Matthew T. O’Brien

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation

A. Means, B. Kemp, C. Langendorf, 2017, Scientific Reports.

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

B. Kemp, M. Parker, C. Langendorf, 2020, The Journal of Biological Chemistry.

Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder

R. Rodriguiz, W. Wetsel, A. Means, 2015, Scientific Reports.

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin–sensitizing effects of metformin

J. Dyck, B. Kemp, D. Hardie, 2013, Nature Medicine.

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

B. Viollet, B. Kemp, K. Sakamoto, 2017, Nature Communications.

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

B. Kemp, G. Steinberg, C. Langendorf, 2014, Chemistry & biology.

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

B. Viollet, B. Kemp, K. Sakamoto, 2017, Nature Communications.