J. Owen

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Apolipoprotein E Inhibits Platelet Aggregation through the L-Arginine:Nitric Oxide Pathway

D. Riddell, A. Graham, J. Owen, 1997, The Journal of Biological Chemistry.

Binding of apoE-rich high density lipoprotein particles by saturable sites on human blood platelets inhibits agonist-induced platelet aggregation.

K. Bruckdorfer, R. Hutton, K. Desai, 1989, Journal of lipid research.

Human Plasma Lipid Modulation in Schistosomiasis Mansoni Depends on Apolipoprotein E Polymorphism

J. S. Owen, A. Domingues, C. S. M. da Fonseca, 2014, PloS one.

Intramuscular injection of a plasmid vector expressing human apolipoprotein E limits progression of xanthoma and aortic atheroma in apoE-deficient mice.

D. Riddell, A. Tagalakis, M. Dunckley, 2000, Human molecular genetics.

Trypanosoma brucei brucei obtains cholesterol from plasma lipoproteins

M. Gillett, J. Owen, 1987 .

Hydrogel and membrane scaffold formulations of Frutalin (breadfruit lectin) within a polysaccharide galactomannan matrix have potential for wound healing.

J. S. Owen, M. Lourenzoni, D. Abraham, 2019, International journal of biological macromolecules.

PLASMA FREE AND ESTERIFIED CHOLESTEROL IN SCHISTOSOMIASIS MANSONI

M. Gillett, A. Coutinho, J. Owen, 1976, The Lancet.

Immobilized Cratylia mollis lectin as a potential matrix to isolate plasma glycoproteins, including lecithin-cholesterol acyltransferase

J. S. Owen, C. Sampaio, L. Coelho, 1997 .

Lecithin-cholesterol acyltransferase (LCAT) as a plasma glycoprotein: an overview

J. S. Owen, J. Kennedy, L. Coelho, 2004 .

Erythrocyte echinocytosis in liver disease. Role of abnormal plasma high density lipoproteins.

J S Owen, N. Mcintyre, D. Harry, 1985, The Journal of clinical investigation.

An inverse correlation between plasma prostacyclin and serum triglycerides.

J. S. Owen, N. Mcintyre, R. Hutton, 1980 .

Neuroacanthocytosis. A clinical, haematological and pathological study of 19 cases.

J S Owen, V. P. Misra, A. Harding, 1991, Brain : a journal of neurology.

Platelet lipid composition and platelet aggregation in human liver disease.

J. S. Owen, N. Mcintyre, K. Bruckdorfer, 1981, Journal of lipid research.

Hydrogenation of plasma lipoproteins by a water-soluble catalyst; its use as a structural probe.

J. S. Owen, P. Quinn, C. Katagiri, 2005, European journal of biochemistry.

Development of therapeutic splice-switching oligonucleotides.

J. S. Owen, P. Disterer, B. Khoo, 2014, Human gene therapy.

An evaluation of the marmoset Callithrix jacchus (sagüi) as an experimental model for the dyslipoproteinemia of human Schistosomiasis mansoni.

J. S. Owen, P. Dolphin, B. Stewart, 1998, Biochimica et biophysica acta.

Lack of RNA–DNA oligonucleotide (chimeraplast) mutagenic activity in mouse embryos

A. Tagalakis, J. Simons, J. Owen, 2005, Molecular reproduction and development.

Oligonucleotide‐mediated gene editing is underestimated in cells expressing mutated green fluorescent protein and is positively associated with target protein expression

P. Disterer, Vanessa C. Evans, I. Papaioannou, 2012, The journal of gene medicine.

Inhibition of ADP-induced platelet aggregation by apoE is not mediated by membrane cholesterol depletion.

J. S. Owen, D. Riddell, J. Owen, 1995, Thrombosis research.

Gene Correction of the Apolipoprotein (Apo) E2 Phenotype to Wild-type ApoE3 by in Situ Chimeraplasty*

J. S. Owen, I. Graham, D. Riddell, 2001, The Journal of Biological Chemistry.

Review article: S‐Adenosyl‐L‐Methionine–a new therapeutic agent in liver disease?

A. Burroughs, J. Owen, E. Osman, 1993, Alimentary pharmacology & therapeutics.

Hemostatic Dysfunction Is Increased in Patients with Hepatosplenic Schistosomiasis Mansoni and Advanced Periportal Fibrosis

J. S. Owen, V. Lima, A. Domingues, 2013, PLoS neglected tropical diseases.

Lecithin:cholesterol acyltransferase deficiency associated with hepatic schistosomiasis mansoni.

