David Altshuler

发表

Efficiency and Power as a Function of Sequence Coverage, SNP Array Density, and Imputation

Joshua M. Korn, Pierre Fontanillas, Eric Banks, 2012, PLoS Comput. Biol..

Analysis of case-control association studies with known risk variants

Peter Kraft, Alkes L. Price, Noah Zaitlen, 2012, Bioinform..

Transferability of Tag SNPs to Capture Common Genetic Variation in DNA Repair Genes Across Multiple Populations

Christopher A. Haiman, Paul I. W. de Bakker, Robert R. Graham, 2005, Pacific Symposium on Biocomputing.

Human Genome Sequence Variation and the Inherited Basis of Common Disease

David Altshuler, 2005, RECOMB.

Organizational challenges in clinical genomic research

David Altshuler, Jill S. Altshuler, D. Altshuler, 2004, Nature.

Genome-Wide Association Study for Coronary Artery Calcification With Follow-Up in Myocardial Infarction

Udo Hoffmann, David M Herrington, Eric Boerwinkle, 2011, Circulation.

Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus

Geoffrey Hom, David Altshuler, Mark J Daly, 2007, Proceedings of the National Academy of Sciences.

Tissue-specific alternative splicing of TCF7L2

Laura J. Scott, Eric P. Hoffman, Richa Saxena, 2009, Human molecular genetics.

Testing for an Unusual Distribution of Rare Variants

Kathryn Roeder, Benjamin M. Neale, Manuel A. Rivas, 2011, PLoS genetics.

Clarifying the PROGINS allele association in ovarian and breast cancer risk: a haplotype-based analysis.

Malcolm C Pike, Brian E Henderson, Daniel O Stram, 2005, Journal of the National Cancer Institute.

A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia

Rohini Rau-Murthy, Jinghui Zhang, Kenneth Offit, 2013, Nature Genetics.

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

Judy H Cho, Shannon D Chilewski, Michael C Zody, 2008, Nature Genetics.

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Christian Gieger, Thomas Meitinger, Inês Barroso, 2009, Nature Genetics.

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program.

David M Nathan, David Altshuler, Jose C Florez, 2006, The New England journal of medicine.

Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines

Elliott Kieff, Emmanouil T. Dermitzakis, Richa Saxena, 2008, PLoS genetics.

Comparing strategies to fine-map the association of common SNPs at chromosome 9p21 with type 2 diabetes and myocardial infarction

Eric Banks, Sekar Kathiresan, Leif Groop, 2011, Nature Genetics.

Common variants at CD40 and other loci confer risk of rheumatoid arthritis

Jing Cui, Kristin G Ardlie, Elizabeth W Karlson, 2008, Nature Genetics.

Accurately Assessing the Risk of Schizophrenia Conferred by Rare Copy-Number Variation Affecting Genes with Brain Function

Joshua M. Korn, Soumya Raychaudhuri, David Altshuler, 2010, PLoS genetics.

Identification of a BRCA2-Specific Modifier Locus at 6p24 Related to Breast Cancer Risk

Mads Thomassen, Julian Peto, Peter A. Fasching, 2013, PLoS genetics.

Erratum: Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci (American Journal of Human Genetics (2012) 90 (410-425))

Suzette J. Bielinski, Christian Gieger, Ingo Ruczinski, 2012 .

Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus

David Altshuler, John C Whittaker, Timothy W Behrens, 2008, Nature Genetics.

A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort.

Malcolm C Pike, Christopher A Haiman, Brian E Henderson, 2003, Human molecular genetics.

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

Alberto Piazza, William Matthai, Flora Peyvandi, 2009, Nature Genetics.

Evaluation of Common Variants in the Six Known Maturity-Onset Diabetes of the Young (MODY) Genes for Association With Type 2 Diabetes

Kristin G Ardlie, Wendy Winckler, Mark Walker, 2007, Diabetes.

Whole population, genome-wide mapping of hidden relatedness.

Alexander Gusev, Itsik Pe'er, David Altshuler, 2009, Genome research.

Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4.

Elizabeth W Karlson, David Altshuler, Lars Alfredsson, 2005, American journal of human genetics.

A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Christiana Kartsonaki, Mads Thomassen, Julian Peto, 2010, Nature Genetics.

Hypothesis-Based Analysis of Gene-Gene Interactions and Risk of Myocardial Infarction

Isaac Subirana, Olle Melander, Nilesh J. Samani, 2012, PloS one.

Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk

Christian Gieger, Xiaofeng Zhu, Paolo Vineis, 2011, Nature.

Genetic fine-mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Christian Gieger, Jason Carey, Steven Wiltshire, 2016 .

Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes

Stefan Johansson, Jason Flannick, Christopher J O'Donnell, 2013, Nature Genetics.

