Peter Kleinebudde

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Methodology for a Variable Rate Control Strategy Development in Continuous Manufacturing Applied to Twin-screw Wet-Granulation and Continuous Fluid-bed Drying

Victoria Pauli, Frantz Elbaz, Peter Kleinebudde, 2018, Journal of Pharmaceutical Innovation.

Springer Handbook of Materials Measurement Methods, H. Czichos, T. Saito, L. Smith (Eds.). Springer Science, Business Media Inc. (2006). 1208 p., 970 illus., €249, ISBN-10: 978-3-540-20785-6

Peter Kleinebudde, 2007 .

From Heuristic to Mathematical Modeling of Drugs Dissolution Profiles: Application of Artificial Neural Networks and Genetic Programming

Sebastian Polak, Renata Jachowicz, Peter Kleinebudde, 2015, Comput. Math. Methods Medicine.

Analysis of pellet properties with use of artificial neural networks.

Jakub Szlęk, Renata Jachowicz, Aleksander Mendyk, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Simulation of a tablet coating process at different scales using DEM.

Johannes Khinast, Peter Kleinebudde, Gregor Toschkoff, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In situ dissolution analysis of pharmaceutical dosage forms using coherent anti-Stokes Raman scattering (CARS) microscopy

Herman L. Offerhaus, Korbinian Löbmann, E. T. Garbacik, 2014, Photonics West - Biomedical Optics.

A critical review on tablet disintegration

Peter Kleinebudde, Julian Quodbach, P. Kleinebudde, 2015, Pharmaceutical development and technology.

Evaluation of the performance of different types of roll compactors

Peter Kleinebudde, Kitti Csordas, 2017 .

Analysis of tablet film coating quality using terahertz pulsed imaging

Thomas Rades, Michael Pepper, Yaochun Shen, 2007 .

From powder to tablets: Investigation of residence time distributions in a continuous manufacturing process train as basis for continuous process verification.

Victoria Pauli, Peter Kleinebudde, Markus Krumme, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Impact of roll compactor scale on ribbon density

Peter Kleinebudde, Ana Pérez Gago, Gavin P. Reynolds, 2017 .

Model-based approach to the design of pharmaceutical roller-compaction processes

Ashish Kumar, Johannes Khinast, Peter Kleinebudde, 2019, International journal of pharmaceutics: X.

Oromucosal film preparations: classification and characterization methods

Maren Preis, Peter Kleinebudde, Jörg Breitkreutz, 2013, Expert opinion on drug delivery.

Special Issue 7th International Granulation Workshop, June 2015.

Peter Kleinebudde, Agba Salman, 2016, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Theme Issue “Granulation”

Peter Kleinebudde, 2001 .

Taste sensing systems (electronic tongues) for pharmaceutical applications.

Peter Kleinebudde, Jörg Breitkreutz, Katharina Woertz, 2011, International journal of pharmaceutics.

Comparison of the Performance of Single Punch and Rotary Tablet Presses from Different Vendors

Peter Kleinebudde, Markus Thommes, Annette Bauer-Brandl, 2018 .

Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying

Victoria Pauli, Peter Kleinebudde, Markus Krumme, 2020, Pharmaceutics.

Model predictive control in pharmaceutical continuous manufacturing: a review from a user's perspective.

Peter Kleinebudde, Markus Krumme, Yves Roggo, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Development of a Raman method to follow the evolution of coating thickness of pellets

Klára Pintye-Hódi, Peter Kleinebudde, Klaus Knop, 2014, Drug development and industrial pharmacy.

Nondestructive Quantification of Pharmaceutical Tablet Coatings using Terahertz Pulsed Imaging and Optical Coherence Tomography

Thomas Rades, Shuncong Zhong, Michael Pepper, 2015 .

How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets.

Wolfgang Grellmann, Peter Kleinebudde, Katrin Reincke, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Suitability of κ-carrageenan pellets for the formulation of multiparticulate tablets with modified release.

Peter Kleinebudde, P. Kleinebudde, Dima Ghanam, 2011, International journal of pharmaceutics.

Solid lipid extrusion with small die diameters--electrostatic charging, taste masking and continuous production.

