Craig S. Donald

发表

Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes.

Andrew G. Leach, A. Plowright, Robert D. M. Davies, 2012, Bioorganic & medicinal chemistry letters.

Flexible synthesis of polyfunctionalised 3-fluoropyrroles.

C. Donald, Thomas J. Cogswell, R. Marquez, 2016, Organic & biomolecular chemistry.

The syntheses of rac-inthomycin A, (+)-inthomycin B and (+)-inthomycin C using a unified synthetic approach

M. R. Webb, X. Franci, R. Taylor, 2008 .

A general route to the Streptomyces-derived inthomycin family: the first synthesis of (+)-inthomycin B

M. R. Webb, R. Taylor, Craig S. Donald, 2006 .

Short and efficient synthesis of fluorinated δ-lactams.

D. Long, C. Donald, Thomas J. Cogswell, 2015, Organic & biomolecular chemistry.

Deuterodehalogenation—a mild method for synthesising deuterated heterocycles

T. Moss, Bryan E. Roberts, G. Noonan, 2014 .

Rapid, two-pot procedure for the synthesis of dihydropyridinones; total synthesis of aza-goniothalamin

Thomas J. Cogswell, R. Marquez, Craig S. Donald, 2020, Beilstein journal of organic chemistry.

Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.

A. Ferguson, L. Drew, W. Shao, 2020, Journal of medicinal chemistry.

Structure-Based Design of Potent and Selective Inhibitors of the Metabolic Kinase PFKFB3.

J. Debreczeni, A. Turnbull, S. Degorce, 2015, Journal of medicinal chemistry.

Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.

Cristian Bodin, Andrew G Leach, James S. Scott, 2012, Journal of medicinal chemistry.

Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity.

S. Boyer, C. Donald, A. Turnbull, 2002, Journal of medicinal chemistry.

Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist.

A. Rabow, D. M. Andrews, G. Walker, 2015, Journal of medicinal chemistry.

Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life.

D. Mckerrecher, C. Johnstone, Craig S Donald, 2011, Bioorganic & medicinal chemistry letters.

An efficient synthesis of 2-alkylpyridines using an alkylation/double decarboxylation strategy

S. Boyd, Craig S. Donald, 2012 .

Making medicinal chemistry more effective--application of Lean Sigma to improve processes, speed and quality.

Nidhal Selmi, Jan Kihlberg, Magnus J. Johansson, 2009, Drug discovery today.

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.

A. Rabow, G. Walker, R. A. Norman, 2016, Cancer research.

Synthesis of 4-Arylthieno[2,3-b]pyridines and 4-Aminothieno[2,3-b]pyridines via a Regioselective Bromination of Thieno[2,3-b]pyridine.

C. Donald, S. Lucas, Janet L Hawkins, 2015, The Journal of organic chemistry.

A comparison of the Still–Gennari and Ando HWE-methodologies with α,β-unsaturated aldehydes; unexpected results with stannyl substituted systems

M. R. Webb, J. McGrady, X. Franci, 2003 .

A Comparison of the Still—Gennari and Ando HWE‐Methodologies with α,β‐Unsaturated Aldehydes: Unexpected Results with Stannyl‐Substituted Systems.

M. R. Webb, J. McGrady, X. Franci, 2004 .

Tricyclic Indazoles-A Novel Class of Selective Estrogen Receptor Degrader Antagonists.

Paul R. J. Davey, James S. Scott, A. Bailey, 2019, Journal of medicinal chemistry.

Design of a potent, soluble glucokinase activator with excellent in vivo efficacy.

D. Mckerrecher, C. Johnstone, Keith M Johnson, 2006, Bioorganic & medicinal chemistry letters.

General methods for the synthesis and late-stage diversification of 2,4-substituted 7-azaindoles

Rebecca E. Meadows, B. Barlaam, Bryan E. Roberts, 2016 .

Regioselective ortho alkylation of nitro indole, carbazole, benzothiophene and benzofuran

S. Groombridge, J. Feron, Craig S. Donald, 2015 .

Abstract DDT01-03: Discovery and pre-clinical pharmacology of AZD9496: An oral, selective estrogen receptor down-regulator (SERD)

A. Rabow, D. M. Andrews, G. Walker, 2015 .

Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.

Andrew G. Leach, James S. Scott, Frederick W. Goldberg, 2012, Journal of medicinal chemistry.