R. B. Clark

发表

Regulation of adenosine 3':5'-monophosphate content in human astrocytoma cells by adenosine and the adenine nucleotides.

R. Gross, J. Perkins, Y. F. Su, 1974, The Journal of biological chemistry.

Regulation of adenylate cyclase from cultured human cell lines by adenosine.

R. Clark, M. Seney, R. B. Clark, 1976, The Journal of biological chemistry.

Specific Muscarinic‐Cholinergic Desensitization in the Neuroblastoma‐Glioma Hybrid NG108‐15

D. Green, R. B. Clark, 1982, Journal of neurochemistry.

Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.

E. Walters, Hongzhen Hu, A. Qian, 2013, The Journal of clinical investigation.

Epinephrine-induced sequestration of the beta-adrenergic receptor in cultured S49 WT and cyc- lymphoma cells.

N. Prashad, J. Friedman, A. Ruoho, 1985, Journal of cyclic nucleotide and protein phosphorylation research.

Factors influencing the effect of hormones on the accumulation of cyclic AMP in cultured human astrocytoma cells.

G. Johnson, J. Perkins, R. Ortmann, 1975, Metabolism: clinical and experimental.

Role of Protein Kinases in the Desensitization-Sensitization of β-Adrenergic Receptor and Prostaglandin Receptor Stimulation of Adenylyl Cyclase

M. Kunkel, R. Clark, J. Friedman, 1990 .

Repetitive endocytosis and recycling of the beta 2-adrenergic receptor during agonist-induced steady state redistribution.

R Barber, J. Trial, B. Dickey, 1996, Molecular pharmacology.

beta-Adrenergic receptors and cyclic AMP responses to epinephrine in cultured human fibroblasts at various population densities.

R. Butcher, J. Dumont, R. Pochet, 1982, Journal of cyclic nucleotide research.

Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni.

R. Butcher, M. A. Proll, R. B. Clark, 1985, Molecular pharmacology.

Comparison of the muscarinic-cholinergic and lysophosphatidate inhibition of fibroblast adenylate cyclase demonstrating desensitization to the cholinergic stimulus.

D. Green, R. B. Clark, 1981, Life sciences.

Agonist-induced Desensitization, Internalization, and Phosphorylation of the sst2A Somatostatin Receptor*

J. Friedman, A. Schonbrunn, C. Eppler, 1997, The Journal of Biological Chemistry.

Measurement of receptor desensitization and internalization in intact cells.

Brian J Knoll, Richard B Clark, B. Knoll, 2002, Methods in enzymology.

Beta 2-adrenergic receptor mutants reveal structural requirements for the desensitization observed with long-term epinephrine treatment.

R. Butcher, R. Clark, M. A. Proll, 1993, Molecular pharmacology.

Adenyl cyclase, phosphodiesterase and cyclic AMP dependent protein kinase of malignant glial cells in culture.

J. Perkins, E. Macintyre, R. B. Clark, 1971, Life sciences. Pt. 1: Physiology and pharmacology.

Potent Gi-mediated inhibition of adenylyl cyclase by a phosphonate analog of monooleylphosphatidate.

M. A. Proll, R. B. Clark, 1991, Molecular pharmacology.

Insulin Inhibits Cardiac Contractility by Inducing a Gi-Biased β2-Adrenergic Signaling in Hearts

D. Parikh, E. Abel, Y. Zhang, 2014, Diabetes.

Differential phosphorylation and dephosphorylation of β2‐adrenoceptor sites Ser262 and Ser355,356

Estrella Foster, Varsha Iyer, T. Tran, 2006, British journal of pharmacology.

Endosome sorting of β2‐adrenoceptors is GRK5 independent

B. J. Knoll, D. Vaughan, R. Clark, 2004 .

Role for the Regulator of G-Protein Signaling Homology Domain of G Protein-Coupled Receptor Kinases 5 and 6 in β2-Adrenergic Receptor and Rhodopsin Phosphorylation

O. Lichtarge, H. Yao, J. McMurray, 2010, Molecular Pharmacology.

Regulation of adenosine 3':5'-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine.

J. Perkins, R. Clark, R. B. Clark, 1971, Proceedings of the National Academy of Sciences of the United States of America.

