J. Brown

发表

Isolation of a human lymphocyte mitogen from wheat germ with N-acetyl-D-glucosamine specificity.

J. Brown, M. A. León, J. Lightbody, 1976, Journal of immunology.

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization.

J. Brown, J. Stafford, S. Chernikova, 2016, Neuro-oncology.

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

H. Vogel, G. Harsh, R. Hoffman, 2010, The Journal of clinical investigation.

Tumor hypoxia can be exploited to preferentially sensitize tumors to fractionated irradiation.

J. Brown, M. Lemmon, J. Brown, 1991, International journal of radiation oncology, biology, physics.

Enhancement of radiation-induced tumor cell killing by the hypoxic cell toxin SR 4233.

M. Lemmon, V. Hirst, E. M. Zeman, 1988, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells.

M. Lemmon, V. Hirst, E. Zeman, 1986, International journal of radiation oncology, biology, physics.

DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.

S. Gamage, W. Denny, W. Wilson, 2004, Journal of medicinal chemistry.

SR-2508: a 2-nitroimidazole amide which should be superior to misonidazole as a radiosensitizer for clinical use.

D. M. Brown, N. Yu, J. Brown, 1981, International journal of radiation oncology, biology, physics.

Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin.

M. Dorie, J. Brown, J. Brown, 1993, Cancer research.

SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours.

J. Brown, J. Brown, J.Martin Brown, 1993, British Journal of Cancer.

Exploiting tumour hypoxia in cancer treatment

J. Brown, W. Wilson, J. Brown, 2004, Nature Reviews Cancer.

Role of glutathione in the radiation response of mammalian cells in vitro and in vivo.

E. Bump, J. Brown, J. Brown, 1990, Pharmacology & therapeutics.

The effect of treatment in fractionated schedules with the combination of X-irradiation and six cytotoxic drugs on the RIF-1 tumor and normal mouse skin.

J. Brown, R. Kallman, P. Lelieveld, 1985, International journal of radiation oncology, biology, physics.

Improving the Predictive Value of Preclinical Studies in Support of Radiotherapy Clinical Trials

C. N. Coleman, M. Dewhirst, C. Coleman, 2016, Clinical Cancer Research.

Preclinical Data on Efficacy of 10 Drug-Radiation Combinations: Evaluations, Concerns, and Recommendations1

James B. Mitchell, James Deye, Jacek Capala, 2016, Translational oncology.

Neutrophil and monocyte adherence in diabetes mellitus, alcoholic cirrhosis, uraemia and elderly patients.

J. Brown, Y. Thong, M. Kelly, 1985, International archives of allergy and applied immunology.

Acute and chronic effects of x irradiation on blood flow in the mouse limb.

J. Probert, R. Kallman, A. Howes, 1974, Radiology.

Hydralazine does not increase hypoxia in tumors growing in preirradiated tissue.

J. Brown, M. Lemmon, J. Brown, 1991, International journal of radiation oncology, biology, physics.

Drug or radiation changes to the host which could affect the outcome of combined modality therapy.

J. Brown, J. Brown, J.Martin Brown, 1979, International journal of radiation oncology, biology, physics.

Cytotoxic effects of the hypoxic cell radiosensitizer Ro 7-0582 to tumor cells in vivo.

J. Brown, J. Brown, 1977, Radiation research.

Selective radiosensitization of the hypoxic cells of mouse tumors with the nitroimidazoles metronidazole and Ro 7-0582.

J. Brown, J. Brown, J. Brown, 1975, Radiation research.

Circulating mouse Flk1+/c-Kit+/CD45- cells function as endothelial progenitors cells (EPCs) and stimulate the growth of human tumor xenografts

J. Russell, J. Brown, J. Brown, 2014, Molecular Cancer.

Chemical Modification of Radiation and Chemotherapy

E. Hall, D. Hirst, T. Kinsella, 1988, American journal of clinical oncology.

Changes in the response of the RIF-1 tumour to melphalan in vivo induced by inhibitors of nuclear ADP-ribosyl transferase.

D. M. Brown, D. Hirst, J. Brown, 1986, British Journal of Cancer.

Enhancement of melphalan cytotoxicity in vivo and in vitro by inhibitors of poly (ADP-ribose) polymerase.

D. M. Brown, D. Hirst, M. Horsman, 1984, International journal of radiation oncology, biology, physics.

The influence of inhibitors of poly (ADP-ribose) polymerase on X-ray-induced potentially lethal damage repair.

D. M. Brown, J. Evans, J. Brown, 1984, The British journal of cancer. Supplement.

The role of apoptosis in cancer development and treatment response

L. Attardi, Laura D. Attardi, J. Martin Brown, 2005, Nature Reviews Cancer.

Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: enzymatic studies.

C. Wolf, K. Biedermann, J. Wang, 1993, British Journal of Cancer.

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Irving L. Weissman, Michael F. Clarke, Maximilian Diehn, 2009, Nature.

Fluorescence in situ hybridization in cancer and radiation biology.

J W Gray, D Pinkel, D. Pinkel, 1994, Radiation research.

Cytotoxic antibody reactivity in sera of melanoma patients against allogeneic and autologous cultured tumor cells and fibroblasts.

E. Matthews, S. Rosenberg, W. Terry, 1982, Cancer research.

Host treatments affecting artificial pulmonary metastases: interpretation of loss of radioactively labelled cells from lungs.

J. Brown, E. Parker, 1979, British Journal of Cancer.

Effect of Dose Fractionation on the Enhancement by Radiation or Cyclophosphamide of Artificial Pulmonary Metastases

G. Marsa, J. Brown, J. Brown, 1978, British Journal of Cancer.

The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.

