M. H. Heemskerk

发表

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses.

M. Raaben, T. Brummelkamp, F. Claas, 2020, Immunity.

The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access

M. Raaben, T. Brummelkamp, J. Neefjes, 2020, bioRxiv.

Characterization of circulating T-, NK-, and NKT cell subsets in patients with colorectal cancer: the peripheral blood immune cell profile

P. Kuppen, C. V. D. van de Velde, A. Vahrmeijer, 2019, Cancer Immunology, Immunotherapy.

Genetic modification of human B-cell development: B-cell development is inhibited by the dominant negative helix loop helix factor Id3.

M. Heemskerk, A. Bakker, H. Spits, 1999, Blood.

Early stages in the development of human T, natural killer and thymic dendritic cells

B. Blom, M. Heemskerk, J. Dongen, 1998, Immunological reviews.

Toll‐like receptor 7/8‐matured RNA‐transduced dendritic cells as post‐remission therapy in acute myeloid leukaemia: results of a phase I trial

W. Hiddemann, K. Spiekermann, A. Moosmann, 2020, Clinical & translational immunology.

Role of spleen macrophages in innate and acquired immune responses against mouse hepatitis virus strain A59.

M. Heemskerk, N. Van Rooijen, C. Boog, 1997, Immunology.

Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia

R. Hagedoorn, M. Kester, J. Falkenburg, 2019, The Journal of clinical investigation.

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status.

E. Jordanova, F. Claas, M. Heemskerk, 2018, Investigative ophthalmology & visual science.

Disruption of αβ but not of γδ T cell development by overexpression of the helix–loop–helix protein Id3 in committed T cell progenitors

J. V. van Dongen, B. Blom, M. Heemskerk, 1999 .

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

G. Nolan, B. Blom, A. Bakker, 1997, The Journal of experimental medicine.

TCR Gene Rearrangements and Expression of the Pre-T Cell Receptor Complex During Human T-Cell Differentiation

B. Blom, M. Heemskerk, J. Dongen, 1999 .

TCR gene rearrangements and expression of the pre-T cell receptor complex during human T-cell differentiation.

J. V. van Dongen, B. Blom, M. Heemskerk, 1999, Blood.

Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells.

Chandler D. Gatenbee, Sandhya Prabhakaran, R. Wenham, 2022, Cancer cell.

Immunopeptidome Analysis of HLA-DPB1 Allelic Variants Reveals New Functional Hierarchies

M. Kester, J. Falkenburg, M. Heemskerk, 2020, The Journal of Immunology.

HGF/SF and its receptor c-MET play a minor role in the dissemination of human B-lymphoma cells in SCID mice

A. Hekman, W. Gerritsen, A. Bakker, 1999, British Journal of Cancer.

Monitoring of indirect allorecognition: wishful thinking or solid data?

A. Amir, D. Roelen, F. Claas, 2007, Tissue antigens.

Healthy cells functionally present TAP-independent SSR1 peptides: implications for selection of clinically relevant antigens

M. Griffioen, R. Spaapen, M. Jongsma, 2020, bioRxiv.

Differential activation of mouse hepatitis virus-specific CD4+ cytotoxic T cells is defined by peptide length.

C. Boog, W. Spaan, V. Schijns, 1995, Immunology.

In vitro generation of mature, naive antigen-specific CD8+ T cells with a single T-cell receptor by agonist selection

M. Heemskerk, A. Langerak, C. Heirman, 2014, Leukemia.

Notch induces human T-cell receptor γδ+ thymocytes to differentiate along a parallel, highly proliferative and bipotent CD4 CD8 double-positive pathway

M. Heemskerk, A. Spek, A. Langerak, 2012, Leukemia.

New tools to monitor the impact of viral infection on the alloreactive T-cell repertoire.

A. Amir, L. D'Orsogna, D. Roelen, 2009, Tissue antigens.

interferon-responsive (ADIR) gene minor histocompatibility antigen encoded by the ATP-dependent reactive T cells recognize an activation-induced - Multiple myeloma

M. Kester, M. Heemskerk, R. Willemze, 2013 .

Uptake of HLA Alloantigens via CD89 and CD206 Does Not Enhance Antigen Presentation by Indirect Allorecognition

D. Roelen, F. Claas, M. Heemskerk, 2016, Journal of immunology research.

SARS-CoV-2-specific CD4+ and CD8+ T cell responses can originate from cross-reactive CMV-specific T cells

S. Gras, R. Hagedoorn, M. Heemskerk, 2022, bioRxiv.

Naturally Processed Non-canonical HLA-A*02:01 Presented Peptides*

J. Drijfhout, J. Rossjohn, S. Gras, 2014, The Journal of Biological Chemistry.

Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7

T. Schumacher, B. Rodenko, H. Ovaa, 2008, Proceedings of the National Academy of Sciences.

CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses

A. Cambi, M. Heemskerk, J. Jansen, 2016, The Journal of Immunology.

HLA Monomers as a Tool to Monitor Indirect Allorecognition

D. Roelen, I. Doxiadis, F. Claas, 2014, Transplantation.

Redirection of antileukemic reactivity of peripheral T lymphocytes using gene transfer of minor histocompatibility antigen HA-2-specific T-cell receptor complexes expressing a conserved alpha joining region.

