Chengguo Xing

发表

Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappaB inhibitors and their anticancer activities.

B. Srinivasan, C. Xing, T. E. Johnson, 2009, Journal of medicinal chemistry.

Chalcone: A Privileged Structure in Medicinal Chemistry.

C. Xing, Zhenyuan Miao, Wannian Zhang, 2017, Chemical reviews.

Penta-O-galloyl-β-D-glucose induces G1 arrest and DNA replicative S-phase arrest independently of P21 cyclin-dependent kinase inhibitor 1A, P27 cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple-negative xenograft growth

Soo-Jin Jeong, Sung-Hoon Kim, J. Lü, 2010, Breast Cancer Research.

Structure-based molecular hybridization design of Keap1-Nrf2 inhibitors as novel protective agents of acute lung injury.

Wannian Zhang, Lijuan Xu, Chunlin Zhuang, 2021, European journal of medicinal chemistry.

Diverse Molecular Targets for Chalcones with Varied Bioactivities

C. Xing, Bo Zhou, Chengguo Xing, 2015, Medicinal chemistry.

Overexpression of Mcl-1 Confers Multidrug Resistance, Whereas Topoisomerase IIβ Downregulation Introduces Mitoxantrone-Specific Drug Resistance in Acute Myeloid Leukemia

Yunfang Li, S. Das, David L. Hermanson, 2013, Molecular Pharmacology.

Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives.

C. Xing, Wannian Zhang, Lijuan Xu, 2019, Journal of medicinal chemistry.

Dual Mechanisms of sHA 14-1 in Inducing Cell Death through Endoplasmic Reticulum and Mitochondria

David D. Thomas, T. Lebien, J. Marchant, 2009, Molecular Pharmacology.

sHA 14-1, a stable and ROS-free antagonist against anti-apoptotic Bcl-2 proteins, bypasses drug resistances and synergizes cancer therapies in human leukemia cell.

Jun Peng, Jialing Lin, C. Xing, 2008, Cancer letters.

A detection system based on giant magnetoresistive sensors and high-moment magnetic nanoparticles demonstrates zeptomole sensitivity: potential for personalized medicine.

Jian-Ping Wang, Ying Jing, Xiaofeng Yao, 2009, Angewandte Chemie.

Small molecules inhibiting Keap1-Nrf2 protein-protein interactions: a novel approach to activate Nrf2 function.

Zhenyuan Miao, Chunlin Zhuang, Zhongli Wu, 2017, MedChemComm.

Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway.

Zhenyuan Miao, Jianzhong Yao, Wannian Zhang, 2014, Journal of medicinal chemistry.

The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers

D. Hatsukami, R. Salloum, S. Hecht, 2020, Cancer Prevention Research.

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.

S. Hecht, M. G. O’Sullivan, S. Balbo, 2014, Carcinogenesis.

Kava Blocks 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone–Induced Lung Tumorigenesis in Association with Reducing O6-methylguanine DNA Adduct in A/J Mice

S. Hecht, M. G. O’Sullivan, S. Balbo, 2014, Cancer Prevention Research.

Direct inhibition of Keap1-Nrf2 Protein-Protein interaction as a potential therapeutic strategy for Alzheimer's disease.

Wannian Zhang, Hao Shang, Ling He, 2020, Bioorganic chemistry.

Chemopreventive Effects of Korean Angelica versus Its Major Pyranocoumarins on Two Lineages of Transgenic Adenocarcinoma of Mouse Prostate Carcinogenesis

Sung-Hoon Kim, Cheng Jiang, J. Lü, 2015, Cancer Prevention Research.

Oral dosing of dihydromethysticin ahead of tobacco carcinogen NNK effectively prevents lung tumorigenesis in A/J mice.

S. Hecht, M. G. O’Sullivan, P. Upadhyaya, 2020, Chemical research in toxicology.

A new chalcone derivative (E)-3-(4-methoxyphenyl)-2-methyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one suppresses prostate cancer involving p53-mediated cell cycle arrests and apoptosis.

J. Lü, B. Srinivasan, Yong Zhang, 2012, Anticancer research.

LKB1 phosphorylation and deactivation in lung cancer by NNAL, a metabolite of tobacco-specific carcinogen, in an isomer-dependent manner

Z. Huo, R. Salloum, A. Zingone, 2022, Oncogene.

NNAL, a major metabolite of tobacco-specific carcinogen NNK, promotes lung cancer progression through deactivating LKB1 in an isomer-dependent manner

A. Zingone, B. Ryan, Yuzhi Wang, 2021, bioRxiv.

After Embedding in Membranes Antiapoptotic Bcl-XL Protein Binds Both Bcl-2 Homology Region 3 and Helix 1 of Proapoptotic Bax Protein to Inhibit Apoptotic Mitochondrial Permeabilization*

D. Andrews, B. Mooers, Zhi Zhang, 2014, The Journal of Biological Chemistry.

A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML.

