Stephen R Quake

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Viral taxonomy derived from evolutionary genome relationships

Tyler J Dougan, Stephen R Quake, S. Quake, 2018, bioRxiv.

Integrated nanoliter systems

Jong Wook Hong, Stephen R Quake, S. Quake, 2003, Nature Biotechnology.

Microfluidic large-scale integration: the evolution of design rules for biological automation.

Jessica Melin, Stephen R Quake, S. Quake, 2007, Annual review of biophysics and biomolecular structure.

Microfluidics Technologies for Low Cell Number Chromatin Immunoprecipitation.

Stephen R Quake, Angela R Wu, 2016, Cold Spring Harbor protocols.

Food allergen detection by mass spectrometry: the role of systems biology

Stephen R Quake, Derek Croote, S. Quake, 2016, npj Systems Biology and Applications.

Significance and statistical errors in the analysis of DNA microarray data

Stephen R Quake, James P Brody, Brian A Williams, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Microfluidic very large scale integration (mVLSI) with integrated micromechanical valves.

Ismail Emre Araci, Stephen R Quake, S. Quake, 2012, Lab on a chip.

A reusable microfluidic device provides continuous measurement capability and improves the detection limit of digital biology.

Stephen R Quake, Michael Robles, I Emre Araci, 2016, Lab on a chip.

Microfluidic serial digital to analog pressure converter for arbitrary pressure generation and contamination-free flow control.

Stephen R Quake, Feiqiao Yu, Mark A Horowitz, 2013, Lab on a chip.

Digital PCR provides sensitive and absolute calibration for high throughput sequencing

Stephen R Quake, Richard A White, Paul C Blainey, 2008, BMC Genomics.

Microfluidic single-cell real-time PCR for comparative analysis of gene expression patterns

Veronica Sanchez-Freire, Stephen R Quake, Tomer Kalisky, 2012, Nature Protocols.

High-throughput single-molecule optofluidic analysis

Ron R Lin, Shimon Weiss, Aaron M. Streets, 2011, Nature Methods.

Analysis of the size distributions of fetal and maternal cell-free DNA by paired-end sequencing.

Stephen R Quake, H Christina Fan, H. C. Fan, 2010, Clinical chemistry.

Microfluidic digital PCR enables rapid prenatal diagnosis of fetal aneuploidy.

Stephen R Quake, H Christina Fan, H. C. Fan, 2009, American journal of obstetrics and gynecology.

Whole-genome molecular haplotyping of single cells

Stephen R Quake, H Christina Fan, H. C. Fan, 2011, Nature Biotechnology.

Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac Cells.

Bin Zhou, Stephen R Quake, