H. Kim

发表

Synthesis of novel (2R,4R)- and (2S,4S)-iso dideoxynucleosides with exocyclic methylene as potential antiviral agents.

Y. Lim, L. Jeong, Jeongmin Kim, 2002, Bioorganic & medicinal chemistry.

Syntheses and Structure—Activity Relationships of Novel Apio and Thioapio Dideoxydidehydronucleosides as Anti-HCMV Agents.

H. Moon, M. Chun, W. J. Choi, 2001 .

RADIOLABELING AND EFFICIENT SYNTHESIS OF TRITIATED 2-CHLORO-N6-(3-IODOBENZYL)ADENOSINE-5'-N-METHYLURON-AMIDE, A POTENT, SELECTIVE A3 ADENOSINE RECEPTOR AGONIST.

K. Jacobson, P. Towers, C. Hawes, 1996, Journal of labelled compounds & radiopharmaceuticals.

Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents.

S. Jang, H. Moon, L. Jeong, 2006, Bioorganic & medicinal chemistry letters.

Potent anti-HIV and anti-HBV activities of (−)-L-β-dioxolane-C and (+)-L-β-dioxolane-T and their asymmetric syntheses.

R. Schinazi, C. K. Chu, L. Jeong, 1992 .

Discovery of a new nucleoside template for human A3 adenosine receptor ligands: D-4'-thioadenosine derivatives without 4'-hydroxymethyl group as highly potent and selective antagonists.

K. Jacobson, Zhang-Guo Gao, H. Moon, 2007, Journal of medicinal chemistry.

A highly efficient synthesis of unnatural l-sugars from d-ribose

H. Moon, W. J. Choi, L. Jeong, 2005 .

A highly stereoselective synthesis of anti-HIV 2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxynucleosides

S. Ahn, C. K. Chu, L. Jeong, 1992 .

A new DNA building block, 4'-selenothymidine: synthesis and modification to 4'-seleno-AZT as a potential anti-HIV agent.

W. J. Choi, L. Jeong, Hea Ok Kim, 2010, Organic letters.

Discovery of a new template for anticancer agents: 2'-deoxy-2'-fluoro-4'-selenoarabinofuranosyl-cytosine (2'-F-4'-seleno-ara-C).

Sun Choi, Sang Kook Lee, W. J. Choi, 2009, Journal of medicinal chemistry.

Design and synthesis of novel 2',3'-dideoxy-4'-selenonucleosides as potential antiviral agents.

W. J. Choi, L. Jeong, Hea Ok Kim, 2008, Bioorganic & medicinal chemistry.

Stereoselective synthesis and conformational study of novel 2',3'-Didehydro-2',3'-dideoxy-4'-selenonucleosides.

Sun Choi, Yoonji Lee, W. J. Choi, 2008, The Journal of organic chemistry.

First synthesis of 4'-selenonucleosides showing unusual Southern conformation.

H. Yun, L. Jeong, X. Hou, 2008, Organic letters.

Stereoselective synthesis of 2'-C-methyl-cyclopropyl-fused carbanucleosides as potential anti-HCV agents.

H. Moon, L. Jeong, Sanghee Kim, 2006, Organic letters.

Synthesis of fluorinated cyclopentenyladenine as potent inhibitor of S-adenosylhomocysteine hydrolase.

H. Moon, M. Chun, W. J. Choi, 2004, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological evaluation of fluoroneplanocin A as the novel mechanism-based inhibitor of S-adenosylhomocysteine hydrolase.

H. Moon, Sang Kook Lee, M. Chun, 2003, Journal of medicinal chemistry.

Stereocontrolled Routes for the Synthesis of Anti-HIV and Anti-HBV Nucleosides

C. K. Chu, L. Jeong, Hea Ok Kim, 1993 .

Fluorocyclopentenyl-cytosine with broad spectrum and potent antitumor activity.

Jin-hee Kim, Sang Kook Lee, W. J. Choi, 2012, Journal of medicinal chemistry.

Design, Synthesis, and Anti-RNA Virus Activity of 6′-Fluorinated-Aristeromycin Analogues

Natacha S. Ogando, L. Jeong, M. V. van Hemert, 2019, Journal of medicinal chemistry.

Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine Receptor Antagonists and Partial Agonists

Steven M. Moss, K. Jacobson, M. Cui, 2014, Journal of medicinal chemistry.

Stereoselective Synthesis Of Homo-Apioneplanocin A As Potential Inhibitor Of S-Adenosylhomocysteine Hydrolase

Jin-hee Kim, H. Moon, M. Chun, 2007, Nucleosides, nucleotides & nucleic acids.

Asymmetric Synthesis of Novel Apio Carbocyclic Nucleoside Analogues as Potential Antiviral and Antitumor Agent

H. Moon, M. Chun, L. Jeong, 2007, Nucleosides, nucleotides & nucleic acids.

Asymmetric synthesis of homo-apioneplanocin A from D-ribose

Jin-hee Kim, H. Moon, M. Chun, 2006 .

STEREOSELECTIVE SYNTHESIS OF 3-HYDROXYMETHYL-D-CYCLOPENTENONE, THE VERSATILE INTERMEDIATE FOR THE SYNTHESIS OF CARBOCYCLIC NUCLEOSIDES

H. Moon, M. Chun, W. J. Choi, 2005, Nucleosides, nucleotides & nucleic acids.

Synthesis of Halogenated 9-(Dihydroxycyclopent-4′-enyl) Adenines and Their Inhibitory Activities Against S-Adenosylhomocysteine Hydrolase

H. Moon, M. Chun, W. J. Choi, 2003, Nucleosides, nucleotides & nucleic acids.

Stereoselective synthesis of a novel apio analogue of neplanocin A as potential S-adenosylhomocysteine hydrolase inhibitor.

H. Moon, M. Chun, L. Jeong, 2002, Organic letters.

Synthesis of enantiomerically pure (2'R,5'S)-(-)-1-(2-hydroxymethyloxathiolan-5-yl)cytosine as a potent antiviral agent against hepatitis B virus (HBV) and human immunodeficiency virus (HIV)

R. Schinazi, C. K. Chu, L. Jeong, 1992 .

Synthesis and biological evaluation of thymine nucleosides fused with 3',4'-tetrahydrofuran ring.

M. Chun, L. Jeong, J. Kim, 2003, Bioorganic & medicinal chemistry letters.

Synthesis of D- and L-apio nucleoside analogues with 2'-hydroxyl group as potential anti-HIV agents.

H. Moon, M. Chun, L. Jeong, 2004, Bioorganic & medicinal chemistry.

Synthesis of 3′-Acetamidoadenosine Derivatives as Potential A3 Adenosine Receptor Agonists

K. Jacobson, Zhang-Guo Gao, M. Chun, 2008, Nucleosides, nucleotides & nucleic acids.

Synthesis and Biological Evaluation of Thymine Nucleosides Fused with 3′,4′-Tetrahydrofuran Ring.

H. Moon, M. Chun, L. Jeong, 2004 .

Stereoselective synthesis and anti-HCV activity of conformationally restricted 2′-C-substituted carbanucleosides

H. Moon, W. J. Choi, L. Jeong, 2012 .

Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme.

W. J. Choi, L. Jeong, Hea Ok Kim, 2011, The Journal of organic chemistry.

Synthesis of Cyclopropyl-Fused Carbocyclic Nucleosides via the Regioselective Opening of Cyclic Sulfites.

Victor E. Marquez, H. Moon, M. Chun, 1999, The Journal of organic chemistry.

Structure-activity relationships of 2'-modified-4'-selenoarabinofuranosyl-pyrimidines as anticancer agents.

Jin-hee Kim, L. Jeong, Jinha Yu, 2014, European journal of medicinal chemistry.

Design, synthesis, and binding of homologated truncated 4'-thioadenosine derivatives at the human A3 adenosine receptors.

K. Jacobson, Sun Choi, W. J. Choi, 2010, Bioorganic & medicinal chemistry.

N6-substituted D-4'-thioadenosine-5'-methyluronamides: potent and selective agonists at the human A3 adenosine receptor.

K. Jacobson, Zhang-Guo Gao, H. Moon, 2003, Journal of medicinal chemistry.

Syntheses and Biological Activity of Neplanocin and Analogues

L. Jeong, D. Tosh, J. A. Lee, 2008 .

Synthesis of novel apio carbocyclic nucleoside analogues as selective a(3) adenosine receptor agonists.

K. Jacobson, H. Moon, M. Chun, 2005, Journal of Organic Chemistry.

Improved and alternative synthesis of d- and l-cyclopentenone derivatives, the versatile intermediates for the synthesis of carbocyclic nucleosides

H. Moon, W. J. Choi, L. Jeong, 2002 .

Stereoselective synthesis of amino-substituted apio dideoxynucleosides through a distant neighboring group effect

M. Chun, W. J. Choi, L. Jeong, 2002 .

Stereoselective functionalization of the 1'-position of 4'-thionucleosides.

