Danilo Meyer

发表

Observation of a stable carbene at the active site of a thiamin enzyme.

P. Neumann, R. Ficner, K. Tittmann, 2013, Nature chemical biology.

Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin

G. Sheldrick, P. Neumann, R. Ficner, 2012, Proceedings of the National Academy of Sciences.

Tuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot Spot

Michael Müller, P. Neumann, R. Ficner, 2015, Chembiochem : a European journal of chemical biology.

Conversion of pyruvate decarboxylase into an enantioselective carboligase with biosynthetic potential.

Michael Müller, K. Tittmann, M. Pohl, 2011, Journal of the American Chemical Society.

Mechanistic and Structural Insight to an Evolved Benzoylformate Decarboxylase with Enhanced Pyruvate Decarboxylase Activity

K. Tittmann, M. McLeish, Cindy Wechsler, 2016 .

A Δ38 Deletion Variant of Human Transketolase as a Model of Transketolase-Like Protein 1 Exhibits No Enzymatic Activity

K. Tittmann, S. Lüdtke, S. Schneider, 2012, PloS one.

Structural and kinetic studies on native intermediates and an intermediate analogue in benzoylformate decarboxylase reveal a least motion mechanism with an unprecedented short-lived predecarboxylation intermediate.

A. Liese, R. Golbik, K. Tittmann, 2009, Biochemistry.

The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography

A. Steinmetz, R. Golbik, K. Tittmann, 2006, Nature chemical biology.

Double duty for a conserved glutamate in pyruvate decarboxylase: evidence of the participation in stereoelectronically controlled decarboxylation and in protonation of the nascent carbanion/enamine intermediate .

P. Neumann, C. Parthier, K. Tittmann, 2010, Biochemistry.

Significant catalytic roles for Glu47 and Gln 110 in all four of the C-C bond-making and -breaking steps of the reactions of acetohydroxyacid synthase II.

A. Steinmetz, R. Golbik, K. Tittmann, 2011, Biochemistry.

Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli.

A. Steinmetz, R. Golbik, K. Tittmann, 2010, Biochemistry.

A Distinct Aromatic Prenyltransferase Associated with the Futalosine Pathway

M. Stubbs, L. Wessjohann, C. Cotrim, 2017 .

Conversion of pyruvate decarboxylase into an enantioselective carboligase with biosynthetic potential.

Michael Müller, K. Tittmann, M. Pohl, 2011, Journal of the American Chemical Society.

Alternating sites reactivity is a common feature of thiamin diphosphate-dependent enzymes as evidenced by isothermal titration calorimetry studies of substrate binding.

R. Golbik, K. Tittmann, Cindy Wechsler, 2013, Biochemistry.