R. Cornea, N. Bleeker, Chengguo Xing, 2013, Molecular pharmaceutics.

Inhibition of mitogen activated protein kinases increases the sensitivity of A549 lung cancer cells to the cytotoxicity induced by a kava chalcone analog.

E. Wattenberg, B. Srinivasan, N. Zeliadt, 2012, Biochemical and biophysical research communications.

Kava as a Clinical Nutrient: Promises and Challenges

R. Salloum, A. C. Liu, Yuzhi Wang, 2020, Nutrients.

CXL146, a Novel 4H-Chromene Derivative, Targets GRP78 to Selectively Eliminate Multidrug-Resistant Cancer Cells

C. Vulpe, C. Xing, A. Tagmount, 2020, Molecular Pharmacology.

Reducing Chemotherapy-Induced DNA Damage via nAChR-Mediated Redox Reprograming—A New Mechanism for SCLC Chemoresistance Boosted by Nicotine

F. Kaye, Z. Huo, G. Warren, 2022, Cancers.

Chemopreventive effect of Korean Angelica root extract on TRAMP carcinogenesis and integrative “omic” profiling of affected neuroendocrine carcinomas

Sung-Hoon Kim, Cheng Jiang, J. Lü, 2015, Molecular carcinogenesis.

Reduction in Colon Cancer Risk by Consumption of Kava or Kava Fractions in Carcinogen-Treated Rats

M. G. O’Sullivan, D. Gallaher, Ahmad Ali Shaik, 2012, Nutrition and cancer.

Gene expression signatures associated with suppression of TRAMP prostate carcinogenesis by a kavalactone‐rich Kava fraction

Cheng Jiang, J. Lü, M. G. O’Sullivan, 2016, Molecular carcinogenesis.

Exploring the Structure-Activity Relationship and Mechanism of a Chromene Scaffold (CXL Series) for Its Selective Antiproliferative Activity toward Multidrug-Resistant Cancer Cells.

Haifeng Sun, C. Xing, C. Cogle, 2018, Journal of medicinal chemistry.

4H-Chromene-based anticancer agents towards multi-drug resistant HL60/MX2 human leukemia: SAR at the 4th and 6th positions.

C. Xing, Bo Zhou, G. Aridoss, 2016, Bioorganic & medicinal chemistry.

Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy.

Yunfang Li, C. Xing, A. Kelekar, 2013, ACS chemical biology.

Structure-activity relationship (SAR) study of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the potential of the lead against multidrug resistance in cancer treatment.

C. Xing, Bo Zhou, G. Aridoss, 2012, Journal of medicinal chemistry.

Structure-activity relationship and molecular mechanisms of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and its analogues.

W. T. Beck, B. Srinivasan, C. Xing, 2011, Journal of medicinal chemistry.

Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues.

B. Srinivasan, C. Xing, S. Das, 2009, Journal of medicinal chemistry.

Single Oral Dose Pharmacokinetics of Decursin, Decursinol Angelate, and Decursinol in Rats

Sung-Hoon Kim, J. Lü, Jinhui Zhang, 2013, Planta Medica.

Characterization of the Fluorescence Properties of 4‐Dialkylaminochalcones and Investigation of the Cytotoxic Mechanism of Chalcones

C. Xing, Bo Zhou, Junxuan Lu, 2016, Archiv der Pharmazie.

In Vitro Metabolism of Pyranocoumarin Isomers Decursin and Decursinol Angelate by Liver Microsomes from Man and Rodents

Sung-Hoon Kim, Cheng Jiang, J. Lü, 2013, Planta Medica.

Prostate Cancer Xenograft Inhibitory Activity and Pharmacokinetics of Decursinol, a Metabolite of Angelica gigas Pyranocoumarins, in Mouse Models.

Cheng Jiang, J. Lü, T. Cooper, 2017, The American Journal of Chinese Medicine.

Cytochrome P450 Isoforms in the Metabolism of Decursin and Decursinol Angelate from Korean Angelica.

Cheng Jiang, J. Lü, C. Xing, 2015, The American journal of Chinese medicine.

Cancer Chemoprevention with Korean Angelica: Active Compounds, Pharmacokinetics, and Human Translational Considerations

Cheng Jiang, J. Lü, Jinhui Zhang, 2015, Current Pharmacology Reports.

Pyranocoumarin Tissue Distribution, Plasma Metabolome and Prostate Transcriptome Impacts of Sub-Chronic Exposure to Korean Angelica Supplement in Mice.

Cheng Jiang, J. Lü, C. Xing, 2016, The American journal of Chinese medicine.

