L. Chang

发表

Carboxyl Group-Modified Myoglobin Induces TNF-α-Mediated Apoptosis in Leukemia Cells

Ying-Jung Chen, Long-Sen Chang, Yi‐Jun Shi, 2022, Pharmaceuticals.

Ovalbumin with Glycated Carboxyl Groups Shows Membrane-Damaging Activity

Ying-Jung Chen, Long-Sen Chang, Yi‐Jun Shi, 2017, International journal of molecular sciences.

Chemical modification of tryptophan residues in α-neurotoxins fromOphiophagus hannah (king cobra) venom

Long-Sen Chang, L. Chang, C. Chang, 1995, Journal of protein chemistry.

The essentiality of calcium ion in the enzymatic activity of Taiwan cobra phospholipase A2

S. R. Lin, Long-Sen Chang, Shinne‐ren Lin, 1996, Journal of protein chemistry.

Suppressive Effects of Siegesbeckia orientalis Ethanolic Extract on Proliferation and Migration of Hepatocellular Carcinoma Cells through Promoting Oxidative Stress, Apoptosis and Inflammatory Responses

Long-Sen Chang, Chi‐Chang Chang, J. Houng, 2022, Pharmaceuticals.

NOXA‐mediated degradation of MCL1 and BCL2L1 causes apoptosis of daunorubicin‐treated human acute myeloid leukemia cells

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2021, Journal of cellular physiology.

Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells.

Yeh-long Chen, C. Chien, Long-Sen Chang, 2010, Life sciences.

Differential expression of human 5S snoRNA genes.

Long-Sen Chang, A. Lieu, Long Sen Chang, 2002, Biochemical and biophysical research communications.

DC-81-Indole conjugate agent induces mitochondria mediated apoptosis in human melanoma A375 cells.

P. Sung, Wan‐Ping Hu, H. Yu, 2007, Chemical research in toxicology.

Calcium‐stimulated mitogen‐activated protein kinase activation elicits Bcl‐xL downregulation and Bak upregulation in notexin‐treated human neuroblastoma SK‐N‐SH cells

Pei-Hsiu Kao, Ku-Chung Chen, L. Chang, 2010, Journal of cellular physiology.

Reactive oxygen species and p38 mitogen‐activated protein kinase induce apoptotic death of U937 cells in response to Naja nigricollis toxin‐γ

Long-Sen Chang, L. Chang, Wen‐Hsin Liu, 2009, Journal of cellular and molecular medicine.

Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells.

Long-Sen Chang, Shinne‐ren Lin, Ku-Chung Chen, 2008, Toxicon : official journal of the International Society on Toxinology.

GENETIC DIVERSITY IN SNAKE VENOM THREE-FINGER PROTEINS AND PHOSPHOLIPASE A2 ENZYMES

Long-Sen Chang, L. Chang, 2007 .

Genetic organization of A chain and B chain of β‐bungarotoxin from Taiwan banded krait (Bungarus multicinctus)

Long-Sen Chang, Pei-Chih Wu, L. Chang, 2000 .

Inhibition of Sp1-mediated survivin and MCL1 expression cooperates with SLC35F2 and myeloperoxidase to modulate YM155 cytotoxicity to human leukemia cells.

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2021, Biochemical pharmacology.

Autophagic HuR mRNA degradation induces survivin and MCL1 downregulation in YM155-treated human leukemia cells.

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2019, Toxicology and applied pharmacology.

The impact of white blood cell count and hemoglobin level on the response to radiotherapy in patients with colorectal cancer

Jaw-Yuan Wang, Long-Sen Chang, Ming-Yii Huang, 2014 .

Furano-1,2-Naphthoquinone Inhibits Src and PI3K/Akt Signaling Pathways in Ca9-22 Human Oral Squamous Carcinoma Cells

Yeh-long Chen, C. Chien, Long-Sen Chang, 2014, Integrative cancer therapies.

Furano‐1,2‐naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells

S. R. Lin, C. Chien, L. Chang, 2010, Cell biochemistry and function.

Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells.

C. Chien, Long-Sen Chang, Shinne‐ren Lin, 2010, Toxicon : official journal of the International Society on Toxinology.

Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation.

Yeh-long Chen, C. Chien, Long-Sen Chang, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation.

C. Chien, Chih-Ming Lu, Shinne‐ren Lin, 2009, Life sciences.

JNK and ERK mitogen-activated protein kinases mediate THDA-induced apoptosis in K562 cells

C. Chien, Long-Sen Chang, Shinne‐ren Lin, 2008, Cell Biology and Toxicology.

Adaphostin promotes caffeine-evoked autocrine Fas-mediated death pathway activation in Bcr/Abl-positive leukaemia cells.

Long-Sen Chang, Wen-Hsin Liu, L. Chang, 2011, The Biochemical journal.

Gallic acid abolishes the EGFR/Src/Akt/Erk-mediated expression of matrix metalloproteinase-9 in MCF-7 breast cancer cells.

Ying-Jung Chen, Chia‐Hui Huang, Yuan‐Chin Lee, 2016, Chemico-biological interactions.

Arecoline‐induced death of human leukemia K562 cells is associated with surface up‐modulation of TNFR2

Ying-Jung Chen, Long-Sen Chang, L. Chang, 2012, Journal of cellular physiology.

Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway.

C. Chiu, Shinne‐ren Lin, P. Tsai, 2012, Toxicon : official journal of the International Society on Toxinology.

Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1

Ying-Jung Chen, Chia‐Hui Huang, Yuan‐Chin Lee, 2017, Apoptosis.

