Yasien Sayed

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Two‐Step Preparation of Highly Pure, Soluble HIV Protease from Inclusion Bodies Recombinantly Expressed in Escherichia coli

D. Sherry, R. Worth, Yasien Sayed, 2020, Current protocols in protein science.

Design, synthesis and biological evaluation of novel 2-(5-aryl-1H-imidazol-1-yl) derivatives as potential inhibitors of the HIV-1 Vpu and host BST-2 protein interaction.

Y. Sayed, M. Bode, E. M. Coyanis, 2020, European journal of medicinal chemistry.

Synthesis and evaluation of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors.

P. T. Kaye, Rosalyn Klein, Temitope O. Olomola, 2013, Bioorganic & medicinal chemistry.

Towards the synthesis of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors

P. T. Kaye, K. Lobb, Rosalyn Klein, 2010 .

Linear and cyclic glycopeptide as HIV protease inhibitors.

M. Soliman, T. Govender, G. E. Maguire, 2013, European journal of medicinal chemistry.

A New Synthetic Method for Tetraazatricyclic Derivatives and Evaluation of Their Biological Properties

K. Lobb, Z. Tshentu, C. Frost, 2018, ChemistrySelect.

Overexpression, Purification and Functional Characterisation of Wild-Type HIV-1 Subtype C Protease and Two Variants Using a Thioredoxin and His-Tag Protein Fusion System

H. Dirr, Ikechukwu Achilonu, Yasien Sayed, 2018, The Protein Journal.

Antimicrobial function of short amidated peptide fragments from the tick‐derived OsDef2 defensin

Y. Sayed, A. Neitz, M. Bester, 2019, Journal of peptide science : an official publication of the European Peptide Society.

Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: a hybrid 2D NMR and docking/QM/MM/MD approach.

Katja Petzold, M. Soliman, Maya M. Makatini, 2011, European journal of medicinal chemistry.

Synthesis and molecular modelling studies of novel carbapeptide analogs for inhibition of HIV-1 protease.

M. Soliman, T. Govender, G. E. Maguire, 2012, European journal of medicinal chemistry.

Novel PCU cage diol peptides as potential targets against wild-type CSA HIV-1 protease: synthesis, biological screening and molecular modelling studies

M. Soliman, T. Govender, G. Maguire, 2012, Medicinal Chemistry Research.

Pentacycloundecane derived hydroxy acid peptides: a new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors.

M. Soliman, T. Govender, G. E. Maguire, 2012, Bioorganic chemistry.

Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease.

Katja Petzold, M. Soliman, Maya M. Makatini, 2011, Bioorganic & medicinal chemistry letters.

Molecular basis of inhibition of Schistosoma japonicum glutathione transferase by ellagic acid: insights into biophysical and structural studies.

H. Dirr, R. Pandian, Ikechukwu Achilonu, 2020, Molecular and biochemical parasitology.

Pentacycloundecane‐diol‐Based HIV‐1 Protease Inhibitors: Biological Screening, 2D NMR, and Molecular Simulation Studies

Katja Petzold, M. Soliman, Maya M. Makatini, 2012, ChemMedChem.

V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity

B. Haynes, S. Karim, L. Morris, 2018, Cell reports.

Protease inhibition in African subtypes of HIV-1.

A. Velázquez‐Campoy, E. Freire, S. Vega, 2003, AIDS reviews.

Euphorbia mauritanica and Kedrostis hirtella extracts can induce anti-proliferative activities in lung cancer cells

L. Motadi, Yasien Sayed, Makhosazana A. Thafeni, 2012, Molecular Biology Reports.

Euphorbia mauritanica and Kedrostis hirtella extracts can induce anti-proliferative activities in lung cancer cells

Y. Sayed, L. Motadi, M. A. Thafeni, 2012, Molecular Biology Reports.

Binding Free Energy Calculations of Nine FDA‐approved Protease Inhibitors Against HIV‐1 Subtype C I36T↑T Containing 100 Amino Acids Per Monomer

T. Govender, G. E. Maguire, H. G. Kruger, 2016, Chemical biology & drug design.

Non-B HIV-1 subtypes in sub-Saharan Africa: impact of subtype on protease inhibitor efficacy

P. Naicker, Yasien Sayed, 2014, Biological chemistry.

Biochemical and thermodynamic characterisation of ligand-binding to class alpha glutathione transferase A1-1

Yasien Sayed, 2010 .

