H. Suzuki

发表

Decreased extra-renal urate excretion is a common cause of hyperuricemia

Y. Shinohara, N. Shinomiya, Y. Sakurai, 2012, Nature Communications.

Chapter 13 – Styrene and Related Compounds*

H. Suzuki, 1967 .

Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system☆

Y. Sugiyama, T. Terasaki, H. Suzuki, 1997 .

Identification of Two Dysfunctional Variants in the ABCG2 Urate Transporter Associated with Pediatric-Onset of Familial Hyperuricemia and Early-Onset Gout

J. Bohata, Hiroshi Suzuki, T. Takada, 2021, International journal of molecular sciences.

Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications

T. Takada, Y. Toyoda, H. Suzuki, 2019, Front. Pharmacol..

Inhibitory effect of Citrus flavonoids on the in vitro transport activity of human urate transporter 1 (URAT1/SLC22A12), a renal re-absorber of urate.

H. Hirata, T. Takada, N. Kobayashi, 2020, NPJ science of food.

Chapter 17 – Polymethine Dyes

H. Suzuki, 1967 .

Serum alkaline phosphatase isoenzymes: An aid to the diagnosis of liver diseases

T. Oda, T. Maki, H. Suzuki, 1970, Gastroenterologia Japonica.

FUNCTIONAL ASSESSMENT OF ABCG2 (BCRP) GENE POLYMORPHISMS TO PROTEIN EXPRESSION IN HUMAN PLACENTA

M. Oshimura, Y. Sugiyama, J. Kigawa, 2005, Drug Metabolism and Disposition.

Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease.

M. Tomita, S. Tsuji, M. Suematsu, 2011, Journal of hepatology.

Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment.

Y. Sugiyama, K. Brouwer, P. Meier, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice

K. Maeda, H. Kusuhara, Y. Sugiyama, 2015, Pharmaceutical Research.

Common dysfunctional variants in ABCG2 are a major cause of early-onset gout

N. Hamajima, K. Wakai, N. Shinomiya, 2013, Scientific Reports.

A Function-Based Genetic Analysis in a Japanese Population Common Defects of ABCG 2 , a High-Capacity Urate Exporter , Cause Gout :

N. Hamajima, K. Wakai, N. Shinomiya, 2010 .

Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population

N. Hamajima, K. Wakai, N. Shinomiya, 2009, Science Translational Medicine.

Characterization of Inhibitory Effect of Carbapenem Antibiotics on the Deconjugation of Valproic Acid Glucuronide

Y. Masuo, Hiroshi Suzuki, A. Hisaka, 2010, Drug Metabolism and Disposition.

Analysis of pharmacokinetic data provided in Japanese package inserts and interview forms focusing on urinary excretion of pharmacologically active species.

A. Hisaka, M. Kusama, Y. Yanagihara, 2006, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Associations between Lifestyle-Related Diseases and Transporters Involved in Intestinal Absorption and Biliary Excretion of Cholesterol.

Hiroshi Suzuki, T. Takada, Y. Yamanashi, 2018, Biological & pharmaceutical bulletin.

Characterization of the Efflux Transport of 17β-Estradiol-d-17β-glucuronide from the Brain across the Blood-Brain Barrier

T. Abe, H. Kusuhara, Y. Sugiyama, 2001 .

General Framework for the Prediction of Oral Drug Interactions Caused by CYP3A4 Induction from In Vivo Information

Akihiro Hisaka, Yoshiyuki Ohno, M. Ueno, 2008, Clinical pharmacokinetics.

General Framework for the Quantitative Prediction of CYP3A4-Mediated Oral Drug Interactions Based on the AUC Increase by Coadministration of Standard Drugs

Akihiro Hisaka, Yoshiyuki Ohno, Hiroshi Suzuki, 2007, Clinical pharmacokinetics.

Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems

Masashi Honma, Masanari Kozawa, H. Suzuki, 2010, Expert opinion on drug discovery.

OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts

N. Shinomiya, T. Tamura, T. Kondo, 2022, Frontiers in Pharmacology.

Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist.

Ming-Rong Zhang, K. Maeda, H. Kusuhara, 2017, Journal of pharmaceutical sciences.

PREDICTION OF IN VIVO DRUG DISPOSITION FROM IN VITRO DATA BASED ON PHYSIOLOGICAL PHARMACOKINETICS

T Iwatsubo, N Hirota, T Ooie, 1996, Biopharmaceutics & drug disposition.

Systematic Analysis of Changes in Drug Exposure in Patients with Renal Dysfunction and Their Relationships with Renal Excretion Ratio of the Drug

Hiroshi Suzuki, A. Hisaka, Ryo Yamaguchi, 2013 .

Prediction of pharmacokinetic drug-drug interaction caused by changes in cytochrome P450 activity using in vivo information.

Akihiro Hisaka, Yoshiyuki Ohno, A. Hisaka, 2010, Pharmacology & therapeutics.

Niemann-Pick C1-Like 1 Overexpression Facilitates Ezetimibe-Sensitive Cholesterol and β-Sitosterol Uptake in CaCo-2 Cells

Hiroshi Suzuki, T. Takada, Y. Yamanashi, 2006, Journal of Pharmacology and Experimental Therapeutics.

Kinetic profile of overall elimination of 5-methyltetrahydropteroylglutamate in rats.

H. Kusuhara, Y. Sugiyama, Y. Kato, 1999, American journal of physiology. Endocrinology and metabolism.

Expression of a putative ATP-binding cassette region, homologous to that in multidrug resistance-associated protein (MRP), is hereditarily defective in Eisai hyperbilirubinemic rats (EHBR)

Y. Sugiyama, Takao Shimizu, K. Kume, 1996 .

Chapter 14 – Stilbene and Related Compounds

H. Suzuki, 1967 .

Multiple common and rare variants of ABCG2 cause gout

T. Merriman, K. Wakai, N. Shinomiya, 2017, RMD Open.

RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β

Kozo Nakamura, E. Wagner, T. Taniguchi, 2002, Nature.

Off-Target Serine/Threonine Kinase 10 Inhibition by Erlotinib Enhances Lymphocytic Activity Leading to Severe Skin Disorders

Masashi Honma, Masashi Honma, Hiroshi Suzuki, 2011, Molecular Pharmacology.

