Justin Lesch

发表

Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.

Adam R. Johnson, P. Lockey, W. Ouyang, 2015, Journal of medicinal chemistry.

Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth

Yongchang Shi, Yu-Chien Chou, K. Yamaguchi, 2011, Molecular Cancer Therapeutics.

Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation

Aly A. Khan, J. DeVoss, I. Mellman, 2013, Nature Immunology.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

J. DeVoss, A. Zarrin, Lawren C. Wu, 2015, Science Signaling.

Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer

D. Danilenko, J. DeVoss, A. Zarrin, 2019, Front. Immunol..

Listeria monocytogenes personalized cancer vaccines drive therapeutic immune responses to cancer derived neoantigens

J. Johnston, J. DeVoss, J. Lesch, 2020, bioRxiv.

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Adam R. Johnson, Z. Modrušan, J. DeVoss, 2018, Nature Communications.

Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNα-driven lupus nephritis.

Adam R. Johnson, Z. Modrušan, J. DeVoss, 2017, JCI insight.

NeuCode Proteomics Reveals Bap1 Regulation of Metabolism.

M. Westphall, J. DeVoss, A. Attie, 2016, Cell reports.

NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Adam R. Johnson, Z. Modrušan, J. DeVoss, 2018, Nature Communications.

PILRα Negatively Regulates Mouse Inflammatory Arthritis

S. Kummerfeld, W. Ouyang, J. DeVoss, 2014, The Journal of Immunology.

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

W. Ouyang, N. Bruggen, J. Lesch, 2014, Nature.

Tumor suppressor BAP1 is essential for thymic development and proliferative responses of T lymphocytes

Thijs J. Hagenbeek, Steve Lianoglou, S. Rutz, 2018, Science Immunology.

Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation

Aly A. Khan, M. Weirauch, J. DeVoss, 2017, The Journal of cell biology.

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

Z. Modrušan, W. Ouyang, Harinder Singh, 2011, Nature Immunology.

PILRα Negatively Regulates Mouse Inflammatory Arthritis

S. Kummerfeld, W. Ouyang, J. DeVoss, 2014, The Journal of Immunology.

Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth

K. Yamaguchi, F. Yakes, A. Joly, 2011, Molecular Cancer Therapeutics.

Preclinical Development Cabozantinib ( XL 184 ) , a Novel MET and VEGFR 2 Inhibitor , Simultaneously Suppresses Metastasis , Angiogenesis , and Tumor Growth

K. Yamaguchi, J. Lesch, F. Yakes, 2011 .

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

S. Rutz, Z. Modrušan, W. Ouyang, 2014, Nature.

An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides

Cleopatra Kozlowski, Xiaoting Wang, J. DeVoss, 2013, Disease Models & Mechanisms.

Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1

Meijuan Zhou, Min Xu, Zora Modrusan, 2013, Nature Immunology.

Image Analysis-Based Approaches for Scoring Mouse Models of Colitis

J. DeVoss, R. Rogers, J. Eastham‐Anderson, 2016, Veterinary pathology.