Hualiang Jiang

发表

Computational target fishing by mining transcriptional data using a novel Siamese spectral-based graph convolutional network

Kaixian Chen, Xiaohong Liu, Feisheng Zhong, 2020, bioRxiv.

KinomeX: a web application for predicting kinome-wide polypharmacology effect of small molecules

Xiaomin Luo, Mingyue Zheng, Kaixian Chen, 2019, Bioinform..

Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies

Chen Cui, Kaixian Chen, Xiaoyu Ding, 2018, Medicinal research reviews.

New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery

Weiliang Zhu, Yun Tang, Kaixian Chen, 2006, Drug Discovery Today: Technologies.

A Genetic Algorithm Based Support Vector Machine Model for Blood-Brain Barrier Penetration Prediction

Xiaomin Luo, Mingyue Zheng, Kaixian Chen, 2015, BioMed research international.

Accelerating All-Atom Normal Mode Analysis with Graphics Processing Unit.

Li Liu, Xiaofeng Liu, Jiayu Gong, 2011, Journal of chemical theory and computation.

Computational drug discovery

Cheng Luo, Hualiang Jiang, Si-sheng Ou-Yang, 2012, Acta Pharmacologica Sinica.

Automated design and optimization of multitarget schizophrenia drug candidates by deep learning

Chen Cui, Zhaojun Li, Yang He, 2020, bioRxiv.

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

Cheng Luo, Hu Zhou, Hualiang Jiang, 2014, Nucleic acids research.

Conformational states of the full-length glucagon receptor

Clinton S Potter, Bridget Carragher, Chris de Graaf, 2015, Nature Communications.

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets

Cheng Luo, Bairong Shen, Zhongjie Liang, 2015, Scientific Reports.

Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors.

Jian Li, Xun Ji, Hualiang Jiang, 2014, Bioorganic & medicinal chemistry.

Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding

George F. Gao, Feng Gao, Kunqian Yu, 2013, Scientific Reports.

[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase.

Honglin Li, Zigang Dong, Hualiang Jiang, 2009, Cancer research.

Elucidating the druggable interface of protein−protein interactions using fragment docking and coevolutionary analysis

Faruck Morcos, José N Onuchic, Hualiang Jiang, 2016, Proceedings of the National Academy of Sciences.

Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: A Combined Computational and Experimental Study.

Liang Li, Pan Deng, Mingyue Zheng, 2017, Journal of medicinal chemistry.

Development of Potent Type I Protein Arginine Methyltransferase (PRMT) Inhibitors of Leukemia Cell Proliferation.

Hao Jiang, Cheng Luo, Fei Ye, 2017, Journal of medicinal chemistry.

Combinatorial Pharmacophore Modeling of Multidrug and Toxin Extrusion Transporter 1 Inhibitors: a Theoretical Perspective for Understanding Multiple Inhibitory Mechanisms

Cheng Luo, Mingyue Zheng, Hualiang Jiang, 2015, Scientific Reports.

(+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice

Jing Chen, Jiming Ye, Mingyue Zheng, 2012, PloS one.

Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOT1L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-l-methionine (SAM)-Dependent Methyltransferase Family.

Hao Jiang, Cheng Luo, Mingyue Zheng, 2017, Journal of medicinal chemistry.

Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA

Chuan He, Hualiang Jiang, Liang Zhang, 2012, Nature chemical biology.

Why are oseltamivir and zanamivir effective against the newly emerged influenza A virus (A/H1N1)?

Cheng Luo, Jianpeng Ma, Weiliang Zhu, 2009, Cell Research.

Techniques used for the discovery of therapeutic compounds: The case of SARS

Xu Shen, Hualiang Jiang, Kaixian Chen, 2006, Drug Discovery Today: Technologies.

Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer.

Cheng Luo, Jin Ren, Ke Chen, 2016, Cancer cell.

Molecular Dynamics Simulations on SDF-1α: Binding with CXCR4 Receptor

Lingling Shen, Gang Pei, Hualiang Jiang, 2003 .

Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections.

Zhiqiang Qin, Antoine Danchin, Yang Wu, 2006, BMC microbiology.

Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase

Cheng Luo, Jie Zhang, Feifei Chen, 2014, Proceedings of the National Academy of Sciences.

Development of a novel class of B-Raf(V600E)-selective inhibitors through virtual screening and hierarchical hit optimization.

Cheng Luo, Weiliang Zhu, Mingyue Zheng, 2012, Organic & biomolecular chemistry.

Recent Advances in Neuraminidase Inhibitor Development as Anti‐influenza Drugs

Fei Zhao, Mingyue Zheng, Rolf Hilgenfeld, 2012, ChemMedChem.

Predicting Hepatotoxicity of Drug Metabolites Via an Ensemble Approach Based on Support Vector Machine

Mingyue Zheng, Hualiang Jiang, Kaixian Chen, 2017, Combinatorial chemistry & high throughput screening.

Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol

Hualiang Jiang, Xiayang Qiu, Mingzhu Wang, 2015, Genes & development.

Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: a drug of traditional chinese medicine origin for the treatment of Alzheimer's disease.

Hualiang Jiang, Xiaomin Luo, Xiaomin Luo, 2003, Current medicinal chemistry.

Reduced Catalytic Activity of P450 2A6 Mutants with Coumarin: A Computational Investigation.

Weihua Li, Yun Tang, Hualiang Jiang, 2009, Journal of chemical theory and computation.

Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation

Yang Li, Zhuxi Chen, Hualiang Jiang, 2015, Scientific Reports.

In silico ADME/T modelling for rational drug design

Cheng Luo, Mingyue Zheng, Hualiang Jiang, 2015, Quarterly Reviews of Biophysics.

The gating charge pathway of an epilepsy-associated potassium channel accommodates chemical ligands

Zhuxi Chen, Ping Li, Hao Li, 2013, Cell Research.

Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir

Yan Zhang, Hualiang Jiang, Sheng-Ce Tao, 2020, bioRxiv.

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization.

Cheng Luo, Hualiang Jiang, Kongkai Zhu, 2017, Journal of medicinal chemistry.

SPHINGOSINE-1-PHOSPHATE: A MISSING COFACTOR FOR THE E3 UBIQUITIN LIGASE TRAF2

Cheng Luo, Sarah Spiegel, Hualiang Jiang, 2010, Nature.

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation.

Cheng Luo, Jing Chen, Chuan He, 2015, Nature chemistry.