F99 is Critical for Dimerization and Activation of South African HIV-1 Subtype C Protease

H. Dirr, P. Naicker, P. Seele, 2013, The Protein Journal.

Molecular dynamics and ligand docking of a hinge region variant of South African HIV-1 subtype C protease.

H. Dirr, Ikechukwu Achilonu, Vijayakumar Balakrishnan, 2018, Journal of molecular graphics & modelling.

A Conserved N-capping Motif Contributes Significantly to the Stabilization and Dynamics of the C-terminal Region of Class Alpha Glutathione S-Transferases*

H. Dirr, Yasien Sayed, D. Kuhnert, 2005, Journal of Biological Chemistry.

Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies.

Vikas Sharma, T. Govender, S. Maseko, 2016, Protein expression and purification.

The Unusual Architecture of RNA-Dependent RNA Polymerase (RdRp)’s Catalytic Chamber Provides a Potential Strategy for Combination Therapy against COVID-19

G. Yahya, Mahmoud A. A. Ibrahim, K. Metwally, 2023, Molecules.

I36T↑T mutation in South African subtype C (C-SA) HIV-1 protease significantly alters protease-drug interactions

Sibusiso B. Maseko, T. Govender, S. Maseko, 2017, Biological chemistry.

Drug Susceptibility and Replication Capacity of a Rare HIV-1 Subtype C Protease Hinge Region Variant

L. Morris, A. Basson, H. Dirr, 2019, Antiviral therapy.

SARS-CoV-2 Spike Protein Unlikely to Bind to Integrins via the Arg-Gly-Asp (RGD) Motif of the Receptor Binding Domain: Evidence From Structural Analysis and Microscale Accelerated Molecular Dynamics

N. Srairi-Abid, K. Ghedira, Ikechukwu Achilonu, 2021, bioRxiv.

The effects of mutating Tyr9 and Arg15 on the structure, stability, conformational dynamics and mechanism of GSTA3-3.

Y. Sayed, S. Stoychev, H. Dirr, 2017, Biophysical chemistry.

Arginine 15 stabilizes an S(N)Ar reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1.

T. Sewell, S. Pelly, H. Dirr, 2010, Biophysical chemistry.

Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors.

Katja Petzold, M. Soliman, Maya M. Makatini, 2012, European journal of medicinal chemistry.

Structural and functional characterization of peptides derived from the carboxy‐terminal region of a defensin from the tick Ornithodoros savignyi

H. Taute, A. Neitz, M. Bester, 2013, Journal of peptide science : an official publication of the European Peptide Society.

Understanding Drug Resistance of Wild-Type and L38HL Insertion Mutant of HIV-1 C Protease to Saquinavir

Sowmya Ramaswamy Krishnan, D. Barh, V. Azevedo, 2023, Genes.

Non-active site mutations in the HIV protease: Diminished drug binding affinity is achieved through modulating the hydrophobic sliding mechanism.

Y. Sayed, R. Pandian, D. Sherry, 2022, International journal of biological macromolecules.

Expression, purification and characterization of a full-length recombinant HIV-1 Vpu from inclusion bodies.

R. Kleynhans, Salerwe Mosebi, Zikhona Njengele, 2016, Protein Expression and Purification.

Elasticity-Associated Functionality and Inhibition of the HIV Protease.

D. Sherry, R. Worth, Yasien Sayed, 2021, Advances in experimental medicine and biology.

Comparison of the Molecular Dynamics and Calculated Binding Free Energies for Nine FDA‐Approved HIV‐1 PR Drugs Against Subtype B and C‐SA HIV PR

M. Soliman, G. Maguire, T. Govender, 2013, Chemical biology & drug design.

The intersubunit lock-and-key motif in human glutathione transferase A1-1: role of the key residues Met51 and Phe52 in function and dimer stability.

H. Dirr, Carla S. Alves, Yasien Sayed, 2006, The Biochemical journal.

The hydrophobic lock‐and‐key intersubunit motif of glutathione transferase A1‐1: implications for catalysis, ligandin function and stability

L. Wallace, H. Dirr, Yasien Sayed, 2000, FEBS letters.

Semi-quantification and Potency Verification of the HIV Protease Inhibitor Based on the Matrix-Capsid Protein Immobilized Nickel (II)/NTA-Tol/Graphene Oxide/SPCE Electrochemical Biosensor

C. Tayapiwatana, J. Jakmunee, Natthawat Semakul, 2023, ACS omega.

Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study.

