J. Mitchell

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Challenges with Developing In Vitro Dissolution Tests for Orally Inhaled Products (OIPs)

Andrew Cooper, D. Christopher, S. Lyapustina, 2012, AAPS PharmSciTech.

Aerodynamic particle size analysis of aerosols from pressurized metered-dose inhalers: Comparison of andersen 8-stage cascade impactor, next generation pharmaceutical impactor, and model 3321 aerodynamic particle sizer aerosol spectrometer

Jolyon P. Mitchell, Mark W. Nagel, K. J. Wiersema, 2003, AAPS PharmSciTech.

Analysis of cascade impactor mass distributions.

Jolyon Mitchell, Craig Dunbar, C. Dunbar, 2005, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

In Vitro Performance Testing for Pulmonary Drug Delivery

Jolyon P. Mitchell, J. McConville, Yoen-Ju Son, 2011 .

A novel, versatile valved holding chamber for delivering inhaled medications to neonates and small children: laboratory simulation of delivery options.

Jolyon P. Mitchell, Robert M Diblasi, D. Coppolo, 2010, Respiratory care.

Development and Evaluation of a Family of Human Face and Upper Airway Models for the Laboratory Testing of Orally Inhaled Products

Jolyon P. Mitchell, D. Coppolo, M. Nagel, 2017, AAPS PharmSciTech.

Inhalation and Nasal Formulations

Jolyon P. Mitchell, J. Mitchell, 2016 .

Urgent Appeal from International Society for Aerosols in Medicine (ISAM) During COVID-19: Clinical Decision Makers and Governmental Agencies Should Consider the Inhaled Route of Administration: A Statement from the ISAM Regulatory and Standardization Issues Networking Group.

Jolyon P. Mitchell, H. Boushey, M. Dolovich, 2020, Journal of aerosol medicine and pulmonary drug delivery.

Next generation pharmaceutical impactor: a new impactor for pharmaceutical inhaler testing. Part III. extension of archival calibration to 15 L/min.

Kumaragovindhan Santhanakrishnan, Virgil A Marple, V. Marple, 2004, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Next generation pharmaceutical impactor (a new impactor for pharmaceutical inhaler testing). Part I: Design.

Dieter Hochrainer, N. C. Miller, Virgil A Marple, 2003, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Product Lifecycle Approach to Cascade Impaction Measurements

Svetlana Lyapustina, Jolyon Mitchell, Terrence P. Tougas, 2011, AAPS PharmSciTech.

In vitro and in vivo aspects of cascade impactor tests and inhaler performance: A review

Jolyon Mitchell, Hak-Kim Chan, H. Chan, 2007, AAPS PharmSciTech.

Non-Pharmaceutical Techniques for Obstructive Airway Clearance Focusing on the Role of Oscillating Positive Expiratory Pressure (OPEP): A Narrative Review

Jolyon P. Mitchell, D. Coppolo, J. Schloss, 2021, Pulmonary Therapy.

Developing Ways to Evaluate in the Laboratory How Inhalation Devices Will Be Used by Patients and Care-Givers: The Need for Clinically Appropriate Testing

J. Suggett, J. Mitchell, 2014, AAPS PharmSciTech.

Improved laboratory test methods for orally inhaled products.

Jolyon P. Mitchell, M. Nagel, J. Mitchell, 2013, Therapeutic delivery.

Improved Quality Control Metrics for Cascade Impaction Measurements of Orally Inhaled Drug Products (OIPs)

Svetlana Lyapustina, Mike Van Oort, Bruce Wyka, 2009, AAPS PharmSciTech.

Performance Characterization of EDA and Its Potential to Improve Decision Making in Product Batch Release

Svetlana Lyapustina, Jolyon P. Mitchell, Terrence P. Tougas, 2013 .

Oral inhalation therapy: meeting the challenge of developing more patient-appropriate devices

Jolyon P. Mitchell, M. Nagel, J. Mitchell, 2009, Expert review of medical devices.

Innovative preclinical models for pulmonary drug delivery research

Jolyon P. Mitchell, J. Sznitman, O. Schmid, 2020, Expert opinion on drug delivery.

Comparison of three valved holding chambers for the delivery of fluticasone propionate-HFA to an infant face model.

Jolyon P. Mitchell, A. Coates, M. Nagel, 2006, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Good Practices for the Laboratory Performance Testing of Aqueous Oral Inhaled Products (OIPs): an Assessment from the International Pharmaceutical Aerosol Consortium on Regulation and Science (IPAC-RS)

R. B. Patel, A. Goodey, W. Doub, 2023, AAPS PharmSciTech.

Appropriate face models for evaluating drug delivery in the laboratory: the current situation and prospects for future advances.

Jolyon P Mitchell, J. Mitchell, 2008, Journal of aerosol medicine and pulmonary drug delivery.