Sun Choi, L. Jeong, Hea Ok Kim, 2006, Organic letters.

Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.

K. Jacobson, Zhang-Guo Gao, H. Moon, 2006, Journal of medicinal chemistry.

Synthesis and biological evaluation of novel thioapio dideoxynucleosides.

H. Moon, M. Chun, W. J. Choi, 2002, Bioorganic & medicinal chemistry.

STRUCTURE-ACTIVITY RELATIONSHIPS OF APIO NUCLEOSIDES AS POTENTIAL ANTIVIRAL AGENTS

H. Moon, M. Chun, W. J. Choi, 2001, Nucleosides, Nucleotides & Nucleic Acids.

STEREOSELECTIVE SYNTHESIS OF NOVEL THIOISO DIDEOXY NUCLEOSIDES WITH EXOCYCLIC METHYLENE AS POTENTIAL ANTIVIRAL AGENTS

M. Chun, L. Jeong, P. Gunaga, 2005, Nucleosides, Nucleotides & Nucleic Acids.

Synthesis and antiviral activity of 2′-fluorohexopyranosyl nucleosides

M. Chun, L. Jeong, H. Kim, 1998, Archives of pharmacal research.

Synthesis and biological evaluation of novel D-2'-azido-2',3'-dideoxyarabinofuranosyl-4'-thiopyrimidines and purines.

H. Moon, L. Jeong, H. Kim, 2002, Bioorganic & Medicinal Chemistry Letters.

SYNTHESIS AND ANTIVIRAL ACTIVITY OF D- AND L-2′-AZIDO-2′,3′-DIDEOXY-4′-THIOPYRIMIDINE AND PURINE NUCLEOSIDES

M. Chun, L. Jeong, H. Kim, 2001, Nucleosides, nucleotides & nucleic acids.

A highly efficient synthesis of L-β-2′-deoxy-4′-thio-1′-purine nucleosides as potential antiviral agents

H. Moon, M. Chun, L. Jeong, 2000 .

A3-adenosine receptors: design of selective ligands and therapeutic prospects.

K. Jacobson, G. Stiles, S. Siddiqi, 1995, Drugs of the future.

Synthesis and Biological Evaluation of Pyrimidine Nucleosides Fused with 3′,4′-Tetrahydrofuran Ring

H. Moon, M. Chun, L. Jeong, 2003, Nucleosides, nucleotides & nucleic acids.

Design, synthesis, and molecular modeling studies of 5'-deoxy-5'-ureidoadenosine: 5'-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase.

Sun Choi, Yoonji Lee, H. Moon, 2007, Bioorganic & medicinal chemistry letters.

Asymmetric Synthesis of Cyclopropyl-fused 2′- C -Methylcarbanucleosides as Potential Anti-HCV Agents

H. Moon, M. Chun, L. Jeong, 2007, Nucleosides, nucleotides & nucleic acids.

X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.

Sun Choi, Yoonji Lee, K. Hwang, 2011, Journal of medicinal chemistry.

Synthesis of 5'-substituted fluoro-neplanocin A analogues: importance of a hydrogen bonding donor at 5'-position for the inhibitory activity of S-adenosylhomocysteine hydrolase.

H. Moon, Sang Kook Lee, M. Chun, 2004, Bioorganic & medicinal chemistry letters.

Preparative and stereoselective synthesis of the versatile intermediate for carbocyclic nucleosides: effects of the bulky protecting groups to enforce facial selectivity.

H. Moon, W. J. Choi, L. Jeong, 2004, The Journal of organic chemistry.

A Short and Efficient Synthesis of l-Thioarabinose Derivative: A Versatile Synthon for the Synthesis of l-2‘-Deoxy- 2‘,2‘-disubstituted-4‘-thionucleosides

H. Moon, M. Chun, L. Jeong, 1998 .

Structural determinants of efficacy at A3 adenosine receptors: modification of the ribose moiety.

K. Jacobson, Zhang-Guo Gao, H. Moon, 2004, Biochemical pharmacology.

Design, synthesis and binding affinity of 3'-fluoro analogues of Cl-IB-MECA as adenosine A3 receptor ligands.

K. Jacobson, Zhang-Guo Gao, H. Moon, 2003, Bioorganic & medicinal chemistry letters.

Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.