M. A. van der Hoorn, M. Kester, J. Falkenburg, 2003, Blood.

Submitted for publication

M. Kester, J. Falkenburg, M. Griffioen, 2014 .

Discovery of T Cell Epitopes Implementing HLA-Peptidomics into a Reverse Immunology Approach

J. Drijfhout, M. Kester, J. Falkenburg, 2013, The Journal of Immunology.

HLA-Peptidomics into a Reverse Discovery of T Cell Epitopes Implementing

J. Drijfhout, M. Kester, J. Falkenburg, 2013 .

The Human Leukocyte Antigen–presented Ligandome of B Lymphocytes*

J. Leunissen, J. Drijfhout, M. Kester, 2013, Molecular & Cellular Proteomics.

Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen

R. de Boer, S. Mancham, J. Kwekkeboom, 2015, The Journal of Immunology.

Accurate quantitation of MHC-bound peptides by application of isotopically labeled peptide MHC complexes.

Peter A van Veelen, Gideon Oudgenoeg, J. Drijfhout, 2014, Journal of proteomics.

Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers

Ton N Schumacher, Sine Reker Hadrup, T. Schumacher, 2009, Nature Methods.

Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer

S. H. van der Burg, C. Meijer, E. Hooijberg, 2011, Journal of Translational Medicine.

T-cell receptor gene transfer for treatment of leukemia.

J. Falkenburg, M. Griffioen, M. H. Heemskerk, 2008, Cytotherapy.

Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex.

R. Hagedoorn, M. A. van der Hoorn, M. Kester, 2007, Blood.

Optimizing TCR gene transfer.

M. Heemskerk, M. H. Heemskerk, 2006, Clinical immunology.

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues

T. Ottenhoff, K. V. van Meijgaarden, K. Franken, 2020, The Journal of Immunology.

Specific T Cell Responses against Minor Histocompatibility Antigens Cannot Generally Be Explained by Absence of Their Allelic Counterparts on the Cell Surface

J. Drijfhout, M. Kester, J. Falkenburg, 2018, Proteomics.

Rapid assessment of the antigenic integrity of tetrameric HLA complexes by human monoclonal HLA antibodies

M. Kester, F. Claas, C. Eijsink, 2006 .

Best Abstracts

J. Drijfhout, F. Koning, M. Kester, 2004, Genes and Immunity.

Allo-HLA-reactive T cells inducing graft-versus-host disease are single peptide specific.

J. Drijfhout, A. Amir, R. Hagedoorn, 2011, Blood.

enteropathy-associated T-cell lymphoma CD3 expression in - loss of surface T-cell receptor Defective synthesis or association of T-cell receptor chains underlies

W. Verbeek, M. Heemskerk, C. Mulder, 2013 .

Treatment with monoclonal anti-CD3 antibody protects against lethal Sendai virus infection by induction of natural killer cells.

W. Kast, C. Melief, J. Bluestone, 1990, Journal of Immunology.

T-cell receptor gene transfer for the treatment of leukemia and other tumors

Mirjam H M Heemskerk, M. H. Heemskerk, 2010, Haematologica.

A CD22-reactive TCR from the T-cell allorepertoire for the treatment of acute lymphoblastic leukemia by TCR gene transfer

R. Hagedoorn, M. Kester, J. Falkenburg, 2016, Oncotarget.

Therapeutic targeting of the BCR-associated protein CD79b in a TCR-based approach is hampered by aberrant expression of CD79b.

R. Hagedoorn, M. Kester, J. Falkenburg, 2015, Blood.

Generation of CD20-specific TCRs for TCR gene therapy of CD20low B-cell malignancies insusceptible to CD20-targeting antibodies

R. Hagedoorn, M. Kester, J. Falkenburg, 2016, Oncotarget.

peptide specific reactive T cells inducing graft-versus-host disease are single - Allo-HLA

J. Drijfhout, A. Amir, R. Hagedoorn, 2014 .

Transcriptional silencing of RFXAP in MHC class II-deficiency.

I. Tezcan, P. J. van den Elsen, M. van Eggermond, 2008, Molecular immunology.

Predominance of MHC class II-restricted CD4+ cytotoxic T cells against mouse hepatitis virus A59.

C. Boog, W. Spaan, H. Schoemaker, 1995, Immunology.

Near-infrared detection and optical follow-up of the GRB990705 afterglow

K. M. Merrill, L. A. Antonelli, P. Vreeswijk, 1999 .

PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy

Karoly Szuhai, Marco W Schilham, M. Schilham, 2018, Oncoimmunology.

Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint

T. Meyer, Leo Swadling, J. McKeating, 2021, Nature Communications.

Determination of the cytotoxic T cell epitopes of mouse hepatitis virus, using elution of viral peptides from class I MHC molecules as an approach.

M. Heemskerk, I. Joosten, C. Boog, 1993, Advances in experimental medicine and biology.

The SPPL3-defined glycosphingolipid repertoire orchestrates HLA class I-mediated immune responses.

M. Raaben, T. Brummelkamp, F. Claas, 2021, Immunity.

Rapid assessment of the antigenic integrity of tetrameric HLA complexes by human monoclonal HLA antibodies.

M. Kester, F. Claas, C. Eijsink, 2005, Journal of immunological methods.

Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors.

J. V. van Dongen, B. Blom, H. Spits, 1999, The EMBO journal.

Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells.

Chandler D. Gatenbee, Sandhya Prabhakaran, R. Wenham, 2022, Cancer cell.

Naturally Processed Non-canonical HLA-A*02:01 Presented Peptides*

J. Drijfhout, S. Gras, Eric Chabrol, 2014, The Journal of Biological Chemistry.

HLA Class I Antigen Expression in Conjunctival Melanoma Is Not Associated With PD-L1/PD-1 Status.

E. Jordanova, F. Claas, B. Ksander, 2018, Investigative ophthalmology & visual science.

Characterization of circulating T-, NK-, and NKT cell subsets in patients with colorectal cancer: the peripheral blood immune cell profile

P. Kuppen, A. Vahrmeijer, E. Bastiaannet, 2019, Cancer Immunology, Immunotherapy.