Caffeine induces matrix metalloproteinase‐2 (MMP‐2) and MMP‐9 down‐regulation in human leukemia U937 cells via Ca2+/ROS‐mediated suppression of ERK/c‐fos pathway and activation of p38 MAPK/c‐jun pathway

Long-Sen Chang, Wen-Hsin Liu, L. Chang, 2010, Journal of cellular physiology.

Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway.

Yeh-long Chen, C. Chien, Long-Sen Chang, 2010, European journal of pharmacology.

CIL-102 induces matrix metalloproteinase-2 (MMP-2)/MMP-9 down-regulation via simultaneous suppression of genetic transcription and mRNA stability.

Long-Sen Chang, Wen-Hsin Liu, Yeh Chen, 2012, The international journal of biochemistry & cell biology.

Taiwan cobra cardiotoxin III suppresses EGF/EGFR-mediated epithelial-to-mesenchymal transition and invasion of human breast cancer MDA-MB-231 cells.

Long-Sen Chang, Shinne‐ren Lin, P. Tsai, 2016, Toxicon : official journal of the International Society on Toxinology.

Docetaxel-triggered SIDT2/NOX4/JNK/HuR signaling axis is associated with TNF-α-mediated apoptosis of cancer cells.

Jing-Ting Chiou, Liang‐Jun Wang, Yuan‐Chin Lee, 2021, Biochemical pharmacology.

Guanidination of notexin promotes its phospholipase A(2) activity-independent fusogenicity on vesicles with lipid-supplied negative curvature.

Ying-Jung Chen, Shinne‐ren Lin, Yi-Ling Chiou, 2012, Toxicon : official journal of the International Society on Toxinology.

Cardiotoxin III suppresses the invasiveness of MDA-MB-231 cells by targeting proto-oncogene tyrosine-protein kinase Src and reversing mesenchymal-to-epithelial transition

Long-Sen Chang, Shinne‐ren Lin, P. Tsai, 2016 .

Modification of substrate inhibition of synaptosomal acetylcholinesterase by cardiotoxins.

M. Sadeghi, A. Moosavi-Movahedi, Long-Sen Chang, 2004, Journal of biochemistry and molecular biology.

Structure-function studies on inhibitory activity of Bungarus multicinctus protease inhibitor-like protein on matrix metalloprotease-2, and invasion and migration of human neuroblastoma SK-N-SH cells.

Long-Sen Chang, Ku-Chung Chen, Wen-Min Chou, 2010, Toxicon : official journal of the International Society on Toxinology.

Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells.

C. Chien, Long-Sen Chang, Shinne‐ren Lin, 2010, Toxicon : official journal of the International Society on Toxinology.

Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells.

Yeh-long Chen, C. Chien, Long-Sen Chang, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

Naphtho[1,2-b]furan-4,5-dione inhibits MDA-MB-231 cell migration and invasion by suppressing Src-mediated signaling pathways

Yeh-long Chen, Long-Sen Chang, Shinne‐ren Lin, 2014, Molecular and Cellular Biochemistry.

Functional roles of EF-hands in human potassium channel-interacting protein 2.2.

Ku-Chung Chen, L. Chang, Liya Lee, 2009, Protein and peptide letters.

Effects of Metal-Binding Properties of Human Kv Channel-Interacting Proteins on their Molecular Structure and Binding with Kv4.2 Channel

Ching-Ping Chen, L. Chang, Liya Lee, 2006, The protein journal.

Protein-protein interactions of KChIP proteins and Kv4.2.

Long-Sen Chang, Ya-Ling Lin, Chia-Yi Chen, 2004, Biochemical and biophysical research communications.

Functional implication with the metal-binding properties of KChIP1.

Long-Sen Chang, Chia-Yi Chen, Tony T Wu, 2003, Biochemical and biophysical research communications.

Sensitivity of PEGylated interferon detection by anti-polyethylene glycol (PEG) antibodies depends on PEG length.

M. Chen, Long-Sen Chang, T. Cheng, 2013, Bioconjugate chemistry.

The suppressive effect of arsenic trioxide on TET2‐FOXP3‐Lyn‐Akt axis‐modulated MCL1 expression induces apoptosis in human leukemia cells

Ying-Jung Chen, Long-Sen Chang, Yi‐Jun Shi, 2018, Toxicology and applied pharmacology.

Synthesis and biological evaluation of thiobenzanilides as anticancer agents.

Long-Sen Chang, Jeh-Jeng Wang, Wan‐Ping Hu, 2008, Bioorganic & medicinal chemistry.

Inhibitory action of naphtho[1,2‐b]furan‐4,5‐dione on hepatocyte growth factor‐induced migration and invasion of MDA‐MB‐231 cells: Mechanisms of action

Yeh-long Chen, Long-Sen Chang, Shinne‐ren Lin, 2014, Clinical and experimental pharmacology & physiology.

Cardiotoxin III suppresses hepatocyte growth factor–stimulated migration and invasion of MDA‐MB‐231 cells

C. Chiu, Shinne‐ren Lin, P. Tsai, 2014, Cell biochemistry and function.

Induction of apoptosis by DC-81-indole conjugate agent through NF-kappaB and JNK/AP-1 pathway.

Long-Sen Chang, P. Sung, Jeh-Jeng Wang, 2008, Chemical research in toxicology.

Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-α expression in hydroquinone-treated leukemia cells

Ying-Jung Chen, Long-Sen Chang, Jing-Ting Chiou, 2022, Cell Biology and Toxicology.

ROS‐mediated p38α MAPK activation and ERK inactivation responsible for upregulation of Fas and FasL and autocrine Fas‐mediated cell death in Taiwan cobra phospholipase A2‐treated U937 cells

Long-Sen Chang, L. Chang, Wen‐Hsin Liu, 2009, Journal of cellular physiology.