Coupling of bone resorption and formation by RANKL reverse signalling

Y. Tabata, J. Penninger, K. Aoki, 2018, Nature.

Itraconazole-Induced Cholestasis: Involvement of the Inhibition of Bile Canalicular Phospholipid Translocator MDR3/ABCB4

S. Tsuji, H. Yoshida, Y. Yatomi, 2011, Molecular Pharmacology.

ABCG2 Transports Sulfated Conjugates of Steroids and Xenobiotics*

Yuichi Sugiyama, Y. Sugiyama, Y. Sugimoto, 2003, Journal of Biological Chemistry.

The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function

Y. Sugiyama, Y. Nimura, N. Tanaka, 2001, American Journal of Gastroenterology.

Recent Advances in Carrier-mediated Hepatic Uptake and Biliary Excretion of Xenobiotics

Y. Sugiyama, M. Yamazaki, H. Suzuki, 1996, Pharmaceutical Research.

Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities

Masashi Honma, Yoshiaki Kariya, H. Suzuki, 2016 .

Systems-based understanding of pharmacological responses with combinations of multidisciplinary methodologies.

Masashi Honma, Yoshiaki Kariya, Hiroshi Suzuki, 2013, Biopharmaceutics & drug disposition.

Mechanisms of RANKL delivery to the osteoclast precursor cell surface

Masashi Honma, Yuki Ikebuchi, H. Suzuki, 2020, Journal of Bone and Mineral Metabolism.

Proposal of a Pharmacokinetically Optimized Dosage Regimen of Antibiotics in Patients Receiving Continuous Hemodiafiltration

T. Fujita, N. Hanafusa, E. Noiri, 2011, Antimicrobial Agents and Chemotherapy.

Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer

Y. Sugiyama, M. Nagino, Y. Nimura, 2005, Langenbeck's Archives of Surgery.

Bile Acid as Therapeutic Agents

Hiroshi Suzuki, T. Takada, Y. Yamanashi, 2017 .

Analysis and Prediction of Drug Transfer into Human Milk Taking into Consideration Secretion and Reuptake Clearances across the Mammary Epithelia

A. Hisaka, Masashi Honma, Kousei Ito, 2011, Drug Metabolism and Disposition.

Identification of the Hepatic Efflux Transporters of Organic Anions Using Double-Transfected Madin-Darby Canine Kidney II Cells Expressing Human Organic Anion-Transporting Polypeptide 1B1 (OATP1B1)/Multidrug Resistance-Associated Protein 2, OATP1B1/Multidrug Resistance 1, and OATP1B1/Breast Cancer R

Kazuya Maeda, Yuichi Sugiyama, Chihiro Kondo, 2005, Journal of Pharmacology and Experimental Therapeutics.

Functional Analysis of SNPs Variants of BCRP/ABCG2

Y. Sugiyama, S. Ozawa, J. Sawada, 2004, Pharmaceutical Research.

Biliary Excretion of 17β-Estradiol 17β-d-Glucuronide Is Predominantly Mediated by cMOAT/MRP2

Y. Sugiyama, A. Morikawa, Hiroshi Suzuki, 2000, Pharmaceutical Research.

Characterization of the Transport Properties of Cloned Rat Multidrug Resistance-associated Protein 3 (MRP3)*

Hiroshi Suzuki, T. Hirohashi, Yuichi Sugiyama, 1999, The Journal of Biological Chemistry.

ABCG2 is a High-Capacity Urate Transporter and its Genetic Impairment Increases Serum Uric Acid Levels in Humans

N. Shinomiya, Y. Kanai, T. Hosoya, 2011, Nucleosides, nucleotides & nucleic acids.

REGULATION OF THE CELL SURFACE EXPRESSION OF HUMAN BCRP/ABCG2 BY THE PHOSPHORYLATION STATE OF AKT IN POLARIZED CELLS

Y. Sugiyama, Y. Gotoh, Hiroshi Suzuki, 2005, Drug Metabolism and Disposition.

Chapter 11. Hepatic Transport

Kazuya Maeda, Yuichi Sugiyama, K. Maeda, 2009 .

Polymorphisms of OATP‐C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

Yuichi Sugiyama, Miyuki Kimura, Kenji Otsubo, 2003, Clinical pharmacology and therapeutics.

Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

Y. Sugiyama, I. Ieiri, Hiroshi Suzuki, 2004, Pharmacogenetics.

Influence of common variants in the pharmacokinetic genes (OATP-C, UGT1A1, and MRP2) on serum bilirubin levels in healthy subjects.

Y. Sugiyama, S. Higuchi, H. Takane, 2004, Hepatology research : the official journal of the Japan Society of Hepatology.

Eight novel single nucleotide polymorphisms in ABCG2/BCRP in Japanese cancer patients administered irinotacan.

Y. Sugiyama, Teruhiko Yoshida, N. Saijo, 2003, Drug metabolism and pharmacokinetics.

Inhibition of Bile Acid Transport across Na+/Taurocholate Cotransporting Polypeptide (SLC10A1) and Bile Salt Export Pump (ABCB 11)-Coexpressing LLC-PK1 Cells by Cholestasis-Inducing Drugs

Yuichi Sugiyama, Hidetaka Akita, Y. Sugiyama, 2006, Drug Metabolism and Disposition.

Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet–Induced Atherosclerosis in LDL Receptor Mutant Mice

Hiroshi Suzuki, T. Takada, Hideaki Yamamoto, 2019, Molecular Pharmacology.

High plasma linezolid concentration and impaired renal function affect development of linezolid-induced thrombocytopenia.

S. Hatakeyama, H. Yotsuyanagi, K. Moriya, 2013, The Journal of antimicrobial chemotherapy.

Modeling of Rifampicin-Induced CYP3A4 Activation Dynamics for the Prediction of Clinical Drug-Drug Interactions from In Vitro Data

H. Kitano, Y. Asai, M. Hashida, 2013, PloS one.

RANKL as a key figure in bridging between the bone and immune system: Its physiological functions and potential as a pharmacological target.

