Kozo Takayama

发表

Creation of a tablet database containing several active ingredients and prediction of their pharmaceutical characteristics based on ensemble artificial neural networks.

Hiroaki Arai, Keisuke Takagaki, Kozo Takayama, 2010, Journal of pharmaceutical sciences.

Neural network based optimization of drug formulations.

Kozo Takayama, Mariko Morishita, Mikito Fujikawa, 2003, Advanced drug delivery reviews.

Formulation optimization of ondansetron transdermal delivery system employing experimental design

Kozo Takayama, Yasuko Obata, Yuriko Ashitaka, 2008 .

Artificial Neural Network as a Novel Method to Optimize Pharmaceutical Formulations

Kozo Takayama, Mikito Fujikawa, Tsuneji Nagai, 2004, Pharmaceutical Research.

Novel algorithm elucidating the tablet dividing mechanism in scored tablets and its experimental verification

Naoto Morita, Kozo Takayama, Tsubasa Sato, 2021 .

Formulation Optimization of Paclitaxel Carried by PEGylated Emulsions Based on Artificial Neural Network

Kozo Takayama, Yoshiyuki Hattori, Y. Maitani, 2004, Pharmaceutical Research.

Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers.

Nicholas A Peppas, Kozo Takayama, Mariko Morishita, 2002, Journal of controlled release : official journal of the Controlled Release Society.

A novel approach to establishing the design space for the oral formulation manufacturing process.

Yoshinori Onuki, Tadashi Norioka, Kozo Takayama, 2013, Chemical & pharmaceutical bulletin.

Latent structure analysis in pharmaceutical formulations using Kohonen's self-organizing map and a Bayesian network.

Yoshinori Onuki, Shingo Kikuchi, Kozo Takayama, 2011, Journal of pharmaceutical sciences.

Quantitative evaluation of in vitro release medium to predict transfer of flunisolide into nasal mucosa of rabbits from ointments

Kozo Takayama, Mariko Morishita, Tsuneji Nagai, 2003 .

Multi-objective simultaneous optimization technique based on an artificial neural network in sustained release formulations

Kozo Takayama, Junichi Takahara, Tsuneji Nagai, 1997 .

Latent structure analysis in the pharmaceutical process of tablets prepared by wet granulation

Yoshinori Onuki, Kozo Takayama, Yasuko Obata, 2016, Drug development and industrial pharmacy.

Computer Optimization of Formulation of Flufenamic Acid/Polyvinylpolypyrrolidone/Methyl Cellulose Solid Dispersions

Kozo Takayama, Tsuneji Nagai, Naoki Nambu, 1983 .

Membrane Microdomain Structures of Liposomes and Their Contribution to the Cellular Uptake Efficiency into HeLa Cells.

Yoshinori Onuki, Kozo Takayama, Yasuko Obata, 2016, Molecular pharmaceutics.

Influence of diisopropyl adipate on percutaneous absorption and subcutaneous tissue penetration of diclofenac from alcoholic gel ointment

Kozo Takayama, Tsuneji Nagai, Hirohisa Okuyama, 1999 .

Promoting effect of O-ethylmenthol on the percutaneous absorption of ketoprofen

Yumiko Nakamura, Kozo Takayama, Tsuneji Nagai, 1996 .

Effect of excipients on breast cancer resistance protein substrate uptake activity.

Yuichi Sugiyama, Tetsuo Yamagata, Kozo Takayama, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Novel Chitosan Particles and Chitosan-Coated Emulsions Inducing Immune Response via Intranasal Vaccine Delivery

Kozo Takayama, Yoshiyuki Hattori, Y. Maitani, 2004, Pharmaceutical Research.

Improvement of the Oral Drug Absorption of Topotecan through the Inhibition of Intestinal Xenobiotic Efflux Transporter, Breast Cancer Resistance Protein, by Excipients

Yuichi Sugiyama, Tetsuo Yamagata, Kozo Takayama, 2007, Drug Metabolism and Disposition.

A new attempt to design erodible terpolymers using computer-optimization methodology

Masaru Yoshida, Kozo Takayama, Tsuneji Nagai, 1992 .

Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats

Kozo Takayama, Mariko Morishita, Isao Morishita, 1992 .

Usefulness of cell-penetrating peptides to improve intestinal insulin absorption.

Noriyasu Kamei, Kozo Takayama, Mariko Morishita, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides.

Noriyasu Kamei, Kozo Takayama, Mariko Morishita, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Optimum Formulation of Griseofulvin/Hydroxypropyl Cellulose Solid Dispersions with Desirable Dissolution Properties

Tsutomu Takai, Kozo Takayama, Tsuneji Nagai, 1984 .

Characterization of the inhibition of breast cancer resistance protein-mediated efflux of mitoxantrone by pharmaceutical excipients.

Yuichi Sugiyama, Tetsuo Yamagata, Kozo Takayama, 2009, International journal of pharmaceutics.

Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats.

Nicholas A Peppas, Kozo Takayama, Mariko Morishita, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Release phenomena of insulin from an implantable device composed of a polyion complex of chitosan and sodium hyaluronate.

Kozo Takayama, Mariko Morishita, Tsuneji Nagai, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Region-Dependent Role of the Mucous/Glycocalyx Layers in Insulin Permeation Across Rat Small Intestinal Membrane

Kozo Takayama, Mariko Morishita, M. Morishita, 2005, Pharmaceutical Research.

[Influence of temperature and humidity on physico-pharmaceutical characteristics of Rasilez(®) tablets].

Takanori Nakajima, Yoshikazu Matsuda, Kozo Takayama, 2014, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Computer optimization for the formulation of controlled-release theophylline tablet made of micronized low-substituted hydroxypropylcellulose and methylcellulose

Kozo Takayama, Tsuneji Nagai, Hiroaki Nakagami, 1994 .

An application of the computer optimization technique to wet granulation process involving explosive growth of particles

Masayuki Matsui, Kozo Takayama, Tsuneji Nagai, 1997 .

Bootstrap re-sampling technique to evaluate the optimal formulation of theophylline tablets predicted by non-linear response surface method incorporating multivariate spline interpolation.

Hiroaki Arai, Chosei Kaseda, Kozo Takayama, 2007, Chemical & pharmaceutical bulletin.

Formulation design of indomethacin gel ointment containing d-limonene using computer optimization methodology

Kozo Takayama, Tsuneji Nagai, Yasuko Obata, 1990 .

Evaluation of the disintegration time of rapidly disintegrating tablets via a novel method utilizing a CCD camera.

Kozo Takayama, Yuki Tsushima, Yutaka Morita, 2002, Chemical & pharmaceutical bulletin.

Evaluation and Optimization of Preparative Variables for Controlled-Release Floatable Microspheres Prepared by Poor Solvent Addition Method

Kozo Takayama, Fumiki Yanagawa, Yasunori Miyazaki, 2008 .

Complexation hydrogels for intestinal delivery of interferon beta and calcitonin.

Nicholas A Peppas, Noriyasu Kamei, Kozo Takayama, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Promoting effect of O-alkylmenthol and o-acylmenthol derivatives on the percutaneous absorption of ketoprofen in rats

Kozo Takayama, Tsuneji Nagai, J. Negishi, 1995 .

Current challenges in non-invasive insulin delivery systems: a comparative review.

Yoshinori Onuki, Kozo Takayama, Mariko Morishita, 2007, Advanced drug delivery reviews.

Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption.

Nicholas A Peppas, Marc C Torjman, Tetsuo Yamagata, 2004, Journal of controlled release : official journal of the Controlled Release Society.

Multi-objective simultaneous optimization based on artificial neural network in a ketoprofen hydrogel formula containing O-ethylmenthol as a percutaneous absorption enhancer

Kozo Takayama, Junichi Takahara, Tsuneji Nagai, 1997 .

Effect of amount and composition of granulating solution on physical characteristics of tablets

Kozo Takayama, Tsuneji Nagai, T. Nagai, 1992 .

Novel Mucosal Insulin Delivery Systems Based on Fusogenic Liposomes

Kozo Takayama, Mariko Morishita, Ken Nishimura, 2005, Pharmaceutical Research.