Piceatannol induces Fas and FasL up-regulation in human leukemia U937 cells via Ca2+/p38alpha MAPK-mediated activation of c-Jun and ATF-2 pathways.

Long-Sen Chang, Wen-Hsin Liu, L. Chang, 2010, The international journal of biochemistry & cell biology.

Phospholipase A2 activity-independent membrane-damaging effect of notexin.

Long-Sen Chang, Shinne‐ren Lin, Pei-Hsiu Kao, 2007, Toxicon : official journal of the International Society on Toxinology.

Chemical modification of arginine residues of Notechis scutatus scutatus notexin.

Long-Sen Chang, Chen-chung Yang, Pei-Fung Wu, 2004, Toxicon : official journal of the International Society on Toxinology.

Chemical modification of notexin fromNotechis scutatus scutatus (Australian tiger snake) venom with pyridoxal-5′-phosphate

L. Chang, L. Chang, 1996, Journal of protein chemistry.

Functional involvement of Lys-6 in the enzymatic activity of phospholipase A2 fromBungarus multicinctus (Taiwan banded krait) snake venom

S. R. Lin, Long-Sen Chang, Shinne‐ren Lin, 1994, Journal of protein chemistry.

Structural determinants of the intrinsic fluorescence emission in notexin and phospholipase A2 enzymes

L. Chang, C. Yang, L. Chang, 1993, Journal of protein chemistry.

B chain is a functional subunit of beta-bungarotoxin for inducing apoptotic death of human neuroblastoma SK-N-SH cells.

Long-Sen Chang, L. Chang, Jeh‐Jeng Wang, 2008, Toxicon : official journal of the International Society on Toxinology.

KChIP3: A binding protein for Taiwan banded krait β-bungarotoxin

Ya-Ling Lin, Pei-Fung Wu, Tony T. Wu, 2006 .

Lys-64 of the A chain is involved in the enzymatic activity and neurotoxic effect of beta-bungarotoxin.

Long-Sen Chang, Yun-Ching Cheng, Y. Chu, 2005, Toxicon : official journal of the International Society on Toxinology.

The structural events associated with the binding of divalent cations to beta-bungarotoxin.

Long-Sen Chang, Yun-Ching Cheng, Y. Chu, 2005, Toxicon : official journal of the International Society on Toxinology.

Both A chain and B chain of beta-bungarotoxin are functionally involved in the facilitation of spontaneous transmitter release in Xenopus nerve-muscle cultures.

Y. Chu, J. Liou, L. Chang, 2004, Toxicon : official journal of the International Society on Toxinology.

Fas/FasL-dependent and -independent activation of caspase-8 in doxorubicin-treated human breast cancer MCF-7 cells: ADAM10 down-regulation activates Fas/FasL signaling pathway.

Long-Sen Chang, L. Chang, Wen‐Hsin Liu, 2011, The international journal of biochemistry & cell biology.

Quinacrine induces the apoptosis of human leukemia U937 cells through FOXP3/miR‐183/&bgr;‐TrCP/SP1 axis‐mediated BAX upregulation

Ying-Jung Chen, Long-Sen Chang, Yi‐Jun Shi, 2017, Toxicology and applied pharmacology.

Taiwan cobra phospholipase A2 suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells.

Ying-Jung Chen, Long-Sen Chang, Shinne‐ren Lin, 2014, Toxicon : official journal of the International Society on Toxinology.

Taiwan cobra phospholipase A2 elicits posttranscriptional up‐regulation of ADAM17 in human neuroblastoma SK‐N‐SH cells

Long-Sen Chang, Shinne‐ren Lin, Yi-Ling Chiou, 2010, Journal of cellular biochemistry.

Hydroquinone-induced FOXP3-ADAM17-Lyn-Akt-p21 signaling axis promotes malignant progression of human leukemia U937 cells

Ying-Jung Chen, Long-Sen Chang, L. Chang, 2016, Archives of Toxicology.

Arsenic trioxide-induced p38 MAPK and Akt mediated MCL1 downregulation causes apoptosis of BCR-ABL1-positive leukemia cells.

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2020, Toxicology and applied pharmacology.

A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1α-mediated signaling.

Wen-Chuan Wu, Long-Sen Chang, Jeh-Jeng Wang, 2011, Toxicology and applied pharmacology.

Modulated mechanism of phosphatidylserine on the catalytic activity of Naja naja atra phospholipase A2 and Notechis scutatus scutatus notexin.

Long-Sen Chang, Shinne‐ren Lin, Yi-Ling Chiou, 2014, Toxicon : official journal of the International Society on Toxinology.

Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins.

Long-Sen Chang, Shinne‐ren Lin, Ya-Ling Lin, 2004, Biochemical and biophysical research communications.

ABT-263-induced MCL1 upregulation depends on autophagy-mediated 4EBP1 downregulation in human leukemia cells.

Long-Sen Chang, Yi‐Jun Shi, Liang‐Jun Wang, 2018, Cancer letters.

Blocking of negative charged carboxyl groups converts Naja atra neurotoxin to cardiotoxin-like protein.

Ying-Jung Chen, Long-Sen Chang, Yi‐Jun Shi, 2020, International Journal of Biological Macromolecules.

Genetic organization of α-bungarotoxins from Bungarus multicinctus (Taiwan banded krait): evidence showing that the production of α-bungarotoxin isotoxins is not derived from edited mRNAs

Long-Sen Chang, Hsien-Bin Huang, Shu-kai Lin, 1999 .

Synthesis and biological evaluation of novel symmetry bis-enediynes.

Shinne‐ren Lin, Ming-Jung Wu, Li-Yi Chen, 2009, European journal of medicinal chemistry.

Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents.

Long-Sen Chang, Shu-Mei Huang, Jeh-Jeng Wang, 2010, Bioorganic & medicinal chemistry.

Cytarabine-induced destabilization of MCL1 mRNA and protein triggers apoptosis in leukemia cells.

Long-Sen Chang, Jing-Ting Chiou, Yuan‐Chin Lee, 2023, Biochemical pharmacology.

Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF-α production in human leukemia cells with expressed Bcr/Abl.

Ying-Jung Chen, Long-Sen Chang, L. Chang, 2013, Biochemical pharmacology.

p38 MAPK/PP2Acα/TTP pathway on the connection of TNF-α and caspases activation on hydroquinone-induced apoptosis.

Long-Sen Chang, Wen-Min Chou, L. Chang, 2013, Carcinogenesis.

BCL2 inhibitor ABT-199 and BCL2L1 inhibitor WEHI-539 coordinately promote NOXA-mediated degradation of MCL1 in human leukemia cells.

Long-Sen Chang, Jing-Ting Chiou, Liang‐Jun Wang, 2022, Chemico-biological interactions.

Cross talk between p38MAPK and ERK is mediated through MAPK-mediated protein phosphatase 2A catalytic subunit α and MAPK phosphatase-1 expression in human leukemia U937 cells.

Ying-Jung Chen, Long-Sen Chang, Shinne‐ren Lin, 2013, Cellular signalling.

Naja nigricollis CMS‐9 enhances the mitochondria‐mediated death pathway in adaphostin‐treated human leukaemia U937 cells

Ying-Jung Chen, Long-Sen Chang, Jeh-Jeng Wang, 2011, Clinical and experimental pharmacology & physiology.

CREB/Sp1-mediated MCL1 expression and NFκB-mediated ABCB1 expression modulate the cytotoxicity of daunorubicin in chronic myeloid leukemia cells.

Long-Sen Chang, Jing-Ting Chiou, Liang‐Jun Wang, 2021, Toxicology and applied pharmacology.

Suppression of ERK signaling evokes autocrine Fas‐mediated death in arachidonic acid‐treated human chronic myeloid leukemia K562 cells

Long-Sen Chang, Ku-Chung Chen, Wen-Hsin Liu, 2009, Journal of cellular physiology.

Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2 pathway.

Long-Sen Chang, Wen-Hsin Liu, L. Chang, 2009, Toxicology letters.

Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca(2+)-evoked activation of p38alpha MAPK and JNK1.

Long-Sen Chang, Ku-Chung Chen, L. Chang, 2009, Toxicology.

Disulfide isomerization and thiol-disulfide exchange of long neurotoxins from the venom of Ophiophagus hannah.

Long-Sen Chang, Shinne‐ren Lin, Hsien-Bin Huang, 2006, Archives of biochemistry and biophysics.

DC-81-enediyne induces apoptosis of human melanoma A375 cells: involvement of the ROS, p38 MAPK, and AP-1 signaling pathways

Long-Sen Chang, P. Sung, Wan‐Ping Hu, 2013, Cell Biology and Toxicology.

The mechanism of cytotoxicity by Naja naja atra cardiotoxin 3 is physically distant from its membrane-damaging effect.

Shinne‐ren Lin, Pei-Hsiu Kao, Ku-Chung Chen, 2007, Toxicon : official journal of the International Society on Toxinology.

Characterization and cloning of long neurotoxin homolog from Naja naja atra

Shinne‐ren Lin, L. Chang, B. Wu, 1998, Biochemistry and molecular biology international.

Discovery of Specific Inhibitors for Intestinal E. coli β-Glucuronidase through In Silico Virtual Screening

T. Cheng, S. Roffler, Kuo-Hsiang Chuang, 2015, TheScientificWorldJournal.

Gallic acid-capped gold nanoparticles inhibit EGF-induced MMP-9 expression through suppression of p300 stabilization and NFκB/c-Jun activation in breast cancer MDA-MB-231 cells.

Ying-Jung Chen, Long-Sen Chang, Chia‐Hui Huang, 2016, Toxicology and applied pharmacology.

Involvement of p38 MAPK- and JNK-modulated expression of Bcl-2 and Bax in Naja nigricollis CMS-9-induced apoptosis of human leukemia K562 cells.

Ying-Jung Chen, Pei-Hsiu Kao, L. Chang, 2010, Toxicon : official journal of the International Society on Toxinology.

Taiwan cobra chymotrypsin inhibitor: cloning, functional expression and gene organization.

Long-Sen Chang, Yun-Ching Cheng, Fang-Jiun Yan, 2005, Biochimica et biophysica acta.

Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells

C. Chien, Long-Sen Chang, Shinne‐ren Lin, 2008, Journal of biochemical and molecular toxicology.

Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells.

Yeh-long Chen, Sheng-Huei Yang, C. Chien, 2007, Leukemia research.

SIRT3, PP2A and TTP protein stability in the presence of TNF‐α on vincristine‐induced apoptosis of leukaemia cells

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2020, Journal of cellular and molecular medicine.

Quinacrine induces apoptosis in human leukemia K562 cells via p38 MAPK-elicited BCL2 down-regulation and suppression of ERK/c-Jun-mediated BCL2L1 expression.

Ying-Jung Chen, Long-Sen Chang, Shinne‐ren Lin, 2015, Toxicology and applied pharmacology.

Inhibition of EGF/EGFR activation with naphtho[1,2-b]furan-4,5-dione blocks migration and invasion of MDA-MB-231 cells.

Yeh-long Chen, Long-Sen Chang, Shinne‐ren Lin, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Synthesis, DNA-binding abilities and anticancer activities of triazole-pyrrolo[2,1-c][1,4]benzodiazepines hybrid scaffolds.

