M. Hughes

发表

CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid

M. P. Hughes, D. Eisenberg, M. Sawaya, 2020, Nature Communications.

The Amyloid State of Proteins

E. L. Guenther, David Eisenberg, Meytal Landau, 2015 .

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle

Aaron M. Johnson, D. Eisenberg, R. Parker, 2018, Nature.

The α-synuclein hereditary mutation E46K unlocks a more stable, pathogenic fibril structure

D. Eisenberg, M. Sawaya, Chuanqi Sun, 2019, Proceedings of the National Academy of Sciences.

The cryoEM structure of the fibril-forming low-complexity domain of hnRNPA2 reveals distinct differences from pathogenic amyloid and shows how mutation converts it to the pathogenic form

D. Eisenberg, M. Sawaya, D. Cascio, 2020, bioRxiv.

The expanding amyloid family: Structure, stability, function, and pathogenesis

D. Eisenberg, R. Riek, José A. Rodríguez, 2021, Cell.

Identifying amyloid-related diseases by mapping mutations in low-complexity protein domains to pathologies

M. P. Hughes, D. Eisenberg, L. Salwínski, 2022, Nature Structural & Molecular Biology.

Atomic Structures of Segments from TDP-43 LCD and insight into Reversible and Pathogenic Aggregation

E. L. Guenther, D. Eisenberg, José A. Rodríguez, 2018, Nature Structural & Molecular Biology.

Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks

M. P. Hughes, D. Eisenberg, José A. Rodríguez, 2018, Science.

Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta

D. Eisenberg, M. Landau, Minglei Zhao, 2013, eLife.

DNA Facilitates Oligomerization and Prevents Aggregation via DNA Networks.

S. Horowitz, B. Docter, Jennifer N. Bourne, 2019, Biophysical journal.

A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins

Jakub W. Wojciechowski, Jianfeng Pei, P. Roy, 2022, bioRxiv.

Correction: Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta

M. P. Hughes, D. Eisenberg, M. Landau, 2013, eLife.

Bioinformatic identification of previously unrecognized amyloidogenic proteins

M. P. Hughes, L. Salwínski, R. Abskharon, 2022, The Journal of Biological Chemistry.

Bioinformatic identification of previously unrecognized amyloidogenic proteins

M. P. Hughes, D. Eisenberg, L. Salwínski, 2022, The Journal of biological chemistry.

Atomic Structures of Segments from TDP-43 LCD and insight into Reversible and Pathogenic Aggregation

E. L. Guenther, D. Eisenberg, José A. Rodríguez, 2018, Nature Structural & Molecular Biology.

Atomic structures of corkscrew‐forming segments of SOD1 reveal varied oligomer conformations

M. Sawaya, S. Sangwan, K. Murray, 2018, Protein science : a publication of the Protein Society.

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication

Vineet D. Menachery, S. Weaver, S. Schultz-Cherry, 2023, bioRxiv.

Extended β-Strands Contribute to Reversible Amyloid Formation.

M. P. Hughes, D. Eisenberg, M. Sawaya, 2022, ACS nano.

Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils

D. Eisenberg, Lukasz Goldschmidt, M. Hughes, 2021, The Journal of biological chemistry.

Protein structure in reversible amyloid formed by low-complexity regions

M. Hughes, 2018 .

Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.

E. L. Guenther, D. Eisenberg, M. Sawaya, 2018 .

The prevalence and distribution in genomes of low-complexity, amyloid-like, reversible, kinked segment (LARKS), a common structural motif in amyloid-like fibrils

M. P. Hughes, D. Eisenberg, L. Goldschmidt, 2020, bioRxiv.

Low-complexity domains adhere by reversible amyloid-like interactions between kinked β-sheets

D. Eisenberg, José A. Rodríguez, M. Sawaya, 2017, bioRxiv.

Cryo-EM structures of the D290V mutant of the hnRNPA2 low-complexity domain suggests how D290V affects phase separation and aggregation

M. Sawaya, D. Cascio, R. Abskharon, 2023, The Journal of biological chemistry.

of Previously Unrecognized Amyloidogenic Proteins

T. Gonen, D. Cascio, D. Boyer, 2022 .