Single Oral Dose Pharmacokinetics of Decursin and Decursinol Angelate in Healthy Adult Men and Women

Cheng Jiang, J. Lü, T. Hale, 2015, PloS one.

Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds.

Sung-Hoon Kim, Cheng Jiang, J. Lü, 2012, Anti-cancer agents in medicinal chemistry.

Quantitative determination of decursin, decursinol angelate, and decursinol in mouse plasma and tumor tissue using liquid-liquid extraction and HPLC.

Sung-Hoon Kim, J. Lü, Lei Wang, 2012, Planta medica.

Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIPL degradation, Ripoptosome formation and autophagy-mediated apoptosis

T. Nyunoya, Y. Lin, Junho Jang, 2015, Oncotarget.

A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy

X. Gou, Han-Ming Shen, B. Srinivasan, 2013, Oncogene.

Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis.

Courtney C Aldrich, C. Xing, C. Aldrich, 2008, Journal of medicinal chemistry.

Kava for the treatment of generalised anxiety disorder (K-GAD): study protocol for a randomised controlled trial

A. Scholey, R. Teschke, C. Suo, 2015, Trials.

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice.

Haifeng Sun, S. Hecht, M. G. O’Sullivan, 2017, Journal of medicinal chemistry.

Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O6-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice.

C. Baglole, C. Xing, P. Upadhyaya, 2016, Chemical research in toxicology.

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

S. Hecht, S. Murphy, P. Upadhyaya, 2016, Drug Metabolism and Disposition.

Chemopreventive Effect of Kava on 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone plus Benzo[a]pyrene–Induced Lung Tumorigenesis in A/J Mice

T. Hanson, S. Hecht, M. G. O’Sullivan, 2007, Cancer Prevention Research.

Diets, Phytochemicals, and Chemoprevention of Tumorigenesis

P. Limburg, T. E. Johnson, Chengguo Xing, 2008, Journal of dietary supplements.

Design, synthesis, and enzymatic characterization of quinazoline-based CYP1A2 inhibitors.

C. Xing, Jordy F. Botello, Pedro Corral, 2019, Bioorganic & medicinal chemistry letters.

Detection and quantification of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) from smoker albumin and its potential as a surrogate biomarker of tobacco-specific nitrosamines exposure and bioactivation.

N. Fujioka, Yi Wang, S. Narayanapillai, 2019, Toxicology letters.

Contribution of Tobacco Use and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone to Three Methyl DNA Adducts in Urine.

N. Fujioka, Yi Wang, S. Narayanapillai, 2018, Chemical research in toxicology.

Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice.

S. Hecht, Lei Wang, M. G. O’Sullivan, 2011, The American journal of Chinese medicine.

Clinical pharmacokinetics of kavalactones after oral dosing of standardized kava extract in healthy volunteers.

C. McCurdy, Abhisheak Sharma, Robyn Nelson, 2022, Journal of ethnopharmacology.

Characterization of different forms of kava (Piper methysticum) products by UPLC-MS/MS

C. McCurdy, Abhisheak Sharma, K. S. Raju, 2021, Planta Medica.

Kava and its Kavalactones Inhibit Norepinephrine-induced Intracellular Calcium Influx in Lung Cancer Cells

C. Xing, Tengfei Bian, Jordy F. Botello, 2019, Planta Medica.

A stable isotope dilution tandem mass spectrometry method of major kavalactones and its applications

B. Avery, C. Xing, S. Eans, 2018, PloS one.

Measuring the Chemical and Cytotoxic Variability of Commercially Available Kava (Piper methysticum G. Forster)

Amanda C. Martin, C. Xing, A. Hegeman, 2014, PloS one.

Flavokawains A and B in Kava, Not Dihydromethysticin, Potentiate Acetaminophen-Induced Hepatotoxicity in C57BL/6 Mice

C. Xing, S. Narayanapillai, P. Leitzman, 2014, Chemical research in toxicology.

Identification of methysticin as a potent and non-toxic NF-kappaB inhibitor from kava, potentially responsible for kava's chemopreventive activity.

C. Xing, David L. Hermanson, Ahmad Ali Shaik, 2009, Bioorganic & medicinal chemistry letters.

Quantitative profiling of cortisol metabolites in human urine by high-resolution accurate-mass MS.

C. Xing, N. Fujioka, Yi Wang, 2018, Bioanalysis.

An Indole-Chalcone Inhibits Multidrug-Resistant Cancer Cell Growth by Targeting Microtubules.

Y. Sham, D. Odde, John K. Lee, 2018, Molecular pharmaceutics.

Investigating miR-9 as a mediator in laryngeal cancer health disparities

Tongjun Gu, Mingyi Xie, R. Renne, 2023, Frontiers in Oncology.

Nanomagnetic competition assay for low-abundance protein biomarker quantification in unprocessed human sera.

