Carol F Petras

5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers.

M. P. Lynch, S. Sakya, Jin Li, 2006, Bioorganic & medicinal chemistry letters.

5-heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure-activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog.

M. P. Lynch, S. Sakya, Jin Li, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors.

S. Sakya, Jin Li, Hengmiao Cheng, 2006, Bioorganic & medicinal chemistry letters.

5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part III: molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile.

S. Sakya, Jin Li, Xinjun Hou, 2007, Bioorganic & medicinal chemistry letters.

Comparative structure-activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition.

M. P. Lynch, S. Sakya, Jin Li, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine.

M. P. Lynch, S. Sakya, Jin Li, 2004, Bioorganic & medicinal chemistry letters.

In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor.

M. P. Lynch, S. Sakya, Jin Li, 2005, Bioorganic & medicinal chemistry.