Ying-Ting Lin, Ying Lin, Long-Sen Chang, 2013, Bioorganic & medicinal chemistry letters.

NFκB- and AP-1-mediated DNA looping regulates matrix metalloproteinase-9 transcription in TNF-α-treated human leukemia U937 cells.

Ying-Jung Chen, Long-Sen Chang, L. Chang, 2015, Biochimica et biophysica acta.

Mechanism of β-bungarotoxin in facilitating spontaneous transmitter release at neuromuscular synapse

S. Ho, J. Liou, L. Chang, 2006, Neuropharmacology.

Suppression of Akt/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression and TNFα-mediated NFκB activation in piceatannol-treated human leukemia U937 cells.

Long-Sen Chang, Wen-Hsin Liu, L. Chang, 2012, Biochemical pharmacology.

Hydroquinone destabilizes BIM mRNA through upregulation of p62 in chronic myeloid leukemia cells.

Long-Sen Chang, Jing-Ting Chiou, Liang‐Jun Wang, 2022, Biochemical pharmacology.

Catalytic activity-independent pathway is involved in phospholipase A(2)-induced apoptotic death of human leukemia U937 cells via Ca(2+)-mediated p38 MAPK activation and mitochondrial depolarization.

Shinne‐ren Lin, Ming-Jung Wu, Yi-Ling Chiou, 2009, Toxicology letters.

Taiwan cobra phospholipase A2‐elicited JNK activation is responsible for autocrine fas‐mediated cell death and modulating Bcl‐2 and Bax protein expression in human leukemia K562 cells

Long-Sen Chang, Ku-Chung Chen, Wen-Hsin Liu, 2009, Journal of cellular biochemistry.

JNK1/c‐Jun and p38α MAPK/ATF‐2 pathways are responsible for upregulation of Fas/FasL in human chronic myeloid leukemia K562 cells upon exposure to Taiwan cobra phospholipase A2

Long-Sen Chang, Yi-Ling Chiou, Ku-Chung Chen, 2009, Journal of cellular biochemistry.

Quercetin modulates activities of Taiwan cobra phospholipase A2 via its effects on membrane structure and membrane-bound mode of phospholipase A2

Shinne‐ren Lin, Yi-Ling Chiou, Wan‐Ping Hu, 2012, Journal of Biosciences.

Bovine serum albumin with glycated carboxyl groups shows membrane-perturbing activities.

Ying-Jung Chen, Long-Sen Chang, Pei-Hsiu Kao, 2014, Archives of biochemistry and biophysics.

Gallic acid downregulates matrix metalloproteinase-2 (MMP-2) and MMP-9 in human leukemia cells with expressed Bcr/Abl.

Ying-Jung Chen, Long-Sen Chang, L. Chang, 2012, Molecular nutrition & food research.

NMR Solution Structure of a Chymotrypsin Inhibitor from the Taiwan Cobra Naja naja atra

P. Güntert, T. Ikeya, Yi-Jan Lin, 2013, Molecules.

INVOLVEMENT OF BOTH ENDOPLASMIC RETICULUM‐ AND MITOCHONDRIA‐DEPENDENT PATHWAYS IN CARDIOTOXIN III‐INDUCED APOPTOSIS IN HL‐60 CELLS

Sheng-Huei Yang, C. Chien, Long-Sen Chang, 2008, Clinical and experimental pharmacology & physiology.

Cardiotoxin III‐induced apoptosis is mediated by Ca2+‐dependent caspase‐12 activation in K562 cells

Sheng-Huei Yang, C. Chien, Long-Sen Chang, 2008, Journal of biochemical and molecular toxicology.

2-(6-aryl-3(Z)-hexen-1,5-diynyl)anilines as a new class of potent antitubulin agents.

Ying-Ting Lin, Ching-Chih Lin, Yi-Ren Hong, 2008, Journal of medicinal chemistry.

Simvastatin induces NFκB/p65 down-regulation and JNK1/c-Jun/ATF-2 activation, leading to matrix metalloproteinase-9 (MMP-9) but not MMP-2 down-regulation in human leukemia cells.

Ying-Jung Chen, Long-Sen Chang, L. Chang, 2014, Biochemical pharmacology.

Antimetastatic effect and mechanism of ovatodiolide in MDA-MB-231 human breast cancer cells.

Long-Sen Chang, Shinne‐ren Lin, P. Tsai, 2011, Chemico-biological interactions.

AMPK inhibition induces MCL1 mRNA destabilization via the p38 MAPK/miR-22/HuR axis in chronic myeloid leukemia cells.

Long-Sen Chang, Jing-Ting Chiou, Yuan‐Chin Lee, 2023, Biochemical pharmacology.

Cardiotoxin III induces apoptosis in T24 cells via reactive oxygen species‐independent mitochondrial death pathway

C. Chien, Shinne‐ren Lin, Mei-Chin Lu, 2004 .

Amsacrine suppresses matrix metalloproteinase‐2 (MMP‐2)/MMP‐9 expression in human leukemia cells

Jen-Tzung Chien, Ying-Jung Chen, Long-Sen Chang, 2014, Journal of cellular physiology.

Naja naja atra and Naja nigricollis cardiotoxins induce fusion of Escherichia coli and Staphylococcus aureus membrane-mimicking liposomes.

Shinne‐ren Lin, Pei-Hsiu Kao, Wan‐Ping Hu, 2012, Toxicon : official journal of the International Society on Toxinology.

Membrane-damaging activities of mannosylated ovalbumin are involved in its antibacterial action.

Ying-Jung Chen, Long-Sen Chang, Yaw-Syan Fu, 2018, Archives of biochemistry and biophysics.