A. Giaccia, J. Brown, Janice M. Y. Brown, 1998, Cancer research.

Partition coefficient as a guide to the development of radiosensitizers which are less toxic than misonidazole.

J. Brown, P. Workman, J. Brown, 1980, Radiation research.

Combinations of Hypoxia-Targeting Compounds and Radiation-Activated Prodrugs with Ionizing Radiation

G. Ahn, J. Brown, J. Brown, 2006 .

Structural and conformational analysis of glycan moieties in situ on isotopically 13C, 15N-enriched recombinant human chorionic gonadotropin.

R. Canfield, J. Brown, S. Ramnarain, 1996, Biochemistry.

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

C. Liao, G. Ahn, M. Dorie, 2010, Proceedings of the National Academy of Sciences.

The pharmacokinetics and tumor and neural tissue penetrating properties of SR-2508 and SR-2555 in the dog--hydrophilic radiosensitizers potentially less toxic than misonidazole.

J. Brown, P. Workman, R. White, 1980, Radiation research.

Radiation injury in the mouse kidney--I. Sequential light microscopic study.

L. F. Fajardo, J. Brown, E. Glatstein, 1977, International journal of radiation oncology, biology, physics.

Sensitizers in Radiotherapy

J. Brown, J. Brown, J. Brown, 1988 .

Inhibition of X-ray-induced potentially lethal damage (PLD) repair in aerobic plateau-phase Chinese hamster cells by misonidazole.

D. M. Brown, C. Dionet, J. Brown, 1984, Radiation research.

The effects of purine nucleoside analogs on the response of the RIF-1 tumor to melphalan in vivo.

D. M. Brown, D. Hirst, M. Horsman, 1986, International journal of radiation oncology, biology, physics.

The role of glutathione and DNA strand break repair in determining the shoulder of the radiation survival curve.

J W Evans, J M Brown, Y C Taylor, 1984, The British journal of cancer. Supplement.

The use of asymmetric-field inversion gel electrophoresis to predict tumor cell radiosensitivity.

A. Giaccia, J. Brown, J. Schwartz, 1992, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

In vitro selection and characterization of a bleomycin-resistant subline of B16 melanoma.

J. Zuckerman, B. Sikic, R. Newman, 1986, Cancer research.

Clinical trials of radiosensitizers: what should we expect?

J. Brown, J. Brown, 1984, International journal of radiation oncology, biology, physics.

Structure-pharmacokinetic relationships for misonidazole analogues in mice

J. Brown, P. Workman, J. Brown, 2004, Cancer Chemotherapy and Pharmacology.

Meeting of the minds on mercury.

J. Brown, P. Workman, N. Yu, 1979, British Journal of Cancer.

Misonidazole neurotoxicity in mice decreased by administration with pyridoxine.

D. M. Brown, P. Eifel, J. Brown, 1983, International journal of radiation oncology, biology, physics.

Factors influencing intracellular uptake and radiosensitization by 2-nitroimidazoles in vitro.

D. M. Brown, R. González-Méndez, J. Brown, 1983, Radiation research.

Clinical perspectives for the use of new hypoxic cell sensitizers.

J. Brown, J. Brown, 1982, International journal of radiation oncology, biology, physics.

Structure-activity relationships of 1-substituted 2-nitroimidazoles: effect of partition coefficient and side-chain hydroxyl groups on radiosensitization in vitro.

D. M. Brown, J. Brown, E. Parker, 1982, Radiation research.

The use of drugs which deplete intracellular glutathione in hypoxic cell radiosensitization.

J. Brown, E. Bump, N. Yu, 1982, International journal of radiation oncology, biology, physics.

Role of glutathione in the hypoxic cell cytotoxicity of misonidazole.

J. Brown, E. Bump, Y. Taylor, 1983, Cancer research.

The mechanisms of cytotoxicity and chemosensitization by misonidazole and other nitroimidazoles.

J. Brown, J. Brown, J. Brown, 1982, International journal of radiation oncology, biology, physics.

Inhibition of DNA replication by tirapazamine.

G. Iliakis, H. Wang, J M Brown, 2001, Cancer research.

Inhibition of DNA Replication by Tirapazamine 1

G. Iliakis, Hongyan Wang, K. Peters, 2001 .

A study of the mechanism by which anticoagulation with warfarin inhibits blood-borne metastases.

J. Brown, J. Brown, 1973, Cancer research.

Targeting bioreductive drugs to tumours: is it necessary to manipulate blood flow?

J. Brown, J. Brown, 1991, International journal of radiation biology.

Overcoming hypoxia-induced apoptotic resistance through combinatorial inhibition of GSK-3β and CDK1.

Colin J. Daniel, E. Furth, R. Sears, 2011, Cancer research.

Apoptosis, p53, and tumor cell sensitivity to anticancer agents.

B. Wouters, J. Brown, Julia Brown, 1999, Cancer research.

Preferential radiosensitization of mouse sarcoma relative to normal skin by chronic intra-arterial infusion of halogenated pyrimidine analogs.

D. Goffinet, J. Cleaver, R. Kallman, 1971, Journal of the National Cancer Institute.

Early and late response of the mouse limb to multifractionated X-irradiation.

A. Howes, J. Brown, J. Brown, 1979, International journal of radiation oncology, biology, physics.

Sensitizers and protectors in radiotherapy

J. Brown, J. Brown, J. Brown, 1985, Cancer.

In vitro and in vivo radiation sensitization by the halogenated pyrimidine 5-chloro-2'-deoxycytidine.

G. Rice, J. Brown, K. Russell, 1986, Cancer research.

A new mouse tumor model system (RIF-1) for comparison of end-point studies.

