S. Bai

发表

Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4- [(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor.

P. Lam, R. Knabb, R. Alexander, 2005, Journal of medicinal chemistry.

Discovery of 1-(2-aminomethylphenyl)-3-trifluoromethyl-N- [3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-4-yl]-1H-pyrazole-5-carboxyamide (DPC602), a potent, selective, and orally bioavailable factor Xa inhibitor(1).

P. Lam, R. Knabb, R. Alexander, 2003, Journal of medicinal chemistry.

Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa.

P. Lam, R. Knabb, R. Wexler, 2006, Bioorganic & Medicinal Chemistry Letters.

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa.

P. Lam, R. Knabb, R. Wexler, 2006, Bioorganic & medicinal chemistry letters.

1-[3-Aminobenzisoxazol-5'-yl]-3-trifluoromethyl-6-[2'-(3-(R)-hydroxy-N-pyrrolidinyl)methyl-[1,1']-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.

P. Lam, K. He, R. Knabb, 2006, Bioorganic & medicinal chemistry letters.

Aminobenzisoxazoles with biaryl P4 moieties as potent, selective, and orally bioavailable factor Xa inhibitors.

P. Lam, R. Knabb, R. Wexler, 2006, Bioorganic & medicinal chemistry letters.

Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors.

P. Lam, K. He, R. Knabb, 2008, Bioorganic & medicinal chemistry letters.

Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors.

P. Lam, K. He, R. Knabb, 2007, Bioorganic & medicinal chemistry letters.

Preparation of 1‐(4‐Methoxyphenyl)‐1H‐pyrazolo[4,3‐d]pyrimidin‐7(6H)‐ones as Potent, Selective and Bioavailable Inhibitors of Coagulation Factor Xa.

P. Lam, R. Knabb, R. Wexler, 2006 .

Structure-based design of novel guanidine/benzamidine mimics: potent and orally bioavailable factor Xa inhibitors as novel anticoagulants.

P. Lam, K. He, R. Knabb, 2003, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of 8-(pyrid-3-yl)pyrazolo[1,5-a]-1,3,5-triazines: potent, orally bioavailable corticotropin releasing factor receptor-1 (CRF1) antagonists.

S. Arneric, G. Trainor, H. Wong, 2009, Journal of medicinal chemistry.