Electrostatics and inhaled medications: influence on delivery via pressurized metered-dose inhalers and add-on devices.

Jolyon P. Mitchell, D. Coppolo, M. Nagel, 2007, Respiratory care.

Appropriate Face Models for Evaluating Drug Delivery in the Laboratory: The Current Situation and Prospects for Future Advances

Jolyon P. Mitchell, J. Mitchell, 2008 .

Valved holding chambers (VHCs) for use with pressurised metered-dose inhalers (pMDIs): a review of causes of inconsistent medication delivery.

Jolyon P Mitchell, Mark W Nagel, M. Nagel, 2007, Primary care respiratory journal : journal of the General Practice Airways Group.

Next generation pharmaceutical impactor (a new impactor for pharmaceutical inhaler testing). Part II: Archival calibration.

Virgil A Marple, S. Murray, V. Marple, 2003, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Measurement of Aerodynamic Particle Size Distribution of Orally Inhaled Products by Cascade Impactor: How to Let the Product Specification Drive the Quality Requirements of the Cascade Impactor

Jolyon P. Mitchell, D. Roberts, J. Mitchell, 2019, AAPS PharmSciTech.

Adapting the Abbreviated Impactor Measurement (AIM) concept to make appropriate inhaler aerosol measurements to compare with clinical data: a scoping study with the "Alberta" idealized throat (AIT) inlet.

Jolyon Mitchell, Mark Copley, Derek Solomon, 2012, Journal of aerosol medicine and pulmonary drug delivery.

Investigation of Dry Powder Inhaler (DPI) Resistance and Aerosol Dispersion Timing on Emitted Aerosol Aerodynamic Particle Sizing by Multistage Cascade Impactor when Sampled Volume Is Reduced from Compendial Value of 4 L

R. Greguletz, Volker Glaab, D. Roberts, 2014, AAPS PharmSciTech.

Moving Forward from "Fine Particle Fraction: The Good and the Bad".

R. B. Patel, S. Lyapustina, S. Stein, 2022, Journal of aerosol medicine and pulmonary drug delivery.

Laser diffractometry as a technique for the rapid assessment of aerosol particle size from inhalers.

Ola Nerbrink, O. Nerbrink, Jolyon P Mitchell, 2006, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Cascade impactors for the size characterization of aerosols from medical inhalers: their uses and limitations.

Jolyon P Mitchell, Mark W Nagel, M. Nagel, 2003, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

The Abbreviated Impactor Measurement (AIM) Concept: Part II—Influence of Evaporation of a Volatile Component—Evaluation with a “Droplet-Producing” Pressurized Metered Dose Inhaler (pMDI)-Based Formulation Containing Ethanol as Cosolvent

M. Nagel, V. Avvakoumova, R. Ali, 2009, AAPS PharmSciTech.

Effect of Sampling Volume on Dry Powder Inhaler (DPI)-Emitted Aerosol Aerodynamic Particle Size Distributions (APSDs) Measured by the Next-Generation Pharmaceutical Impactor (NGI) and the Andersen Eight-Stage Cascade Impactor (ACI)

D. Roberts, M. Hammond, H. Mohammed, 2012, AAPS PharmSciTech.

Jolyon P. Mitchell, Mark Copley, Daryl L. Roberts, 2012, AAPS PharmSciTech.

Considerations for the development and practice of cascade impaction testing, including a mass balance failure investigation tree.

Svetlana Lyapustina, Terrence Tougas, Bruce Wyka, 2003, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Particle Size Analysis of Aerosols from Medicinal Inhalers

Jolyon P. Mitchell, Mark W. Nagel, M. Nagel, 2004 .

Physical Causes of APSD Changes in Aerosols from OIPs and Their Impact on CI Measurements

Jolyon P. Mitchell, Beth Morgan, Helen Strickland, 2013 .

A Comparison of the Performance of Efficient Data Analysis Versus Fine Particle Dose as Metrics for the Quality Control of Aerodynamic Particle Size Distributions of Orally Inhaled Pharmaceuticals

Jolyon P. Mitchell, A. Goodey, S. Lyapustina, 2017, AAPS PharmSciTech.

Good Cascade Impactor Practices, AIM and EDA for Orally Inhaled Products

Jolyon P. Mitchell, Terrence P. Tougas, Svetlana Lyapustina, 2013, Springer US.

An in vitro study to investigate the use of a breath-actuated, small-volume, pneumatic nebulizer for the delivery of methacholine chloride bronchoprovocation agent.

Jolyon P. Mitchell, M. Nagel, C. Doyle, 2003, Respiratory care.

Clinically relevant test methods to establish in vitro equivalence for spacers and valved holding chambers used with pressurized metered dose inhalers (pMDIs).

