Leilei Jiang

发表

Solid-state NMR reveals the structural transformation of the TDP-43 amyloidogenic region upon fibrillation.

J. Wang, Hong-Yu Hu, Junxia Lu, 2020, Journal of the American Chemical Society.

O‐GlcNAcylation of TDP‐43 suppresses proteinopathies and promotes TDP‐43’s mRNA splicing activity

Yi Liang, Hong-Yu Hu, Hui Sun, 2021, EMBO reports.

The N-terminal dimerization is required for TDP-43 splicing activity

Hong-Yu Hu, Jian-Hua He, Jun-Ye Hong, 2017, Scientific Reports.

Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

Jian Zhao, Hong-Yu Hu, Wen-tian He, 2016, Scientific Reports.

TDP‐35 sequesters TDP‐43 into cytoplasmic inclusions through binding with RNA

Hong-Yu Hu, Hai-Yin Li, Leilei Jiang, 2015, FEBS letters.

Structural Transformation of the Amyloidogenic Core Region of TDP-43 Protein Initiates Its Aggregation and Cytoplasmic Inclusion*

Jian Zhao, Hong-Yu Hu, Jian-Hua He, 2013, The Journal of Biological Chemistry.

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

H. Yue, Hong-Yu Hu, Wen-tian He, 2017, Scientific Reports.

PolyQ‐expanded huntingtin and ataxin‐3 sequester ubiquitin adaptors hHR23B and UBQLN2 into aggregates via conjugated ubiquitin

H. Yue, Hong-Yu Hu, Wen-tian He, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Aggregation of the 35‐kDa fragment of TDP‐43 causes formation of cytoplasmic inclusions and alteration of RNA processing

Hong-Yu Hu, Yuan-yuan Xie, Lei-Lei Jiang, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

PolyQ-expanded proteins impair cellular proteostasis of ataxin-3 through sequestering the co-chaperone HSJ1 into aggregates

H. Yue, Hong-Yu Hu, Lei-Lei Jiang, 2021, Scientific Reports.

Structural and dynamic studies reveal that the Ala-rich region of ataxin-7 initiates α-helix formation of the polyQ tract but suppresses its aggregation

H. Yue, Hong-Yu Hu, Hui Yang, 2019, Scientific Reports.

Aggregation of Polyglutamine-expanded Ataxin 7 Protein Specifically Sequesters Ubiquitin-specific Protease 22 and Deteriorates Its Deubiquitinating Function in the Spt-Ada-Gcn5-Acetyltransferase (SAGA) Complex*

Jian Zhao, Hong-Yu Hu, Wen-tian He, 2015, The Journal of Biological Chemistry.

Aggregation of Polyglutamine-Expanded Ataxin-7 Specifically Sequesters Ubiquitin-Specific Protease 22 and Deteriorates Its Deubiquitinating Function in SAGA Complex *

Jian Zhao, Hong-Yu Hu, Wen-tian He, 2015 .

PABPN1 aggregation is driven by Ala expansion and poly(A)-RNA binding, leading to CFIm25 sequestration that impairs alternative polyadenylation

Hong-Yu Hu, Leilei Jiang, Xiao-Fang Yin, 2023, The Journal of biological chemistry.

RNA-assisted sequestration of RNA-binding proteins by cytoplasmic inclusions of the C-terminal 35-kDa fragment of TDP-43.

Hong-Yu Hu, Wenlu Guan, Shu-Xian Zhang, 2022, Journal of cell science.

HSP90 recognizes the N-terminus of huntingtin involved in regulation of huntingtin aggregation by USP19

H. Yue, Hong-Yu Hu, Wen-tian He, 2017, Scientific Reports.

Domain interactions reveal auto-inhibition of the deubiquitinating enzyme USP19 and its activation by HSP90 in modulation of huntingtin aggregation.

Hong-Yu Hu, Wen-tian He, Jun-Ye Hong, 2020, The Biochemical journal.

Coaggregation of polyglutamine (polyQ) proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis

H. Yue, Hong-Yu Hu, Jun-Ye Hong, 2023, Acta biochimica et biophysica Sinica.