Hiroshi Suzuki, Masashi Honma, Yuki Ikebuchi, 2020, Pharmacology & therapeutics.

The induction of RANKL molecule clustering could stimulate early osteoblast differentiation.

T. Ando, K. Aoki, R. Murali, 2019, Biochemical and Biophysical Research Communications - BBRC.

Omega-3 Polyunsaturated Fatty Acids Inhibit the Function of Human URAT1, a Renal Urate Re-absorber

Hiroshi Suzuki, H. Hirata, T. Takada, 2020, Nutrients.

REVIEW ARTICLE PREDICTION OF IN VIVO DRUG DISPOSITION FROM IN VITRO DATA BASED ON PHYSIOLOGICAL PHARMACOKTNETICS

Y. Sugiyama, Hiroshi Suzuki, T. Iwatsubo, 1996 .

A Novel Method to Estimate Long‐Term Chronological Changes From Fragmented Observations in Disease Progression

T. Iwatsubo, Hiroshi Suzuki, T. Moritoyo, 2018, Clinical pharmacology and therapeutics.

Clinical Importance of Drug-Drug Interaction Between Warfarin and Prednisolone and Its Potential Mechanism in Relation to the Niemann-Pick C1-Like 1-Mediated Pathway.

Hiroshi Suzuki, T. Takada, S. Ito, 2019, Circulation journal : official journal of the Japanese Circulation Society.

Rab27a and Rab27b are involved in stimulation‐dependent RANKL release from secretory lysosomes in osteoblastic cells

N. Udagawa, T. Ninomiya, Y. Nakamichi, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Vps33a Mediates RANKL Storage in Secretory Lysosomes in Osteoblastic Cells

Hiroshi Suzuki, Masashi Honma, Yoshiaki Kariya, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Persistent drug interaction between aprepitant and warfarin in patients receiving anticancer chemotherapy

A. Hisaka, Ryo Yamaguchi, Y. Ohno, 2014, International Journal of Clinical Pharmacy.

Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis

T. Takada, Y. Toyoda, H. Suzuki, 2016, Scientific Reports.

Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis.

Hiroshi Suzuki, M. Kuroda, T. Takada, 2013, Biochimica et biophysica acta.

Assessment of Drug-Drug Interaction between Warfarin and Aprepitant and Its Effects on PT-INR of Patients Receiving Anticancer Chemotherapy.

Hiroshi Suzuki, A. Hisaka, Ryo Yamaguchi, 2016, Biological & pharmaceutical bulletin.

Soy Isoflavone Genistein Inhibits an Axillary Osmidrosis Risk Factor ABCC11: In Vitro Screening and Fractional Approach for ABCC11-Inhibitory Activities in Plant Extracts and Dietary Flavonoids

Hiroshi Suzuki, H. Hirata, T. Takada, 2020, Nutrients.

Clinical and Molecular Evidence of ABCC11 Protein Expression in Axillary Apocrine Glands of Patients with Axillary Osmidrosis

T. Ishikawa, H. Nakagawa, T. Takada, 2017, International journal of molecular sciences.

Regulation of the Axillary Osmidrosis-Associated ABCC11 Protein Stability by N-Linked Glycosylation: Effect of Glucose Condition

T. Ishikawa, T. Takada, H. Miyata, 2016, PloS one.

Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice

A. Aiba, K. Nakao, N. Shinomiya, 2020, Proceedings of the National Academy of Sciences.

Prediction of Drug Transfer into Milk Considering Breast Cancer Resistance Protein (BCRP)-Mediated Transport

A. Hisaka, Kousei Ito, T. Takada, 2015, Pharmaceutical Research.

Posttranslational regulation of Abcc2 expression by SUMOylation system.

Y. Kanai, N. Anzai, S. Tsukita, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Febuxostat inhibited axillary osmidrosis risk factor ATP‐binding cassette transporter C11 in vitro

T. Takada, Y. Toyoda, H. Suzuki, 2020, The Journal of dermatology.

Identification of hepatic NPC1L1 as an NAFLD risk factor evidenced by ezetimibe‐mediated steatosis prevention and recovery

K. Takeda, M. Umezawa, T. Takada, 2019, FASEB bioAdvances.

Identification of Febuxostat as a New Strong ABCG2 Inhibitor: Potential Applications and Risks in Clinical Situations

Hirotaka Matsuo, Hiroshi Miyata, Hiroshi Suzuki, 2016, Front. Pharmacol..

NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy

Yusuke Masuo, Y. Masuo, Hiroshi Suzuki, 2015, Science Translational Medicine.

Apical/Basolateral Surface Expression of Drug Transporters and its Role in Vectorial Drug Transport

Y. Sugiyama, T. Horie, Kousei Ito, 2005, Pharmaceutical Research.

Treatment of Hyperbilirubinemia in Eisai Hyperbilirubinemic Rat by Transfecting Human MRP2/ABCC2 Gene

Y. Sugiyama, Hiroshi Suzuki, Masakazu Hirouchi, 2005, Pharmaceutical Research.

Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2.

Y. Sugiyama, P. Meier, J. Aoki, 2004, Molecular pharmacology.

Characterization of the Cellular Localization, Expression Level, and Function of SNP Variants of MRP2/ABCC2

Y. Sugiyama, S. Ozawa, J. Sawada, 2004, Pharmaceutical Research.

Transfected Rat cMOAT Is Functionally Expressed on the Apical Membrane in Madin-Darby Canine Kidney (MDCK) Cells

Y. Sugiyama, Takao Shimizu, K. Kume, 1998, Pharmaceutical Research.

Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition.

Y. Sugiyama, Hiroshi Suzuki, H. Suzuki, 2002, Advanced drug delivery reviews.

Multidrug resistance-associated protein2 (MRP2) plays an important role in the biliary excretion of glutathione conjugates of 4-hydroxynonenal.