J. Gray, P. Twentyman, R. Kallman, 1980, Journal of the National Cancer Institute.

Prolonged carotid arterial radiosensitizer infusion and radiation therapy of mouse gliomas.

D. Goffinet, H. Kaplan, M. Bagshaw, 1972, The American journal of roentgenology, radium therapy, and nuclear medicine.

Therapeutic targets in radiotherapy.

J. Brown, J. Brown, J.Martin Brown, 2001, International journal of radiation oncology, biology, physics.

Radiation-induced damage, repair and exchange formation in different chromosomes of human fibroblasts determined by fluorescence in situ hybridization.

I. Johnstone, M. Kovacs, J. Evans, 1994, Radiation research.

Molecular characterization of a high A2 beta thalassemia by direct sequencing of single strand enriched amplified genomic DNA.

D. Weatherall, S. Thein, C. Hesketh, 1989, Blood.

The polymerase chain reaction: current and future clinical applications.

Jennifer M. Brown, J. Lynch, J. Brown, 1990, Journal of medical genetics.

A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity

Ronald W. Davis, G. Giaever, A. Chu, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Stable translocations detected by fluorescence in situ hybridization: a rapid surrogate end point to evaluate the efficacy of a potentiator of tumor response to radiotherapy.

K. Yudoh, M. Kovacs, D. Menke, 1997, Cancer research.

Prediction of human cell radiosensitivity: comparison of clonogenic assay with chromosome aberrations scored using premature chromosome condensation with fluorescence in situ hybridization.

K. Sasai, K Sasai, J W Evans, 1994, International journal of radiation oncology, biology, physics.

Complementation of the radiosensitive phenotype in severe combined immunodeficient mice by human chromosome 8.

E. Stanbridge, C. Kirchgessner, D. Araujo, 1993, Cancer research.

Visualization of nonreciprocal chromosome exchanges in irradiated human fibroblasts by fluorescence in situ hybridization.

M. Kovacs, J. Brown, J. Brown, 1993, Radiation research.

Chromosomal radiosensitivity at intrachromosomal telomeric sites

A. Giaccia, J. Lucas, James W. Evans, 1993, Genes, chromosomes & cancer.

The prediction of human tumor radiosensitivity in situ: an approach using chromosome aberrations detected by fluorescence in situ hybridization.

M. Kovacs, J. Evans, J. Brown, 1992, International journal of radiation oncology, biology, physics.

The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity.

A. Giaccia, J. Brown, N. Denko, 1991, Cancer research.

The use of fluorescence in situ hybridisation combined with premature chromosome condensation for the identification of chromosome damage.

D. Pinkel, A. Giaccia, A. Giaccia, 1991, British Journal of Cancer.

Cell status — dead or alive?

J. Brown, J. Brown, J. Brown, 1996, Nature Medicine.

Apoptosis Genes and Resistance to Cancer Therapy: What Does the Experimental and Clinical Data Tell Us?

G. Wilson, Martin Brown, J. Brown, 2003, Cancer biology & therapy.

The tumor radiobiology of SRS and SBRT: are more than the 5 Rs involved?

David J Brenner, David J Carlson, D. Brenner, 2014, International journal of radiation oncology, biology, physics.

Macrophage Exclusion after Radiation Therapy (MERT): A First in Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma

Robyn L. Ball, L. Recht, D. Born, 2019, Clinical Cancer Research.

The Promise of Targeting Macrophages in Cancer Therapy

L. Recht, J. Brown, S. Strober, 2017, Clinical Cancer Research.

A new recurrent translocation, t(5;11)(q35;p15.5), associated with del(5q) in childhood acute myeloid leukemia. The UK Cancer Cytogenetics Group (UKCCG)

L. Kearney, J. Harbott, O. Haas, 1999, Blood.

DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine.

D. Bloch, Q. Le, J. Brown, 1999, Neoplasia.

Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors.

M. Lemmon, Janice M. Y. Brown, J. Brown, 1990, Cancer research.

Radiosensitization of hypoxic cells in vivo by SR 2508 at low radiation doses: a preliminary report.

J. Brown, N. Yu, J. Brown, 1984, International journal of radiation oncology, biology, physics.

An Early Oxygen-Dependent Step Is Required for Dexamethasone-Induced Apoptosis of Immature Mouse Thymocytes1

J. Torres-Roca, L. Herzenberg, L. Herzenberg, 2000, The Journal of Immunology.

Apoptosis of Immature Mouse Thymocytes Required for Dexamethasone-Induced An Early Oxygen-Dependent Step Is

J. Torres-Roca, L. Herzenberg, P. Katsikis, 2000 .

Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors.

Luigi Naldini, Napoleone Ferrara, Michele De Palma, 2010, The American journal of pathology.

Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature

G. Ahn, J. Brown, J. Brown, 2009, Angiogenesis.

Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells.

G. Ahn, J. Brown, J. Brown, 2008, Cancer cell.

Radiation Damage to Tumor Vasculature Initiates a Program that Promotes Tumor Recurrences.

J. Brown, J. Brown, J. Brown, 2020, International journal of radiation oncology, biology, physics.

Macrophage exclusion after radiation therapy (MERT): A new and effective way to increase the therapeutic ratio of radiotherapy.

L. Recht, Reena P. Thomas, S. Nagpal, 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Green fluorescent protein is a suitable reporter of tumor hypoxia despite an oxygen requirement for chromophore formation.

D. Vordermark, T. Shibata, J. M. Brown, 2001, Neoplasia.

Development of a hypoxia-responsive vector for tumor-specific gene therapy

A. Giaccia, T. Shibata, J. Brown, 2000, Gene Therapy.

Tumor hypoxia in cancer therapy.