K. Jacobson, Philippe van Rompaey, S. van Calenbergh, 2006, Journal of medicinal chemistry.

Synthesis of N 6-Substituted 3′-Ureidoadenosine Derivatives as Highly Potent Agonists at the Mutant A3 Adenosine Receptor

K. Jacobson, Zhang-Guo Gao, H. Moon, 2007, Nucleosides, nucleotides & nucleic acids.

SYNTHESIS OF 3′-UREIDOADENOSINE ANALOGUES AND THEIR BINDING AFFINITY TO THE A3 ADENOSINE RECEPTOR

K. Jacobson, Zhang-Guo Gao, M. Chun, 2005, Nucleosides, nucleotides & nucleic acids.

Design and synthesis of 3'-ureidoadenosine-5'-uronamides: effects of the 3'-ureido group on binding to the A3 adenosine receptor.

K. Jacobson, Zhang-Guo Gao, M. Chun, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of novel tert-azido or tert-amino substituted penciclovir analogs.

H. Moon, M. Chun, L. Jeong, 2004, Organic & biomolecular chemistry.

Structure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands.

K. Jacobson, Sun Choi, Zhang-Guo Gao, 2012, Journal of medicinal chemistry.

Design and synthesis of N(6)-substituted-4'-thioadenosine-5'-uronamides as potent and selective human A(3) adenosine receptor agonists.

K. Jacobson, Zhang-Guo Gao, H. Moon, 2009, Bioorganic & medicinal chemistry.

Structure-activity relationships of truncated adenosine derivatives as highly potent and selective human A3 adenosine receptor antagonists.

Sang Kook Lee, Kenneth A Jacobson, K. Jacobson, 2009, Bioorganic & medicinal chemistry.

Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists.

K. Jacobson, Zhang-Guo Gao, W. J. Choi, 2008, Bioorganic & medicinal chemistry letters.

Stereoselective Synthesis of 1′-Functionalized-4′-Thionucleosides

K. Jacobson, Zhang-Guo Gao, H. Moon, 2007, Nucleosides, nucleotides & nucleic acids.

Design, Synthesis, and Anti-Tumor Activity of 4′-Thionucleosides as Potent and Selective Agonists at the Human A3 Adenosine Receptor

K. Jacobson, Zhang-Guo Gao, H. Moon, 2007, Nucleosides, nucleotides & nucleic acids.

Design, synthesis, and biological activity of N6-substituted-4'-thioadenosines at the human A3 adenosine receptor.

K. Jacobson, Zhang-Guo Gao, H. Moon, 2006, Bioorganic & medicinal chemistry.

A Short and Efficient Synthesis of L-Thioarabinose Derivative: A Versatile Synthon for the Synthesis of L-2′-Deoxy-2′,2′-disubstituted-4′-thionucleosides.

H. Moon, M. Chun, L. Jeong, 1998 .

Synthesis and Antiviral Activity of Novel D- and L-2′-Azido-2′,3′-dideoxyribofuranosyl-4′-thiopyrimidines and Purines.

L. Jeong, Y. Kim, H. Suh, 2001 .

Synthesis and Biological Evaluation of Novel D-2′-Azido-2′,3′-dideoxyarabinofuranosyl-4′-thiopyrimidines and Purines.

H. Moon, L. Jeong, H. Kim, 2002 .

A Highly Efficient Synthesis of L‐β‐2′‐Deoxy‐4′‐thio‐1′‐purine Nucleosides as Potential Antiviral Agents.

H. Moon, M. Chun, L. Jeong, 2000 .

Synthesis of novel D-2'-deoxy-2'-C-difluoromethylene-4'-thiocytidine as a potential antitumor agent.

H. Moon, M. Chun, L. Jeong, 2002, Organic letters.

N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.

S. Y. Kim, Taehee Kang, Jeewoo Lee, 2003, Bioorganic & medicinal chemistry letters.

Design, synthesis, and anticancer activity of fluorocyclopentenyl-pyrimidines.

W. J. Choi, L. Jeong, Mikyung Yun, 2005, Nucleic acids symposium series.

Structure–Activity Relationships of 1,3-Dialkylxanthine Derivatives at Rat A 3 Adenosine Receptors

Jacobson, G. Stiles, X. Ji, 2018 .

Activation of Hippocampal Adenosine A3 Receptors Produces a Desensitization of A1 Receptor-Mediated Responses in Rat Hippocampus

T. Dunwiddie, K. Jacobson, L. Diao, 1997, The Journal of Neuroscience.

2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists.

K. Jacobson, T. K. Harden, X. Ji, 2003, Journal of medicinal chemistry.

Synthesis of 2-alkyl-substituted-N6-methyladenine derivatives as potential adenosine receptor ligand

Hea Ok Kim, H. Kim, 2001, Archives of pharmacal research.

