V. Hook

发表

Metabolomics Analyses of 14 Classical Neurotransmitters by GC-TOF with LC-MS Illustrates Secretion of 9 Cell-Cell Signaling Molecules from Sympathoadrenal Chromaffin Cells in the Presence of Lithium.

O. Fiehn, T. Kind, S. Samra, 2019, ACS chemical neuroscience.

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

Francine E. Garrett-Bakelman, Scott M Smith, Stuart M. C. Lee, 2019, Science.

Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders

C. Peters, T. Reinheckel, Vivian V. H. Hook, 2022, Pharmacological Reviews.

Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: Protease gene knockout and inhibitor studies

C. Peters, T. Reinheckel, T. Foulon, 2009, Peptides.

The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L.

J. Mccammon, W. Gerwick, Hyukjae Choi, 2014, Journal of natural products.

Proteases for processing proneuropeptides into peptide neurotransmitters and hormones.

Jill L. Wegrzyn, S. Bark, J. Wegrzyn, 2008, Annual review of pharmacology and toxicology.

Prohormone Thiol Protease

V. Hook, 2013 .

α1‐Antichymotrypsin‐Like Proteins I and II Purified from Bovine Adrenal Medulla Are Enriched in Chromaffin Granules and Inhibit the Proenkephalin Processing Enzyme “Prohormone Thiol Protease”

S. Yasothornsrikul, Shin‐Rong Hwang, C. Sei, 1999, Journal of neurochemistry.

Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin L

W. Gerwick, L. Beretta, R. Payne, 2021, Journal of medicinal chemistry.

Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L

W. Gerwick, L. Beretta, R. Payne, 2020, bioRxiv.

Design of gallinamide A analogs as potent inhibitors of the cysteine proteases human cathepsin L and Trypanosoma cruzi cruzain.

Paul D. Boudreau, W. Gerwick, L. McCall, 2019, Journal of medicinal chemistry.

Expansion of the mycobacterial "PUPylome".

Vineet Bafna, Pieter C Dorrestein, Jeramie Watrous, 2010, Molecular bioSystems.

Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons

Charisse N. Winston, R. Rissman, C. Lietz, 2021, ACS omega.

Zinc regulation of aminopeptidase B involved in neuropeptide production

Shin‐Rong Hwang, V. Hook, 2008, FEBS Letters.

Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions.

D. Wolan, W. Gerwick, Anthony J. O’Donoghue, 2021, ACS chemical biology.

The Emerging Role of Spinal Dynorphin in Chronic Pain: A Therapeutic Perspective.

T. Yaksh, Vivian V. H. Hook, Sonia Podvin, 2016, Annual review of pharmacology and toxicology.

Secretory vesicle aminopeptidase B related to neuropeptide processing: molecular identification and subcellular localization to enkephalin‐ and NPY‐containing chromaffin granules

T. Foulon, S. Bark, Shin‐Rong Hwang, 2007, Journal of neurochemistry.

Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development

Sonia Podvin, Amy Hsu, V. Hook, 2018, Journal of Molecular Neuroscience.

NeuroPedia: neuropeptide database and spectral library

Nuno Bandeira, Yoona Kim, Steven Bark, 2011, Bioinform..

Proteases and the emerging role of protease inhibitors in prohormone processing

Shin‐Rong Hwang, N. Tezapsidis, V. Hook, 1994, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Differential Neuropeptidomes of Dense Core Secretory Vesicles (DCSV) Produced at Intravesicular and Extracellular pH Conditions by Proteolytic Processing

C. Lietz, Michael C Yoon, Zhenze Jiang, 2021, ACS chemical neuroscience.

Novel Chromaffin Granule Serpins, Endopin 1 and Endopin 2

S. Yasothornsrikul, Vivian V. H. Hook, Shin‐Rong Hwang, 2002, Annals of the New York Academy of Sciences.

Synapsin-caveolin-1 mitigates cognitive deficits and neurodegeneration in Alzheimer’s disease mice

J. Trojanowski, S. Wagner, A. Miyanohara, 2020, bioRxiv.

Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington’s Disease

S. Rosenthal, K. Fisch, Vivian V. H. Hook, 2022, Journal of Huntington's disease.

Bioinformatic analyses of mammalian 5'-UTR sequence properties of mRNAs predicts alternative translation initiation sites

Jill L. Wegrzyn, Faramarz Valafar, Vivian Hook, 2008, BMC Bioinformatics.

Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B.

W. Gerwick, Anthony J. O’Donoghue, Vivian V. H. Hook, 2022, Biochemistry.

Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.

R. Rissman, Michael C Yoon, G. Hook, 2020, Biochimica et biophysica acta. Proteins and proteomics.

The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H‐D exchange mass spectrometry

Virgil L. Woods, Sheng Li, Tong Liu, 2012, Protein science : a publication of the Protein Society.

Dysregulation of Neuropeptide and Tau Peptide Signatures in Human Alzheimer’s Disease Brain

R. Rissman, Zhenze Jiang, Sonia Podvin, 2022, ACS chemical neuroscience.

Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry

O. Fiehn, T. Cajka, Vivian V. H. Hook, 2018, Journal of The American Society for Mass Spectrometry.

Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication.

D. O'Connor, C. Sigurdson, A. L. La Spada, 2010, Journal of proteome research.

The proteasome as a drug target in the metazoan pathogen, Schistosoma mansoni.

Brian M. Suzuki, G. Salvesen, W. Gerwick, 2019, ACS infectious diseases.

Multiple clinical features of Huntington’s disease correlate with mutant HTT gene CAG repeat lengths and neurodegeneration

Sonia Podvin, Holly T Reardon, Katrina Yin, 2018, Journal of Neurology.

Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia

D. Jeste, P. Dorrestein, Tanya T. Nguyen, 2021, Molecular Psychiatry.

Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses*

Charisse N. Winston, R. Rissman, C. Lietz, 2020, Molecular & Cellular Proteomics.

The Protein Architecture of Human Secretory Vesicles Reveals Differential Regulation of Signaling Molecule Secretion by Protein Kinases

D. O'Connor, T. Ideker, M. Smoot, 2012, PloS one.

The future of proteomic analysis in biological systems and molecular medicine.

S. Bark, V. Hook, 2007, Molecular bioSystems.

Cathepsin B Deficiency Improves Memory Deficits and Reduces Amyloid-β in hAβPP Mouse Models Representing the Major Sporadic Alzheimer’s Disease Condition

G. Hook, Mark Kindy, V. Hook, 2023, Journal of Alzheimer's disease : JAD.

Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems

N. Bandeira, Vivian V. H. Hook, V. Hook, 2015, Journal of The American Society for Mass Spectrometry.

Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing.

Nitin Gupta, Pavel Pevzner, P. Pevzner, 2010, Journal of proteome research.

Detecting low-abundance vasoactive peptides in plasma: progress toward absolute quantitation using nano liquid chromatography-mass spectrometry.

R. Blantz, Vivian V. H. Hook, M. Lortie, 2009, Analytical biochemistry.

Mass Spectrometry-Based Visualization of Molecules Associated with Human Habitats.

Nuno Bandeira, Rob Knight, Jelena Todoric, 2016, Analytical chemistry.

Linear and accurate quantitation of proenkephalin-derived peptides by isotopic labeling with internal standards and mass spectrometry.

S. Bark, Vivian Hook, Steven J Bark, 2009, Analytical biochemistry.

Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD

J. Trojanowski, S. Wagner, A. Miyanohara, 2021, Molecular therapy. Methods & clinical development.

Multiple domains of endopin 2A for serpin cross-class inhibition of papain.

Vivian V. H. Hook, Shin‐Rong Hwang, V. Hook, 2007, Archives of biochemistry and biophysics.

