H. Han

发表

Design and synthesis of piperazine acetate podophyllotoxin ester derivatives targeting tubulin depolymerization as new anticancer agents.

Yong-Hua Yang, Wenxue Sun, G. Lu, 2017, Bioorganic & medicinal chemistry letters.

Discovery of fluoroquinolone derivatives as potent, selective inhibitors of PI3Kγ

Hongwei Han, W. Zhong, Shao Sha, 2015 .

Design, synthesis and anti-cancer evaluation of novel podophyllotoxin derivatives as potent tubulin-targeting agents

Yong-Hua Yang, G. Lu, Y. Pang, 2018, Medicinal Chemistry Research.

One pot synthesis of aryl nitriles from aromatic aldehydes in a water environment

Yonghua Yang, Xiaoming Wang, Jinliang Qi, 2021, RSC advances.

Novel Shikonin Derivatives Targeting Tubulin as Anticancer Agents

Yong-Hua Yang, A. Kulek, Hongyan Lin, 2014, Chemical biology & drug design.

Assessment of shikonin and acetyl-shikonin for mitigating quorum sensing potential of C. violaceum

T. Yin, Yonghua Yang, Zhongling Wen, 2021, Plant Growth Regulation.

Antiviral activity of shikonin ester derivative PMM-034 against enterovirus 71 in vitro

Wenjie Zhu, Xiaoyong Wang, Yu-Shun Yang, 2017, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Antiviral activity of a synthesized shikonin ester against influenza A (H1N1) virus and insights into its mechanism.

Yonghua Yang, Xiaoming Wang, G. Lu, 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Design, synthesis and biological evaluation of shikonin thio-glycoside derivatives: new anti-tubulin agents

Deyan Yin, Yong-Hua Yang, Hongwei Han, 2014 .

Synthesis, characterization and biological evaluation of formononetin derivatives as novel EGFR inhibitors via inhibiting growth, migration and inducing apoptosis in breast cancer cell line

Yong-Hua Yang, Wenxue Sun, Hongwei Han, 2017 .

Synthesis of novel aryl dithian valeryl podophyllotoxin ester derivatives as potential antitubulin agents

Yong-Hua Yang, Hongwei Han, Hongyan Lin, 2015 .

Differential relieving effects of shikonin and its derivatives on inflammation and mucosal barrier damage caused by ulcerative colitis

T. Yin, Yonghua Yang, Wenxue Sun, 2021, PeerJ.

Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors.

Yong-Hua Yang, Yu-Shun Yang, Wenxue Sun, 2018, European journal of medicinal chemistry.

Shikonin N-benzyl matrinic acid ester derivatives as novel telomerase inhibitors with potent activity against lung cancer cell lines.

T. Yin, Faxiang Lin, Yonghua Yang, 2021, Bioorganic & medicinal chemistry letters.

Identification of new shikonin derivatives as STAT3 inhibitors

Peng-Fei Wang, Yong-Hua Yang, Hongwei Han, 2017, Biochemical pharmacology.

Natural naphthoquinones isolated from Lithospermum erythrorhizon suppress dextran sulfate sodium-induced murine experimental colitis

T. Yin, Yonghua Yang, Wenxue Sun, 2019, bioRxiv.

Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo

Yong-Hua Yang, Wenxue Sun, Hongwei Han, 2020, Chinese Medicine.

Assembly and shifts of the bacterial rhizobiome of field grown transgenic maize line carrying mcry1Ab and mcry2Ab genes at different developmental stages

T. Yin, Yong-Hua Yang, Zhongling Wen, 2020, Plant Growth Regulation.

Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR.

Yonghua Yang, Wenxue Sun, Zhongling Wen, 2019, Bioorganic & medicinal chemistry.

Novel Podophyllotoxin Derivatives as Potential Tubulin Inhibitors: Design, Synthesis, and Antiproliferative Activity Evaluation

Yong-Hua Yang, Wenxue Sun, Minkai Yang, 2018, Chemistry & biodiversity.

Anti‐microbial efficacy, mechanisms and druggability evaluation of the natural flavonoids

Yonghua Yang, Zhongling Wen, Minkai Yang, 2022, Journal of applied microbiology.

PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.

T. Yin, Yonghua Yang, Zhongling Wen, 2023, European journal of medicinal chemistry.

Discovering Podophyllotoxin Derivatives as Potential Anti‐Tubulin Agents: Design, Synthesis and Biological Evaluation

T. Yin, Yonghua Yang, Zhongling Wen, 2020 .

A modified natural small molecule inhibits triple-negative breast cancer growth by interacting with Tubb3

T. Yin, Yonghua Yang, Zhongling Wen, 2023, Phytomedicine.

Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.

T. Yin, Yonghua Yang, Hongwei Han, 2021, Bioorganic chemistry.

Design, synthesis and anti-cancer activity evaluation of podophyllotoxin-norcantharidin hybrid drugs.

Yong-Hua Yang, Wenxue Sun, Hongwei Han, 2016, Bioorganic & medicinal chemistry letters.

Novel shikonin derivative suppresses tumor growth and metastasis intervention of Wnt/β-catenin pathway

T. Yin, Wencai Jie, Yonghua Yang, 2023, Process Biochemistry.

Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment.

T. Yin, Yonghua Yang, Zhongling Wen, 2023, Bioorganic chemistry.

The evaluation of potent antitumor activities of shikonin coumarin-carboxylic acid, PMMB232 through HIF-1α-mediated apoptosis.

Yong-Hua Yang, Wenxue Sun, Hongwei Han, 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.