Antibacterial and membrane-damaging activities of mannosylated bovine serum albumin.

Ying-Jung Chen, Long-Sen Chang, Yaw-Syan Fu, 2015, Archives of biochemistry and biophysics.

Fusogenicity of Naja naja atra cardiotoxin-like basic protein on sphingomyelin vesicles containing oxidized phosphatidylcholine and cholesterol.

Ying-Jung Chen, Long-Sen Chang, Shinne‐ren Lin, 2013, Journal of biochemistry.

Antibacterial and membrane‐damaging activities of β‐bungarotoxin B chain

Long-Sen Chang, Pei-Hsiu Kao, Yaw-Syan Fu, 2013, Journal of peptide science : an official publication of the European Peptide Society.

Phospholipase A2 activity-dependent and -independent fusogenic activity of Naja nigricollis CMS-9 on zwitterionic and anionic phospholipid vesicles.

Ying-Jung Chen, Long-Sen Chang, Shinne‐ren Lin, 2011, Toxicon : official journal of the International Society on Toxinology.

Bactericidal effect of Naja nigricollis toxin γ is related to its membrane-damaging activity

Long-Sen Chang, Pei-Hsiu Kao, Wan‐Ping Hu, 2011, Peptides.

Membrane-damaging activity of Taiwan cobra cardiotoxin 3 is responsible for its bactericidal activity.

Long-Sen Chang, Shinne‐ren Lin, Pei-Hsiu Kao, 2011, Toxicon : official journal of the International Society on Toxinology.

Interaction of Naja naja atra cardiotoxin 3 with H-trisaccharide modulates its hemolytic activity and membrane-damaging activity.

Shinne‐ren Lin, Pei-Hsiu Kao, L. Chang, 2010, Toxicon : official journal of the International Society on Toxinology.

Roles of lysine residues and N-terminal alpha-amino group in membrane-damaging activity of Taiwan cobra cardiotoxin 3 toward anionic and zwitterionic phospholipid vesicles.

Shinne‐ren Lin, Yi-Ling Chiou, Pei-Hsiu Kao, 2010, Toxicon : official journal of the International Society on Toxinology.

Effect of cholesterol on membrane-damaging activity of Naja nigricollis toxin gamma toward phospholipid vesicles.

Yi-Ling Chiou, L. Chang, Jeh‐Jeng Wang, 2009, Toxicon : official journal of the International Society on Toxinology.

Differential binding to phospholipid bilayers modulates membrane-damaging activity of Naja naja atra cardiotoxins.

Shinne‐ren Lin, Pei-Hsiu Kao, L. Chang, 2009, Toxicon : official journal of the International Society on Toxinology.

Membrane-bound conformation of Naja nigricollis toxin gamma affects its membrane-damaging activity.

Ming-Jung Wu, Pei-Hsiu Kao, L. Chang, 2009, Toxicon : official journal of the International Society on Toxinology.

Functional and structural properties of cardiotoxin isomers produced by blocking negatively charged groups.

Yi‐Jun Shi, Jing-Ting Chiou, Liang‐Jun Wang, 2022, Archives of biochemistry and biophysics.

Naja atra Cardiotoxin 1 Induces the FasL/Fas Death Pathway in Human Leukemia Cells

Long-Sen Chang, Jing-Ting Chiou, Liang‐Jun Wang, 2021, Cells.

Status of Asp29 and Asp40 in the Interaction of Naja atra Cardiotoxins with Lipid Bilayers

Long-Sen Chang, Chi-Yu Lu, Yi‐Jun Shi, 2020, Toxins.

Naja atra Cardiotoxin 3 Elicits Autophagy and Apoptosis in U937 Human Leukemia Cells through the Ca2+/PP2A/AMPK Axis

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2019, Toxins.

Naja atra cardiotoxins enhance the protease activity of chymotrypsin.

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2019, International journal of biological macromolecules.

Guanidination of notexin alters its membrane-damaging activity in response to sphingomyelin and cholesterol

Long-Sen Chang, Shinne‐ren Lin, Yi-Ling Chiou, 2010, Journal of Biosciences.

Separation and Structure-Function Studies of Taiwan Cobra Cardiotoxins

Shinne‐ren Lin, Kee‐Lung Chang, L. Chang, 2002, Journal of protein chemistry.

A Turn-on Fluorescence Sensor for Heparin Detection Based on a Release of Taiwan Cobra Cardiotoxin from a DNA Aptamer or Adenosine-Based Molecular Beacon

Long-Sen Chang, Wan‐Ping Hu, Yi‐Jun Shi, 2018, Molecules.

Structural factors affect the interactions of anticardiotoxin antibodies and cobra venom cardiotoxins

Shinne‐ren Lin, L. Chang, Yen‐ren Lo, 1998, Biochemistry and molecular biology international.

Membrane-bound conformation and phospholipid components modulate membrane-damaging activity of Taiwan cobra cardiotoxins.

Shinne‐ren Lin, Ming-Jung Wu, Pei-Hsiu Kao, 2009, Toxicon : official journal of the International Society on Toxinology.

Carboxyl group-modified myoglobin shows membrane-permeabilizing activity.

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2022, Archives of biochemistry and biophysics.

Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3‐kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III‐treated A549 cells

C. Chien, Shinne‐ren Lin, Jung-Chen Su, 2010, Clinical and experimental pharmacology & physiology.

Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells.

Sheng-Huei Yang, C. Chien, Long-Sen Chang, 2007, Toxicon : official journal of the International Society on Toxinology.

HDAC6 promotes aggressive development of liver cancer by improving egfr mRNA stability

Sheau-Fang Yang, sHen-nien Wang, Y. Yeh, 2022, Neoplasia.