Y. Sugiyama, Hiroshi Suzuki, T. Horie, 2002, Free radical biology & medicine.

Transcellular Transport of Organic Anions Across a Double-transfected Madin-Darby Canine Kidney II Cell Monolayer Expressing Both Human Organic Anion-transporting Polypeptide (OATP2/SLC21A6) and Multidrug Resistance-associated Protein 2 (MRP2/ABCC2)*

T. Abe, Y. Sugiyama, Kousei Ito, 2002, The Journal of Biological Chemistry.

ATP-dependent Transport of Bile Salts by Rat Multidrug Resistance-associated Protein 3 (Mrp3)*

H. Takikawa, Hiroshi Suzuki, T. Hirohashi, 2000, The Journal of Biological Chemistry.

cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3) 1

Y. Sugiyama, C. Tyson, T. Hirohashi, 1998 .

Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3

Y. Sugiyama, Hiroshi Suzuki, Kousei Ito, 2008, Pharmacogenetics and genomics.

Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.

Y. Sugiyama, K. Itoh, Masayuki Yamamoto, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Sinusoidal Efflux of Taurocholate Is Enhanced in Mrp2-Deficient Rat Liver

Y. Sugiyama, H. Akita, Hiroshi Suzuki, 2001, Pharmaceutical Research.

Transport Activity of Human MRP3 Expressed in Sf9 Cells: Comparative Studies with Rat MRP3

Y. Sugiyama, H. Takikawa, H. Akita, 2004, Pharmaceutical Research.

Sinusoidal efflux of taurocholate correlates with the hepatic expression level of Mrp3.

Y. Sugiyama, H. Akita, Hiroshi Suzuki, 2002, Biochemical and biophysical research communications.

The expression levels of plasma membrane transporters in the cholestatic liver of patients undergoing biliary drainage and their association with the impairment of biliary secretory function.

Y. Sugiyama, Y. Nimura, N. Tanaka, 2001 .

Functional Analysis of a Canalicular Multispecific Organic Anion Transporter Cloned from Rat Liver*

Y. Sugiyama, Takao Shimizu, K. Kume, 1998, The Journal of Biological Chemistry.

Genipin enhances Mrp2 (Abcc2)‐mediated bile formation and organic anion transport in rat liver

Y. Sugiyama, N. Tanaka, H. Akita, 2004, Hepatology.

Etiologic significance of defects in cholesterol, phospholipid, and bile acid metabolism in the liver of patients with intrahepatic calculi

Y. Sugiyama, Y. Nimura, N. Tanaka, 2001, Hepatology.

Differences in Substrate Specificity among Glutathione Conjugates (GS‐X) Pump Family Members: Comparison between Multidrug Resistance‐associated Protein and a Novel Transporter Expressed on a Cisplatin‐resistant Cell Line (KCP‐4)

Y. Sugiyama, S. Akiyama, Hiroshi Suzuki, 1999, Japanese journal of cancer research : Gann.

Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.

Y. Sugiyama, Hiroshi Suzuki, A. Hofmann, 2005, Biochimica et biophysica acta.

Characterization of Polarized Expression of Point- or Deletion-Mutated Human BCRP/ABCG2 in LLC-PK1 Cells

Y. Sugiyama, T. Takada, H. Suzuki, 2005, Pharmaceutical Research.

Novel mutations identified in the human multidrug resistance-associated protein 2 (MRP2/ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome.

Y. Sugiyama, N. Tanaka, Y. Matsuzaki, 2003, Hepatology research : the official journal of the Japan Society of Hepatology.

Bezafibrate induces multidrug‐resistance P‐Glycoprotein 3 expression in cultured human hepatocytes and humanized livers of chimeric mice

K. Yoshizato, Hiroshi Suzuki, T. Yokoi, 2007, Hepatology research : the official journal of the Japan Society of Hepatology.

Primary active transport of organic anions on bile canalicular membrane in humans.

Y. Sugiyama, Y. Kato, C. Tyson, 1999, American journal of physiology. Gastrointestinal and liver physiology.

In vivo Cisplatin Resistance Depending upon Canalicular Multispecific Organic Anion Transporter (cMOAT)

Y. Sugiyama, K. Miyamoto, M. Nomura, 1999, Japanese journal of cancer research : Gann.

Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11

Y. Sugiyama, H. Akita, Hiroshi Suzuki, 2005, Hepatology.

Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport

Hiroshi Suzuki, Naoko Yoshida, T. Takada, 2008, Drug Metabolism and Disposition.

Pharmacokinetic Study of the Hepatobiliary Transport of Indomethacin

Y. Sugiyama, Hiroshi Suzuki, H. Kouzuki, 2000, Pharmaceutical Research.

Pharmacokinetic/pharmacodynamic analysis of neutrophil proliferation induced by rhG-CSF in patients receiving antineoplastic drugs.

T. Iga, Hiroshi Suzuki, Y. Yamada, 2004, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Hepatic Drug Metabolism

Y. Sugiyama, H. Suzuki, 2004 .

Design of a drug delivery system for targeting based on pharmacokinetic consideration

Y. Sugiyama, Hiroshi Suzuki, T. Seita, 1996 .

Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep.

Y. Sugiyama, H. Akita, A. Hofmann, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump.

Yuichi Sugiyama, Bruno Stieger, Hidetaka Akita, 2005, American journal of physiology. Gastrointestinal and liver physiology.

FIC1-mediated stimulation of FXR activity is decreased with PFIC1 mutations in HepG2 cells

Hiroshi Suzuki, T. Takada, Saori Koh, 2009, Journal of Gastroenterology.

Receptor for activated C‐kinase 1 regulates the cellular localization and function of ABCB4

Y. Kanai, N. Anzai, Hiroshi Suzuki, 2009, Hepatology research : the official journal of the Japan Society of Hepatology.

Polymorphisms in the ABCC2 (cMOAT/MRP2) gene found in 72 established cell lines derived from Japanese individuals: an association between single nucleotide polymorphisms in the 5'-untranslated region and exon 28.

Y. Sugiyama, Yoshiro Saito, S. Ishida, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Notable Drug–Drug Interaction Between Etizolam and Itraconazole in Poor Metabolizers of Cytochrome P450 2C19

T. Iwatsubo, T. Moritoyo, A. Hisaka, 2017, Journal of clinical pharmacology.

Ticlopidine, a Cholestatic Liver Injury-Inducible Drug, Causes Dysfunction of Bile Formation via Diminished Biliary Secretion of Phospholipids: Involvement of Biliary-Excreted Glutathione-Conjugated Ticlopidine Metabolites

T. Santa, Hiroshi Suzuki, Kousei Ito, 2013, Molecular Pharmacology.

Elucidation of the molecular mechanisms underlying adverse reactions associated with a kinase inhibitor using systems toxicology

Samik Ghosh, Hiroaki Kitano, Yukio Homma, 2015, npj Systems Biology and Applications.