Peter Kleinebudde, Hans-Jürgen Hamann, P. Kleinebudde, 2011, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Prediction of tablet velocity in pan coaters for scale-up

Peter Kleinebudde, P. Kleinebudde, Ronny Mueller, 2007 .

Real-time monitoring of particle size distribution in a continuous granulation and drying process by near infrared spectroscopy.

Victoria Pauli, Peter Kleinebudde, Markus Krumme, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Properties of microcrystalline cellulose and powder cellulose after extrusion/spheronization as studied by fourier transform Raman spectroscopy and environmental scanning electron microscopy

Peter Kleinebudde, Andreas Heilmann, Siegfried Wartewig, 2003, AAPS PharmSci.

Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography

Yaochun Shen, Thomas Rades, Shuncong Zhong, 2011 .

Investigating the relationship between drug distribution in solid lipid matrices and dissolution behaviour using Raman spectroscopy and mapping.

Peter Kleinebudde, Maike Windbergs, Keith C Gordon, 2010, Journal of pharmaceutical sciences.

Optimization of pellets manufacturing process using rough set theory

Roman Słowiński, Jerzy Krysiński, Peter Kleinebudde, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Mathematical modeling of an aqueous film coating process in a Bohle Lab-Coater: Part 2: Application of the model

Peter Kleinebudde, Susanne Page, Karl-Heinrich Baumann, 2008, AAPS PharmSciTech.

Development of an in‐line Raman spectroscopic method for continuous API quantification during twin‐screw wet granulation

Peter Kleinebudde, P. Kleinebudde, J. Harting, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The Crystallite-Gel-Model for Microcrystalline Cellulose in Wet-Granulation, Extrusion, and Spheronization

Peter Kleinebudde, P. Kleinebudde, 1997, Pharmaceutical Research.

From Mini to Micro Scale—Feasibility of Raman Spectroscopy as a Process Analytical Tool (PAT)

Klára Pintye-Hódi, Peter Kleinebudde, Klaus Knop, 2011, Pharmaceutics.

Optimization of the inter-tablet coating uniformity for an active coating process at lab and pilot scale.

Johannes Khinast, Peter Kleinebudde, Gregor Toschkoff, 2013, International journal of pharmaceutics.

Chemical imaging of oral solid dosage forms and changes upon dissolution using coherent anti-Stokes Raman scattering microscopy.

Peter Kleinebudde, Maike Windbergs, Herman L Offerhaus, 2009, Analytical chemistry.

Simplified end‐to‐end continuous manufacturing by feeding API suspensions in twin‐screw wet granulation

Peter Kleinebudde, Markus Krumme, Adrian Schmidt, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Coating uniformity and coating efficiency in a Bohle Lab-Coater using oval tablets.

Peter Kleinebudde, P. Kleinebudde, Susanne Tobiska, 2003, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Experimental Analysis of Tablet Properties for Discrete Element Modeling of an Active Coating Process

Johannes Khinast, Peter Kleinebudde, Gregor Toschkoff, 2013, AAPS PharmSciTech.

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution

Herman L. Offerhaus, Peter Kleinebudde, Clare J. Strachan, 2014, Journal of visualized experiments : JoVE.

Direct Pelletization in a Rotary Processor Controlled by Torque Measurements. I. Influence of Process Variables

Peter Kleinebudde, Jakob Kristensen, Torben Schæfer, 2000, Pharmaceutical development and technology.

A data mining approach to optimize pellets manufacturing process based on a decision tree algorithm.

Jerzy Krysiński, Peter Kleinebudde, Markus Thommes, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Coherent anti-stokes Raman scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets

Herman L. Offerhaus, Cornelis Otto, Peter Kleinebudde, 2009 .

Mathematical modeling of an aqueous film coating process in a Bohle Lab-Coater, Part 1: Development of the model

Peter Kleinebudde, Susanne Page, Karl-Heinrich Baumann, 2008, AAPS PharmSciTech.

Investigating dissolution performance critical areas on coated tablets: a case study using terahertz pulsed imaging.

Yaochun Shen, Thomas Rades, Michael Pepper, 2010, Journal of pharmaceutical sciences.