Cathepsin B Dipeptidyl Carboxypeptidase and Endopeptidase Activities Demonstrated across a Broad pH Range

Vivian V. H. Hook, Michael C Yoon, A. O’Donoghue, 2022, Biochemistry.

Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling

H. Qing, Vivian V. H. Hook, G. Hook, 2020, Journal of neurochemistry.

Mitochondrial Dysfunction in NnaD Mutant Flies and Purkinje Cell Degeneration Mice Reveals a Role for Nna Proteins in Neuronal Bioenergetics

Gennifer E. Merrihew, M. MacCoss, D. Goodlett, 2010, Neuron.

Distinct Dibasic Cleavage Specificities of Neuropeptide-Producing Cathepsin L and Cathepsin V Cysteine Proteases Compared to PC1/3 and PC2 Serine Proteases

Vivian V. H. Hook, Michael C Yoon, Zhenze Jiang, 2022, ACS chemical neuroscience.

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma

G. Baselli, E. Kistler, G. Tedeschi, 2020, Molecules.

Discovery of pH-Selective Marine and Plant Natural Product Inhibitors of Cathepsin B Revealed by Screening at Acidic and Neutral pH Conditions

W. Gerwick, C. Caffrey, E. Glukhov, 2022, ACS omega.

Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development

Sonia Podvin, Amy Hsu, V. Hook, 2018, Journal of Molecular Neuroscience.

Penetrating Traumatic Brain Injury Triggers Subacute Dysregulation of Cathepsin B Protein Levels Independently of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid.

C. Robertson, Kevin K. W. Wang, G. Sarkis, 2020, Journal of neurotrauma.

Mutation in the substrate-binding site of aminopeptidase B confers new enzymatic properties.

C. Etchebest, P. Nicolas, T. Foulon, 2011, Biochimie.

A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells

F. Frueh, F. Raushel, L. Beretta, 2021, ACS chemical biology.

Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range

Michael C Yoon, Von V Phan, Sonia Podvin, 2023, Biochemistry.

Differential accessibilities of dibasic prohormone processing sites of proenkephalin to the aqueous environment revealed by H-D exchange mass spectrometry.

Virgil L. Woods, Sheng Li, Vivian V. H. Hook, 2009, Biochemistry.

Bioinformatics Applications Note Databases and Ontologies Neuropedia: Neuropeptide Database and Spectral Library

N. Bandeira, S. Bark, Yoo-Sook Kim, 2022 .

Evaluation of bumetanide as a potential therapeutic agent for Alzheimer’s disease

H. Feldman, R. Tanzi, Doo Yeon Kim, 2023, Frontiers in pharmacology.

The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury.

M. Kindy, M. Pierschbacher, Jin Yu, 2014, Journal of neurotrauma.

Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate

M. Kindy, K. Grabstein, G. Hook, 2015, Front. Neurol..

A Commensal Dipeptidyl Aminopeptidase with Specificity for N-Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro.

D. Wolan, Anthony J. O’Donoghue, Janice H. Xu, 2018, ACS chemical biology.

Demonstration of GTG as an alternative initiation codon for the serpin endopin 2B-2.

J. Wegrzyn, Shin‐Rong Hwang, V. Hook, 2005, Biochemical and biophysical research communications.

Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses.

Charisse N. Winston, R. Rissman, C. Lietz, 2020, Molecular & Cellular Proteomics.

The novel bovine serpin endopin 2C demonstrates selective inhibition of the cysteine protease cathepsin L compared to the serine protease elastase, in cross-class inhibition.

V. Turk, V. Stoka, Vivian V. H. Hook, 2005, Biochemistry.

Proteases for processing proneuropeptides into peptide neurotransmitters and hormones.

S. Bark, J. Wegrzyn, Shin‐Rong Hwang, 2008, Annual review of pharmacology and toxicology.