Amanda M. Mathis

发表

Dications that target the DNA minor groove: compound design and preparation, DNA interactions, cellular distribution and biological activity.

W. Wilson, Binh Nguyen, D. Boykin, 2005, Current medicinal chemistry. Anti-cancer agents.

Accumulation and Intracellular Distribution of Antitrypanosomal Diamidine Compounds DB75 and DB820 in African Trypanosomes

D. Boykin, J. Hall, R. Tidwell, 2006, Antimicrobial Agents and Chemotherapy.

Accumulation and Intracellular Distribution of Aromatic Diamidines in African Trypanosomes

Amanda M. Mathis, 2007 .

Antiparasitic compounds that target DNA.

W. Wilson, D. Boykin, J. Hall, 2008, Biochimie.

Diphenyl Furans and Aza Analogs: Effects of Structural Modification on In Vitro Activity, DNA Binding, and Accumulation and Distribution in Trypanosomes

W. Wilson, Arvind Kumar, D. Boykin, 2007, Antimicrobial Agents and Chemotherapy.

Imidazopyridazine hepatitis C virus polymerase inhibitors. Structure-activity relationship studies and the discovery of a novel, traceless prodrug mechanism.

Ryan Lauchli, A. Mathis, John F. Miller, 2014, Journal of medicinal chemistry.

A randomized, double blind, dose escalation, first time in human study to assess the safety, tolerability, pharmacokinetics, and antiviral activity of single doses of GSK2485852 in chronically infected hepatitis C subjects

D. Wilfret, K. Adkison, A. Spaltenstein, 2014, Clinical pharmacology in drug development.

Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIα) inhibitors as anti hepatitis C (HCV) agents.

C. Moore, A. Mathis, J. Botyánszki, 2014, Journal of medicinal chemistry.

Abstracts from the 10th C1-inhibitor deficiency workshop

William H. Yang, A. Szilágyi, M. Margaglione, 2017, Allergy, Asthma & Clinical Immunology.

Population pharmacokinetic modeling and simulations of berotralstat for prophylactic treatment of attacks of hereditary angioedema

W. Sheridan, M. Sale, M. Cornpropst, 2022, Clinical and translational science.

Design of N-Benzoxaborole Benzofuran GSK8175—Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor

D. J. Price, John Miller, Shawn P. Williams, 2019, Journal of medicinal chemistry.

Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.

R. Hamatake, Z. Hong, Shawn P. Williams, 2014, Journal of medicinal chemistry.

A novel class of fast‐acting antimalarial agents: Substituted 15‐membered azalides

F. Gamo, S. Alihodžić, Mirjana Bukvić, 2020, British journal of pharmacology.

BCX9930, an Oral Factor D Inhibitor, for the Potential Treatment of Alternative Pathway Mediated Diseases: Interim Results of a Phase 1 Study in Healthy Subjects

W. Sheridan, M. Davidson, Y. Babu, 2020 .

An update on the progress of galidesivir (BCX4430), a broad-spectrum antiviral

B. Gowen, D. Walling, A. Mathis, 2021, Antiviral Research.

Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization.

D. J. Price, M. Thomson, R. Crosby, 2012, ACS medicinal chemistry letters.

Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Liping Wang, R. Nolte, E. Stewart, 2012, Journal of medicinal chemistry.

A direct-acting antiviral drug abrogates viremia in Zika virus–infected rhesus macaques

Dane R. Schalk, A. Perelson, K. Best, 2020, Science Translational Medicine.

Galidesivir limits Rift Valley fever virus infection and disease in Syrian golden hamsters

B. Gowen, Brady T. Hickerson, J. Westover, 2018, Antiviral Research.

Hepatitis C replication inhibitors that target the viral NS4B protein.

D. J. Price, R. Hamatake, Z. Hong, 2014, Journal of medicinal chemistry.

Activity of Galidesivir in a Hamster Model of SARS-CoV-2

H. Bielefeldt-Ohmann, R. Bowen, Airn E. Hartwig, 2021, Viruses.

Single Dose IV Peramivir is Safe and Effective in the Treatment of Pediatric Influenza

Priyesh Mehta, S. Coleman, W. Sheridan, 2017, Open Forum Infectious Diseases.

Preclinical Characterization and In Vivo Efficacy of GSK8853, a Small-Molecule Inhibitor of the Hepatitis C Virus NS4B Protein

R. Hamatake, J. Vamathevan, T. Shimada, 2015, Antimicrobial Agents and Chemotherapy.

A Cell Fractionation Approach for the Quantitative Analysis of Subcellular Drug Disposition

Muralikrishna Duvvuri, J. Krise, Amanda Mathis, 2004, Pharmaceutical Research.

Pharmacokinetics and Safety of the Nucleoside Analog Antiviral Drug Galidesivir Administered to Healthy Adult Subjects

W. Sheridan, D. Walling, Ray Taylor, 2022, Clinical pharmacology in drug development.

Antiparasitic compounds that target DNA.

D. Boykin, F. Tanious, D. Tevis, 2008, Biochimie.