History of whole pelvis plus para-aortic radiation is a risk factor associated with febrile neutropenia during chemotherapy for recurrent cervical cancer

Y. Osuga, Hiroshi Suzuki, Takehito Yamamoto, 2021, International Journal of Clinical Oncology.

Kinetic Analysis of Hepatobiliary Transport for Conjugated Metabolites in the Perfused Liver of Mutant Rats (EHBR) with Hereditary Conjugated Hyperbilirubinemia

Y. Sugiyama, Kazuo Kobayashi, Hiroshi Suzuki, 1995, Pharmaceutical Research.

NPC1L1 Facilitates Sphingomyelin Absorption and Regulates Diet-Induced Production of VLDL/LDL-associated S1P

Hiroshi Suzuki, T. Takada, Hideaki Yamamoto, 2020, Nutrients.

VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body

Y. Masuo, M. Harada‐Shiba, T. Takada, 2017, Scientific Reports.

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

Y. Kamatani, Y. Okada, T. Merriman, 2016, Annals of the rheumatic diseases.

Identification of an exporter that regulates vitamin C supply from blood to the brain

Y. Ikegaya, T. Takada, R. Koyama, 2022, iScience.

Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet

Hiroshi Suzuki, T. Takada, Y. Yamanashi, 2019, Lipids in Health and Disease.

Reduced Atherosclerotic Lesions in Mice Deficient for Total or Macrophage-Specific Expression of Scavenger Receptor-A

T. Kodama, M. Linton, V. Babaev, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARα-mediated redistribution of ABCB4 Published, JLR Papers in Press, July 16, 2004. DOI 10.1194/jlr.M400132-JLR200

Y. Sugiyama, N. Tanaka, Hiroshi Suzuki, 2004, Journal of Lipid Research.

Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4.

Y. Sugiyama, N. Tanaka, Hiroshi Suzuki, 2004, Journal of lipid research.

Novel function of Niemann‐Pick C1‐like 1 as a negative regulator of Niemann‐Pick C2 protein

Hiroshi Suzuki, T. Takada, Y. Yamanashi, 2012, Hepatology.

Apoptotic Thymocyte Clearance in Scavenger Receptor Class A-Deficient Mice Is Apparently Normal

Siamon Gordon, Hiroshi Suzuki, S. Gordon, 2000, The Journal of Immunology.

Niemann-Pick C1-Like 1 Mediates α-Tocopherol Transport

T. Takada, Kazuya Narushima, Y. Yamanashi, 2008, Molecular Pharmacology.

Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12

N. Shinomiya, K. Takeuchi, I. Inoue, 2021, Rheumatology.

Identification of a dysfunctional splicing mutation in the SLC22A12/URAT1 gene causing renal hypouricaemia type 1: a report on two families

N. Shinomiya, R. Fujimaru, T. Takada, 2020, Rheumatology.

Kinetics of Quinolone Antibiotics in Rats: Efflux from Cerebrospinal Fluid to the Circulation

Y. Sugiyama, T. Terasaki, Hiroshi Suzuki, 1996, Pharmaceutical Research.

Human NPC1L1 Expression is Positively Regulated by PPARα

Hiroshi Suzuki, K. Inui, T. Terada, 2011, Pharmaceutical Research.

Regulatory Mechanisms of RANKL Presentation to Osteoclast Precursors

Hiroshi Suzuki, Masashi Honma, Yoshiaki Kariya, 2014, Current Osteoporosis Reports.

Organic cation transporter/solute carrier family 22a is involved in drug transfer into milk in mice.

H. Kusuhara, Hiroshi Suzuki, A. Hisaka, 2014, Journal of pharmaceutical sciences.

Statistical studies on morphology and clinical features of fulminant hepatitis A survey of 118 cases in the authors’ department

T. Shikata, T. Kanetaka, T. Oda, 1973, Gastroenterologia Japonica.

Transporters for the Intestinal Absorption of Cholesterol, Vitamin E, and Vitamin K

T. Takada, Y. Yamanashi, Yusuke Tanaka, 2017, Journal of atherosclerosis and thrombosis.

ATP-dependent transport of organic anions into isolated basolateral membrane vesicles from rat intestine.

H. Kusuhara, Y. Sugiyama, Hiroshi Suzuki, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2

K. Wakai, N. Shinomiya, M. Kawaguchi, 2016, Scientific Reports.

ABCG2 Dysfunction Increases Serum Uric Acid by Decreased Intestinal Urate Excretion

N. Shinomiya, T. Takada, A. Nakayama, 2014, Nucleosides, nucleotides & nucleic acids.

Title Modeling of Rifampicin-Induced CYP 3 A 4 Activation Dynamics for the Prediction of Clinical Drug-Drug Interactions from In Vitro Data

H. Kitano, Y. Asai, M. Hashida, 2018 .

Novel dysfunctional variant in ABCG2 as a cause of severe tophaceous gout: biochemical, molecular genetics and functional analysis.

K. Pavelka, Hiroshi Suzuki, J. Závada, 2016, Rheumatology.

Molecular mechanisms of membrane transport of vitamin E.

Hiroshi Suzuki, T. Takada, H. Suzuki, 2010, Molecular nutrition & food research.

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes

Hirotaka Matsuo, Ituro Inoue, Nariyoshi Shinomiya, 2015, Annals of the rheumatic diseases.

Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2.

Takuhiro Yamaguchi, S. Amano, A. Kuchiba, 2012, Ophthalmology.

Niemann-Pick C 1-Like 1 Overexpression Facilitates Ezetimibe-Sensitive Cholesterol and-Sitosterol Uptake in CaCo-2 Cells

Hiroshi Suzuki, T. Takada, H. Suzuki, 2007 .

ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload

K. Wakai, N. Shinomiya, Y. Sakurai, 2014, Scientific Reports.

Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein 1 in mouse embryo fibroblasts.

Yuichi Sugiyama, Ken Itoh, Masayuki Yamamoto, 2003, Biochemical and biophysical research communications.

Biliary Excretion of Glycyrrhizin in Rats: Kinetic Basis for Multiplicity in Bile Canalicular Transport of Organic Anions

Y. Sugiyama, Hiroshi Suzuki, H. Shimamura, 1996, Pharmaceutical Research.

RANKL subcellular trafficking and regulatory mechanisms in osteocytes

Hiroshi Suzuki, Masashi Honma, Yoshiaki Kariya, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis

N. Udagawa, T. Ninomiya, Y. Nakamichi, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Frequency distribution of phenol sulfotransferase 1A1 activity in platelet cells from healthy Japanese subjects.

S. Ozawa, Y. Ohno, Hiroshi Suzuki, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Dysfunctional ABCG2 gene polymorphisms are associated with serum uric acid levels and all-cause mortality in hemodialysis patients

M. Urashima, N. Shinomiya, T. Yokoo, 2020, Human Cell.

Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice.

H. Kusuhara, Y. Sugiyama, K. Takeuchi, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Common dysfunctional variants of ABCG2 have stronger impact on hyperuricemia progression than typical environmental risk factors

K. Wakai, N. Shinomiya, Y. Sakurai, 2014, Scientific Reports.

A common variant of organic anion transporter 4 (OAT4/SLC22A11) gene is associated with renal underexcretion type gout.

N. Hamajima, N. Shinomiya, M. Naito, 2014, Drug metabolism and pharmacokinetics.

Characterization of the Transport Properties of a Quinolone Antibiotic, Fleroxacin, in Rat Choroid Plexus

Y. Sugiyama, T. Terasaki, T. Ooie, 1996, Pharmaceutical Research.

Analysis of Drug Efflux Systems in the Blood-brain and Blood-cerebrospinal Fluid Barriers

Hiroshi Suzuki, H. Suzuki, 2000 .

Determination of the Rate-Limiting Step in the Hepatic Elimination of YM796 by Isolated Rat Hepatocytes

Y. Sugiyama, Hiroshi Suzuki, T. Iwatsubo, 2004, Pharmaceutical Research.

Theoretical considerations on quantitative prediction of drug-drug interactions.

Akihiro Hisaka, Yoshiyuki Ohno, A. Hisaka, 2010, Drug metabolism and pharmacokinetics.

Comparative Studies on in Vitro Methods for Evaluating in Vivo Function of MDR1 P-Glycoprotein

Yuichi Sugiyama, Y. Sugiyama, Y. Adachi, 2001, Pharmaceutical Research.

Role of Breast Cancer Resistance Protein (Bcrp1/Abcg2) in the Extrusion of Glucuronide and Sulfate Conjugates from Enterocytes to Intestinal Lumen

Yuichi Sugiyama, Y. Sugiyama, Y. Adachi, 2005, Molecular Pharmacology.

In Vitro/in Vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

Y. Sugiyama, Kiyomi Ito, C. Tyson, 2001, Biopharmaceutics & drug disposition.

Prediction of Drug Transfer into Milk Considering Breast Cancer Resistance Protein (BCRP)-Mediated Transport

A. Hisaka, Kousei Ito, T. Takada, 2015, Pharmaceutical Research.

Assessment of Intestinal Availability (FG) of Substrate Drugs of Cytochrome P450s by Analyzing Changes in Pharmacokinetic Properties Caused by Drug–Drug Interactions

Mikiko Nakamura, A. Hisaka, Saori Koh, 2014, Drug Metabolism and Disposition.

A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility

N. Hamajima, K. Wakai, N. Shinomiya, 2013, Human Cell.

Common variant of PDZ domain containing 1 (PDZK1) gene is associated with gout susceptibility: A replication study and meta-analysis in Japanese population.

N. Shinomiya, M. Naito, S. Kawai, 2016, Drug metabolism and pharmacokinetics.

NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport.

Hiroshi Suzuki, T. Yoshikado, T. Takada, 2011, Gastroenterology.

Analysis of the Disposition of a Novel p38 MAPK Inhibitor, AKP-001, and Its Metabolites in Rats with a Simple Physiologically Based Pharmacokinetic Model

Akihiro Hisaka, A. Hisaka, Hiroshi Suzuki, 2015, Drug Metabolism and Disposition.

Quantitative Evaluation of the Function of Small Intestinal P-Glycoprotein: Comparative Studies Between in Situ and in Vitro

Y. Sugiyama, Y. Adachi, H. Suzuki, 2003, Pharmaceutical Research.

Principles of Pharmacokinetics: Predicting Human Pharmacokinetics in Drug Discovery

A. Hisaka, Takehito Yamamoto, H. Suzuki, 2011 .

Spontaneous Production of Glutathione-Conjugated Forms of 1,2-Dichloropropane: Comparative Study on Metabolic Activation Processes of Dihaloalkanes Associated with Occupational Cholangiocarcinoma

Hiroshi Suzuki, T. Takada, Y. Toyoda, 2017, Oxidative medicine and cellular longevity.

Effects of Osthol Isolated from Cnidium monnieri Fruit on Urate Transporter 1

Y. Kato, T. Makino, T. Takada, 2018, Molecules.

A New Physiologically Based Pharmacokinetic Model for the Prediction of Gastrointestinal Drug Absorption: Translocation Model

A. Hisaka, H. Ando, H. Suzuki, 2015, Drug Metabolism and Disposition.

A Proposal for a Pharmacokinetic Interaction Significance Classification System (PISCS) Based on Predicted Drug Exposure Changes and Its Potential Application to Alert Classifications in Product Labelling

Y. Sugiyama, A. Hisaka, M. Kusama, 2009, Clinical pharmacokinetics.

Utilization of ATP-depleted cells in t e analysis of tauroc by isolated rat hepatocytes

Y. Sugiyama, T. Iga, M. Yamazaki, 1992 .

Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P 4503A4

Y. Sugiyama, Kiyomi Ito, Hiroshi Suzuki, 1999, AAPS PharmSci.

Role of ABC transporters for the biliary excretion of organic anions

Y. Sugiyama, Takao Shimizu, K. Kume, 1996 .

Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients

Y. Kamatani, Y. Okada, T. Merriman, 2020, Annals of the Rheumatic Diseases.

Establishment of optimized in vitro assay methods for evaluating osteocyte functions

Masashi Honma, Yoshiaki Kariya, Yuki Ikebuchi, 2013, Journal of Bone and Mineral Metabolism.

