E. Johnson

发表

Evidence of a Novel Event during Neuronal Death Development of Competence-to-Die in Response to Cytoplasmic Cytochrome c

Eugene M. Johnson, M. Deshmukh, E. Johnson, 1998, Neuron.

Why do neurons die when deprived of trophic factor?

D. P. Martin, Eugene M. Johnson, T. Koike, 1989, Neurobiology of Aging.

Expression and function of GDNF family ligands and receptors in the carotid body

J. Milbrandt, Leo H. Wang, M. Leitner, 2005, Experimental Neurology.

A “calcium set-point hypothesis” of neuronal dependence on neurotrophic factor

J. Franklin, T. Koike, E. Johnson, 1992, Experimental Neurology.

Expression and possible function of nerve growth factor receptors on Schwann cells

P. Distefano, Eugene M. Johnson, M. Taniuchi, 1988, Trends in Neurosciences.

Destruction of the sympathetic nervous system in neonatal rats and hamsters by vinblastine: prevention by concomitant administration of nerve growth factor

Eugene M. Johnson, E. Johnson, 1978, Brain Research.

Intrinsic and extrinsic pathway signaling during neuronal apoptosis

Charles A. Harris, K. Moulder, Eugene M. Johnson, 2002, The Journal of cell biology.

Transplantation of embryonic stem cells overexpressing Bcl-2 promotes functional recovery after transient cerebral ischemia

Ling Wei, D. Gottlieb, D. Choi, 2005, Neurobiology of Disease.

Caspase Inhibition Extends the Commitment to Neuronal Death Beyond Cytochrome c Release to the Point of Mitochondrial Depolarization

Eugene M. Johnson, K. Kuida, M. Deshmukh, 2000, The Journal of cell biology.

Artemin Is a Vascular-Derived Neurotropic Factor for Developing Sympathetic Neurons

J. Milbrandt, Eugene M. Johnson, A. Bruce, 2002, Neuron.

Gene Targeting Reveals a Critical Role for Neurturin in the Development and Maintenance of Enteric, Sensory, and Parasympathetic Neurons

J. Milbrandt, Eugene M. Johnson, W. Snider, 1999, Neuron.

Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex

J. Milbrandt, Eugene M. Johnson, H. Enomoto, 1998, Neuron.

Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

R. Vejsada, C. Henderson, J. Milbrandt, 1998, Neuron.

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

S. Estus, Eugene M. Johnson, R. Freeman, 1994, Neuron.

Presenilin-1 Protects against Neuronal Apoptosis Caused by Its Interacting Protein PAG

A. Goate, Jane Y. Wu, Eugene M. Johnson, 2002, Neurobiology of Disease.

Neurotrophin and GDNF family ligands promote survival and alter excitotoxic vulnerability of neurons derived from murine embryonic stem cells

D. Gottlieb, Eugene M. Johnson, D. Choi, 2005, Experimental Neurology.

Cyclosporin A inhibits caspase-independent death of NGF-deprived sympathetic neurons

Eugene M. Johnson, Louis K. Chang, E. Johnson, 2002, The Journal of cell biology.

Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: role in neurodegenerative diseases.

D. S. Zahm, W. Burke, Eugene M. Johnson, 2004, Neurotoxicology.

Events that Commit Neurons to Die After Trophic Factor Deprivation

Eugene M. Johnson, M. Deshmukh, G. Putcha, 2001 .

Catecholamine-Derived Aldehyde Neurotoxins

D. S. Zahm, W. Burke, Eugene M. Johnson, 2000 .

BAX Translocation Is a Critical Event in Neuronal Apoptosis: Regulation by Neuroprotectants, BCL-2, and Caspases

Eugene M. Johnson, M. Deshmukh, G. Putcha, 1999, The Journal of Neuroscience.

Placement of the BCL2 Family Member BAX in the Death Pathway of Sympathetic Neurons Activated by Trophic Factor Deprivation

S. Korsmeyer, Eugene M. Johnson, C. Knudson, 1998, Experimental Neurology.

Alternating metabolic pathways in NGF-deprived sympathetic neurons affect caspase-independent death

R. Schmidt, Eugene M. Johnson, Louis K. Chang, 2003, The Journal of cell biology.

BAX Is Required for Neuronal Death after Trophic Factor Deprivation and during Development

S. Korsmeyer, Eugene M. Johnson, W. Snider, 1996, Neuron.

Chronic guanethidine treatment increases cardiac β-adrenergic receptors

R. Lefkowitz, Eugene M. Johnson, B. Weiss, 1978, Nature.

Role of BCL-2 in the survival and function of developing and mature sympathetic neurons

S. Korsmeyer, Eugene M. Johnson, L. Greenlund, 1995, Neuron.

Molecular genetics of neuronal survival

Eugene M. Johnson, W. Snider, L. Greenlund, 1995, Current Opinion in Neurobiology.

Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death

Eugene M. Johnson, T. Deckwerth, L. Greenlund, 1995, Neuron.

Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis

J. Milbrandt, C. Naughton, Eugene M. Johnson, 2004, Development.

Exogenous Smac Induces Competence and Permits Caspase Activation in Sympathetic Neurons

Xiaodong Wang, Eugene M. Johnson, M. Deshmukh, 2002, The Journal of Neuroscience.

MIXED LINEAGE KINASE INHIBITOR CEP- 1347 FAILS TO DELAY DISABILITY IN EARLY PARKINSON DISEASE

Eugene M. Johnson, Eugene M Johnson, Leo H Wang, 2008, Neurology.

Analysis of Events Leading to Neuronal Death after Infection with E1-Deficient Adenoviral Vectors

Eugene M. Johnson, D. Creedon, R. Easton, 1998, Molecular and Cellular Neuroscience.

Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis

K. Moulder, A. Strasser, Eugene M. Johnson, 2001, Neuron.

Lipid rafts in neuronal signaling and function

J. Milbrandt, Eugene M. Johnson, M. Encinas, 2002, Trends in Neurosciences.

NGF Utilizes c-Ret Via a Novel GFL-Independent, Inter-RTK Signaling Mechanism to Maintain the Trophic Status of Mature Sympathetic Neurons

J. Milbrandt, Eugene M. Johnson, B. Tsui-Pierchala, 2002, Neuron.

The Biology of Nerve Growth Factor in Vivo

C. Wilcox, P. Manning, E. Johnson, 1988 .

Species and structural specificity of the lipopigment accumulation and neuronal destruction induced by N-(2-guanidinoethyl)-4-methyl-1,2,5,6-tetrahydropyridine (guanacline)

R. Rydel, M. Palmatier, P. Manning, 1986, Brain Research.

Protection from guanethidine-induced neuronal destruction by nerve growth factor: Effect of NGF on immune function

Eugene M. Johnson, J. Russell, P. Manning, 1985, Brain Research.

Guanethidine-Induced Destruction of Sympathetic Neurons: An Autoimmune "Disease" Prevented by Nerve Growth Factor

P. Manning, E. Johnson, 1984 .

Mixed-lineage kinases: a target for the prevention of neurodegeneration.

Eugene M. Johnson, Eugene M Johnson, Leo H Wang, 2004, Annual review of pharmacology and toxicology.

Bax Deletion Further Orders the Cell Death Pathway in Cerebellar Granule Cells and Suggests a Caspase-independent Pathway to Cell Death

S. Korsmeyer, K. Moulder, Eugene M. Johnson, 1997, The Journal of cell biology.

Cell death genes in invertebrates and (maybe) vertebrates

S. Estus, Eugene M. Johnson, R. Freeman, 1993, Current Opinion in Neurobiology.

Glial Cell Line-Derived Neurotrophic Factor Promotes the Survival of Early Postnatal Spinal Motor Neurons in the Lateral and Medial Motor Columns in Slice Culture

J. Milbrandt, Eugene M. Johnson, W. Rakowicz, 2002, The Journal of Neuroscience.

Inhibition of Apoptotic Signaling Cascades Causes Loss of Trophic Factor Dependence during Neuronal Maturation

Eugene M. Johnson, M. Deshmukh, G. Putcha, 2000, The Journal of cell biology.

