H. Tanji

发表

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2016, Immunity.

Toll-like receptor 8 senses degradation products of single-stranded RNA

Toshiyuki Shimizu, M. Taoka, Y. Yamauchi, 2015, Nature Structural &Molecular Biology.

Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds

Xiaoqiang Guo, Toshiyuki Shimizu, Toshiyuki Shimizu, 2014, Journal of medicinal chemistry.

Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity

Toshiyuki Shimizu, Giuseppe Caruso, Diptesh Sil, 2015, Journal of medicinal chemistry.

Small-molecule inhibition of TLR8 through stabilization of its resting state

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2017, Nature chemical biology.

Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles.

Toshiyuki Shimizu, Giuseppe Caruso, U. Ohto, 2016, Journal of medicinal chemistry.

Structure‐Based Design of Novel Human Toll‐like Receptor 8 Agonists

Diptesh Sil, U. Ohto, Diptesh Sil, 2014, ChemMedChem.

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

Toshiyuki Shimizu, S. Uchiyama, Elena Krayukhina, 2015, Nature.

Structure and function of toll-like receptor 8.

Toshiyuki Shimizu, U. Ohto, H. Tanji, 2014, Microbes and infection.

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

Takuma Shibata, Toshiyuki Shimizu, Toshiyuki Shimizu, 2013, Science.

Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2018, Cell chemical biology.

Rationally designed small-molecule inhibitors targeting an unconventional pocket on the TLR8 protein-protein interface.

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2020, Journal of medicinal chemistry.

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

O. Levy, Toshiyuki Shimizu, Nikunj M. Shukla, 2015, PloS one.

Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists

Toshiyuki Shimizu, H. Yin, Shuangshuang Jiang, 2021, Nature Communications.

Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8

Takuma Shibata, Toshiyuki Shimizu, Toshiyuki Shimizu, 2016, Proceedings of the National Academy of Sciences.

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

Toshiyuki Shimizu, S. Uchiyama, Elena Krayukhina, 2015, Nature.