Toxicological implications of hepatobiliary transporters.

Y. Sugiyama, Y. Kato, Hiroshi Suzuki, 2002, Toxicology.

BILIARY EXCRETION MECHANISM OF IRINOTECAN CPT-1 1 AND ITS METABOLITES IN HUMANS AND RATS: INVOLVEMENT OF cMOAT and P-gp

Y. Sugiyama, X. Chu, Y. Kato, 1998 .

Role of MRP family proteins in the export of organic anion compounds from liver and intestine

Y. Sugiyama, X. Chu, Takao Shimizu, 1997 .

Integrative and theoretical research on the architecture of a biological system and its disorder

H. Kitano, Y. Asai, Y. Kurachi, 2019, The Journal of Physiological Sciences.

Determinants of Intestinal Availability for P-glycoprotein Substrate Drugs Estimated by Extensive Simulation With Mathematical Absorption Models.

H. Hatakeyama, Hiroshi Suzuki, A. Hisaka, 2017, Journal of pharmaceutical sciences.

Quantitative Prediction of In Vivo Drug-drug Interactions from In Vitro Data : Effects of Active Transport of Inhibitors into the Liver

Y. Sugiyama, Kiyomi Ito, T. Iwatsubo, 2000 .

Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels

N. Osada, N. Shinomiya, T. Tamura, 2019, Annals of the rheumatic diseases.

Cholesterol-Lowering Effect of Ezetimibe in Uridine Diphosphate Glucuronosyltransferase 1A-Deficient (Gunn) Rats

Hiroshi Suzuki, Masashi Honma, Takehito Yamamoto, 2007, Drug Metabolism and Disposition.

GLYCOPROTEIN BY VALSPODAR IN GENE TRANSFECTANT SYSTEMS

Y. Sugiyama, Kiyomi Ito, Y. Kato, 2000 .

Ursodeoxycholic acid stimulates the formation of the bile canalicular network.

Hiroshi Suzuki, Kousei Ito, T. Yoshikado, 2012, Biochemical pharmacology.

Transfer Entropy Analysis of Information Flow in a Stock Market

Kiyoshi Izumi, Fujio Toriumi, F. Toriumi, 2017 .

Hepatic Niemann-Pick C1-Like 1 exacerbates non-alcoholic fatty liver disease by re-absorbing specific biliary oxysterols.

Hiroshi Suzuki, T. Takada, J. Shoda, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection

Yukiko Kurihara, Akiyo Matsumoto, Hiroyuki Aburatani, 1997, Nature.

Quantitative Prediction of in Vivo Profiles of CYP3A4 Induction in Humans from in Vitro Results with a Reporter Gene Assay

Masashi Honma, Masashi Honma, Hiroshi Suzuki, 2009, Drug Metabolism and Disposition.

Receptor for Activated C-Kinase 1 Regulates the Cell Surface Expression and Function of ATP Binding Cassette G2

Y. Kanai, N. Anzai, Hiroshi Suzuki, 2010, Drug Metabolism and Disposition.

Involvement of multidrug resistance-associated protein 2 in in vivo cisplatin resistance of rat hepatoma AH66 cells.

Y. Sugiyama, K. Miyamoto, M. Nomura, 2002, Anticancer research.

Excretion of GSSG and Glutathione Conjugates Mediated by MRP1 and CM0AT/MRP2

Y. Sugiyama, H. Suzuki, H. Suzuki, 1998, Seminars in liver disease.

Transporters for bile acids and organic anions.

Y. Sugiyama, H. Suzuki, H. Suzuki, 1999, Pharmaceutical biotechnology.

Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats.

Y. Sugiyama, K. Kume, H. Suzuki, 1998, Molecular pharmacology.

Characterization of inducible nature of MRP3 in rat liver.

Y. Sugiyama, T. Ishikawa, P. Meier, 2000, American journal of physiology. Gastrointestinal and liver physiology.

Bayesian estimation of pharmacokinetic parameters of vancomycin in patients with decreasing renal function.

Hiroshi Suzuki, A. Hisaka, Takehito Yamamoto, 2012, Journal of pharmaceutical sciences.

Transport of Drugs Across the Hepatic Sinusoidal Membrane: Sinusoidal Drug Influx and Efflux in the Liver

Y. Sugiyama, H. Suzuki, H. Suzuki, 2000, Seminars in liver disease.

Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.

Y. Sugiyama, Y. Kato, H. Suzuki, 1997, Cancer research.

Primary active transport of organic anions on bile canalicular membrane in humans.

Y. Sugiyama, Y. Kato, C. Tyson, 1999, The American journal of physiology.

ABCG2/BCRP Dysfunction as a Major Cause of Gout

N. Shinomiya, T. Hosoya, T. Takada, 2011, Nucleosides, nucleotides & nucleic acids.

Ethnic differences in ATP-binding cassette transporter, sub-family G, member 2 (ABCG2/BCRP): genotype combinations and estimated functions.

K. Wakai, N. Shinomiya, Hiroshi Suzuki, 2014, Drug metabolism and pharmacokinetics.

Peptide drugs accelerate BMP‐2‐induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling

Y. Tabata, K. Aoki, R. Murali, 2016, BioEssays : news and reviews in molecular, cellular and developmental biology.

Immunohistochemical and in situ hybridization study of urate transporters GLUT9/URATv1, ABCG2, and URAT1 in the murine brain

S. Shibata, Hiroshi Suzuki, N. Tomioka, 2016, Fluids and Barriers of the CNS.

Contribution of Protein Binding, Lipid Partitioning, and Asymmetrical Transport to Drug Transfer into Milk in Mouse Versus Human

A. Hisaka, Masashi Honma, T. Igarashi, 2013, Pharmaceutical Research.

Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice

K. Maeda, H. Kusuhara, Y. Sugiyama, 2015, Pharmaceutical Research.

Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.

