N. McClenaghan

发表

Differential Acute and Long Term Actions of Succinic Acid Monomethyl Ester Exposure on Insulin-Secreting BRIN-BD11 Cells

P. Flatt, N. Mcclenaghan, S. Picton, 2001, International journal of experimental diabetes research.

Long-Term Beneficial Effects of Vanadate, Tungstate, and Molybdate on Insulin Secretion and Function of Cultured Beta Cells

P. Flatt, B. Green, Hui-Kang Liu, 2004, Pancreas.

Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide.

P. Flatt, A. Ball, N. Mcclenaghan, 2000, European journal of pharmacology.

Stem Cell-Based Approaches for the Treatment of Diabetes

C. Kelly, Cara C. S. Flatt, N. McClenaghan, 2011, Stem cells international.

Culture and Function of Electrofusion-Derived Clonal Insulin-Secreting Cells Immobilized on Solid and Macroporous Microcarrier Beads

M. Hamid, P. Flatt, N. Mcclenaghan, 2000, Bioscience reports.

Directed differentiation of progenitor cells towards an islet-cell phenotype.

P. Flatt, N. Mcclenaghan, C. Kelly, 2012, American journal of stem cells.

Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism

L. Brennan, P. Newsholme, P. Flatt, 2006, The FEBS journal.

Acute and long‐term effects of nateglinide on insulin secretory pathways

P. Flatt, A. Ball, N. McClenaghan, 2004, British journal of pharmacology.

Engineering of a glucose-responsive surrogate cell for insulin replacement therapy of experimental insulin-dependent diabetes.

D. Grube, J. Klempnauer, S. Lenzen, 2000, Human gene therapy.

Physiological and pharmacological regulation of insulin release: insights offered through exploitation of insulin‐secreting cell lines

P. Flatt, N. Mcclenaghan, N. McClenaghan, 1999, Diabetes, obesity & metabolism.

Molecular characterization of the glucose-sensing mechanism in the clonal insulin-secreting BRIN-BD11 cell line.

S. Lenzen, M. Elsner, M. Tiedge, 1998, Biochemical and biophysical research communications.

Differential molecular and cellular responses of GLP-1 secreting L-cells and pancreatic alpha cells to glucotoxicity and lipotoxicity.

P. Flatt, R. Moffett, S. Vasu, 2015, Experimental cell research.

Responses of GLP1-secreting L-cells to cytotoxicity resemble pancreatic β-cells but not α-cells.

P. Flatt, R. Moffett, S. Vasu, 2015, Journal of molecular endocrinology.

Evidence for a sustained increase in clonal beta-cell basal intracellular Ca2+ levels after incubation in the presence of newly diagnosed Type-1 diabetic patient sera. Possible role in serum-induced inhibition of insulin secretion.

P. Newsholme, J. Nolan, I. Green, 2002, The Journal of endocrinology.

COMPARISON OF THE SECRETORY PROPERTIES OF FOUR INSULIN-SECRETING CELL LINES

M. Hamid, P. Flatt, N. Mcclenaghan, 2002, Endocrine research.

Understanding Bioanalytical Chemistry: Principles and Applications

V. Gault, N. McClenaghan, 2009 .

Taurine rescues pancreatic β‐cell stress by stimulating α‐cell transdifferentiation

P. Flatt, A. Tarasov, R. Moffett, 2023, BioFactors.

L-Alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic beta-cell line and protects from pro-inflammatory cytokine-induced apoptosis.

P. Newsholme, P. Flatt, N. Mcclenaghan, 2005, Clinical science.

Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia

P. Flatt, N. Mcclenaghan, J. McCluskey, 2013, Islets.

N‐acetyl‐GLP‐1: a DPP IV‐resistant analogue of glucagon‐like peptide‐1 (GLP‐1) with improved effects on pancreatic β‐cell‐associated gene expression

P. Flatt, B. Green, Hui-Kang Liu, 2004, Cell biology international.

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.

P. Newsholme, J. Nolan, P. Flatt, 2004, Clinical science.

Enhancement of homocysteine toxicity to insulin-secreting BRIN-BD11 cells in combination with alloxan.

S. Lenzen, M. Elsner, P. Flatt, 2012, The Journal of endocrinology.

Dys)Regulation of Insulin Secretion by Macronutrients

P. Newsholme, K. Keane, C. Gaudel, 2015 .

Nutrient regulation of insulin secretion and beta-cell functional integrity.

