R. Guy

发表

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

D. Kyle, M. Phillips, J. Gow, 2012, Journal of medicinal chemistry.

Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single-Enantiomer cis-Imidazolines for Protein–Protein Inhibition

Tyler A. Davis, Jaeki Min, Kristin E. Finch, 2014, The Journal of organic chemistry.

Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents.

R. Guy, M. Kastan, Jaeki Min, 2016, Journal of medicinal chemistry.

Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases.

R. Guy, J. Craig, D. Warhurst, 2007, Biochemical pharmacology.

Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation.

Bhuvanesh Singh, R. Guy, B. Schulman, 2018, Journal of medicinal chemistry.

Anticancer Properties of Distinct Antimalarial Drug Classes

K. Chibale, M. Phillips, R. Guy, 2013, PloS one.

Dihydroquinazolinone Inhibitors of Proliferation of Blood and Liver Stage Malaria Parasites

J. Clardy, Jaeki Min, M. Connelly, 2013, Antimicrobial Agents and Chemotherapy.

Lead optimization of antimalarial propafenone analogues.

A. Furimsky, W. A. Guiguemde, Julie Clark, 2012, Journal of Medicinal Chemistry.

Evaluation of Diarylureas for Activity Against Plasmodium falciparum.

J. Derisi, R. Guy, J. L. Weisman, 2010, ACS medicinal chemistry letters.

Antimalarial activity of thiosemicarbazones and purine derived nitriles.

R. Guy, W. A. Guiguemde, J. Mallari, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationship of dual-stage antimalarial pyrazolo[3,4-b]pyridines.

E. Winzeler, F. Gamo, R. Guy, 2020, Journal of medicinal chemistry.

An α-Helical Peptidomimetic Inhibitor of the HIV-1 Rev−RRE Interaction

M. Daugherty, R. Guy, A. Frankel, 2006 .

Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models.

J. Derisi, R. Guy, L. Iyer, 2010, Journal of medicinal chemistry.

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

R. Guy, Yuko Sato, Jaeki Min, 2015, PloS one.

Optimization of Diastereomeric Dihydropyridines as Antimalarials

J. Burrows, Roman Manetsch, Alexis N Lacrue, 2024, European Journal of Medicinal Chemistry.