Jolyon Mitchell, M. Dolovich, Myrna B Dolovich, 2012, Journal of aerosol medicine and pulmonary drug delivery.

The delivery of chlorofluorocarbon-propelled versus hydrofluoroalkane-propelled beclomethasone dipropionate aerosol to the mechanically ventilated patient: a laboratory study.

Jolyon P. Mitchell, K. J. Wiersema, M. Nagel, 2003, Respiratory care.

The importance of nonelectrostatic materials in holding chambers for delivery of hydrofluoroalkane albuterol.

J. L. Rau, K. J. Wiersema, Jolyon P Mitchell, 2006, Respiratory care.

Minimizing Variability of Cascade Impaction Measurements in Inhalers and Nebulizers

C. Quale, D. Cipolla, D. Christopher, 2008, AAPS PharmSciTech.

Particle Standards: Their Development and Application

Jolyon P. Mitchell, J. Mitchell, 2000 .

Measurement of the Physical Properties of Nuclear Aerosols

Jolyon P. Mitchell, A. Nichols, J. Mitchell, 1988 .

Reflections on Digital Health Tools for Respiratory Applications.

David Cipolla, Svetlana Lyapustina, Andy Dundon, 2020, Journal of aerosol medicine and pulmonary drug delivery.

Relative Precision of Inhaler Aerodynamic Particle Size Distribution (APSD) Metrics by Full Resolution and Abbreviated Andersen Cascade Impactors (ACIs): Part 1

Svetlana Lyapustina, Terrence Tougas, Jolyon P. Mitchell, 2010, AAPS PharmSciTech.

Canadian Standards Association standard CAN/CSA/Z264.1-02:2002: a new voluntary standard for spacers and holding chambers used with pressurized metered-dose inhalers.

M. Dolovich, Jolyon P Mitchell, Myrna B Dolovich, 2004, Canadian respiratory journal.

Spatial aerosol flow maldistribution: A design flaw confounding the proper calibration and data interpretation of stages “0” and “1” of the Andersen eight-stage nonviable cascade impactor

Jolyon P. Mitchell, D. Roberts, J. Mitchell, 2017 .

Cascade Impactor (CI) Mensuration—An Assessment of the Accuracy and Precision of Commercially Available Optical Measurement Systems

Jolyon Mitchell, Steve Nichols, Frank Chambers, 2010, AAPS PharmSciTech.

The Characterization of Water‐Droplet Aerosols by polytec optical particle analysers

Jolyon P. Mitchell, A. Nichols, A. V. Santen, 1989 .

Experimental Assessment and Calibration of an Inertial Spectrometer

A. Nichols, J. Mitchell, 1988 .

Non-impactor-Based Methods for Sizing of Aerosols Emitted from Orally Inhaled and Nasal Drug Products (OINDPs)

Svetlana Lyapustina, Terrence Tougas, Jolyon Mitchell, 2011, AAPS PharmSciTech.

Performance of Large-Volume versus Small-Volume Holding Chambers with Chlorofluorocarbon-Albuterol and Hydrofluoroalkane-Albuterol Sulfate

J. L. Rau, M. Nagel, J. Mitchell, 1999 .

Performance of large- and small-volume valved holding chambers with a new combination long-term bronchodilator/anti-inflammatory formulation delivered by pressurized metered dose inhaler.

Jolyon P. Mitchell, K. J. Wiersema, M. Nagel, 2002, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

Addressing the problem of noncompliance with inhalers by design: the 'patient-friendly' approach.

Jolyon P. Mitchell, J. Mitchell, 2011, Therapeutic delivery.

The 18th Congress of the International Society for Aerosols in Medicine.

S. Nichols, J. Mitchell, 2011, Therapeutic delivery.

The AIM and EDA Concepts: Why They Are Needed and How They Fit Together

Jolyon P. Mitchell, Terrence P. Tougas, T. Tougas, 2013 .

The Abbreviated Impactor Measurement (AIM) Concept: Part 1—Influence of Particle Bounce and Re-Entrainment—Evaluation with a “Dry” Pressurized Metered Dose Inhaler (pMDI)-Based Formulation

M. Nagel, V. Avvakoumova, R. Ali, 2009, AAPS PharmSciTech.

Determination of Passive Dry Powder Inhaler Aerodynamic Particle Size Distribution by Multi-Stage Cascade Impactor: International Pharmaceutical Aerosol Consortium on Regulation & Science (IPAC-RS) Recommendations to Support Both Product Quality Control and Clinical Programs

R. B. Patel, A. Goodey, W. Doub, 2019, AAPS PharmSciTech.

Clinically Relevant In Vitro Testing of Orally Inhaled Products—Bridging the Gap Between the Lab and the Patient

Jolyon P. Mitchell, M. Nagel, J. Suggett, 2016, AAPS PharmSciTech.