M. Abdel‐Aziz

发表

Novel pyrrol-2(3H)-ones and pyridazin-3(2H)-ones carrying quinoline scaffold as anti-proliferative tubulin polymerization inhibitors.

S. N. Bukhari, M. Ramadan, G. Abuo-Rahma, 2018, Bioorganic chemistry.

Synthesis, cytotoxic activity, and tubulin polymerization inhibitory activity of new pyrrol-2(3H)-ones and pyridazin-3(2H)-ones.

A. Gamal-Eldeen, S. Abbas, Eman A M Beshr, 2016, Bioorganic chemistry.

Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies.

S. N. Bukhari, H. Abdel-Rahman, H. A. El-Sherief, 2018, Bioorganic chemistry.

Novel quinoline incorporating 1,2,4-triazole/oxime hybrids: Synthesis, molecular docking, anti-inflammatory, COX inhibition, ulceroginicity and histopathological investigations.

Heba A. Hassan, T. Kaoud, K. Dalby, 2017, Bioorganic chemistry.

1,3,4-oxadiazole/chalcone hybrids: Design, synthesis, and inhibition of leukemia cell growth and EGFR, Src, IL-6 and STAT3 activities.

M. Montano, S. Abbas, Dalia Abdelhamid, 2019, Bioorganic chemistry.

Novel Quinazolin‐4(3H)‐one/Schiff Base Hybrids as Antiproliferative and Phosphodiesterase 4 Inhibitors: Design, Synthesis, and Docking Studies

B. Gary, G. Piazza, Joshua C. Canzoneri, 2014, Archiv der Pharmazie.

Synthesis and Antibacterial Activity of 4‐Aryl‐2‐(1‐substituted ethylidene)thiazoles

S. Bräse, M. Nieger, E. El-Sheref, 2013, Archiv der Pharmazie.

Synthesis and anti-mycobacterial evaluation of some pyrazine-2-carboxylic acid hydrazide derivatives.

M. Abdel-Aziz, H. Abdel-Rahman, M. Abdel‐Aziz, 2010, European journal of medicinal chemistry.

1,2,4-Triazole/oxime hybrids as new strategy for nitric oxide donors: Synthesis, anti-inflammatory, ulceroginicity and antiproliferative activities.

G. Abuo-Rahma, Eman A M Beshr, T. Ali, 2014, European journal of medicinal chemistry.

Synthesis of novel spiro(indolone‐3,2′‐[1,3,4]thiadiazol)‐2‐ones and evaluation of their antidepressant and anticonvulsant activities

S. Bräse, Alaa A. Hassan, S. M. Mostafa, 2011 .

Efficient and Facile Synthesis of Substituted Aminothiadiazolylhydrazonoindolin‐2‐ones

S. Bräse, M. Nieger, Alaa A. Hassan, 2016 .

Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives.

A. Gouda, M. Radwan, Adel A Marzouk, 2020, Bioorganic chemistry.

Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy.

Mai E. Shoman, Atsushi Narumi, H. Konno, 2021, European journal of medicinal chemistry.

Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation.

A. Gouda, M. Abdel-Aziz, Adel A Marzouk, 2020, Bioorganic chemistry.

New quinoline/1,2,4-triazole hybrids as dual inhibitors of COX-2/5-LOX and inflammatory cytokines: Design, synthesis, and docking study

Heba A. Hassan, M. Otsuka, A. Gouda, 2021 .

Design and Synthesis of Substituted Pyridazinone‐1‐Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors

H. Tinsley, B. Gary, G. Piazza, 2016, Archiv der Pharmazie.

An Efficient Synthesis of Thiazolidine‐4‐ones with Antitumor and Antioxidant Activities

A. Gamal-Eldeen, A. Aly, Alan B. Brown, 2012 .

Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors.

A. Abdelazeem, H. Abdel-Rahman, H. A. El-Sherief, 2018, European journal of medicinal chemistry.

Thieno[2,3‐d]pyrimidines in the Synthesis of Antitumor and Antioxidant Agents

A. Gamal-Eldeen, A. Aly, Alan B. Brown, 2010, Archiv der Pharmazie.

Structure-based design, synthesis and antiproliferative action of new quizoline-4-one/chalcone hybrids as EGFR inhibitors

Heba A. Hassan, M. Hisham, Heba A Hassan, 2022, Journal of Molecular Structure.

Novel N-4-piperazinyl-ciprofloxacin-chalcone hybrids: synthesis, physicochemical properties, anticancer and topoisomerase I and II inhibitory activity.

Youngjoo Kwon, M. Sayed, G. E. Abuo-Rahma, 2013, European journal of medicinal chemistry.

