C. Alves da Costa

发表

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new beta-amyloid peptide production inhibitors and their activities on various classes of protease.

O. Pourquié, F. Bihel, J. Kraus, 2003, Bioorganic & medicinal chemistry.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Direct α-synuclein promoter transactivation by the tumor suppressor p53

E. Duplan, F. Checler, C. A. D. Alves da Costa, 2016, Molecular Neurodegeneration.

Direct α-synuclein promoter transactivation by the tumor suppressor p53

E. Duplan, F. Checler, C. Giordano, 2016, Molecular Neurodegeneration.

p53 in neurodegenerative diseases and brain cancers.

F. Checler, C. Alves da Costa, 2014, Pharmacology & therapeutics.

Parkin as a Molecular Bridge Linking Alzheimer’s and Parkinson’s Diseases?

F. Checler, C. A. D. Alves da Costa, C. Alves da Costa, 2022, Biomolecules.

p53 Is Regulated by and Regulates Members of the γ-Secretase Complex

J. Dunys, F. Checler, C. A. D. Alves da Costa, 2010, Neurodegenerative Diseases.

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1

A. Brice, H. Ariga, E. Duplan, 2013, Journal of Cell Science.

p53‐Dependent control of cell death by nicastrin: lack of requirement for presenilin‐dependent γ‐secretase complex

P. S. St George-Hyslop, J. Dunys, F. Checler, 2009, Journal of neurochemistry.

Therapeutic potential of parkin as a tumor suppressor via transcriptional control of cyclins in glioblastoma cell and animal models

A. Idbaih, E. Duplan, Lila Rouland, 2021, Theranostics.

Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology

T. Goiran, E. Duplan, Wejdane El Manaa, 2021, Autophagy.

Primary Cultured Neurons Devoid of Cellular Prion Display Lower Responsiveness to Staurosporine through the Control of p53 at Both Transcriptional and Post-transcriptional Levels*

J. Bourdon, F. Checler, C. A. D. Alves da Costa, 2004, Journal of Biological Chemistry.

The Transcription Factor Function of Parkin: Breaking the Dogma

E. Duplan, Lila Rouland, F. Checler, 2019, Front. Neurosci..

Presenilin-Dependent γ-Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease

P. S. St George-Hyslop, F. Checler, C. Sunyach, 2006, The Journal of Neuroscience.

Overexpression of PrPc triggers caspase 3 activation: potentiation by proteasome inhibitors and blockade by anti‐PrP antibodies

F. Checler, C. A. D. Alves da Costa, E. Paitel, 2002, Journal of neurochemistry.

Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer’s Disease

E. Duplan, Wejdane El Manaa, F. Checler, 2019, Cells.

Neprilysin activity and expression are controlled by nicastrin

P. S. St George-Hyslop, J. Dunys, F. Checler, 2006, Journal of neurochemistry.

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.

F. Checler, C. A. D. Alves da Costa, C. Sunyach, 2005, Neuron.

Interplay between Parkin and p53 Governs a Physiological Homeostasis That Is Disrupted in Parkinson's Disease and Cerebral Cancer

F. Checler, C. A. D. Alves da Costa, C. Alves da Costa, 2013, Neurodegenerative Diseases.

Parkin: Much More than a Simple Ubiquitin Ligase

F. Checler, C. A. D. Alves da Costa, C. Alves da Costa, 2011, Neurodegenerative Diseases.

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

M. Mattson, F. Checler, R. Amson, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?

F. Checler, Frédéric Checler, Cristine Alves da Costa, 2011, Cellular signalling.

Presenilins at the crossroad of a functional interplay between PARK2/PARKIN and PINK1 to control mitophagy: Implication for neurodegenerative diseases

T. Goiran, F. Checler, C. Alves da Costa, 2017, Autophagy.

Presenilin‐directed inhibitors of γ‐secretase trigger caspase 3 activation in presenilin‐expressing and presenilin‐deficient cells

P. S. St George-Hyslop, F. Checler, C. A. D. Alves da Costa, 2004, Journal of neurochemistry.

Effect of protein kinase A inhibitors on the production of Aβ40 and Aβ42 by human cells expressing normal and Alzheimer's disease‐linked mutated βAPP and presenilin 1

F. Checler, P. Marambaud, K. Ancolio, 1999, British journal of pharmacology.

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease.

F. Checler, C. A. D. Alves da Costa, B. Vincent, 2002, The Journal of biological chemistry.

JLK isocoumarin inhibitors: Selective γ‐secretase inhibitors that do not interfere with notch pathway in vitro or in vivo

F. Checler, C. A. D. Alves da Costa, P. Marambaud, 2003, Journal of neuroscience research.

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

P. S. St George-Hyslop, F. Checler, C. Sunyach, 2006, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Study on the Putative Contribution of Caspases and the Proteasome to the Degradation of Aph-1a and Pen-2

P. S. St George-Hyslop, J. Dunys, F. Checler, 2007, Neurodegenerative Diseases.

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes α-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.

R. Cappai, J. Dunys, F. Checler, 2006, The Journal of Biological Chemistry.

Catabolism of endogenous and overexpressed APH1a and PEN2: evidence for artifactual involvement of the proteasome in the degradation of overexpressed proteins.

P. S. St George-Hyslop, J. Dunys, F. Checler, 2006, The Biochemical journal.

α-Synuclein Lowers p53-dependent Apoptotic Response of Neuronal Cells

F. Checler, C. A. D. Alves da Costa, B. Vincent, 2002, The Journal of Biological Chemistry.

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.

O. Pourquié, F. Bihel, J. Kraus, 2001, Nature cell biology.

Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.

F. Checler, C. A. D. Alves da Costa, P. Marambaud, 1999, British journal of pharmacology.

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation

T. Goiran, E. Duplan, Lila Rouland, 2018, Cell Death & Differentiation.

Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells.

F. Checler, K. Ancolio, C. Alves da Costa, 2000, Neuroscience letters.

p53 Is Regulated by and Regulates Members of the γ-Secretase Complex

J. Dunys, F. Checler, R. Pardossi-Piquard, 2010, Neurodegenerative Diseases.