J Martin Brown, J. Brown, J. Brown, 2007, Methods in enzymology.

Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia.

A. Giaccia, M. Lemmon, T. Davis, 1996, Gene therapy.

Chemotherapeutic tumour targeting using clostridial spores.

A. Giaccia, J. Brown, M. Lemmon, 1995, FEMS microbiology reviews.

Selectable insertion and deletion mutagenesis of the human cytomegalovirus genome using the Escherichia coli guanosine phosphoribosyl transferase (gpt) gene.

J. Brown, J. Vieira, E. Mocarski, 1995, The Journal of general virology.

Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies.

J. Brown, J M Brown, JM Brown, 2000, Molecular medicine today.

Hypofractionation results in reduced tumor cell kill compared to conventional fractionation for tumors with regions of hypoxia.

P. Keall, B. Loo, Zhe Chen, 2011, International journal of radiation oncology, biology, physics.

Vasculogenesis: a crucial player in the resistance of solid tumours to radiotherapy.

J. Brown, J. Brown, J M Brown, 2014, The British journal of radiology.

Loss of p21Waf1/Cip1 sensitizes tumors to radiation by an apoptosis-independent mechanism.

A. Giaccia, J. Brown, B. Wouters, 1997, Cancer research.

A sensitive assay for the detection cytotoxic antibodies to mammalian cell surface antigens.

W. Thorpe, S. Rosenberg, J. Brown, 1979, Journal of immunological methods.

The cancer-associated Sm-like oncogene: a novel target for the gene therapy of pancreatic cancer.

D. Watson, D. Cole, J. Vournakis, 2000, Surgery.

Radiosensitization, thiol oxidation, and inhibition of DNA repair by SR 4077.

J. Brown, Y. Taylor, M. A. Baker, 1988, Radiation research.

Radiosensitization by diamide analogs and arsenicals.

G. P. Jacobs, E. Bump, J. Brown, 1986, International journal of radiation oncology, biology, physics.

The irradiated tumor microenvironment: role of tumor-associated macrophages in vascular recovery

J. Russell, J. Brown, J. Brown, 2013, Front. Physiol..

Report of NCI Ad Hoc Working Group on the Risks Associated With Mammography in Mass Screening for the Detection of Breast Cancer

G. Beebe, J. Brown, A. Upton, 1977 .

Deficiency in Bre1 Impairs Homologous Recombination Repair and Cell Cycle Checkpoint Response to Radiation Damage in Mammalian Cells

J. Brown, O. Razorenova, J. Game, 2010, Radiation research.

Tumor Microenvironment and the Response to Anticancer Therapy

J Martin Brown, J. Brown, J. Brown, 2002, Cancer biology & therapy.

Pancreatic tumors show high levels of hypoxia.

A. Koong, Q. Le, V. Mehta, 2000, International journal of radiation oncology, biology, physics.

Modified ice study: a phase II study of an intensive, modified ICE regimen (ifosfamide, carboplatin and etoposide) in patients with better prognosis, small cell lung cancer.

M. Muers, M. Peake, H. Hosker, 1998, Lung cancer.

Targeting SDF-1/CXCR4 to inhibit tumour vasculature for treatment of glioblastomas

D. Tseng, J. Brown, D. A. Vasquez-Medrano, 2011, British Journal of Cancer.

Targeting the Post-Irradiation Tumor Microenvironment in Glioblastoma via Inhibition of CXCL12

F. Wenz, M. Glas, V. Umansky, 2019, Cancers.

The effect of acute x-irradiation on the cell proliferation kinetics of induced carcinomas and their normal counterpart.

J. Brown, 1970, Radiation research.

Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction.

A. Koong, A. Giaccia, J. Brown, 1994, International journal of radiation oncology, biology, physics.

Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats

M. Merchant, L. Recht, H. Kohrt, 2014, British Journal of Cancer.

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

A. Giaccia, J. Brown, J. R. Sun, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Enhancing effect of misonidazole on the response of the RIF-1 tumour to cyclophosphamide.

D. Hirst, M. Law, J. Brown, 1981, British Journal of Cancer.

The shape of the dose-response curve for radiation carcinogenesis. Extrapolation to low doses.

J. Brown, J. Brown, 1977, Radiation research.

Radiosensitivity and the oxygen effect measured at different phases of the mitotic cycle using synchronously dividing cells of the root meristem of Vicia faba.

E. Hall, J. Brown, J. Cavanagh, 1968, Radiation research.

High-dose and fractionation effects in stereotactic radiation therapy: Analysis of tumor control data from 2965 patients.

D. Brenner, I. Shuryak, D. Carlson, 2015, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Combining precision radiotherapy with molecular targeting and immunomodulatory agents: a guideline by the American Society for Radiation Oncology.

J. Sarkaria, K. Camphausen, P. Choyke, 2018, The Lancet. Oncology.

A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy

A. Giaccia, J. Brown, B. Wouters, 1999, Oncogene.

Reassessing the organization of the UL42-UL43 region of the human cytomegalovirus strain AD169 genome.

J. Brown, E. Mocarski, M. Prichard, 1997, Virology.

The effect of time between X-irradiation and chemotherapy on the growth of three solid mouse tumors--I. Adriamycin.

J. Brown, P. Twentyman, R. Kallman, 1979, International journal of radiation oncology, biology, physics.

Immunity to infections following hematopoietic cell transplantation.

I. Weissman, J. Shizuru, J. Brown, 2001, Current opinion in immunology.

The influence of irradiation of the tumor bed on tumor hypoxia: measurements by radiation response, oxygen electrodes, and nitroimidazole binding.

