K. Sakaniwa

Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-like Receptor 7 and 8.

Toshiyuki Shimizu, H. Yin, Rosaura Padilla-Salinas, 2019, Journal of medicinal chemistry.

Small-molecule inhibition of TLR8 through stabilization of its resting state

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2017, Nature chemical biology.

Targeting the innate immune receptor TLR8 using small-molecule agents

Toshiyuki Shimizu, K. Sakaniwa, 2020, Acta crystallographica. Section D, Structural biology.

Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2018, Cell chemical biology.

TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction

M. Ikeguchi, H. Shigematsu, Toshiyuki Shimizu, 2023, Nature Communications.

Rationally designed small-molecule inhibitors targeting an unconventional pocket on the TLR8 protein-protein interface.

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2020, Journal of medicinal chemistry.

Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2021, Nature Communications.

A novel Toll-like receptor 7/8-specific antagonist E6742 Ameliorates clinically relevant disease parameters in murine models of lupus.

S. Ishizaka, Qian Chen, Toshiyuki Shimizu, 2023, European journal of pharmacology.