Novel 1,3,4-oxadiazole/oxime hybrids: Synthesis, docking studies and investigation of anti-inflammatory, ulcerogenic liability and analgesic activities.

T. Kaoud, Eman A M Beshr, Mai E. Shoman, 2016, Bioorganic chemistry.

Synthesis of [1,2,4]triazolo[3,4‐b][1,3]thiazine‐5‐carboxylates via one‐pot reaction of N‐substituted‐hydrazino‐carbothioamides with diethyl maleate

A. Aly, Yusria R. Ibrahim, M. Abdel‐Aziz, 2009 .

Synthesis and Antibacterial Activity of New Substituted Ethylidenehydrazinylidene-1,3-thiazol-4-ones

Alaa A. Hassan, N. Mohamed, Kamal M. El-Shaieb, 2014 .

Synthesis of New 4-Oxo-thiazolidine-5-ylidenes of Antitumor and Antioxidant Activities

A. Gamal-Eldeen, A. Aly, Alan B. Brown, 2010 .

Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities.

Alaa A. Hassan, G. E. Abuo-Rahma, M. Abdel-aziz, 2009, European journal of medicinal chemistry.

Synthesis, Anticancer Assessment, and Molecular Docking of Novel Chalcone-Thienopyrimidine Derivatives in HepG2 and MCF-7 Cell Lines

R. Almeer, A. Gouda, M. Abdel-Daim, 2021, Oxidative medicine and cellular longevity.

New 1,2,4-triazole-Chalcone hybrids induce Caspase-3 dependent apoptosis in A549 human lung adenocarcinoma cells.

S. Abbas, Dalia Abdelhamid, A. A. Abd El-Hafeez, 2018, European journal of medicinal chemistry.

New 1,3,4-oxadiazole/oxime hybrids: Design, synthesis, anti-inflammatory, COX inhibitory activities and ulcerogenic liability.

T. Kaoud, Eman A M Beshr, Mai E. Shoman, 2017, Bioorganic chemistry.

1,3,4-oxadiazole-2-thione Derivatives; Novel Approach for Anticancer and Tubulin Polymerization Inhibitory Activities.

A. Gamal-Eldeen, O. Aly, K. Metwally, 2015, Anti-cancer agents in medicinal chemistry.

New nitric oxide donating 1,2,4-triazole/oxime hybrids: synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities.

G. Abuo-Rahma, Eman A M Beshr, T. Ali, 2013, Bioorganic & medicinal chemistry.

Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities.

A. Abdelazeem, M. Abdel-Aziz, H. Abdel-Rahman, 2019, Anti-cancer agents in medicinal chemistry.

Design, synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors.

S. N. Bukhari, A. Gouda, M. Abdelrahman, 2020, Bioorganic chemistry.

Synthesis and Antibacterial Activity of 4‐Aryl‐2‐(1‐substituted ethylidene)thiazoles.

M. Nieger, E. El-Sheref, S. Braese, 2013 .

Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies.

T. Kaoud, N. Farag, G. E. Abuo-Rahma, 2014, European journal of medicinal chemistry.

Synthesis and Identification of New N,N-Disubstituted Thiourea, and Thiazolidinone Scaffolds Based on Quinolone Moiety as Urease Inhibitor

S. Bräse, A. Aly, Alan B. Brown, 2022, Molecules.

Development of 2'-aminospiro [pyrano[3,2-c]quinoline]-3'-carbonitrile derivatives as non-ATP competitive Src kinase inhibitors that suppress breast cancer cell migration and proliferation.

T. Kaoud, K. Dalby, A. Aly, 2021, Bioorganic chemistry.

Synthesis and investigation of anti-inflammatory activity and gastric ulcerogenicity of novel nitric oxide-donating pyrazoline derivatives.

M. Morsy, Mai E. Shoman, O. Aly, 2009, European journal of medicinal chemistry.

Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide.

G. Abuo-Rahma, H. Farag, Mohamed F. Radwan, 2009, Bioorganic & medicinal chemistry.

C‐(2‐Chloroquinoline‐3‐yl)‐N‐phenyl Nitrone: New Synthetic Antioxidant Inhibits Proliferation and Induces Apoptosis of Breast Carcinoma MCF‐7 Cells

A. Gamal-Eldeen, M. Ramadan, M. Abdel-Aziz, 2006, Archiv der Pharmazie.

Functionality of 4-amino-5-hydrazinyl-4H-1,2,4-triazole-3-thiol in synthesis of new fused triazolotriazines and triazolotriazepines of potential gram negative antibacterial activity

A. Aly, G. F. Gad, M. Abdel‐Aziz, 2011 .

Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors.

