Gary E Eichenbaum

First-in-human study to evaluate the safety, tolerability and pharmacokinetics of a novel analgesic and antipyretic drug with structural similarity to acetaminophen.

E. Kuffner, C. M. Flores, C. Gelotte, 2022, Regulatory toxicology and pharmacology : RTP.

Preclinical safety assessment of JNJ-10450232 (NTM-006), a structural analog of acetaminophen, that does not cause hepatotoxicity at supratherapeutic doses.

E. Kuffner, D. Gallacher, C. M. Flores, 2023, Regulatory toxicology and pharmacology : RTP.

Implications of retinal effects observed in chronic toxicity studies on the clinical development of a CNS-active drug candidate.

J. V. Hoeve, G. Aguirre, G. Pandina, 2014, Regulatory toxicology and pharmacology : RTP.

JNJ-10450232 (NTM-006), A novel non-opioid with structural similarities to acetaminophen, produces relatively long-lasting analgesia after a single dose in patients undergoing 3rd molar extraction.

E. Kuffner, C. M. Flores, C. Gelotte, 2023, Regulatory toxicology and pharmacology : RTP.

Methods to evaluate and improve the injection site tolerability of intravenous formulations prior to first-in-human testing.

L. Lammens, J. Zhou, A. Loószová, 2013, Journal of pharmacological and toxicological methods.

Implications of retinal effects observed in chronic toxicity studies on the clinical development of a CNS-active drug candidate.

J. V. Hoeve, G. Aguirre, G. Pandina, 2014, Regulatory toxicology and pharmacology : RTP.