The structural and functional contribution of N‐terminal region and His‐47 on Taiwan cobra phospholipase A2

Long-Sen Chang, Shinne‐ren Lin, Pei-Hsiu Kao, 2008, Journal of peptide science : an official publication of the European Peptide Society.

cDNA sequence analysis of a novel neurotoxin homolog from Taiwan banded krait

Long-Sen Chang, Jordge Lin, L. Chang, 1997, Biochemistry and molecular biology international.

DNA Aptamers against Taiwan Banded Krait α-Bungarotoxin Recognize Taiwan Cobra Cardiotoxins

Ying-Jung Chen, Long-Sen Chang, Wan‐Ping Hu, 2016, Toxins.

Purification and characterization of a novel phospholipase A2 from king cobra (Ophiophagus hannah) venom

L. Chang, C. Chang, J. Chiou, 1995, Journal of protein chemistry.

Biochemistry and Molecular Biology of Snake Neurotoxin

Long-Sen Chang, Chen-chung Yang, L. Chang, 1999 .

Polymorphisms in EGFR, GSTP1, XPD, DPD, ERCC1, and UTG1A1 of colorectal cancer patients treated with 5-fluorouracil plus oxaliplatin or irinotecan chemotherapy

Jaw-Yuan Wang, Long-Sen Chang, Yi-Lin Wu, 2014 .

Evaluation of Gallic Acid-Coated Gold Nanoparticles as an Anti-Aging Ingredient

Ying-Jung Chen, Long-Sen Chang, Yunqing Wu, 2021, Pharmaceuticals.

Suppression of ADAM17-mediated Lyn/Akt Pathways Induces Apoptosis of Human Leukemia U937 Cells

Long-Sen Chang, Wen-Hsin Liu, L. Chang, 2010, The Journal of Biological Chemistry.

Beta-Bungarotoxin induction of neurite outgrowth in NB41A3 cells.

Long-Sen Chang, Pei-Fung Wu, Y. Kao, 2008, Toxicon : official journal of the International Society on Toxinology.

Inhibition of Src activation with cardiotoxin III blocks migration and invasion of MDA-MB-231 cells.

Long-Sen Chang, Shinne‐ren Lin, Chien-Chih Chiu, 2013, Toxicon : official journal of the International Society on Toxinology.

Cardiotoxin III Inhibits Hepatocyte Growth Factor‐Induced Epithelial‐Mesenchymal Transition and Suppresses Invasion of MDA‐MB‐231 Cells

Long-Sen Chang, Shinne‐ren Lin, P. Tsai, 2016, Journal of biochemical and molecular toxicology.

Effects of cardiotoxin III on NF-kappaB function, proliferation, and apoptosis in human breast MCF-7 cancer cells.

C. Chien, Long-Sen Chang, Shinne‐ren Lin, 2009, Oncology research.

Antimetastatic potential of cardiotoxin III involves inactivation of PI3K/Akt and p38 MAPK signaling pathways in human breast cancer MDA-MB-231 cells.

C. Chien, Long-Sen Chang, Shinne‐ren Lin, 2012, Life sciences.

Functional role of EF-hands 3 and 4 in membrane-binding of KChIP1

Long-Sen Chang, Ku-Chung Chen, Yanling Liao, 2009, Journal of Biosciences.

DC-81-enediyne induces apoptosis of human melanoma A375 cells: involvement of the ROS, p38 MAPK, and AP-1 signaling pathways

P. Sung, Wan‐Ping Hu, Chia-Chen Hsu, 2013, Cell Biology and Toxicology.

Compound C induces autophagy and apoptosis in parental and hydroquinone-selected malignant leukemia cells through the ROS/p38 MAPK/AMPK/TET2/FOXP3 axis

Ying-Jung Chen, Yi‐Jun Shi, Jing-Ting Chiou, 2020, Cell Biology and Toxicology.

Origin of Functional Diversities in Taiwan Banded Krait (Bungarus multicinctus) Three-finger Proteins

Long-Sen Chang, Pei-Hsiu Kao, L. Chang, 2009 .

Genetic organization of Bungarus multicinctus protease inhibitor-like proteins.

Long-Sen Chang, Yun-Ching Cheng, Jeh-Jeng Wang, 2008, Toxicon : official journal of the International Society on Toxinology.

Brazilein suppresses migration and invasion of MDA-MB-231 breast cancer cells.

Y. Wu, F. Chang, Long-Sen Chang, 2013, Chemico-biological interactions.

Solution structure of γ‐bungarotoxin: The functional significance of amino acid residues flanking the RGD motif in integrin binding

W. Chuang, J. Shiu, Yu‐Chen Liu, 2004, Proteins.

Cardiotoxin III induces c‐jun N‐terminal kinase‐dependent apoptosis in HL‐60 human leukaemia cells

Sheng-Huei Yang, C. Chien, Long-Sen Chang, 2008, Cell biochemistry and function.

Inhibition of EGFR pathway promotes the cytotoxicity of ABT-263 in human leukemia K562 cells by blocking MCL1 upregulation.

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2020, Biochemical pharmacology.

Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis.

Ying-Jung Chen, Long-Sen Chang, Yi‐Jun Shi, 2021, International journal of biological macromolecules.

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase.

M. Anderson, Long-Sen Chang, A. Meister, 1993, The Journal of biological chemistry.

Functional Contribution of Ca2+ and Mg2+ to the Intermolecular Interaction of Visinin-like Proteins

L. Chang, Liya Lee, Feng-Fin Jheng, 2006, The protein journal.

Selective activation of pro-anti-IL-1β antibody enhances specificity for autoinflammatory disorder therapy

Long-Sen Chang, T. Cheng, Chih-Hung Chuang, 2021, Scientific Reports.