M. Ramadan, T. Ali, Syed Nasir Abbas Bukhari, 2019, Bioorganic & medicinal chemistry.

Selectivity of N‐aroyl‐N′‐arylthioureas towards 2‐(1,3‐dioxo‐1H‐inden‐2(3H)‐ylidene)malononitrile. New synthesis of (Z)‐N‐((E)‐4‐amino‐1‐aryl‐5‐cyano‐6‐oxo‐1H‐indeno[1,2‐d][1,3]‐ thiazepin‐2(6H)‐ylidene)‐4‐arylamides of antitumor and antioxidant activities

A. Gamal-Eldeen, A. Aly, Alan B. Brown, 2010 .

Synthesis, anti-inflammatory activity and ulcerogenic liability of novel nitric oxide donating/chalcone hybrids.

H. Farag, G. E. Abuo-Rahma, Mai A E Mourad, 2012, Bioorganic & medicinal chemistry.

Synthesis and hybridization property of novel 2',5'-isoDNA mimic chiral peptide nucleic acids.

M. Otsuka, T. Yamasaki, M. Abdel‐Aziz, 2003, Bioorganic & medicinal chemistry letters.

Effect of lateral substitution of different polarity on the mesophase behaviour in pure and mixed states of 4-(4′-substituted phenylazo)-2-substituted phenyl-4″-alkoxy benzoates

A. Fahmi, M. Alaasar, M. Naoum, 2011 .

Design, synthesis, mechanistic studies and in silico ADME predictions of benzimidazole derivatives as novel antifungal agents.

Dalal A Abou el-Ella, H. Abdel-Rahman, R. Ibrahem, 2020, Bioorganic chemistry.

New potent ciprofloxacin-uracil conjugates as DNA gyrase and topoisomerase IV inhibitors against methicillin-resistant Staphylococcus aureus.

M. Samir, M. Ramadan, H. M. Halby, 2022, Bioorganic & medicinal chemistry.

1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.

Eman A M Beshr, O. Aly, Islam M Abdel-Rahman, 2014, European journal of medicinal chemistry.

Novel Mannich bases of ciprofloxacin with improved physicochemical properties, antibacterial, anticancer activities and caspase-3 mediated apoptosis.

A. Hayallah, Muhamad Mustafa, Islam M Abdel-Rahman, 2021, Bioorganic chemistry.

Synthesis and screening of anti-cancer, antioxidant, and anti-inflammatory activities of novel galloyl pyrazoline derivatives

A. Gamal-Eldeen, M. Abdel‐Aziz, Mohamed Abdel-Aziz, 2009 .

A New Ciprofloxacin-derivative Inhibits Proliferation and Suppresses the Migration Ability of HeLa Cells

Qing‐Li Zhao, T. Nikaido, S. Awale, 2020, AntiCancer Research.

Cell Cycle Arrest and Apoptotic Effect of 7-(4-(N-substituted carbamoylmethyl) piperazin-1-yl) Ciprofloxacin-derivative on HCT 116 and A549 Cancer Cells

M. Fathy, M. Nazmy, Rania Alaaeldin, 2020, AntiCancer Research.

JNK signaling as a target for anticancer therapy

Heba A. Hassan, Heba A Hassan, Atsushi Narumi, 2021, Pharmacological Reports.

Synthesis, Cytotoxic Properties and Tubulin Polymerization Inhibitory Activity of Novel 2‐Pyrazoline Derivatives

Kamalika Mukherjee, M. Abdel-Aziz, O. Aly, 2012, Archiv der Pharmazie.

Tetracyanoethylene as a mediator and building block in synthesis of 5-substituted amino-1,3,4-thiadiazolyl-1H-pyrazole derivatives

J. Mague, M. Akkurt, F. Abdel-latif, 2016 .

EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules.

M. Mohamed, A. Hayallah, B. Youssif, 2019, Bioorganic chemistry.

Anti-Proliferative and Pro-Apoptotic Activities of Synthesized 3,4,5 Tri-Methoxy Ciprofloxacin Chalcone Hybrid, through p53 Up-Regulation in HepG2 and MCF7 Cell Lines

M. Fathy, M. Nazmy, M. Eisa, 2021, Asian Pacific journal of cancer prevention : APJCP.

Novel Benzimidazole/Hydrazone Derivatives as Promising Anticancer Lead Compounds: Design, Synthesis, and Molecular Docking Study

Martha M. Morcoss, El-Shimaa M. N. Abdelhafez, M. Abdel‐Aziz, 2020 .

STAT3 transcription factor as target for anti-cancer therapy

Heba A. Hassan, M. Abdel-Aziz, Heba A Hassan, 2020, Pharmacological Reports.