K. Lenos

发表

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

Colin Watts, Jian Teng, Ravi S. Narayan, 2020, Nature Communications.

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Maria C. Lecca, D. M. Miedema, G. Stassi, 2018, Nature Cell Biology.

Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

Maria C. Lecca, D. M. Miedema, M. Nowak, 2019, Proceedings of the National Academy of Sciences.

Behavioral factors to modulate immunotherapy efficacy in cancer

L. Vermeulen, A. Evers, L. Buffart, 2022, Frontiers in Immunology.

Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas

Maria C. Lecca, Kristiaan J. Lenos, D. M. Miedema, 2020, Cell stem cell.

HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of the HDMX Gene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity*

J. Richter, A. Jochemsen, J. Blaydes, 2010, The Journal of Biological Chemistry.

Loss of bone morphogenetic protein signaling in fibroblasts results in CXCL12-driven serrated polyp development

Kristiaan J. Lenos, T. van Wezel, J. C. Hardwick, 2022, Journal of Gastroenterology.

Molecular characterization of colorectal cancer related peritoneal metastatic disease

Maria C. Lecca, Kristiaan J. Lenos, D. M. Miedema, 2022, Nature Communications.

Oncogenic BRAFV600E drives expression of MGL ligands in the colorectal cancer cell line HT29 through N-acetylgalactosamine-transferase 3

Ernesto Rodriguez, S. V. van Vliet, N. Sahasrabudhe, 2018, Biological chemistry.

Chromosomal copy number heterogeneity predicts survival rates across cancers

D. M. Miedema, J. Tuynman, B. Ylstra, 2021, Nature Communications.

Cancer stem cells: here, there, and everywhere

D. M. Miedema, L. Vermeulen, M. Bijlsma, 2018, Molecular & cellular oncology.

Alternate splicing of the p53 inhibitor HDMX offers a superior prognostic biomarker than p53 mutation in human cancer.

H. Taubert, A. Jochemsen, A. Cleton-Jansen, 2012, Cancer research.

Functions of MDMX in the Modulation of the p53-Response

A. Jochemsen, K. Lenos, 2011, Journal of biomedicine & biotechnology.

Chapter 2 Functions of MDMX in the Modulation of the p 53 Response

A. Jochemsen, K. Lenos, 2011 .

Human T Cell Activation Results in Extracellular Signal-regulated Kinase (ERK)-Calcineurin-dependent Exposure of Tn Antigen on the Cell Surface and Binding of the Macrophage Galactose-type Lectin (MGL)* ♦

Kristiaan J. Lenos, J. Garcia-Vallejo, Y. van Kooyk, 2013, The Journal of Biological Chemistry.

Cancer stem cells don't waste their time cleaning-low proteasome activity, a marker for cancer stem cell function.

L. Vermeulen, K. Lenos, 2016, Annals of translational medicine.

A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue

D. M. Miedema, S. Lyons, L. Vermeulen, 2019, Nature Protocols.

Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer.

Maria C. Lecca, Kristiaan J. Lenos, D. M. Miedema, 2021, Cell reports.

Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer

G. Stassi, R. Beijersbergen, L. Vermeulen, 2023, Journal of Experimental & Clinical Cancer Research.

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

Maria C. Lecca, T. Lagerweij, T. Wurdinger, 2020, Nature Communications.

c-Abl Phosphorylates Hdmx and Regulates Its Interaction with p53*

T. Holak, A. Jochemsen, G. Popowicz, 2009, Journal of Biological Chemistry.

Function and regulation of SUMOylation in the p 53 pathway : a role for RNF 4 ?

Kristiaan J. Lenos, A. Jochemsen, K. Lodder, 2011 .

Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts

A. Jochemsen, A. Teunisse, K. Szuhai, 2011, Molecular Cancer.

MGL ligand expression is correlated to BRAF mutation and associated with poor survival of stage III colon cancer patients

G. Meijer, B. Carvalho, C. Pritchard, 2015, Oncotarget.

Alternative splicing of HDMX predicts p53 inactivation and bad prognosis

Kristiaan J. Lenos, A. Jochemsen, A. Cleton-Jansen, 2011 .

A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity

Maria C. Lecca, L. Vermeulen, P. Tanis, 2020, Laboratory Investigation.

Chapter 7 FAU expression is essential for proliferation and affects the drug sensitivity of osteosarcoma cells

Kristiaan J. Lenos, A. Jochemsen, A. Teunisse, 2011 .

Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas

Maria C. Lecca, D. M. Miedema, L. Vermeulen, 2021, Cell stem cell.

Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer.

Maria C. Lecca, D. M. Miedema, L. Vermeulen, 2021, Cell reports.

A marker-independent lineage-tracing system to quantify clonal dynamics and stem cell functionality in cancer tissue

D. M. Miedema, S. Lyons, L. Vermeulen, 2019, Nature Protocols.

Using picoliter droplet deposition to track clonal competition in adherent and organoid cancer cell cultures

P. Krawczyk, K. Lenos, Haibin Qian, 2023, Scientific reports.

Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases

J. Medema, P. Snaebjornsson, S. V. van Hooff, 2024, Cell reports. Medicine.