J. Brown, M. Lemmon, I. Kim, 1993, Radiation research.

Integrating phenotypic and expression profiles to map arsenic-response networks

T. Ideker, R. Kelley, A. Haugen, 2004, Genome Biology.

Genome-Wide Identification of Genes Conferring Resistance to the Anticancer Agents Cisplatin , Oxaliplatin , and

L. Lazzeroni, M. Dorie, James A. L. Brown, 2004 .

Preferential tumor radiosensitization by analogs of nicotinamide and benzamide.

D. M. Brown, J. Brown, M. Lemmon, 1986, International journal of radiation oncology, biology, physics.

Pharmacological modification of tumor blood flow: lack of correlation between alteration of mean arterial blood pressure and changes in tumor perfusion.

J. Brown, H. Stone, A. Minchinton, 1992, International journal of radiation oncology, biology, physics.

The effect of alterations in haematocrit on tumour sensitivity to X-rays.

D. Hirst, J. Brown, J. Hazlehurst, 1984, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Tirapazamine: a hypoxia-activated topoisomerase II poison.

K. Peters, J. Brown, J. Brown, 2002, Cancer research.

The potentiation of radiation damage by nicotinamide in the SCCVII tumour in vivo.

J. Overgaard, M. Horsman, P. Wood, 1990, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Mechanism of action of the selective tumor radiosensitizer nicotinamide.

J. Brown, J. Overgaard, M. Lemmon, 1988, International journal of radiation oncology, biology, physics.

High-dose single-fraction radiotherapy: exploiting a new biology?

Albert C Koong, A. Koong, J Martin Brown, 2008, International journal of radiation oncology, biology, physics.

Influence of localized preinoculation irradiation of the foot on lymphatic metastasis from a primary tumor growing in the foot.

D. Rappaport, J. Brown, 1979, Radiation research.

The RAD6/BRE1 Histone Modification Pathway in Saccharomyces Confers Radiation Resistance Through a RAD51-Dependent Process That Is Independent of RAD18

J. Game, J. Martin Brown, John C. Game, 2006, Genetics.

A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia.

A. Koong, A. Giaccia, Q. Le, 2005, Cancer research.

Tumor hypoxia is important in radiotherapy, but how should we measure it?

Q. Le, J. Brown, J. Brown, 2002, International journal of radiation oncology, biology, physics.

Cell Killing and Chromosome Aberrations by Ionizing Radiations: Brother, Can You Paradigm?

J. Bedford, J. Brown, J. Brown, 2021, International journal of radiation oncology, biology, physics.

NCI's anticancer drug screening program may not be selecting for clinically active compounds.

J. Brown, J. Brown, J. Brown, 1997, Oncology research.

7.06 – Tumor Radiation Biology

E. Graves, J. Brown, J. Brown, 2014 .

Radiosensitization by nicotinamide in vivo: a greater enhancement of tumor damage compared to that of normal tissues.

M. Horsman, D. Chaplin, J M Brown, 1987, Radiation research.

Apoptosis: mediator or mode of cell killing by anticancer agents?

B. Wouters, B. Wouters, J. Brown, 2001, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Does Apoptosis Contribute to Tumor Cell Sensitivity to Anticancer Agents

B. Wouters, J. Brown, J. Brown, 1999 .

Apoptosis , p 53 , and Tumor Cell Sensitivity to Anticancer Agents 1

B. Wouters, J. Brown, J. Brown, 1999 .

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

A. Giaccia, J. Brown, C. Koumenis, 1996, Proceedings of the National Academy of Sciences of the United States of America.

In vitro growth of murine T cells. III. Method for separation of T cell growth factor (TCGF) from concanavalin A and biological activity of the resulting TCGF.

S. Rosenberg, S. Schwarz, P. Spiess, 1980, Journal of immunological methods.

Characterization of the DNA double strand break repair defect in scid mice.

J. Brown, M. Mezzina, C. Chang, 1993, Cancer research.

Is Equipment Development Stifling Innovation in Radiation Oncology?

J. Adler, J. Brown, J. Brown, 2015, International journal of radiation oncology, biology, physics.

Detection of a human sarcoma-associated antigen with monoclonal antibodies.

J. Brown, J. Brown, J. Brown, 1983, Cancer research.

Hypoxic cytotoxic agents: a new approach to cancer chemotherapy.

J. Brown, J. Brown, J. Brown, 2000, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

Characterization of the breakpoint of a 3.5-kb deletion of the beta-globin gene.

D. Weatherall, S. Best, J. Lynch, 1991, Genomics.

The effect of lung irradiation on the incidence of pulmonary metastases in mice.

J. Brown, J. Brown, 1973, The British journal of radiology.

The effect of time between X-irradiation and chemotherapy on the growth of three solid mouse tumors. III. Cis-diamminedichloroplatinum.

J. Brown, P. Twentyman, R. Kallman, 1979, International journal of radiation oncology, biology, physics.

Misonidazole chemosensitization of EMT6 spheroids to melphalan.

J. Brown, M. Horsman, P. Wood, 1989, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Enhancement of Alkylating Agent Cytotoxicity by Radiation Sensitizers

D. Hirst, J. Brown, M. Horsman, 1986 .

The effect of timing on chemosensitization by clinical levels of SR-2508.

D. Hirst, M. Horsman, J. Hazlehurst, 1984, International journal of radiation oncology, biology, physics.

Enhancement of melphalan-induced tumour cell killing by misonidazole: an interaction of competing mechanisms.