In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes.

Peter Kleinebudde, Miriam Pein, Klaus Knop, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Validation of Raman spectroscopic procedures in agreement with ICH guideline Q2 with considering the transfer to real time monitoring of an active coating process.

Peter Kleinebudde, Klaus Knop, P. Kleinebudde, 2010, Journal of pharmaceutical and biomedical analysis.

Monitoring of an active coating process for two-layer tablets-model development strategies.

Peter Kleinebudde, Klaus Knop, Adrian Funke, 2013, Journal of pharmaceutical sciences.

Process analytical technology for continuous manufacturing tableting processing: A case study

Victoria Pauli, Frantz Elbaz, Peter Kleinebudde, 2019, Journal of pharmaceutical and biomedical analysis.

Impact of screw elements on continuous granulation with a twin-screw extruder.

Peter Kleinebudde, Dejan Djuric, P. Kleinebudde, 2008, Journal of pharmaceutical sciences.

Performance of tablet disintegrants: impact of storage conditions and relative tablet density

Peter Kleinebudde, Julian Quodbach, P. Kleinebudde, 2015, Pharmaceutical development and technology.

Spray models for discrete element simulations of particle coating processes

Johannes Khinast, Peter Kleinebudde, Gregor Toschkoff, 2013 .

Comparison of a laboratory and a production coating spray gun with respect to scale-up

Peter Kleinebudde, P. Kleinebudde, Ronny Mueller, 2007, AAPS PharmSciTech.

Comparison Study of Laboratory and Production Spray Guns in Film Coating: Effect of Pattern Air and Nozzle Diameter

Peter Kleinebudde, P. Kleinebudde, Ronny Müller, 2006, Pharmaceutical development and technology.

Validation of Terahertz coating thickness measurements using X-ray microtomography.

Peter Kleinebudde, Klaus Knop, J Axel Zeitler, 2012, Molecular pharmaceutics.

Impact of fill‐level in twin‐screw granulation on critical quality attributes of granules and tablets

Peter Kleinebudde, Markus Krumme, Robin Meier, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance.

Yaochun Shen, Thomas Rades, Michael Pepper, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Assessment of test methods evaluating mucoadhesive polymers and dosage forms: an overview.

Maren Preis, Peter Kleinebudde, Jörg Breitkreutz, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Orthogonal Redundant Monitoring of a New Continuous Fluid-Bed Dryer for Pharmaceutical Processing by Means of Mass and Energy Balance Calculations and Spectroscopic Techniques.

Victoria Pauli, Frantz Elbaz, Peter Kleinebudde, 2019, Journal of pharmaceutical sciences.

Modeling of an Active Tablet Coating Process.

Johannes G Khinast, Peter Kleinebudde, Gregor Toschkoff, 2015, Journal of pharmaceutical sciences.

Improved bioavailability of darunavir by use of kappa-carrageenan versus microcrystalline cellulose as pelletisation aid.

Lieven Baert, Peter Kleinebudde, Markus Thommes, 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Continuous Manufacturing of Pharmaceuticals

Jukka Rantanen, Johannes Khinast, Peter Kleinebudde, 2017 .

Influence of scale-up on the abrasion of tablets in a pan coater.

Peter Kleinebudde, Ronny Mueller, 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Terahertz pulsed imaging as an analytical tool for sustained-release tablet film coating.

Yaochun Shen, Thomas Rades, Michael Pepper, 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Two-Step Solid Lipid Extrusion as a Process to Modify Dissolution Behavior

Peter Kleinebudde, Maike Windbergs, P. Kleinebudde, 2010, AAPS PharmSciTech.

Prediction of dissolution time and coating thickness of sustained release formulations using Raman spectroscopy and terahertz pulsed imaging.

Peter Kleinebudde, J Axel Zeitler, Klaus Knop, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Evaluation of critical process parameters for inter-tablet coating uniformity of active-coated GITS using Terahertz Pulsed Imaging.

Peter Kleinebudde, Klaus Knop, Adrian Funke, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Continuous granulation with a twin-screw extruder: Impact of material throughput

Peter Kleinebudde, Dejan Djuric, P. Kleinebudde, 2010, Pharmaceutical development and technology.

