

Hans Förstl, R. Zerfass, W. Müller, 1996, Life sciences.

Impaired calcium regulation in subcortical vascular encephalopathy.

M. Hennerici, Hans Förstl, A. Eckert, 1997, Stroke.

Free Intracellular Calcium in Peripheral Cells in Alzheimer’s Disease

M. Hennerici, Hans Förstl, R. Zerfass, 1997, Neurobiology of Aging.

Mass spectral characterization of phloroglucinol derivatives hyperforin and adhyperforin.

D. Volmer, G. Eckert, L. Sleno, 2006, Rapid communications in mass spectrometry : RCM.

DL-sodium lactate reduces alpha1-adrenergic receptor binding in rat and mouse brain

H. Beckmann, W. Müller, Sabine Rick, 1985, Psychiatry Research.

The effect of carbamazepine on endocrine and sleep EEG variables in a patient with 48-hour rapid cycling, and healthy controls.

D. Riemann, F. Hohagen, M. Berger, 1993, Neuropsychobiology.

Should Plasma or Urinary MHPG be Measured in Psychiatric Research? A Critical Comment

J. Filser, H. Beckmann, W. Müller, 1986, British Journal of Psychiatry.

Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice

W. Müller, H. Pilch, W. Müller, 2004, Psychopharmacology.

Effects of beta-amyloid peptides on the fluidity of membranes from frontal and parietal lobes of human brain. High potencies of A beta 1-42 and A beta 1-43.

N. Cairns, W. Gattaz, A. Maras, 1998, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Noncompetitive NMDA Receptor Antagonists with Fast Open-Channel Blocking Kinetics and Strong Voltage-Dependency as Potential Therapeutic Agents for Alzheimer's Dementia

P. Riederer, W. Müller, E. Mutschler, 1995, Pharmacopsychiatry.

The Complexity of the Dopaminergic Synapses and their Modulation by Antipsychotics

K Leuner, W E Müller, K. Leuner, 2006, Pharmacopsychiatry.

Dopamine in the Prefrontal Cortex and its Different Modulation by Conventional and Atypical Antipsychotics

K. Leuner, W. Müller, 2007 .

Effects of piracetam on N-methyl-D-aspartate receptor properties in the aged mouse brain.

S. Cohen, W. Müller, 1993, Pharmacology.

Clinically used antidepressant drugs.

S. Kasper, W. Müller, 1997, Pharmacopsychiatry.

Alzheimer's disease: new perspectives on therapeutic targets and pathways. Foreword.

Grace Y Sun, Walter E Müller, Gunter P Eckert, 2012, Molecular neurobiology.