J. Brown, M. Horsman, J. Evans, 1984, British Journal of Cancer.

Sensitization of normal and malignant tissue to cyclophosphamide by nitroimidazoles with different partition coefficients.

D. Hirst, J. Hazlehurst, J. Brown, 1984, British Journal of Cancer.

Effect of clinical levels of misonidazole on the response of tumour and normal tissues in the mouse to alkylating agents.

D. Hirst, J. Brown, J. Brown, 1982, British Journal of Cancer.

Enhancement of CCNU cytotoxicity by misonidazole: possible therapeutic gain.

D. Hirst, J. Brown, J. Hazlehurst, 1982, British Journal of Cancer.

The Role of Tumor Hypoxia in Head and Neck Cancer Radiotherapy

A. Giaccia, Q. Le, J. Brown, 2005 .

4 – Chemical Modifiers of Radiation Response

J. Brown, C. Koch, M. Parliament, 2010 .

Reoxygenation and rehypoxiation in the SCCVII mouse tumor.

J. Brown, I. Kim, J. Brown, 1994, International journal of radiation oncology, biology, physics.

Role of Glutathione in the Hypoxie Cell Cytotoxicity of Misonidazole1

J. Brown, E. Bump, Y. Taylor, 1983 .

Cells at intermediate oxygen levels can be more important than the "hypoxic fraction" in determining tumor response to fractionated radiotherapy.

B. Wouters, J M Brown, B G Wouters, 1997, Radiation research.

Localization of radiolabeled monoclonal antibody in a human soft tissue sarcoma xenograft.

J. Brown, T. K. Gupta, J. Greager, 1985, Journal of the National Cancer Institute.

Primary T-cell and activated macrophage response associated with tumor protection using peptide/poly-N-acetyl glucosamine vaccination.

J. Brown, D. Cole, J. Vournakis, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Characterization of a sustained-release delivery system for combined cytokine/peptide vaccination using a poly-N-acetyl glucosamine-based polymer matrix.

J. Brown, D. Cole, J. Vournakis, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Studies on the mechanism of chemosensitization by misonidazole in vitro.

E. Bump, Y. Taylor, J. Brown, 1982, International journal of radiation oncology, biology, physics.

Multimodal Concepts for Integration of Cytotoxic Drugs

M. Mehta, J. Brown, C. Nieder, 2006 .

The effect of time between X-irradiation and chemotherapy on the growth of three solid mouse tumors--II. Cyclophosphamide.

J. Brown, P. Twentyman, R. Kallman, 1979, International journal of radiation oncology, biology, physics.

The effect of time between X-irradiation and chemotherapy on the growth of three solid mouse tumors. VI. BCNU.

P. Twentyman, R. Kallman, P. Lelieveld, 1979, International journal of radiation oncology, biology, physics.

Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin

B. Wouters, B. Siim, B. Wouters, 1999, British Journal of Cancer.

Tirapazamine: a new drug producing tumor specific enhancement of platinum-based chemotherapy in non-small-cell lung cancer.

J. Brown, B. Wouters, L. Wang, 1999, Annals of oncology : official journal of the European Society for Medical Oncology.

1,2,4-Benzotriazine 1,4-dioxides. An important class of hypoxic cytotoxins with antitumor activity.

K. Ryan, M. Dorie, A. Kelson, 1998, Anti-cancer drug design.

Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia.

B. Siim, M. Dorie, D. Menke, 1997, Cancer research.

Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine

J. Brown, M. Dorie, J. Brown, 1997, Cancer Chemotherapy and Pharmacology.

Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro.

P. V. van Zijl, B. Siim, P. V. Zijl, 1996, British Journal of Cancer.

Tumour hypoxia: the picture has changed in the 1990s.

A. Giaccia, J. Brown, J. Brown, 1994, International journal of radiation biology.

Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation.

J. Brown, K. Biedermann, J. Wang, 1992, Cancer research.

Improving the effectiveness of the bioreductive antitumor agent SR 4233 by induced hypoxia.

J. Brown, A. Minchinton, J. Brown, 1992, Advances in experimental medicine and biology.

Aerobic radiosensitization by SR 4233 in vitro and in vivo.

J. Brown, M. Lemmon, E. M. Zeman, 1990, International journal of radiation oncology, biology, physics.

The hypoxic cell: a target for selective cancer therapy--eighteenth Bruce F. Cain Memorial Award lecture.

Janice M. Y. Brown, J. Brown, J. Brown, 1999, Cancer research.

Effect of partition coefficient on the ability of nitroimidazoles to enhance the cytotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea.

D. Hirst, J. Brown, J. Hazlehurst, 1983, Cancer research.

The optimum time for irradiation relative to tumour concentration of hypoxic cell sensitizers.

N. Yu, J. Brown, J. Brown, 1980, The British journal of radiology.

Mechanism of sensitization of Chinese hamster ovary cells to melphalan by hypoxic treatment with misonidazole.

J. Brown, Y. Taylor, J. Evans, 1983, Cancer research.

The therapeutic potential of misonidazole enhancement of alkylating agent cytotoxicity.

D. Hirst, J. Brown, J. Brown, 1982, International journal of radiation oncology, biology, physics.

Response to the RIF-1 tumor in vitro and in C3H/Km mice to X-radiation (cell survival, regrowth delay, and tumor control), chemotherapeutic agents, and activated macrophages.

S. Zamvil, J. Brown, P. Twentyman, 1980, Journal of the National Cancer Institute.

The effect of BCNU on mouse skin and spinal cord in single drug and radiation exposures.

