Bei Wang

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).

K. Scearce-Levie, Jianping Yin, Xingrong Liu, 2015, Journal of medicinal chemistry.

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

E. Huang, K. Scearce-Levie, Z. Modrušan, 2017, Science Translational Medicine.

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis

C. Pozniak, D. Kirkpatrick, K. Newton, 2013, The Journal of cell biology.

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

C. Pozniak, R. Watts, A. Ghosh, 2011, The Journal of cell biology.

Sca ff old-Hopping and Structure-Based Discovery of Potent , Selective , And Brain Penetrant N ‐ ( 1 H ‐ Pyrazol-3-yl ) pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase ( DLK , MAP 3 K 12 )

K. Scearce-Levie, Jianping Yin, Xingrong Liu, 2015 .

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

Zhiyu Jiang, Jing Yang, M. Tessier-Lavigne, 2013, Proceedings of the National Academy of Sciences.

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

K. Scearce-Levie, K. Stark, C. Ly, 2015, Journal of medicinal chemistry.

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult

M. Tessier-Lavigne, Z. Modrušan, J. Kaminker, 2017, eLife.