J. S. Owen, M. Gillett, J. Owen, 1978, Scandinavian journal of clinical and laboratory investigation. Supplementum.

Detection of a Protein in Human Platelet Membranes which Binds Low-density Lipoproteins.

J. S. Owen, K. Bruckdorfer, D. Hassall, 1990, Platelets.

Trypanosoma brucei brucei and high-density lipoproteins: old and new thoughts on the identity and mechanism of the trypanocidal factor in human serum.

J. S. Owen, B. Betschart, P. Lorenz, 1995, Parasitology today.

Oligonucleotide-directed gene-editing technology: mechanisms and future prospects

Ioannis Papaioannou, James S Owen, J Paul Simons, 2012, Expert opinion on biological therapy.

Acanthocytosis, Retinitis Pigmentosa, and Pallidal Degeneration

A. E. Harding, J. S. Owen, C. Marsden, 1995, Neurology.

Decreased erythrocyte membrane fluidity and altered lipid composition in human liver disease.

J. S. Owen, N. Mcintyre, K. Bruckdorfer, 1981, Journal of lipid research.

Two novel missense mutations in ABCA1 result in altered trafficking and cause severe autosomal recessive HDL deficiency.

C. Higgins, A. Sardini, C. Albrecht, 2004, Biochimica et biophysica acta.

Nitric oxide and platelet aggregation.

D. Riddell, J. Owen, James S. Owen, 1999, Vitamins and hormones.

Validation of oligonucleotide-mediated gene editing

P. Disterer, J. Simons, J. Owen, 2009, Gene Therapy.

Use of internally nuclease‐protected single‐strand DNA oligonucleotides and silencing of the mismatch repair protein, MSH2, enhances the replication of corrected cells following gene editing

P. Disterer, I. Papaioannou, J. Owen, 2009, The journal of gene medicine.

Oligonucleotide Therapeutics to Treat Dyslipoproteinemia and Atherosclerosis

I. Papaioannou, J. Owen, 2009 .

Gene Therapy for Apolipoprotein A-I and HDL—The Ultimate Treatment for Atherosclerosis

J. S. Owen, P. Disterer, E. Osman, 2008 .

ApoE gene therapy to treat hyperlipidemia and atherosclerosis.

Vanessa C. Evans, Julian D. Harris, J. Owen, 2006, Current opinion in molecular therapeutics.

ApoE gene therapy: an overview and update

J. S. Owen, J. Owen, 2005 .

Exon skipping of hepatic APOB pre-mRNA with splice-switching oligonucleotides reduces LDL cholesterol in vivo.

P. Disterer, B. Khoo, S. Waddington, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Transgenic mice expressing human apolipoprotein A-I have sera with modest trypanolytic activity in vitro but remain susceptible to infection by Trypanusoma brucei brucei

T. Hughes, J. Owen, T. Gillett, 2002 .

Ability of S-Adenosyl-L-Methionine to Ameliorate Lipoprotein-Induced Membrane Lipid Abnormalities and Cellular Dysfunctions in Human Liver Disease

J. S. Owen, A. Burroughs, S. Rafique, 1992 .

Trypanosoma brucei brucei: differences in the trypanocidal activity of human plasma and its relationship to the level of high density lipoproteins.

M. Gillett, J. Owen, 1991, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Targeted In Situ Gene Correction of Dysfunctional APOE Alleles to Produce Atheroprotective Plasma ApoE3 Protein

J. Simons, I. Papaioannou, J. Owen, 2012, Cardiology research and practice.

Frutapin, a lectin from Artocarpus incisa (breadfruit): cloning, expression and molecular insights

J. S. Owen, Jingxu Guo, A. Coker, 2017, Bioscience reports.

Delivery of human apolipoprotein (apo) E to liver by an (E1 - , E3 - , polymerase - , pTP - ) adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice

J. S. Owen, I. Graham, G. Dickson, 2006 .

Lipids, Alcohol and the Liver

J S Owen, J. Owen, 1987 .

Apolipoprotein E and regulation of cytokine-induced cell adhesion molecule expression in endothelial cells.

J. S. Owen, D. Riddell, A. Stannard, 1998, Atherosclerosis.

The aggregation of isolated human platelets in the presence of lipoproteins and prostacyclin.