D. Goffinet, S. Schoeppel, P. Lelieveld, 1979, International journal of radiation oncology, biology, physics.

Mechanism of Sensitizaron of Chinese Hamster Ovary Cells to Melphalan by Hypoxie Treatment with Misonidazole 1

Y. Taylor, James W. Evans, J. Brown, 2006 .

Cytotoxicity of misonidazole in vivo under conditions of prolonged contact of drug with the tumour cells.

N. Yu, J. Brown, J. Brown, 1979, The British journal of radiology.

The influence of hemoglobin level on radiobiological hypoxia in tumors.

D. Hirst, J. Brown, 1986, Advances in experimental medicine and biology.

Therapeutic advantage of hypoxic cells in tumors: a theoretical study.

A. Koong, J. Brown, J. Brown, 1991, Journal of the National Cancer Institute.

Influence of heat on the intracellular uptake and radiosensitization of 2-nitroimidazole hypoxic cell sensitizers in vitro.

D. M. Brown, G. Hahn, M. Cohen, 1983, Cancer research.

Dose escalation, not "new biology," can account for the efficacy of stereotactic body radiation therapy with non-small cell lung cancer.

David J Brenner, David J Carlson, D. Brenner, 2013, International journal of radiation oncology, biology, physics.

DNA cross-linking and cytotoxicity of the alkylating cyanomorpholino derivative of doxorubicin in multidrug-resistant cells.

B. Sikic, J. Brown, S. Scudder, 1988, Journal of the National Cancer Institute.

Bacterial Systems for Tumor-Specific Gene Therapy

P. Lambin, J. Brown, J. Theys, 2005 .

Structure-activity relationships for benzotriazine di-N-oxides.

M. Lemmon, J. Adams, C. Pearson, 1989, International journal of radiation oncology, biology, physics.

Structure−Activity Relationships of 1,2,4-Benzotriazine 1,4-Dioxides as Hypoxia-Selective Analogues of Tirapazamine

S. Gamage, W. Denny, W. Wilson, 2003 .

Clinical Cancer esearch cer Therapy : Preclinical rmacokinetic / Pharmacodynamic Modeling Identifies 0000 and SN 29751 as Tirapazamine Analogues with roved Tissue Penetration and Hypoxic R l Killing in Tumors

W. Denny, J. Brown, W. Wilson, 2010 .

Selective Potentiation of the Hypoxic Cytotoxicity of Tirapazamine by Its 1-N-Oxide Metabolite SR 4317

J. Brown, W. Wilson, M. Hay, 2004, Cancer Research.

Production and characterization of a monoclonal antibody to bovine estrogen sulfotransferase.

J. Adams, C. Beattie, J. Brown, 1987, Hybridoma.

Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs.

Timothy W Secomb, William R Wilson, Kevin O Hicks, 2006, Journal of the National Cancer Institute.

Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells.

Y. Pommier, W. Wilson, S. Powell, 2008, Cancer research.

Metabolism of SR 4233 by Chinese hamster ovary cells: basis of selective hypoxic cytotoxicity.

V. Hirst, E. Zeman, M. A. Baker, 1988, Cancer research.

Keynote address: hypoxic cell radiosensitizers: where next?

J. Brown, J. Brown, 1989, International journal of radiation oncology, biology, physics.

Cardiac mural thrombi caused by radiation.

L. F. Fajardo, J. Brown, J. Brown, 1973, Radiation research.

Radiosensitization by hypoxic pretreatment with misonidazole: an interaction of damage at the DNA level.

Y. Taylor, J. Evans, J. Brown, 1987, Radiation Research.

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation.

J M Brown, J. Brown, J. Brown, 1979, The British journal of radiology.

Transcriptional activation of hypoxia-inducible factor-1 (HIF-1) in myeloid cells promotes angiogenesis through VEGF and S100A8

K. S. Kim, I. Weissman, J. Cooke, 2014, Proceedings of the National Academy of Sciences.

Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy.

B. Loo, R. Pai, A. Koong, 2015, International journal of radiation oncology, biology, physics.

Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy.

A. Giaccia, T. Shibata, J. Brown, 2002, Neoplasia.

Pre- and post-irradiation adiosensitization by SR 4233

J. Brown, E. M. Zeman, J. Brown, 1989 .

Radiosensitization in multifraction schedules. II. Greater sensitization by 2-nitroimidazoles than by oxygen.

Y. Taylor, J. Brown, J. Brown, 1987, Radiation research.

Exploitation of kinetic differences between normal and malignant cells.

J. Brown, J. Brown, 1975, Radiology.

Radiosensitization in multifraction schedules. I. Evidence for an extremely low oxygen enhancement ratio.

Y. Taylor, J. Brown, J. Brown, 1987, Radiation research.

In vitro hepatotoxicity of SR 4233 (3-amino-1,2,4-benzotriazine-1,4-dioxide), a hypoxic cytotoxin and potential antitumor agent.

J. Trudell, A. K. Costa, M. A. Baker, 1989, Cancer research.

Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro.

G. Hahn, A. Koong, A. Giaccia, 1992, International journal of radiation oncology, biology, physics.

J. Brown, D. Vordermark, D. Menke, 2003, Radiation research.

Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation.

B. Strulovici, A. Giaccia, J. Brown, 1992, British Journal of Cancer.

Dynamin impacts homology-directed repair and breast cancer response to chemotherapy

B. Győrffy, S. Mello, C. Wiese, 2018, The Journal of clinical investigation.

Endogenous Markers of Tumor Hypoxia

D. Vordermark, J. Brown, J. Brown, 2003, Strahlentherapie und Onkologie.

Evaluation of hypoxia-inducible factor-1α (HIF-1α) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: In vitro and xenograft studies

D. Vordermark, J. Brown, J. Brown, 2003 .

Evaluation of hypoxia-inducible factor-1alpha (HIF-1alpha) as an intrinsic marker of tumor hypoxia in U87 MG human glioblastoma: in vitro and xenograft studies.