T. Sewell, H. Dirr, Salerwe Mosebi, 2005, Journal of molecular biology.

Amide hydrogen exchange in HIV–1 subtype B and C proteases – insights into reduced drug susceptibility and dimer stability

S. Stoychev, H. Dirr, P. Naicker, 2014, The FEBS journal.

Novel PCU cage diol peptides as potential targets against wild-type CSA HIV-1 protease: synthesis, biological screening and molecular modelling studies

M. Soliman, T. Govender, G. E. Maguire, 2013, Medicinal Chemistry Research.

Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance

M. Soliman, Mahmoud A. A. Ibrahim, M. Fernandes, 2013, Journal of biomolecular structure & dynamics.

Active-Site Mutations in the South African Human Immunodeficiency Virus Type 1 Subtype C Protease Have a Significant Impact on Clinical Inhibitor Binding: Kinetic and Thermodynamic Study

L. Morris, Y. Sayed, H. Dirr, 2008, Journal of Virology.

Class Pi glutathione transferase unfolds via a dimeric and not monomeric intermediate: functional implications for an unstable monomer.

L. Wallace, D. Balchin, H. Dirr, 2010, Biochemistry.

Residue 219 impacts on the dynamics of the C-terminal region in glutathione transferase A1-1: implications for stability and catalytic and ligandin functions.

H. Dirr, J. Burke, Salerwe Mosebi, 2003, Biochemistry.

Energetics of Glutathione Binding to Human Eukaryotic Elongation Factor 1 Gamma: Isothermal Titration Calorimetry and Molecular Dynamics Studies

M. Tomescu, H. Dirr, Ikechukwu Achilonu, 2016, The Protein Journal.

Energetics of ligand binding to human glutathione transferase A1-1: Tyr-9 associated localisation of the C-terminal helix is ligand-dependent.

D. Balchin, H. Dirr, Yasien Sayed, 2011, Biophysical chemistry.

Characterization of the binding of 8-anilinonaphthalene sulfonate to rat class Mu GST M1-1.

R. Armstrong, H. Dirr, Salerwe Mosebi, 2008, Biophysical chemistry.

Synthesis, 2D-NMR and molecular modelling studies of pentacycloundecane lactam-peptides and peptoids as potential HIV-1 wild type C-SA protease inhibitors

Katja Petzold, M. Soliman, Maya M. Makatini, 2013, Journal of enzyme inhibition and medicinal chemistry.

Characterization of bromosulphophthalein binding to human glutathione S-transferase A1-1: thermodynamics and inhibition kinetics.

H. Dirr, Yasien Sayed, Doris Kolobe, 2004, The Biochemical journal.

Thermodynamics of the ligandin function of human class Alpha glutathione transferase A1-1: energetics of organic anion ligand binding.

H. Dirr, J. Hornby, Yasien Sayed, 2002, The Biochemical journal.

HIV Protease Hinge Region Insertions at Codon 38 Affect Enzyme Kinetics, Conformational Stability and Dynamics

Salerwe Mosebi, R. Worth, Yasien Sayed, 2023, The Protein Journal.

Double trouble? Gag in conjunction with double insert in HIV protease contributes to reduced DRV susceptibility.

L. Morris, A. Basson, H. Dirr, 2019, The Biochemical journal.

Low Frequency of Protease Inhibitor Resistance Mutations and Insertions in HIV-1 Subtype C Protease Inhibitor-Naïve Sequences.

L. Morris, G. Hunt, V. Pillay, 2019, AIDS research and human retroviruses.

Obtaining high yield recombinant Enterococcus faecium nicotinate nucleotide adenylyltransferase for X-ray crystallography and biophysical studies.

R. Pandian, Ikechukwu Achilonu, Olamide Jeje, 2023, International journal of biological macromolecules.

Unveiling a Hidden Pocket in HIV-1 Protease: New Insights Into Retroviral Protease Cantilever-Tip Region Characteristics.

D. Sherry, Yasien Sayed, 2024, Proteins.