J. S. Owen, K. Bruckdorfer, D. Hassall, 1983, The Biochemical journal.

Splenectomy Improves Hemostatic and Liver Functions in Hepatosplenic Schistosomiasis Mansoni

V. Lima, A. Domingues, E. Lopes, 2015, PloS one.

Inability of plasma high-density lipoproteins to inhibit cell adhesion molecule expression in human coronary artery endothelial cells.

J. S. Owen, S. Allen, A. Graham, 2001, Atherosclerosis.

Elevated levels of erythrocyte-conjugated dienes indicate increased lipid peroxidation in schistosomiasis mansoni patients.

J. S. Owen, H. Facundo, C. Brandt, 2004, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Construction and characterization of polycistronic retrovirus vectors for sustained and high-level co-expression of apolipoprotein A-I and lecithin-cholesterol acyltransferase.

G. Dickson, L. Fan, J. Owen, 1999, Atherosclerosis.

Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle.

J. S. Owen, I. Graham, G. Dickson, 2011, Metabolism: clinical and experimental.

Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1(-), E3(-), polymerase(-)] adenovirus vector expressing human apoE.

J. S. Owen, I. Graham, G. Dickson, 2002, Human molecular genetics.

A study of the structure of the gene for lecithin: cholesterol acyltransferase in four unrelated individuals with familial lecithin: cholesterol acyltransferase deficiency.

S. Humphries, C. Vergani, A. Catapano, 1988, Clinical science.

Complete deficiency of plasma lecithin‐cholesterol acyltransferase (LCAT) activity due to a novel homozygous mutation (Gly‐30‐Ser) in the LCAT gene

G. Watts, G. Assmann, P. Cullen, 1996, Human mutation.

Transgenic mice expressing human apolipoprotein A-I have sera with modest trypanolytic activity in vitro but remain susceptible to infection by Trypanosoma brucei brucei.

T. Hughes, M. Gillett, J. Owen, 1992, Journal of lipid research.

Extrahepatic Cell Membrane Lipid Abnormalities and Cellular Dysfunction in Liver Disease

J. S. Owen, J. Owen, 2012, Drugs.

Abnormal high density lipoproteins from patients with liver disease regulate cholesterol metabolism in cultured human skin fibroblasts.

J. S. Owen, N. Mcintyre, D. Harry, 1984, Journal of lipid research.

ATP-binding cassette A1 protein and HDL homeostasis.

J. V. Mulcahy, J. Owen, 2002, Atherosclerosis. Supplements.

A Brazilian regional basic diet-induced chronic malnutrition drives liver inflammation with higher ApoA-I activity in C57BL6J mice

J. S. Owen, M. Guedes, R. Oriá, 2020, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Evidence for a paraoxonase-independent inhibition of low-density lipoprotein oxidation by high-density lipoprotein.

J. S. Owen, A. Graham, S. Rafique, 1997, Atherosclerosis.

Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice.

J. S. Owen, I. Graham, G. Dickson, 2009, Atherosclerosis.

Human apolipoprotein E expression from mouse skeletal muscle by electrotransfer of nonviral DNA (plasmid) and pseudotyped recombinant adeno-associated virus (AAV2/7).

I. Graham, G. Dickson, Vanessa C. Evans, 2008, Human gene therapy.

Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells

J. S. Owen, S. Sacre, A. Stannard, 2003, FEBS letters.

Cell-derived Apolipoprotein E (ApoE) Particles Inhibit Vascular Cell Adhesion Molecule-1 (VCAM-1) Expression in Human Endothelial Cells*

A. von Eckardstein, P. Cullen, G. Dickson, 2001, The Journal of Biological Chemistry.

Lipoproteins, cell membranes and cellular functions

N. Mcintyre, M. Gillett, J. Owen, 1984 .

How does interferon inhibit HCV cell entry?

Meleri Jones, J. Owen, 2008, Gut.

Scavenger Receptor BI and BII Expression Levels Modulate Hepatitis C Virus Infectivity

James S. Owen, Joe Grove, Peter Balfe, 2007, Journal of Virology.

Heterogeneity in the properties of the trypanolytic factor in normal human serum.

J. S. Owen, B. Betschart, R. James, 1994, Molecular and biochemical parasitology.

Characteristics of the binding of human and bovine high-density lipoproteins by bloodstream forms of the African trypanosome, Trypanosoma brucei brucei.

J. S. Owen, M. Gillett, J. Owen, 1992, Biochimica et biophysica acta.

Human serum resistant Trypanosoma brucei rhodesiense accumulates similar amounts of fluorescently-labelled trypanolytic human HDL3 particles as human serum sensitive T.b. brucei.

