Y. Irukayama-tomobe

发表

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies

M. Iyo, I. Sora, M. Itokawa, 2015, Molecular Brain.

A Single Nucleotide Polymorphism of the Neuropeptide B/W Receptor-1 Gene Influences the Evaluation of Facial Expressions

T. Sakurai, Noriya Watanabe, Naoki Furutani, 2012, PloS one.

Effects of Medium-chain Triglyceride (MCT) Application to SHR on Cardiac Function, Hypertrophy and Expression of Endothelin-1 mRNA and other Genes

N. Shimojo, I. Yamaguchi, T. Miyauchi, 2004, Journal of cardiovascular pharmacology.

Stimulation of peroxisome-proliferator-activated receptor alpha (PPAR alpha) attenuates cardiac fibrosis and endothelin-1 production in pressure-overloaded rat hearts.

I. Yamaguchi, T. Miyauchi, K. Goto, 2002, Clinical science.

Peroxisome proliferator-activated receptor-gamma activators inhibit endothelin-1-related cardiac hypertrophy in rats.

I. Yamaguchi, T. Miyauchi, K. Goto, 2002, Clinical science.

Essential Role of p38 Mitogen-activated Protein Kinase in Contact Hypersensitivity*

A. Utani, M. Karin, S. Asada, 2002, The Journal of Biological Chemistry.

The benefit of medium-chain triglyceride therapy on the cardiac function of SHRs is associated with a reversal of metabolic and signaling alterations.

N. Shimojo, T. Miyauchi, Y. Irukayama-Tomobe, 2008, American journal of physiology. Heart and circulatory physiology.

Aging-induced decrease in the PPAR-α level in hearts is improved by exercise training

M. Matsuda, I. Yamaguchi, T. Miyauchi, 2002 .

Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-kappa-B pathway.

I. Yamaguchi, T. Miyauchi, S. Sakai, 2004, Journal of the American College of Cardiology.

Association of An Orexin 1 Receptor 408Val Variant with Polydipsia–Hyponatremia in Schizophrenic Subjects

T. Sakurai, Kazuo Yamada, Y. Iwayama, 2005, Biological Psychiatry.

Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B

T. Sakurai, M. Yanagisawa, Hirokazu Tanaka, 2009, Proceedings of the National Academy of Sciences.

Involvement of Endogenous Endothelin-1 in Exercise-Induced Redistribution of Tissue Blood Flow: An Endothelin Receptor Antagonist Reduces the Redistribution

M. Matsuda, I. Yamaguchi, T. Miyauchi, 2002, Circulation.

Oxygen radicals mediate the final exacerbation of endothelin-1-induced gastric ulcer in rat.

T. Miyauchi, K. Goto, A. Nakahara, 2001, European journal of pharmacology.

Peripherally administered orexin improves survival of mice with endotoxin shock

M. Yanagisawa, Satoru Takahashi, M. Hamada, 2016, eLife.

Exercise training improves ageing-induced decrease in eNOS expression of the aorta.

M. Matsuda, T. Miyauchi, S. Maeda, 2003, Acta physiologica Scandinavica.

Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training.

M. Matsuda, I. Yamaguchi, T. Miyauchi, 2002, American journal of physiology. Heart and circulatory physiology.

Pathway -terminal Kinase 2 Partly via Blockade of C-jun Nh Α Activated Receptor- − Proliferator Induced Cardiac Hypertrophy Is Inhibited by Activation of Peroxisome − Endothelin-1 Endothelin-1–induced Cardiac Hypertrophy Is Inhibited by Activation of Peroxisome Proliferator–activated Receptor-␣ Part

Y. Kasuya, I. Yamaguchi, T. Miyauchi, 2004 .

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.

M. Yanagisawa, H. Gouda, H. Nagase, 2015, Journal of medicinal chemistry.

Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

K. Vogt, T. Sakurai, M. Yanagisawa, 2017, Proceedings of the National Academy of Sciences.

Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies.

Yurie Watanabe, M. Yanagisawa, D. Kuroda, 2017, Journal of medicinal chemistry.

OX2R-selective orexin agonism is sufficient to ameliorate cataplexy and sleep/wake fragmentation without inducing drug-seeking behavior in mouse model of narcolepsy

Hiromasa Funato, Y. Nagumo, Y. Irukayama-Tomobe, 2022, PloS one.

Essential structure of orexin 1 receptor antagonist YNT-707: Conversion of the 16-cyclopropylmethyl group to the 16-sulfonamide group in D-nor-nalfurafine derivatives

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2022, Bioorganic & Medicinal Chemistry Letters.

Effects of the delta opioid receptor agonist KNT-127 on electroencephalographic activity in mice

M. Yanagisawa, H. Nagase, A. Saitoh, 2018, Pharmacological reports : PR.

Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies

M. Iyo, I. Sora, M. Itokawa, 2015, Molecular Brain.

Discovery of Orexin 2 Receptor Selective and Dual Orexin Receptor Agonists based on the Tetralin Structure: Switching of Receptor Selectivity by Chirality on the Tetralin Ring.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2022, Bioorganic & Medicinal Chemistry Letters.

Effect of sevoflurane preconditioning on sleep reintegration after alteration by lipopolysaccharide

Y. Irukayama-Tomobe, T. Kanbayashi, Hiromu Tanaka, 2022, Journal of sleep research.

Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium-derived factors, endothelin-1 and nitric oxide, in healthy young humans.

J. Sugawara, S. Kuno, M. Matsuda, 2001, Life sciences.

Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.

T. Sakurai, M. Yanagisawa, H. Gouda, 2021, European journal of medicinal chemistry.

Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine.

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2020, Bioorganic & medicinal chemistry letters.

Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2019, Bioorganic & medicinal chemistry letters.

Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity.

M. Yanagisawa, Y. Nagumo, Y. Irukayama-Tomobe, 2019, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2021, Bioorganic & medicinal chemistry letters.

Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors.

M. Yanagisawa, Y. Nagumo, H. Nagase, 2022, Bioorganic & medicinal chemistry letters.

Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2019, Bioorganic & medicinal chemistry.

Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2017, Bioorganic & medicinal chemistry letters.

Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.

M. Yanagisawa, H. Gouda, Y. Nagumo, 2017, Bioorganic & medicinal chemistry letters.

The Peroxisome Proliferator-activated Receptor α Activator Fenofibrate Inhibits Endothelin-1-induced Cardiac Fibroblast Proliferation

I. Yamaguchi, T. Miyauchi, K. Goto, 2004, Journal of cardiovascular pharmacology.

Activation of Peroxisome Proliferator-activated Receptor-α Decreases Endothelin-1-induced p38 Mitogen-activated Protein Kinase Activation in Cardiomyocytes

Y. Kasuya, I. Yamaguchi, T. Miyauchi, 2004, Journal of cardiovascular pharmacology.

Effects of aging and subsequent exercise training on gene expression of endothelin-1 in rat heart.

M. Matsuda, I. Yamaguchi, T. Miyauchi, 2002, Clinical science.

Y. Kasuya, I. Yamaguchi, T. Miyauchi, 2022 .