Jian-Ping Wang, Ying Jing, Xiaofeng Yao, 2010, Journal of the American Chemical Society.

Angelica gigas: Signature Compounds, In Vivo Anticancer, Analgesic, Neuroprotective and Other Activities, and the Clinical Translation Challenges.

J. Raman, Cheng Jiang, J. Lü, 2022, The American journal of Chinese medicine.

Identification of GAPDH as a protein target of the saframycin antiproliferative agents.

C. Xing, A. Myers, J. Barbay, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1.

Y. Sham, Xiaohu Tang, C. Xing, 2007, Bioorganic & medicinal chemistry.

Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles.

David D. Thomas, G. He, Ji Li, 2016, Biochemical and biophysical research communications.

Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides.

Guodong Liu, C. Xing, Lijuan Xu, 2022, Journal of medicinal chemistry.

Autophagy‐Mediated Degradation of IAPs and c‐FLIPL Potentiates Apoptosis Induced by Combination of TRAIL and Chal‐24

T. Nyunoya, X. Gou, Y. Lin, 2016, Journal of cellular biochemistry.

SERCA as a target for cancer therapies

D. Casemore, Chengguo Xing, 2015 .

Preparation of penta-O-galloyl-β-D-glucose from tannic acid and plasma pharmacokinetic analyses by liquid-liquid extraction and reverse-phase HPLC.

Sung-Hoon Kim, J. Lü, Lei Wang, 2011, Journal of pharmaceutical and biomedical analysis.

Ethyl-2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H- chromene-3-carboxylate (HA 14-1), a prototype small-molecule antagonist against antiapoptotic Bcl-2 proteins, decomposes to generate reactive oxygen species that induce apoptosis.

C. Xing, Jignesh M. Doshi, Defeng Tian, 2007, Molecular pharmaceutics.

Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer.

C. Xing, Jignesh M. Doshi, Defeng Tian, 2006, Journal of medicinal chemistry.

Chalcone-based inhibitors against hypoxia-inducible factor 1--structure activity relationship studies.

B. Srinivasan, C. Xing, T. E. Johnson, 2011, Bioorganic & medicinal chemistry letters.

WL-276, an antagonist against Bcl-2 proteins, overcomes drug resistance and suppresses prostate tumor growth.

J. Slaton, Liangyou Wang, Defeng Tian, 2008, Cancer research.

Rapid identification of Keap1-Nrf2 small-molecule inhibitors through structure-based virtual screening and hit-based substructure search.

Y. Sham, Wannian Zhang, Chunlin Zhuang, 2014, Journal of medicinal chemistry.

Single Oral Dose Pharmacokinetics of Decursin and Decursinol Angelate in Healthy Adult Men and Women

Cheng Jiang, J. Lü, T. Hale, 2015, PloS one.

4H-Chromene-based anticancer agents towards multi-drug resistant HL60/MX2 human leukemia: SAR at the 4th and 6th positions.

Bo Zhou, G. Aridoss, Xinghua Zhao, 2016, Bioorganic & Medicinal Chemistry.

Structure-activity relationship and molecular mechanisms of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and its analogues.

W. T. Beck, B. Srinivasan, R. Tang, 2011, Journal of medicinal chemistry.

Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues.

B. Srinivasan, S. Das, Jignesh M. Doshi, 2009, Journal of medicinal chemistry.

A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo

Wei Zhang, Sung-Hoon Kim, Cheng Jiang, 2012, Investigational New Drugs.

Antagonists Against Anti-Apoptotic Bcl-2 Family Proteins for Cancer Treatment.

Jignesh M. Doshi, Chengguo Xing, 2008 .

Diallyl Disulfide Blocks Cigarette Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced Lung Tumorigenesis via Activation of the Nrf2 Antioxidant System and Suppression of NF-κB Inflammatory Response.

Wannian Zhang, Chunlin Zhuang, Zhuo Qu, 2023, Journal of agricultural and food chemistry.

Development of dimeric modulators for anti-apoptotic Bcl-2 proteins.

D. Andrews, Liangyou Wang, F. Kong, 2008, Bioorganic & medicinal chemistry letters.

Autophagy‐Mediated Degradation of IAPs and c‐FLIPL Potentiates Apoptosis Induced by Combination of TRAIL and Chal‐24

T. Nyunoya, X. Gou, Y. Lin, 2016, Journal of cellular biochemistry.

Diets, Phytochemicals, and Chemoprevention of Tumorigenesis

P. Limburg, T. E. Johnson, Chengguo Xing, 2008, Journal of dietary supplements.

Unambiguous Identification of β‐Tubulin as the Direct Cellular Target Responsible for the Cytotoxicity of Chalcone by Photoaffinity Labeling

P. Villalta, Bo Zhou, Y. Lin, 2016, ChemMedChem.