β2-Adrenergic Receptor Desensitization, Internalization, and Phosphorylation in Response to Full and Partial Agonists*

A. Seibold, R Barber, A. Schonbrunn, 1997, The Journal of Biological Chemistry.

Regulation of cellular signal transduction pathways by desensitization and amplification

R. B. Clark, 1994 .

Profile of Brian K. Kobilka and Robert J. Lefkowitz, 2012 Nobel Laureates in Chemistry

R. B. Clark, 2013, Proceedings of the National Academy of Sciences.

Localization of the sites mediating desensitization of the beta(2)-adrenergic receptor by the GRK pathway.

B. J. Knoll, A. Seibold, J. Friedman, 2000, Molecular pharmacology.

Desensitization of β2-Adrenergic Receptors with Mutations of the Proposed G Protein-coupled Receptor Kinase Phosphorylation Sites*

J. Friedman, A Seibold, B G January, 1998, The Journal of Biological Chemistry.

A1 and A2 adenosine receptors regulate adenylate cyclase in cultured human lung fibroblasts

R. Butcher, R. Clark, M. A. Proll, 1986, Molecular and Cellular Endocrinology.

Evidence for the shuttle model for GSα activation of adenylyl cyclase

R. Clark, R. Barber, A. Krumins, 1997 .

Probing the roles of protein kinases in g-protein-coupled receptor desensitization.

T. Rich, R. B. Clark, 2003, Molecular pharmacology.

Salmeterol stimulation dissociates beta2-adrenergic receptor phosphorylation and internalization.

Nicola A Hanania, N. Hanania, Hui Peng, 2007, American journal of respiratory cell and molecular biology.

Role of the G Protein-coupled Receptor Kinase Site Serine Cluster in β2-Adrenergic Receptor Internalization, Desensitization, and β-Arrestin Translocation*

David J. Vaughan, Tuan M. Tran, Jacqueline Friedman, 2006, Journal of Biological Chemistry.

Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation.

Jacqueline Friedman, D. Vaughan, J. Friedman, 2006, The Journal of biological chemistry.

Phosphorylation of the proline-rich domain of Xp95 modulates Xp95 interaction with partner proteins.

R. Kobayashi, Chuanfeng Wu, J. Kuang, 2007, The Biochemical journal.

Identification and Cloning of Xp95, a Putative Signal Transduction Protein in Xenopus Oocytes*

C. Wu, M. Weil, J. Kuang, 1999, The Journal of Biological Chemistry.

Endogenous GTP and the regulation of epinephrine stimulation of adenylate cyclase.

R. B. Clark, 1978, Journal of cyclic nucleotide research.

Roles of GRK and PDE4 Activities in the Regulation of β2 Adrenergic Signaling

Thomas C. Rich, Tuan M. Tran, Richard B. Clark, 2008, The Journal of general physiology.

Okadaic acid induces both augmentation and inhibition of beta 2-adrenergic stimulation of cAMP accumulation in S49 lymphoma cells.

S. Shenolikar, M. Kunkel, J. Friedman, 1993, The Journal of biological chemistry.

Sensitization of adenylyl cyclase by P2 purinergic and M5 muscarinic receptor agonists in L cells.

M. Birnbaumer, J. Friedman, R. D. Halligan, 1991, Molecular pharmacology.

Quantitative Modeling of GRK-Mediated β2AR Regulation

Thomas C. Rich, Carmen W. Dessauer, Tuan M. Tran, 2010, PLoS Comput. Biol..

β2 adrenergic receptor 5′ haplotypes influence promoter activity

E. Boerwinkle, M. Abdellatif, L. Shimmin, 2002, British journal of pharmacology.

Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies.

J. Friedman, Robert H Moore, T. Tran, 2004, Molecular pharmacology.

β2-Adrenergic Receptor Lacking the Cyclic AMP-Dependent Protein Kinase Consensus Sites Fully Activates Extracellular Signal-Regulated Kinase 1/2 in Human Embryonic Kidney 293 Cells: Lack of Evidence for Gs/Gi Switching.

R. Clark, J. Friedman, B. Babu, 2002 .

Salmeterol‐induced desensitization, internalization and phosphorylation of the human β2‐adrenoceptor

B. J. Knoll, A. Seibold, R. Clark, 1998, British journal of pharmacology.

Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.