J. S. Owen, P. Lorenz, D. Hassall, 1995, Molecular and biochemical parasitology.

Lysis of African trypanosomes by human plasma lipoproteins

M. Gillett, J. Owen, 1987 .

Lecithin-cholesterol acyltransferase activity and lipid concentrations in plasma of the brazilian oppossum (Didelphis azarae azarae)

J. S. Owen, V. Lima, M. Gillett, 1980 .

Plasma lipoprotein metabolism and lipid transport

N. Mcintyre, J. Owen, 1982 .

Human scavenger receptor class B type II (SR-BII) and cellular cholesterol efflux.

J. S. Owen, D. Riddell, J. V. Mulcahy, 2004, The Biochemical journal.

The secondary structure of apolipoproteins in human HDL3 particles after chemical modification of their tyrosine, lysine, cysteine or arginine residues. A Fourier transform infrared spectroscopy study.

J. S. Owen, D. Chapman, E. Herzyk, 1988, Biochimica et biophysica acta.

Hereditary lecithin-cholesterol acyltransferase deficiency. Case report of a German patient.

M. Clemens, P. Weber, K. Desai, 1987, American journal of clinical pathology.

Lecithin‐cholesterol acyltransferase deficiency presenting with acute pancreatitis: effect of infusion of normal plasma on triglyceride‐rich lipoproteins

G. F. Watts, K. Mitropoulos, A. Al-bahrani, 1995, Journal of internal medicine.

Human high density lipoproteins stimulate endothelin-1 release by cultured human renal proximal tubular cells.

J. S. Owen, J. Moorhead, A. Ong, 1994, Kidney international.

Role of ABC1 gene in cholesterol efflux and atheroprotection

J. S. Owen, J. Owen, 1999, The Lancet.

A first British case of fish-eye disease presenting at age 75 years: a double heterozygote for defined and new mutations affecting LCAT structure and expression.

P. Pritchard, D. Vallance, A. Winder, 1999, Journal of clinical pathology.

Effects of peroxynitrite on plasma components of the reverse cholesterol transport pathway

J. S. Owen, A. Graham, D. V. Vinogradov, 1998, FEBS letters.

Deficiency of lecithin:cholesterol acyltransferase due to compound heterozygosity of two novel mutations (Gly33Arg and 30 bp ins) in the LCAT gene.

G. Assmann, P. Cullen, H. Wiebusch, 1995, Human molecular genetics.

Fish-eye disease at 76 year

D. Vallance, A. Winder, R. Wray, 1993 .

Lecithin-cholesterol acyltransferase and the lipoprotein abnormalities of parenchymal liver disease.

J. S. Owen, N. Mcintyre, D. Harry, 1979, Clinical science.

Plasma lecithin:cholesterol acyltransferase activity and the lipoprotein abnormalities of liver disease.

J. S. Owen, N. Mcintyre, D. Harry, 1978, Scandinavian journal of clinical and laboratory investigation. Supplementum.

Reversal of extrahepatic membrane cholesterol deposition in patients with chronic liver diseases by S-adenosyl-L-methionine.

A. Burroughs, M. Guardascione, S. Rafique, 1992, Clinical science.

Lipids, lipoproteins, and cell membranes.

J. S. Owen, N. Mcintyre, D. Harry, 1982, Progress in liver diseases.

Determination of the Proportion of Cholesteryl Ester in Plasma

J. Owen, Vera Ramalho, J. S. Mederios, 1978, Annals of clinical biochemistry.

Plasma Lipoproteins and the Regulation of Cellular Function

J. S. Owen, J. Owen, 1984 .

Increased Na(+)-dependent D-glucose transport and altered lipid composition in renal cortical brush-border membrane vesicles from bile duct-ligated rats.

J. S. Owen, N. Mcintyre, J. Scoble, 1992, Journal of lipid research.

Plasma lipids, lipoproteins and cell membranes.

J. S. Owen, M. Gillett, J. Owen, 1983, Biochemical Society transactions.

Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction

P. Murdock, C. Dingwall, J. Owen, 2005, Neurobiology of Aging.

Determination of lecithin:cholesterol acyltransfer in mouse plasma and the influence of mercaptoethanol and sulphydryl blocking agents on its activity.

J. S. Owen, M. Gillett, V. Ramalho, 1979, Comparative biochemistry and physiology. B, Comparative biochemistry.

Erythrocyte lipid composition and sodium transport in human liver disease.

N. Mcintyre, J. Owen, 1978, Biochimica et biophysica acta.

Ophthalmoplegia and ptosis in congenital fiber type disproportion.

