T. G. Holt

发表

The discovery of high affinity agonists of GPR109a with reduced serum shift and improved ADME properties.

J. Tata, S. Colletti, J. Imbriglio, 2011, Bioorganic & medicinal chemistry letters.

Eudistomins A-Q, β-carbolines from the antiviral Caribbean tunicate Eudistoma olivaceum

K. Rinehart, J. Gilmore, M. Mascal, 1987 .

Discovery of novel tricyclic full agonists for the G-protein-coupled niacin receptor 109A with minimized flushing in rats.

Kenneth K. Wu, Q. Deng, Hong C Shen, 2009, Journal of medicinal chemistry.

Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.

M. Forrest, Kenneth K. Wu, Q. Deng, 2010, Journal of medicinal chemistry.

Biologically active natural products

R. Sakai, K. Rinehart, D. Seigler, 1990 .

Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata

Paul A. Keifer, Furong Sun, Kenneth L. Rinehart, 1990 .

Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.

Hong C Shen, X. Tong, Qing Chen, 2010, Bioorganic & medicinal chemistry letters.

Anthranilic acid replacements in a niacin receptor agonist.

D. Blom, Hong C Shen, J. Tata, 2010, Bioorganic & medicinal chemistry letters.

Bioactive compounds from aquatic and terrestrial sources.

R. Sakai, K. Rinehart, C. Grimmelikhuijzen, 1990, Journal of natural products.

Pharmacological activation and genetic manipulation of cystathionine beta-synthase alter circulating levels of homocysteine and hydrogen sulfide in mice.

N. Geoghagen, Kristian K. Jensen, W. Ni, 2011, European journal of pharmacology.

Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.

M. Forrest, Kenneth K. Wu, Q. Deng, 2007, Journal of medicinal chemistry.

Biomarker discovery in rat plasma for estrogen receptor‐α action

P. Griffin, S. Rohrer, E. Rohde, 2005 .

Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists.

Hong C Shen, J. Tata, S. Colletti, 2008, Bioorganic & medicinal chemistry letters.

A simple in vitro model to study the stability of acylglucuronides.

J. Pivnichny, T. Holt, Zhesheng Chen, 2007, Journal of pharmacological and toxicological methods.

Pyrazole acids as niacin receptor agonists for the treatment of dyslipidemia.

D. Blom, J. Tata, S. Colletti, 2009, Bioorganic & medicinal chemistry letters.

GPR109a agonists. Part 2: pyrazole-acids as agonists of the human orphan G-protein coupled receptor GPR109a.

J. Tata, S. Colletti, E. Carballo-Jane, 2010, Bioorganic & medicinal chemistry letters.

Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications.

Claude Dufresne, Gergely M Makara, Bernard K. Choi, 2009, Assay and drug development technologies.

Bioactive Compounds from Aquatic and Terrestrial Sources

Paul A. Keifer, David S. Seigler, Kenneth L. Rinehart, 1991 .

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

M. Reitman, D. Macneil, R. Berger, 2008, Bioorganic & medicinal chemistry letters.

Discovery of imidazole carboxamides as potent and selective CCK1R agonists.

M. Reitman, D. Macneil, S. Qian, 2008, Bioorganic & medicinal chemistry letters.

Expanding the Scope of HTMS Methods

Bernard K. Choi, N. Geoghagen, Kristian K. Jensen, 2011 .

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.

M. Reitman, D. Macneil, R. Berger, 2008, Bioorganic & medicinal chemistry letters.

Label-free high-throughput screening via mass spectrometry: a single cystathionine quantitative method for multiple applications.

Bernard K. Choi, N. Geoghagen, Kristian K. Jensen, 2009, Assay and drug development technologies.

Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A.

Hong C Shen, X. Tong, Qing Chen, 2010, Bioorganic & medicinal chemistry letters.