M. Kunkel, J. Johnson, J. Friedman, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Direct evidence for the role of the coupling proteins in forskolin activation of adenylate cyclase.

D. Green, R. B. Clark, Richard B Clark, 1982, Journal of cyclic nucleotide research.

Regulation of adenosine 3',5'-monophosphate content in human astrocytoma cells by isoproterenol and carbachol.

R. Gross, R. Clark, R. B. Clark, 1977, Molecular pharmacology.

Characterization of β2-Adrenergic Receptor Dephosphorylation: Comparison with the Rate of Resensitization

Jacqueline Friedman, J. Friedman, Robert H Moore, 2007, Molecular Pharmacology.

β‐Adrenergic receptor desensitization of wild‐type but not cyc lymphoma cells unmasked by submillimolar Mg2+

M. Kunkel, J. Johnson, J. Friedman, 1987, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Adenylate cyclase coupling proteins are not essential for agonist-specific desensitization of lymphoma cells.

R. Clark, D. Green, R. B. Clark, 1981, The Journal of biological chemistry.

Differences in the forskolin activation of adenylate cyclases in wild-type and variant lymphoma cells.

R. Butcher, R. Clark, T. Goka, 1982, Molecular pharmacology.

Salmeterol Efficacy and Bias in the Activation and Kinase-Mediated Desensitization of β2-Adrenergic Receptors

Sharat J. Vayttaden, R. Clark, L. E. Gimenez, 2015, Molecular Pharmacology.

Beta(2)-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for G(s)/G(i) switching.

J. Friedman, R. Clark, B. Babu, 2002, Molecular pharmacology.

Identification of a specific domain in the beta-adrenergic receptor required for phorbol ester-induced inhibition of catecholamine-stimulated adenylyl cyclase.

C. Strader, R. Dixon, J. Johnson, 1990, Molecular pharmacology.

Multiple non-specific effects of sphingosine on adenylate cyclase and cyclic AMP accumulation in S49 lymphoma cells preclude its use as a specific inhibitor of protein kinase C.

R. B. Clark, J. Johnson, 1990, Biochemical Journal.

Identification of a specific site required for rapid heterologous desensitization of the beta-adrenergic receptor by cAMP-dependent protein kinase.

C. Strader, R. Dixon, J. Friedman, 1989, Molecular pharmacology.

Cell‐free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP‐dependent protein kinase

S. Shenolikar, M. Kunkel, J. Friedman, 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Desensitization of adenylate cyclase in cultured fibroblasts with prostaglandin E1 and epinephrine.

R. Butcher, R. Clark, R. B. Clark, 1979, The Journal of biological chemistry.

Homologous desensitization of beta-adrenergic receptors in lymphoma cells is not altered by the inactivation of Ni (Gi), the inhibitory guanine nucleotide regulatory protein.

J. Friedman, T. Goka, M. A. Proll, 1986, The Biochemical journal.

Beta-adrenergic receptor levels and function after growth of S49 lymphoma cells in low concentrations of epinephrine.

R. Butcher, T. Goka, R. Barber, 1992, Molecular pharmacology.

Inhibition of cyclic AMP accumulation in hamster adipocytes with phosphatidic acid: differences and similarities with alpha adrenergic effects.

T. Honeyman, R. Serio, K. Mcmahon, 1980, Journal of cyclic nucleotide research.

Phosphorylation of the beta2-adrenergic receptor in plasma membranes by intrinsic GRK5.

Rasmus Jorgensen, T. Tran, Tuan M Tran, 2007, Biochemistry.

Endosome sorting of beta 2-adrenoceptors is GRK5 independent.

D. Vaughan, R. Clark, Robert H. Moore, 2004, British journal of pharmacology.

Roles of GRK and PDE4 Activities in the Regulation of β2 Adrenergic Signaling

T. Rich, T. Tran, R. B. Clark, 2008, The Journal of general physiology.

Phorbol ester-induced augmentation and inhibition of epinephrine-stimulated adenylate cyclase in S49 lymphoma cells.

T. Goka, R. B. Clark, J. Johnson, 1986, Journal of cyclic nucleotide and protein phosphorylation research.

Epinephrine desensitization of adenylate cyclase from cyc- and S49 cultured lymphoma cells.

J. Friedman, R. Clark, D. Green, 1981, Journal of cyclic nucleotide research.