P. Newsholme, C. Gaudel, N. McClenaghan, 2010, Advances in experimental medicine and biology.

Effects of metformin on BRIN‐BD11 beta‐cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas

C. Bailey, N. Irwin, P. Flatt, 2010, Diabetes, obesity & metabolism.

Actions of glucagon-like peptide-1 on KATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide.

P. Flatt, A. Ball, N. McClenaghan, 2006, The Journal of endocrinology.

Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic beta-cell line.

P. Newsholme, P. Flatt, N. Mcclenaghan, 2006, The Journal of endocrinology.

A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line: metabolism of L-alanine is important to the regulation of insulin secretion.

L. Brennan, K. Brindle, P. Newsholme, 2002, Diabetes.

A comparative study of amino acid consumption by rat islet cells and the clonal beta-cell line BRIN-BD11 - the functional significance of L-alanine.

P. Newsholme, J. Nolan, P. Flatt, 2003, The Journal of endocrinology.

Characterization of a Novel Glucose-Responsive Insulin-Secreting Cell Line, BRIN-BD11, Produced by Electrofusion

E. Ah-Sing, P. Flatt, F. O'Harte, 1996, Diabetes.

NKCC transport mediates the insulinotropic effects of taurine and other small neutral amino acids.

L. Brennan, P. Flatt, A. Tarasov, 2023, Life sciences.

Na+ cotransport by metabolizable and nonmetabolizable amino acids stimulates a glucose-regulated insulin-secretory response.

P. Flatt, N. Mcclenaghan, C. Barnett, 1998, Biochemical and biophysical research communications.

Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line.

P. Flatt, N. Mcclenaghan, C. Barnett, 1996, The Journal of endocrinology.

Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility.

M. Hamid, P. Flatt, N. Mcclenaghan, 2012, The Journal of endocrinology.

Development and Functional Characterization of Insulin-releasing Human Pancreatic Beta Cell Lines Produced by Electrofusion*

R. Gomis, M. Hamid, P. Flatt, 2011, The Journal of Biological Chemistry.

Induced desensitization of the insulinotropic effects of antidiabetic drugs, BTS 67 582 and tolbutamide

P. Flatt, A. Ball, N. Mcclenaghan, 2000, British journal of pharmacology.

35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.

Thomas J. Smith, B. M. Rasmussen, V. C. Phan, 1999, Diabetologia.

Implanting 1.1B4 human β-cell pseudoislets improves glycaemic control in diabetic severe combined immune deficient mice

P. Flatt, A. D. Green, S. Vasu, 2016, World journal of diabetes.

L-arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge.

P. Newsholme, P. H. D. de Bittencourt, P. Flatt, 2011, The Journal of endocrinology.

Homocysteine-Induced Impairment of Insulin Secretion From Clonal Pancreatic BRIN-BD11 &bgr;-Cells Is Not Prevented by Catalase

P. Flatt, S. Patterson, N. McClenaghan, 2007, Pancreas.

Cystic Fibrosis–Related Diabetes: Pathophysiology and Therapeutic Challenges

C. Kelly, N. McClenaghan, Ryan Kelsey, 2019, Clinical medicine insights. Endocrinology and diabetes.

Metabolic and K(ATP) channel-independent actions of keto acid initiators of insulin secretion.

P. Flatt, N. Mcclenaghan, N. McClenaghan, 2000, Pancreas.

Glucose and non-glucidic nutrients exert permissive effects on 2-keto acid regulation of pancreatic beta-cell function.

P. Flatt, N. Mcclenaghan, N. McClenaghan, 1999, Biochimica et biophysica acta.

Molecular Mechanisms of Toxicity and Cell Damage by Chemicals in a Human Pancreatic Beta Cell Line, 1.1B4

P. Flatt, N. Mcclenaghan, S. Vasu, 2016, Pancreas.

Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells

P. Flatt, A. D. Green, S. Vasu, 2015, Pflügers Archiv - European Journal of Physiology.

Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4.

P. Flatt, N. Mcclenaghan, J. McCluskey, 2014, Biochimica et biophysica acta.

Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4

P. Flatt, N. Mcclenaghan, J. McCluskey, 2013, Biological chemistry.

Role of islet structure and cellular interactions in the control of insulin secretion

P. Flatt, C. Kelly, N. McClenaghan, 2011, Islets.

Comparison of Insulin Release From MIN6 Pseudoislets and Pancreatic Islets of Langerhans Reveals Importance of Homotypic Cell Interactions

P. Flatt, N. Mcclenaghan, J. McCluskey, 2010, Pancreas.

Islet-intrinsic effects of CFTR mutation

C. Kelly, A. Harper, F. M. Koivula, 2016, Diabetologia.

Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide.