Probing the binding site of the A1 adenosine receptor reengineered for orthogonal recognition by tailored nucleosides.

K. Jacobson, Zhang-Guo Gao, K. Palaniappan, 2007, Biochemistry.

Synthesis of 2′,3′-didehydro-2′,3′-dideoxy-2′-fluoro apionucleosides as potential antiviral agents

H. Moon, L. Jeong, Hea Ok Kim, 2002 .

Conversion of A3 adenosine receptor agonists into selective antagonists by modification of the 5'-ribofuran-uronamide moiety.

K. Jacobson, Zhang-Guo Gao, L. Jeong, 2006, Bioorganic & medicinal chemistry letters.

The antitumor effect of LJ-529, a novel agonist to A3 adenosine receptor, in both estrogen receptor–positive and estrogen receptor–negative human breast cancers

G. Kong, Sung-Dae Cho, Ji-Youn Jung, 2006, Molecular Cancer Therapeutics.

Design and Synthesis of A3 Adenosine Receptor Ligands, 3′-Fluoro Analogues of Cl-IB-MECA

K. Jacobson, H. Moon, M. Chun, 2003, Nucleosides, nucleotides & nucleic acids.

Structure-activity relationships of truncated D- and l-4'-thioadenosine derivatives as species-independent A3 adenosine receptor antagonists.

Jacobson, K. Jacobson, Zhang-Guo Gao, 2008, Journal of medicinal chemistry.

Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine.

K. Jacobson, Sun Choi, Zhang-Guo Gao, 2010, ACS medicinal chemistry letters.

1,3-dioxolanylpurine nucleosides (2R,4R) and (2R,4S) with selective anti-HIV-1 activity in human lymphocytes.

R. Schinazi, C. K. Chu, L. Jeong, 1993, Journal of medicinal chemistry.

2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.

K. Jacobson, G. Stiles, X. Ji, 1994, Journal of medicinal chemistry.

Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y(1) receptor ligands.

S. Moro, K. Jacobson, P. Herdewijn, 2000, Journal of medicinal chemistry.

L-beta-(2S,4S)- and L-alpha-(2S,4R)-dioxolanyl nucleosides as potential anti-HIV agents: asymmetric synthesis and structure-activity relationships.

R. Schinazi, C. K. Chu, L. Jeong, 1993, Journal of medicinal chemistry.

Discovery of a new template for anticancer agents: 2'-deoxy-2'-fluoro-4'-selenoarabinofuranosyl-cytosine (2'-F-4'-seleno-ara-C).

Sun Choi, W. J. Choi, L. Jeong, 2009, Journal of medicinal chemistry.

An efficient synthesis of enantiomerically pure (+)-(2S,5R)-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine [(+)-BCH-189] from d-galactose

Sean W. Carrigan, C. K. Chu, L. Jeong, 1992 .

Synthesis and anti-hepatitis C virus (HCV) activity of 3'-C-substituted-methyl pyrimidine and purine nucleosides.

Dong-Eun Kim, W. J. Choi, L. Jeong, 2010, Bioorganic & medicinal chemistry.

Structure-activity relationships of 9-alkyladenine and ribose-modified adenosine derivatives at rat A3 adenosine receptors.

K. Jacobson, G. Stiles, X. Ji, 1995, Journal of medicinal chemistry.

Synthesis and structure‐activity relationships of pyridoxal‐6‐arylazo‐5′‐phosphate and phosphonate derivatives as P2 receptor antagonists

G. Burnstock, K. Jacobson, T. K. Harden, 1998, Drug development research.

Synthesis and Anti-Renal Fibrosis Activity of Conformationally Locked Truncated 2-Hexynyl-N6-Substituted-(N)-Methanocarba-nucleosides as A3 Adenosine Receptor Antagonists and Partial Agonists

Steven M. Moss, M. Cui, Sun Choi, 2014, Journal of Medicinal Chemistry.

Discovery of A New Human A2A Adenosine Receptor Agonist, Truncated 2-Hexynyl-4′-thioadenosine

K. Jacobson, Sun Choi, Zhang-Guo Gao, 2010 .

Syntheses of D- and L-cyclopentenone derivatives using ring-closing metathesis: versatile intermediates for the synthesis of D- and L-carbocyclic nucleosides.

H. Moon, M. Chun, W. J. Choi, 2001, The Journal of organic chemistry.

Asymmetric synthesis of 1,3-dioxolane-pyrimidine nucleosides and their anti-HIV activity.

R. Schinazi, S. Ahn, C. K. Chu, 1992, Journal of medicinal chemistry.