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

R. Schreiber, Eugene M. Johnson, S. Rodig, 1998, Cell.

Neurturin and persephin promote the survival of embryonic basal forebrain cholinergic neurons in vitro

J. Milbrandt, J. Golden, E. Johnson, 2003, Experimental Neurology.

The GDNF family ligands and receptors — implications for neural development

Hideki Enomoto, J. Milbrandt, Eugene M. Johnson, 2000, Current Opinion in Neurobiology.

Expression of Neurturin, GDNF, and GDNF Family-Receptor mRNA in the Developing and Mature Mouse

J. Milbrandt, Eugene M. Johnson, J. Demaro, 1999, Experimental Neurology.

Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: Support for nigral targeting in Parkinson's disease

Eugene M. Johnson, J. Kordower, R. Bartus, 2011, Neurobiology of Disease.

TrnR2, a Novel Receptor That Mediates Neurturin and GDNF Signaling through Ret

J. Milbrandt, Eugene M. Johnson, D. Zimonjic, 1997, Neuron.

Neurturin, a relative of glial-cell-line-derived neurotrophic factor

J. Milbrandt, Eugene M. Johnson, R. Heuckeroth, 1996, Nature.

Localization of FGF receptor mRNA in the adult rat central nervous system by in situ hybridization

Eugene M. Johnson, A. Wanaka, E. Johnson, 1990, Neuron.

Relationship of referral source, race, and wait time on preintake attrition

J. Daniels, E. Johnson, W. Sparks, 2003 .

Immunosuppressive agents prevent guanethidine-induced destruction of rat sympathetic neurons

Eugene M. Johnson, J. Russell, P. Manning, 1982, Brain Research.

4 – NEUROTROPHIC FACTORS

M. Tuszynski, Eugene M. Johnson, E. Johnson, 2008 .

Functional Mapping of Receptor Specificity Domains of Glial Cell Line-derived Neurotrophic Factor (GDNF) Family Ligands and Production of GFRα1 RET-specific Agonists*

J. Milbrandt, Eugene M. Johnson, M. Tansey, 2000, The Journal of Biological Chemistry.

Dopamine-Dependent Compensation Maintains Motor Behavior in Mice with Developmental Ablation of Dopaminergic Neurons

Robert W Gereau, Masato Hoshi, Judith P Golden, 2013, The Journal of Neuroscience.

GFRα1-Deficient Mice Have Deficits in the Enteric Nervous System and Kidneys

J. Milbrandt, Eugene M. Johnson, W. Snider, 1998, Neuron.

Glial Cell Line-Derived Neurotrophic Factor-Dependent Recruitment of Ret into Lipid Rafts Enhances Signaling by Partitioning Ret from Proteasome-Dependent Degradation

J. Milbrandt, Eugene M. Johnson, B. Pierchala, 2006, The Journal of Neuroscience.

Critical and distinct roles for key RET tyrosine docking sites in renal development.

J. Milbrandt, Eugene M. Johnson, Sanjay Jain, 2006, Genes & development.

GFRα1 Expression in Cells Lacking RET Is Dispensable for Organogenesis and Nerve Regeneration

J. Milbrandt, Eugene M. Johnson, H. Enomoto, 2004, Neuron.

The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis

E. Wagner, Eugene M. Johnson, C. Besirli, 2005, The Journal of cell biology.

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 1: Where have we been and what have we learned?

Eugene M. Johnson, R. Bartus, E. Johnson, 2017, Neurobiology of Disease.

RET Is Dispensable for Maintenance of Midbrain Dopaminergic Neurons in Adult Mice

Judith P Golden, J. Milbrandt, E. Pehek, 2006, The Journal of Neuroscience.

JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis

Eugene M. Johnson, S. Frank, A. Maroney, 2003, Neuron.

Inhibition of the c-Jun N-Terminal Kinase Signaling Pathway by the Mixed Lineage Kinase Inhibitor CEP-1347 (KT7515) Preserves Metabolism and Growth of Trophic Factor-Deprived Neurons

Charles A. Harris, Eugene M. Johnson, A. Maroney, 2002, The Journal of Neuroscience.

JNK-independent Activation of c-Jun during Neuronal Apoptosis Induced by Multiple DNA-damaging Agents*

Eugene M. Johnson, C. Besirli, E. Johnson, 2003, Journal of Biological Chemistry.

Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium

J. Franklin, Eugene M. Johnson, E. Johnson, 1992, Trends in Neurosciences.

Neurturin-Mediated Ret Activation Is Required for Retinal Function

J. Milbrandt, Eugene M. Johnson, M. Brantley, 2008, The Journal of Neuroscience.

Nomenclature of GPI-Linked Receptors for the GDNF Ligand Family

L. M. Goodman, J. Treanor, J. Milbrandt, 1997, Neuron.

TGFβ Trophic Factors Differentially Modulate Motor Axon Outgrowth and Protection from Excitotoxicity

J. Milbrandt, J. Rothstein, Eugene M. Johnson, 2000, Experimental Neurology.

Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs

Eugene M. Johnson, J. P. Schwartz, J. Pearson, 1982, Brain Research.

The role of nerve growth factor in modulating herpes simplex virus reactivation in vivo

J. Pepose, R. Brady, Steven F. Lee, 1994, Graefe's Archive for Clinical and Experimental Ophthalmology.

Development and Maintenance of Renal Hypertension in Normal and Guanethidine Sympathectomized Rats

B. K. Hartman, G. Marshall, Eugene M. Johnson, 1975, Circulation research.

GFRα-Mediated Localization of RET to Lipid Rafts Is Required for Effective Downstream Signaling, Differentiation, and Neuronal Survival

J. Milbrandt, Eugene M. Johnson, M. Tansey, 2000, Neuron.

Phosphatidylinositol 3-Kinase Is Required for the Trophic, But Not the Survival-Promoting, Actions of NGF on Sympathetic Neurons

Eugene M. Johnson, G. Putcha, E. Johnson, 2000, The Journal of Neuroscience.

Control of Neuronal Size Homeostasis by Trophic Factor–mediated Coupling of Protein Degradation to Protein Synthesis

J. Franklin, Eugene M. Johnson, E. Johnson, 1998, The Journal of cell biology.

Tyrosine 981, a Novel Ret Autophosphorylation Site, Binds c-Src to Mediate Neuronal Survival*

R. Crowder, J. Milbrandt, Eugene M. Johnson, 2004, Journal of Biological Chemistry.

The Long and Short Isoforms of Ret Function as Independent Signaling Complexes*

R. Crowder, J. Milbrandt, Eugene M. Johnson, 2002, The Journal of Biological Chemistry.

GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family

J. Milbrandt, Eugene M. Johnson, C. Keck, 1998 .

RET Signaling Is Required for Survival and Normal Function of Nonpeptidergic Nociceptors

Robert W Gereau, Hideki Enomoto, Masato Hoshi, 2010, The Journal of Neuroscience.

Dok-6, a Novel p62 Dok Family Member, Promotes Ret-mediated Neurite Outgrowth*

R. Crowder, J. Milbrandt, Eugene M. Johnson, 2004, Journal of Biological Chemistry.

Neurotrophic molecules

D. Snider, W. Snider, E. Johnson, 1989, Annals of neurology.

Mixed-Lineage Kinase Inhibitors Require the Activation of Trk Receptors to Maintain Long-Term Neuronal Trophism and Survival

Eugene M. Johnson, Leo H. Wang, E. Johnson, 2005, Journal of Pharmacology and Experimental Therapeutics.

Multiple Channel Interactions Explain the Protection of Sympathetic Neurons from Apoptosis Induced by Nerve Growth Factor Deprivation

Eugene M. Johnson, S. Yu, S. Xia, 2002, The Journal of Neuroscience.

Behavioral effects of early deprivation of nerve growth factor: Some similarities with familial dysautonomia

S. Finger, J. Bell, M. Gruenthal, 1982, Brain Research.

Time course of the development of neurotransmitter synthesizing enzymes in the superior cervical ganglion and adrenal gland of the hamster

P. Jonas, R. Macia, E. Johnson, 1979, Journal of Neurochemistry.

Effect of destruction of the postganglionic sympathetic neurons in neonatal rats on development of choline acetyltransferase and survival of preganglionic cholinergic neurons

M. Caserta, L. Ross, E. Johnson, 1977, Brain Research.

Identification of JNK‐dependent and ‐independent components of cerebellar granule neuron apoptosis

Charles A. Harris, Eugene M. Johnson, A. Maroney, 2002, Journal of neurochemistry.

