C. Lozano

Novel Specific Metallo-β-Lactamase Inhibitor ANT2681 Restores Meropenem Activity to Clinically Effective Levels against NDM-Positive Enterobacterales

I. Morrissey, D. Davies, M. Lemonnier, 2021, Antimicrobial Agents and Chemotherapy.

Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacterales and Acinetobacter baumannii.

I. Morrissey, D. Davies, S. Mangani, 2020, Journal of medicinal chemistry.

ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-producing Enterobacteriaceae.

D. Davies, S. Mangani, P. Warn, 2020, ACS infectious diseases.

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model

N. Jennings, D. Davies, S. Mangani, 2018, ACS infectious diseases.

Discovery of a Novel Metallo-β-Lactamase Inhibitor That Potentiates Meropenem Activity against Carbapenem-Resistant Enterobacteriaceae

I. Morrissey, D. Davies, S. Magnet, 2018, Antimicrobial Agents and Chemotherapy.

Chemical Optimization of Selective Pseudomonas aeruginosa LasB Elastase Inhibitors and Their Impact on LasB-Mediated Activation of IL-1β in Cellular and Animal Infection Models

D. Davies, M. Lemonnier, Doris L. LaRock, 2023, ACS infectious diseases.

Higher levels of Pseudomonas aeruginosa LasB elastase expression are associated with early-stage infection in cystic fibrosis patients

M. Everett, M. Murris, M. Zalacain, 2023, Scientific reports.

Meropenem-ANT3310, a unique β-lactam-β-lactamase inhibitor combination with expanded antibacterial spectrum against Gram-negative pathogens including carbapenem-resistant Acinetobacter baumannii

Simon Leiris, Kirsty Holden, J. Bousquet, 2024, Antimicrobial agents and chemotherapy.