Y. Sugiyama, H. Takikawa, H. Akita, 2001, Biochimica et biophysica acta.

Transport properties of 3′‐azido‐3′‐deoxythymidine and 2′,3′‐dideoxyinosine in the rat choroid plexus

Y. Sugiyama, K. Takasawa, H. Suzuki, 1997, Biopharmaceutics & drug disposition.

Distributed model analysis of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine distribution in brain tissue and cerebrospinal fluid.

Y. Sugiyama, T. Terasaki, H. Suzuki, 1997, The Journal of pharmacology and experimental therapeutics.

Kinetic analysis of the transport of the quinolone antibiotics across the blood-brain barrier and blood-CSF barrier

Y. Sugiyama, T. Terasaki, T. Ooie, 1993 .

Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter

Shingo Suzuki, M. Suico, T. Shuto, 2014, Scientific Reports.

LXR Alpha Transactivates Mouse Organic Solute Transporter Alpha and Beta via IR-1 Elements Shared with FXR

H. Fujii, Hiroshi Suzuki, T. Takada, 2007, Pharmaceutical Research.

Chapter 23 – Azobenzenes and Related Compounds

Hiroshi Suzuki, H. Suzuki, 1967 .

Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR.

Y. Sugiyama, Takao Shimizu, K. Kume, 1997, The American journal of physiology.

Comparative hepatic transport of desglycylated and cyclic metabolites of rilmazafone in rats: Analysis by multiple indicator dilution method

Y. Sugiyama, S. Miyauchi, H. Suzuki, 1993, Biopharmaceutics & drug disposition.

Biliary excretion mechanism of CPT-11 and its metabolites in humans: involvement of primary active transporters.

Y. Sugiyama, X. Chu, Y. Kato, 1998, Cancer research.

Integrative and theoretical research on the architecture of a biological system and its disorder

Yoshiyuki Asai, Hiroaki Kitano, Hiroshi Suzuki, 2019, The Journal of Physiological Sciences.

HNF4α is a Crucial Modulator of the Cholesterol-Dependent Regulation of NPC1L1

Hiroshi Suzuki, T. Takada, Y. Iwayanagi, 2008, Pharmaceutical Research.

Apolipoproteins and lipoprotein receptors in glomeruli in human kidney diseases.

T. Kodama, H. Itakura, Hiroshi Suzuki, 1993, Kidney international.

Active efflux of CPT-11 and its metabolites in human KB-derived cell lines.

Y. Sugiyama, X. Chu, S. Akiyama, 1999, The Journal of pharmacology and experimental therapeutics.

VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body

Y. Masuo, M. Harada‐Shiba, Hiroshi Suzuki, 2017, Scientific Reports.

Where should we go?

H. Suzuki, 2012, Drug metabolism and pharmacokinetics.

Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice.

T. Kodama, K. V. van Dijk, R. Frants, 1999, Atherosclerosis.

Na(+)-independent multispecific anion transporter mediates active transport of pravastatin into rat liver.

Y. Sugiyama, H. Suzuki, M. Yamazaki, 1993, The American journal of physiology.

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine.

Y. Sugiyama, H. Suzuki, H Suzuki, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

HNF4alpha is a crucial modulator of the cholesterol-dependent regulation of NPC1L1.

Hiroshi Suzuki, T. Takada, Y. Iwayanagi, 2008, Pharmaceutical research.

Mechanisms of Niemann-Pick type C1 Like 1 protein degradation in intestinal epithelial cells.

P. Malhotra, W. Alrefai, P. Dudeja, 2019, American journal of physiology. Cell physiology.

Colocalization of scavenger receptor in CD68 positive foam cells in verruciform xanthoma.

T. Kodama, M. Furue, H. Sugiyama, 1995, Journal of dermatological science.

The role of P-glycoprotein and canalicular multispecific organic anion transporter in the hepatobiliary excretion of drugs.

H. Kusuhara, Y. Sugiyama, H. Suzuki, 1998, Journal of pharmaceutical sciences.

Identification of ABCG2 Dysfunction as a Major Factor Contributing to Gout

N. Shinomiya, Y. Kanai, Y. Sakurai, 2011, Nucleosides, nucleotides & nucleic acids.

Lack of Improvement of Oral Absorption of ME3277 by Prodrug Formation Is Ascribed to the Intestinal Efflux Mediated by Breast Cancer Resistant Protein (BCRP/ABCG2)

Yuichi Sugiyama, Chihiro Kondo, Hiroyuki Kusuhara, 2005, Pharmaceutical Research.

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes

A. Takahashi, N. Hamajima, N. Shinomiya, 2015, Annals of the rheumatic diseases.

Species differences in the transport activity for organic anions across the bile canalicular membrane.

Y. Sugiyama, Kumiko Konno, H. Suzuki, 1999, The Journal of pharmacology and experimental therapeutics.

Molecular cloning and nucleotide sequencing of nuclear genes coding for the chloroplast ribosomal proteins L13, L24, L28 of rice (Oryza sativa L.)

N. Tsutsumi, Hiroshi Suzuki, A. Hirai, 1996 .

Receptor for activated C‐kinase 1 regulates the cellular localization and function of ABCB4

Y. Kanai, N. Anzai, Kousei Ito, 2009, Hepatology research : the official journal of the Japan Society of Hepatology.

Molecular mechanisms of membrane transport of vitamin E.

T. Takada, H. Suzuki, 2010, Molecular nutrition & food research.

In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers

T. Takada, Y. Yamanashi, H. Suzuki, 2009, Pharmacogenetics and genomics.

Effect of mixing method on the mixing degree during the preparation of triturations.

T. Iga, F. Komada, Y. Yanagihara, 2004, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain.

H. Kusuhara, Y. Sugiyama, H. Suzuki, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Clinical Importance of Drug-Drug Interaction Between Warfarin and Prednisolone and Its Potential Mechanism in Relation to the Niemann-Pick C1-Like 1-Mediated Pathway.

T. Takada, Sayo M Ito, H. Suzuki, 2019, Circulation Journal.