Clinical tests of neurotrophic factors for human neurodegenerative diseases, part 2: Where do we stand and where must we go next?

Eugene M. Johnson, R. Bartus, E. Johnson, 2017, Neurobiology of Disease.

Muscle spindle number is normal in guinea pigs with reduced dorsal root ganglia following in utero deprivation of nerve growth factor

N. Laing, P. Osborne, E. Johnson, 1988, Brain Research.

The role of NGF in sensory neurons in vivo

Eugene M. Johnson, H. Yip, K. Rich, 1986, Trends in Neurosciences.

Postnatal development of survival responsiveness in rat sympathetic neurons to leukemia inhibitory factor and ciliary neurotrophic factor

J. Milbrandt, S. Estus, Eugene M. Johnson, 1994, Neuron.

Partial purification of a parasympathetic neurotrophic factor in pig lung

Eugene M. Johnson, T. Wallace, E. Johnson, 1987, Brain Research.

Characterization of choline acetyltransferase-sustaining and survival-promoting activities for parasympathetic neurons in pig lung

T. Wallace, E. Johnson, 1986, Brain Research.

Time and dose dependencies of effects of nerve growth factor on sympathetic and sensory neurons in neonatal rats

Eugene M. Johnson, H. Kornblum, E. Johnson, 1982, Brain Research.

Effects of long-term nerve growth factor deprivation on the nervous system of the adult rat: An experimental autoimmune approach

Eugene M. Johnson, P. D. Gorin, E. Johnson, 1980, Brain Research.

Effects of autoimmune NGF deprivation in the adult rabbit and offspring

Eugene M. Johnson, R. Rydel, J. Pearson, 1982, Brain Research.

Destruction of sympathetic and sensory neurons in the developing rat by a monoclonal antibody against the nerve growth factor (NGF) receptor

Eugene M. Johnson, P. Osborne, M. Taniuchi, 1989, Brain Research.

The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis

E. Wagner, Eugene M. Johnson, C. Besirli, 2005, The Journal of cell biology.

Nerve Growth Factor Promotes the Survival of Sympathetic Neurons through the Cooperative Function of the Protein Kinase C and Phosphatidylinositol 3-Kinase Pathways*

Eugene M. Johnson, B. Pierchala, Rebecca Ahrens, 2004, Journal of Biological Chemistry.

The limited role of NH 2 -terminal c-Jun phosphorylation in neuronal apoptosis: Identiﬁcation of the nuclear pore complex as a potential target of the JNK pathway

E. Wagner, Eugene M. Johnson, C. Besirli, 2005 .

Fibroblast growth factor receptor‐bearing neurons in the CNS: Identification by receptor‐mediated retrograde transport

Eugene M. Johnson, I. Ferguson, E. Johnson, 1991, The Journal of comparative neurology.

Central nervous system and peripheral nerve growth factor provide trophic support critical to mature sensory neuronal survival

Eugene M. Johnson, H. Yip, E. Johnson, 1985, Nature.

Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects

Eugene M. Johnson, W. Snider, J. Pinzone, 1988, Neuron.

Reversible Physiological Alterations in Sympathetic Neurons Deprived of NGF but Protected from Apoptosis by Caspase Inhibition or Bax Deletion

J. Werth, Eugene M. Johnson, S. Rothman, 2000, Experimental Neurology.

Characterization of the retrograde transport of nerve growth factor (NGF) using high specific activity [125I]NGF

Eugene M. Johnson, R. Bradshaw, R. Andres, 1978, Brain Research.

Ventral rhizotomy enhances regeneration of uninjured sensory neurons

Eugene M. Johnson, K. Rich, E. Johnson, 1985, Brain Research.

Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120)

R. Bartus, F. Gage, M. Tansey, 2013, Neurobiology of Disease.

The effects of drugs which destroy the sympathetic nervous system on the retrograde transport of nerve growth factor

R. Bradshaw, R. Andres, R. Macia, 1979, Brain Research.

Models of chemotherapy drug-induced peripheral neuropathy

Eugene M. Johnson, J. Golden, E. Johnson, 2004 .

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis

S. Estus, Eugene M. Johnson, R. Bravo, 1994, The Journal of cell biology.