J. Brown, D. Vordermark, J. Brown, 2003, International journal of radiation oncology, biology, physics.

Tumor radiosensitization by nicotinamide: a result of improved perfusion and oxygenation.

J. Brown, M. Horsman, D. Chaplin, 1989, Radiation research.

Estimating DNA repair by sequential evaluation of head and neck tumor radiation sensitivity using the comet assay.

A. Koong, Q. Le, J. Brown, 2002, Archives of otolaryngology--head & neck surgery.

Oxygen tension measurements of tumors growing in mice.

M. Adam, M. Dorie, J M Brown, 1999, International journal of radiation oncology, biology, physics.

A Role for Lsm1p in Response to Ultraviolet-Radiation Damage in Saccharomyces cerevisiae

Kelly E McCann, J. Brown, Tatiana Spicakova, 2008, Radiation research.

Induction and repair of chromosome aberrations in scid cells measured by premature chromosome condensation.

J. Brown, C. Kirchgessner, J. Evans, 1996, Radiation research.

Inhibiting homologous recombination for cancer therapy

J. Game, S. Chernikova, J. Brown, 2012, Cancer biology & therapy.

The use of rodent tumors in experimental cancer therapy. Conclusions and recommendations from an international workshop.

J. Brown, R. Hill, J. Denekamp, 1985 .

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.

James B. Mitchell, A. Harris, G. Semenza, 2004, Cancer research.

Roentgen Diagnosis of Spontaneous Internal Biliary Fistulae, Especially Those Involving the Common Duct1

L. Garland, J. Brown, 1942 .

Development of investigational radiation modifiers.

James B. Mitchell, C. N. Coleman, K. Camphausen, 2003, Journal of the National Cancer Institute.

Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A

W. Wilson, L. Thompson, G. Atwell, 2009, Molecular Cancer Therapeutics.

DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.

Rachelle S. Singleton, W. Wilson, M. Dorie, 2009, Cancer research.

Green Fluorescent Protein is a Suitable Reporter of Tumor Hypoxia Despite an Oxygen Requirement for Chromophore Formation 1

D. Vordermark, T. Shibata, J. Brown, 2001 .

Long-term recovery of connective tissue after irradiation.

J. Probert, J. Brown, J. Brown, 1973, Radiology.

Short-term costs of conventional vs laparoscopic assisted surgery in patients with colorectal cancer (MRC CLASICC trial)

P. Quirke, P. Guillou, N. Bosanquet, 2006, British Journal of Cancer.

The frequency of translocations after treatment for Hodgkin's disease.

J. Brown, L. Smith, M. Mori, 1992, International journal of radiation oncology, biology, physics.

M. Stephen Meyn, ataxia telangiectasia and cellular responses to DNA damage. Cancer Res., 55:5991-6001, 1995.

J. Brown, J. Brown, 1997, Cancer research.

Changes in misonidazole binding with hypoxic fraction in mouse tumors.

D. Hirst, J. Brown, J. Hazlehurst, 1985, International journal of radiation oncology, biology, physics.

Timing of breast cancer surgery in relation to menstrual cycle phase: no effect on 3-year prognosis: The ITS Study

M. Dowsett, T. Perren, J. Sainsbury, 2007, British Journal of Cancer.

The Potential Benefit of Hypoxic Cytotoxins in Radio-Oncology

J. Brown, J. Brown, 2000 .

In vivo 1H MR spectroscopy of human head and neck lymph node metastasis and comparison with oxygen tension measurements.

E. Adalsteinsson, J. Star-Lack, D. Spielman, 2000, AJNR. American journal of neuroradiology.

Enhancement of the antitumor effect of flavone acetic acid by the bioreductive cytotoxic drug SR 4233 in a murine carcinoma.

J. Brown, J. R. Sun, J. Brown, 1989, Cancer research.

Comparison of the comet assay and the oxygen microelectrode for measuring tumor oxygenation in head-and-neck cancer patients.

D. Bloch, A. Koong, Q. Le, 2003, International journal of radiation oncology, biology, physics.

Deficiency in mammalian histone H2B ubiquitin ligase Bre1 (Rnf20/Rnf40) leads to replication stress and chromosomal instability.

J. Brooks, M. Nicolau, J. Higgins, 2012, Cancer research.

Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (tirapazamine) and by nicotinamide with carbogen.

J. Brown, M. Dorie, D. Menke, 1994, International journal of radiation oncology, biology, physics.

Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: Experimental models and clinical perspectives

G. Ahn, J. Brown, J. Brown, 2009, Cell cycle.

Letter: Comparison of tumour growth delay with cell survival.

A. Howes, J. Brown, 1974, The British journal of radiology.

Discrepancies between measured changes of radiobiological hypoxic fraction and oxygen tension monitoring using two assay systems.

J. Brown, K. Sasai, J. Brown, 1994, International journal of radiation oncology, biology, physics.

Effects of X-irradiation on the cell population kinetics in a model tumour and normal tissue system: implications for the treatment of human malignancies.

R. Berry, J. Brown, 1969, British Journal of Radiology.

The use of pyrimidine analogues in radiotherapy.

F. Ellis, J. Brown, J. Brown, 1969, The British journal of radiology.

Progress and prospects in hematopoietic stem cell expansion and transplantation.

I. Weissman, J. Brown, J. Brown, 2004, Experimental hematology.

Early and late radiation changes following a second course of irradiation.

J. Probert, J. Brown, 1975, Radiology.