Tsung-Chih Chen

发表

Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents.

Hsu-Shan Huang, Dah-Shyong Yu, Chun-Liang Chen, 2015, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of tetracyclic azafluorenone derivatives with topoisomerase I inhibitory properties as potential anticancer agents

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2016 .

Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation

Y. Yen, Shih-Hsiung Wu, Hsu-Shan Huang, 2015, Oncotarget.

Ring fusion strategy for the synthesis of anthra[2,3-d]oxazole-2-thione-5,10-dione homologues as DNA topoisomerase inhibitors and as antitumor agents.

J. Guh, D. Chang, Wen-Wei Chang, 2014, European journal of medicinal chemistry.

Ring fusion strategy for synthesis and lead optimization of sulfur-substituted anthra[1,2-c][1,2,5]thiadiazole-6,11-dione derivatives as promising scaffold of antitumor agents.

J. Guh, Hsu-Shan Huang, Dah-Shyong Yu, 2015, European journal of medicinal chemistry.

Structure-based design, synthesis and biological evaluation of novel anthra[1,2-d]imidazole-6,11-dione homologues as potential antitumor agents.

Hsu-Shan Huang, Jing-Jer Lin, Dah-Shyong Yu, 2013, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases.

Sung-Bau Lee, Ting-Yu Chang, Mei-Hsiang Lin, 2020, European journal of medicinal chemistry.

Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination

C. Chiang, Hsu-Shan Huang, A. Ali, 2016, PloS one.

Synthesis, Telomerase Evaluation and Anti‐Proliferative Studies on Various Series of Diaminoanthraquinone‐Linked Aminoacyl Residue Derivatives

Hsu-Shan Huang, Jing-Jer Lin, K. Huang, 2012, Archiv der Pharmazie.

Development of 1‐Amino‐4‐(phenylamino)anthraquinone‐2‐sulfonate Sodium Derivatives as a New Class of Inhibitors of RANKL‐Induced Osteoclastogenesis

D. Chang, Wei-Hsin Sun, Hsu-Shan Huang, 2016, Archiv der Pharmazie.

Synthesis and biological evaluation of anthra[1,9-cd]pyrazol-6(2H)-one scaffold derivatives as potential anticancer agents

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2015 .

Synthesis and biological evaluation of anthra [ 1 , 9-cd ] pyrazol-6 ( 2 H )-one scaffold derivatives as potential anticancer agents

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2015 .

Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives.

J. Guh, Hsu-Shan Huang, Jing-Jer Lin, 2012, European journal of medicinal chemistry.

Design, synthesis and evaluation of telomerase inhibitory, hTERT repressing, and anti-proliferation activities of symmetrical 1,8-disubstituted amidoanthraquinones.

D. Chang, Hsu-Shan Huang, Jing-Jer Lin, 2012, European journal of medicinal chemistry.

New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules

S. Chiou, Hsu-Shan Huang, Dah-Shyong Yu, 2013, PloS one.

Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin.

Hwei-Jen Lee, Shih-Ming Huang, Hsu-Shan Huang, 2011, The international journal of biochemistry & cell biology.

Synthesis, cytotoxicity and human telomerase inhibition activities of a series of 1,2-heteroannelated anthraquinones and anthra[1,2-d]imidazole-6,11-dione homologues.

Hsu-Shan Huang, Jing-Jer Lin, Jing-Ru Jhan, 2009, Bioorganic & medicinal chemistry.

Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.

Tsung-Chih Chen, J. Guh, D. Chang, 2013, European journal of medicinal chemistry.

NSC746364, a G-quadruplex-stabilizing agent, suppresses cell growth of A549 human lung cancer cells through activation of the ATR/Chk1-dependent pathway.

Chieh-Hsi Wu, Chun-Hsu Pan, Hsu-Shan Huang, 2014, Journal of pharmacological sciences.

Design, synthesis and antiproliferative evaluation of fluorenone analogs with DNA topoisomerase I inhibitory properties.

J. Guh, D. Chang, Hsu-Shan Huang, 2013, Bioorganic & medicinal chemistry.

Novel inhibitors of RANKL-induced osteoclastogenesis: Design, synthesis, and biological evaluation of 6-(2,4-difluorophenyl)-3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-diones.

D. Chang, Hsu-Shan Huang, Feng-Cheng Liu, 2015, Bioorganic & medicinal chemistry.

Discovery of 5-(2',4'-difluorophenyl)-salicylanilides as new inhibitors of receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis.

D. Chang, Hsu-Shan Huang, Tsung-Chih Chen, 2015, European journal of medicinal chemistry.

Synthesis and evaluation of new 3-substituted-4-chloro-thioxanthone derivatives as potent anti-breast cancer agents

Hsu-Shan Huang, A. Ali, Tsung-Chih Chen, 2015 .

Modified salicylanilide and 3-phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione derivatives as novel inhibitors of osteoclast differentiation and bone resorption.

D. Chang, H. Sytwu, Hsu-Shan Huang, 2014, Journal of medicinal chemistry.

A New Application of Parallel Synthesis Strategy for Discovery of Amide-Linked Small Molecules as Potent Chondroprotective Agents in TNF-α-Stimulated Chondrocytes

Ling-Jun Ho, J. Lai, Hsu-Shan Huang, 2016, PloS one.

Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption.

D. Chang, Hsu-Shan Huang, Tsung-Chih Chen, 2016, European journal of medicinal chemistry.

Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways

A. Wu, Kuo-Hsing Ma, Hsu-Shan Huang, 2017, Oncotarget.