P. Flatt, A. Ball, N. Mcclenaghan, 2005, Biochemical pharmacology.

Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K(ATP) channel components.

P. Flatt, A. Ball, J. McCluskey, 2004, Pharmacological research.

Glycation of Insulin in the Islets of Langerhans of Normal and Diabetic Animals

P. Flatt, N. Mcclenaghan, C. Barnett, 1996, Diabetes.

Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic beta-cell line.

P. Newsholme, P. Flatt, N. Mcclenaghan, 2007, The Journal of endocrinology.

Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure.

P. Flatt, A. Ball, N. Mcclenaghan, 2001, Biochemical pharmacology.

Drug-induced desensitization of insulinotropic actions of sulfonylureas.

P. Flatt, A. Ball, N. Mcclenaghan, 2000, Biochemical and biophysical research communications.

Stimulation of insulin secretion in clonal BRIN-BD11 cells by the imidazoline derivatives KU14r and RX801080.

P. Flatt, A. Ball, N. Mcclenaghan, 2000, Pharmacological research.

Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 beta-cell insulin secretion and signal transduction.

P. Newsholme, P. Flatt, A. Kiely, 2009, The Journal of endocrinology.

Pseudoislets as primary islet replacements for research

N. Morgan, T. Maffucci, M. D. Turner, 2010, Islets.

13C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and γ-glutamyl cycle activity in a clonal pancreatic beta-cell line

L. Brennan, P. Newsholme, P. Flatt, 2003, Diabetologia.

Short-term CFTR inhibition reduces islet area in C57BL/6 mice

N. Irwin, M. Flodström-Tullberg, C. Kelly, 2019, Scientific Reports.

Determining the relationship between dietary carbohydrate intake and insulin resistance

N. McClenaghan, 2005, Nutrition Research Reviews.

Deleterious Effects of Supplementation with Dehydroepiandrosterone Sulphate or Dexamethasone on Rat Insulin-Secreting Cells Under In Vitro Culture Condition

P. Flatt, B. Green, Hui-Kang Liu, 2006, Bioscience reports.

Cell-to-cell communication and cellular environment alter the somatostatin status of delta cells.

P. Flatt, N. Mcclenaghan, C. Kelly, 2010, Biochemical and biophysical research communications.

Improved antioxidative defence protects insulin-producing cells against homocysteine toxicity.

S. Lenzen, P. Flatt, N. Mcclenaghan, 2016, Chemico-biological interactions.

Function of a long‐term, GLP‐1‐treated, insulin‐secreting cell line is improved by preventing DPP IV‐mediated degradation of GLP‐1

P. Flatt, B. Green, N. Mcclenaghan, 2005, Diabetes, obesity & metabolism.

Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion.

L. Brennan, P. Newsholme, P. Flatt, 2006, The Journal of endocrinology.

D-glucose metabolism in BRIN-BD11 islet cells.

W. Malaisse, P. Flatt, J. Rasschaert, 1996, Biochemical and molecular medicine.

Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets.

Aline Bittencourt, P. Newsholme, P. Flatt, 2012, The Journal of endocrinology.

Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 beta-cell insulin secretion and signal transduction.

P. Newsholme, P. Flatt, N. Mcclenaghan, 2009, The Journal of endocrinology.

The role of diet in diabesity

N. Mcclenaghan, N. McClenaghan, 2006 .

Physiological regulation of the pancreatic β‐cell: functional insights for understanding and therapy of diabetes

N. McClenaghan, 2007, Experimental physiology.

Prolonged exposure to homocysteine results in diminished but reversible pancreatic β‐cell responsiveness to insulinotropic agents

P. Flatt, S. Patterson, J. McCluskey, 2007, Diabetes/metabolism research and reviews.

Homocysteine and other structurally-diverse amino thiols can alter pancreatic beta cell function without evoking cellular damage.

P. Flatt, S. Patterson, N. Mcclenaghan, 2006, Biochimica et biophysica acta.

Prolonged L-alanine exposure induces changes in metabolism, Ca(2+) handling and desensitization of insulin secretion in clonal pancreatic beta-cells.