Multiple rare alleles at LDLR and APOA5 confer risk for early-onset myocardial infarction

David M. Herrington, Adam Kiezun, Peter Donnelly, 2014, Nature.

Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program

Alan R. Shuldiner, Richa Saxena, Paul W. Franks, 2010, Diabetes.

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Christian Gieger, Alex Doney, Inês Barroso, 2010, Nature Genetics.

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

Christian Gieger, Uwe Völker, Mario Falchi, 2009, Nature Genetics.

Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone.

David M Nathan, David Altshuler, Jose C Florez, 2007, The Journal of clinical endocrinology and metabolism.

Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration

Johanna M Seddon, David Altshuler, Mark J Daly, 2006, Nature Genetics.

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

Marta E Alarcón-Riquelme, David Altshuler, Mark Daly, 2006, Nature Genetics.

Common Single Nucleotide Polymorphisms in TCF7L2 Are Reproducibly Associated With Type 2 Diabetes and Reduce the Insulin Response to Glucose in Nondiabetic Individuals

Kristin G Ardlie, Richa Saxena, Peter Almgren, 2006, Diabetes.

Choosing Haplotype-Tagging SNPS Based on Unphased Genotype Data Using a Preliminary Sample of Unrelated Subjects with an Example from the Multiethnic Cohort Study

Christopher A. Haiman, Daniel O. Stram, Malcolm C. Pike, 2003, Human Heredity.

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

Thomas Meitinger, Pierre Fontanillas, Stefan Johansson, 2014, Nature Genetics.

TXNIP Regulates Peripheral Glucose Metabolism in Humans

Allan Vaag, Richa Saxena, Richard T. Lee, 2007, PLoS medicine.

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms

Sungkyoung Choi, Taesung Park, Gonçalo Abecasis, 2016, Human molecular genetics.

The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Eric S. Lander, Thomas J. Hudson, Cecilia M. Lindgren, 2000, Nature Genetics.

Clinical risk factors, DNA variants, and the development of type 2 diabetes.

Peter Almgren, Bo Isomaa, Tiinamaija Tuomi, 2008, The New England journal of medicine.

A Genome-Wide Association Study Identifies LIPA as a Susceptibility Gene for Coronary Artery Disease

Olli Saarela, Frank Kee, Kaisa Silander, 2011, Circulation. Cardiovascular genetics.

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

Pierre Fontanillas, Mark-Anthony Bray, Jason Flannick, 2014, Proceedings of the National Academy of Sciences.

Association of common variation in the HNF1alpha gene region with risk of type 2 diabetes.

Kristin G Ardlie, Wendy Winckler, Peter Almgren, 2005, Diabetes.

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Christian Gieger, Jingyuan Fu, Thomas Meitinger, 2011, Nature Genetics.

Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus

Nicola L. Beer, Pablo Cingolani, Mark I. McCarthy, 2015, PLoS genetics.

Reply to "Statistical concerns about the GSEA procedure"

Nick Patterson, David Altshuler, Mark J Daly, 2004, Nature Genetics.

Modeling and E-M Estimation of Haplotype-Specific Relative Risks from Genotype Data for a Case-Control Study of Unrelated Individuals

Daniel O. Stram, David Altshuler, Brian E. Henderson, 2003, Human Heredity.

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.

He Zhang, Thomas Meitinger, Raimund Erbel, 2014, The New England journal of medicine.

Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction.

Flora Peyvandi, Sekar Kathiresan, Daniela Lina, 2011, Atherosclerosis.

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Taesung Park, Christian Gieger, Tien Yin Wong, 2017, Scientific Data.

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

John Spertus, Markus Perola, Eric Boerwinkle, 2012, The Lancet.

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.

Christian Gieger, Ingo Ruczinski, Tom R. Gaunt, 2012, American journal of human genetics.

Association between microdeletion and microduplication at 16p11.2 and autism

Joshua M. Korn, Yiping Shen, Manuel A. R. Ferreira, 2008 .

Evaluating empirical bounds on complex disease genetic architecture

Jason Flannick, David Altshuler, Shamil Sunyaev, 2013, Nature Genetics.

Variants in MTNR1B influence fasting glucose levels

Inês Barroso, Paul Scheet, Nicole Soranzo, 2009, Nature Genetics.

Once and again-issues surrounding replication in genetic association studies.

David Altshuler, Joel N Hirschhorn, D. Altshuler, 2002, The Journal of clinical endocrinology and metabolism.

Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study.

Brian E Henderson, David Altshuler, Joel N Hirschhorn, 2005, American journal of human genetics.

TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

Anbupalam Thalamuthu, Wentian Li, David Altshuler, 2007, The New England journal of medicine.

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

David Altshuler, Mark J Daly, Chris Cotsapas, 2008, Nature Genetics.