Critical factors in the measurement of tablet film coatings using terahertz pulsed imaging.

Peter Kleinebudde, Klaus Knop, Adrian Funke, 2013, Journal of pharmaceutical sciences.

Monitoring the film coating unit operation and predicting drug dissolution using terahertz pulsed imaging.

Yaochun Shen, Thomas Rades, Michael Pepper, 2009, Journal of pharmaceutical sciences.

Application of mixtures of polymeric carriers for dissolution enhancement of fenofibrate using hot-melt extrusion.

Peter Kleinebudde, P. Kleinebudde, M. Fischbach, 2012, International journal of pharmaceutics.

Physicochemical properties and hemolytic effect of different lipid emulsion formulations using a mixture of emulsifiers

Peter Kleinebudde, P. Kleinebudde, B. Müller, 1999 .

Application of mixtures of polymeric carriers for dissolution enhancement of oxeglitazar using hot-melt extrusion.

Peter Kleinebudde, P. Kleinebudde, M. Fischbach, 2012, International journal of pharmaceutics.

Tablet disintegration studied by high-resolution real-time magnetic resonance imaging.

Jens Frahm, Amir Moussavi, Peter Kleinebudde, 2014, Journal of pharmaceutical sciences.

Analysis of matrix dosage forms during dissolution testing using raman microscopy.

Thomas Rades, Peter Kleinebudde, Maike Windbergs, 2011, Journal of pharmaceutical sciences.

pplication of artificial neural networks ( ANNs ) and genetic programming ( GP ) or prediction of drug release from solid lipid matrices

Renata Jachowicz, Peter Kleinebudde, Aleksander Mendyk, 2012 .

A new apparatus for real-time assessment of the particle size distribution of disintegrating tablets.

Peter Kleinebudde, Julian Quodbach, P. Kleinebudde, 2014, Journal of pharmaceutical sciences.

Systematic classification of tablet disintegrants by water uptake and force development kinetics

Peter Kleinebudde, Julian Quodbach, P. Kleinebudde, 2014, The Journal of pharmacy and pharmacology.

In‐line monitoring of multi‐layered film‐coating on pellets using Raman spectroscopy by MCR and PLS analyses

Peter Kleinebudde, P. Kleinebudde, Jin Hisazumi, 2017, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Compression behaviour of kappa-carrageenan pellets.

Peter Kleinebudde, Dima Ghanam, Issa Hassan, 2010, International journal of pharmaceutics.

Coating Uniformity: Influence of Atomizing Air Pressure

Peter Kleinebudde, Susanne Tobiska, 2003, Pharmaceutical development and technology.

Use of kappa-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion/spheronisation. II. Influence of drug and filler type.

Peter Kleinebudde, Markus Thommes, P. Kleinebudde, 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Mechanism of drug release from polymethacrylate-based extrudates and milled strands prepared by hot-melt extrusion.

Peter Kleinebudde, Klaus Knop, P. Kleinebudde, 2009, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Evaluation of critical process parameters for intra-tablet coating uniformity using terahertz pulsed imaging.

Peter Kleinebudde, Klaus Knop, Adrian Funke, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Experiments with an instrumented twin-screw extruder using a single-step granulation/extrusion process

Peter Kleinebudde, Hans Lindner, 1993 .

Influence of storage condition on properties of MCC II-based pellets with theophylline-monohydrate.

Peter Kleinebudde, Markus Thommes, Cornelia Krueger, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Feasibility of Raman spectroscopy as PAT tool in active coating

Peter Kleinebudde, Klaus Knop, Carsten Uerpmann, 2009, Drug development and industrial pharmacy.

Controlled release of active as a consequence of the die diameter in solid lipid extrusion.

Peter Kleinebudde, Hans-Jürgen Hamann, P. Kleinebudde, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Performance qualification of an electronic tongue based on ICH guideline Q2.

Peter Kleinebudde, Katharina Woertz, Corinna Tissen, 2010, Journal of pharmaceutical and biomedical analysis.

In situ dissolution analysis using CARS microscopy

Herman L. Offerhaus, E. T. Garbacik, A. L. Fussell, 2013 .