L. Brennan, P. Newsholme, P. Flatt, 2009, Clinical science.

Induction of a Glucose‐Dependent Insulin Secretory Response by the Nonmetabolizable Amino Acid α‐Aminoisobutyric Acid

A. Berts, N. Mcclenaghan, B. Hellman, 1997, Pancreas.

Glycine transformation of Ca2+ oscillations into a sustained increase parallels potentiation of insulin release.

A. Tengholm, N. Mcclenaghan, E. Gylfe, 1992, Biochimica et biophysica acta.

Engineering cultured insulin-secreting pancreatic B-cell lines

P. Flatt, N. Mcclenaghan, N. McClenaghan, 1999, Journal of Molecular Medicine.

Overexpression of the malate–aspartate NADH shuttle member Aralar1 in the clonal β-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism

P. Newsholme, P. Flatt, N. Mcclenaghan, 2009, Clinical science.

The role of glucagon‐ and somatostatin‐secreting cells in the regulation of insulin release and beta‐cell function in heterotypic pseudoislets

P. Flatt, N. Mcclenaghan, J. McCluskey, 2010, Diabetes/metabolism research and reviews.

Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic beta-cell glucose-sensing, cellular signal transduction and integrity.

P. Flatt, S. Patterson, N. McClenaghan, 2007, Archives of biochemistry and biophysics.

Hexose recognition by insulin-secreting BRIN-BD11 cells.

P. Flatt, N. Mcclenaghan, A. Gray, 1996, Biochemical and biophysical research communications.

Review Article Stem Cell-based Approaches for the Treatment of Diabetes 1. the Need for Islet Cell Replacement Strategies

N. Mcclenaghan, C. Kelly, Cara C. S. Flatt, 2011 .

Effects of Long‐Term Exposure to Nicotinamide and Sodium Butyrate on Growth, Viability, and the Function of Clonal Insulin Secreting Cells

P. Flatt, B. Green, Hui-Kang Liu, 2004, Endocrine research.

Evaluation of the role of N-methyl-D-aspartate (NMDA) receptors in insulin secreting beta-cells.

N. Irwin, P. Flatt, S. Patterson, 2016, European journal of pharmacology.

Molecular Mechanisms of Toxicity and Cell Damage by Chemicals in a Human Pancreatic Beta Cell Line, 1.1B4

P. Flatt, S. Vasu, N. McClenaghan, 2016, Pancreas.

Pro-inﬂammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic b -cell line

P. Newsholme, P. Flatt, N. Mcclenaghan, 2007 .

Evaluation of the role of N-methyl-D-aspartate (NMDA) receptors in insulin secreting beta-cells.

N. Irwin, S. Patterson, R. Moffett, 2016, European journal of pharmacology.

A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL16), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones

P. Flatt, L. Marenah, F. O'Harte, 2006, Biological chemistry.

Determining the relationship between dietary carbohydrate intake and insulin resistance

N. McClenaghan, 2005, Nutrition Research Reviews.

Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility.

M. Hamid, P. Flatt, J. McCluskey, 2012, The Journal of endocrinology.

FUNCTIONAL EXAMINATION OF MICROENCAPSULATED BIOENGINEERED INSULIN‐SECRETING BETA‐CELLS

M. Hamid, P. Flatt, N. Mcclenaghan, 2001, Cell biology international.

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic beta-cell insulin secretion, growth and functional integrity.

P. Newsholme, J. Nolan, P. Flatt, 2004, Clinical science.

Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells

C. Bailey, N. Irwin, P. Flatt, 2010, Biological chemistry.

Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K(ATP) channel components.

P. Flatt, A. Ball, J. McCluskey, 2004, Pharmacological Research.

ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.

R. M. Shepherd, J. Chapman, P. Flatt, 1999, Diabetes.

Mechanisms of amino acid-induced insulin secretion from the glucose-responsive BRIN-BD11 pancreatic B-cell line.

P. Flatt, C. Barnett, N. McClenaghan, 1996, The Journal of endocrinology.

Insulin‐releasing action of the novel antidiabetic agent BTS 67 582

C. Bailey, P. Flatt, N. Mcclenaghan, 1998, British journal of pharmacology.

Acute and Long-term Effects of Peroxisome Proliferator-activated Receptor-γ Activation on the Function and Insulin Secretory Responsiveness of Clonal Beta-Cells

C. Bailey, N. Irwin, P. Flatt, 2010, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.