Albendazole-Induced SIRT3 Upregulation Protects Human Leukemia K562 Cells from the Cytotoxicity of MCL1 Suppression

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2020, International journal of molecular sciences.

Non‐mitotic effect of albendazole triggers apoptosis of human leukemia cells via SIRT3/ROS/p38 MAPK/TTP axis‐mediated TNF‐&agr; upregulation

Y. Chou, Ying-Jung Chen, Long-Sen Chang, 2019, Biochemical pharmacology.

Mutagenesis Studies on the N-terminus and Thr54 of Naja naja atra (Taiwan cobra) Chymotrypsin Inhibitor

Long-Sen Chang, Ching-Ping Chen, Fang-Jiun Yan, 2006, The protein journal.

Modification of Lys-6 and Lys-65 Affects the Structural Stability of Taiwan Cobra Phospholipase A2

Long-Sen Chang, Yun-Ching Cheng, Ching-Ping Chen, 2006, The protein journal.

The Association Between p38 MAPK‐Mediated TNF‐α/TNFR2 up‐Regulation and 2‐(4‐Aminophenyl)‐7‐Methoxybenzothiazole‐Induced Apoptosis in Human Leukemia U937 Cells

Ying-Jung Chen, Long-Sen Chang, Wen-Hsin Liu, 2016, Journal of cellular physiology.

Upregulation of Fas and FasL in Taiwan cobra phospholipase A2‐treated human neuroblastoma SK‐N‐SH cells through ROS‐ and Ca2+‐mediated p38 MAPK activation

Long-Sen Chang, Shinne‐ren Lin, Pei-Hsiu Kao, 2009, Journal of cellular biochemistry.

cDNA sequence analysis and mutagenesis studies on the a chain of Β-bungarotoxin from Taiwan banded krait

Pei-Fung Wu, L. Chang, Chun‐chang Chang, 1996, Journal of protein chemistry.

Modification of carboxyl groups converts α-lactalbumin into an active molten globule state with membrane-perturbing activity and cytotoxicity.

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2020, International journal of biological macromolecules.

Design, synthesis and antimetastatic evaluation of 1-benzothiazolylphenylbenzotriazoles for photodynamic therapy in oral cancer cells

K. Kuo, Wan‐Ping Hu, G. C. Senadi, 2016 .

The functional involvement of Lys-38 in the heavy subunit of rat kidney γ-glutamylcysteine synthetase: Chemical modification and mutagenesis studies

L. Chang, L. Chang, 1996, Journal of protein chemistry.

BCL2L1 inhibitor A-1331852 inhibits MCL1 transcription and triggers apoptosis in acute myeloid leukemia cells.

Long-Sen Chang, Jing-Ting Chiou, Yuan‐Chin Lee, 2023, Biochemical pharmacology.

Detection of Naja atra Cardiotoxin Using Adenosine-Based Molecular Beacon

Ying-Jung Chen, Long-Sen Chang, Wan‐Ping Hu, 2017, Toxins.

Molecular Cloning and Evolution of the Genes Encoding the Precursors of Taiwan Cobra Cardiotoxin and Cardiotoxin-Like Basic Protein

Long-Sen Chang, Shu-kai Lin, C. Chung, 2004, Biochemical Genetics.

p38 MAPK activation and mitochondrial depolarization mediate the cytotoxicity of Taiwan cobra phospholipase A2 on human neuroblastoma SK-N-SH cells.

Long-Sen Chang, Shinne‐ren Lin, Pei-Hsiu Kao, 2008, Toxicology letters.

GSK3β suppression inhibits MCL1 protein synthesis in human acute myeloid leukemia cells

Long-Sen Chang, Yi‐Jun Shi, Jing-Ting Chiou, 2020, Journal of cellular physiology.

Mutations on N‐terminal region of Taiwan cobra phospholipase A2 result in structurally distorted effects

Long-Sen Chang, Shinne‐ren Lin, Yi-Ling Chiou, 2008, Journal of peptide science : an official publication of the European Peptide Society.

The Structural Variations of ε-Amino Groups in Phospholipase A2 Enzymes from Naja naja atra and Bungarus Multicinctus Venoms

Long-Sen Chang, Shinne‐ren Lin, L. Chang, 1997, Journal of protein chemistry.

Probing Calcium Ion-Induced Conformational Changes of Taiwan Cobra Phospholipase A2 by Trinitrophenylation of Lysine Residues

Long-Sen Chang, Shinne‐ren Lin, L. Chang, 1997, Journal of protein chemistry.

Membrane-damaging activity with A chain and B chain of beta-bungarotoxin.

Long-Sen Chang, Shinne‐ren Lin, Pei-Hsiu Kao, 2009, Toxicon : official journal of the International Society on Toxinology.

Divergence of genes encoding B chains of β-bungarotoxins

Long-Sen Chang, Yun-Ching Cheng, Ku-Chung Chen, 2006 .

The organization of the genes encoding the A chains of beta-bungarotoxins: evidence for the skipping of exon.

Long-Sen Chang, Y. Chu, L. Chang, 2002, Toxicon : official journal of the International Society on Toxinology.

Energy transfer from tryptophan residues of proteins to 8-anilinonaphthalene-1-sulfonate

Ehr-ya Wen, L. Chang, Chun‐chang Chang, 1994, Journal of Protein Chemistry.

The essentiality of His-47 and the N-terminal region for the binding of 8-anilinonaphthalene-1-sulfonate with Taiwan cobra phospholipase A2

Long-Sen Chang, Chun-chang Chang, Ehr-ya Wen, 1996, Journal of protein chemistry.