L. Kline, S. Oh, J. Benton, 1981, Journal of pediatric ophthalmology and strabismus.

Failure to generate atheroprotective apolipoprotein AI phenotypes using synthetic RNA/DNA oligonucleotides (chimeraplasts)

I. Graham, G. Dickson, M. Ogris, 2003, The journal of gene medicine.

Gene repair validation

J. S. Owen, I. Graham, G. Dickson, 2001, Nature Biotechnology.

Membrane lipid changes in erythrocytes, liver and kidney in acute and chronic experimental liver disease in rats.

J. S. Owen, N. Mcintyre, S. Kawata, 1987, Biochimica et biophysica acta.

Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range.

Paul C Beard, P. Beard, T. Allen, 2012, Journal of biomedical optics.

Comparison of the cytolytic effects in vitro on Trypanosoma brucei brucei of plasma, high density lipoproteins, and apolipoprotein A-I from hosts both susceptible (cattle and sheep) and resistant (human and baboon) to infection.

M. Gillett, J. Owen, 1992, Journal of lipid research.

Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts)

J. S. Owen, A. Tagalakis, J. Dickson, 2007, Journal of Molecular Neuroscience.

Correction of the neuropathogenic human apolipoprotein E 4 gene ( APOE 4 ) to APOE 3 in vitro using synthetic RNA / DNA oligonucleotides ( chimeraplasts )

J. S. Owen, A. Tagalakis, J. Simons, 2005 .

Incubation of porcine high-density lipoprotein with the apical surface of LLC-PK1 renal tubular cells sustains the properties of orientated monolayers.

J. S. Owen, B. Hendry, C. Streather, 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

HDL particles as the trypanosome-killing factor in human serum: An exclusive or inconclusive role?

B. Betschart, P. Lorenz, J. Owen, 1996, Parasitology today.

Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

J. S. Owen, E. F. Oliveira-Filho, R. Oriá, 2021, World journal of gastroenterology.

Hepatitis C virus (HCV) tends to associate preferentially with high-density lipoproteins by standard ultracentrifugal fractionation of plasma from patients with chronic HCV infection

S. Khakoo, G. Dusheiko, David Brown, 1998 .

Platelet Aggregation and Plasma Lipoproteins in Alcoholics During Alcohol Withdrawal

R. Hutton, K. Desai, J. Owen, 1986, Thrombosis and Haemostasis.

Low Density Lipoprotein Binding by Cultured Human Skin Fibroblasts; the Inhibitory Effect of High-Density Lipoprotein from Patients with Liver Disease

N. Mcintyre, D. Harry, R. C. Day, 1981 .

Plasma lipoproteins and cellular metabolism

J. Owen, 1981, Nature.

Does the Abnormal Apoprotein Composition of High-Density Lipoprotein in Patients with Liver Disease Contribute to Their Anaemia?

N. Mcintyre, D. Harry, J. Owen, 1981 .

Lecithin:cholesterol acyltransferase deficiency and cell membrane lipids and function in human liver disease.

N. Mcintyre, J. Lucy, D. Harry, 1978, Scandinavian journal of clinical and laboratory investigation. Supplementum.

Chemically induced cell fusion in vitro of erythrocytes from patients with liver diseases [proceedings].

J. Lucy, K. Bruckdorfer, J. Owen, 1977, Biochemical Society transactions.

Platelet cholesterol content and platelet aggregation.

N. Mcintyre, R. Hutton, J. Owen, 1980, New England Journal of Medicine.

Decreased membrane fluidity in erythrocytes from patients with liver diseases [proceedings].

N. Mcintyre, K. Bruckdorfer, J. Owen, 1979, Biochemical Society Transactions.

Plasma Lecithin—Cholesterol Acyl Transferase Activity and the Lipoprotein Abnormalities of Parenchymal Liver Disease

N. Mcintyre, D. Harry, R. C. Day, 1978 .

Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane.

J. S. Owen, A. Soutar, D. Riddell, 2001, Journal of lipid research.

Blood platelets do not contain the low-density receptor-related protein (LRP).

D. Riddell, J. Gliemann, D. V. Vinogradov, 1998, Biochemical Society transactions.

The molecular basis for apolipoprotein E-induced activation of nitric oxide synthase — Functional coupling of apoE receptor 2 to NOS III *

A. Soutar, D. Riddell, N. Chadwick, 1999 .

Cholesterol deposition in renal brush-border membranes — The initiating factor for Na retention in liver disease?

Y. Imai, J. Owen, 1989 .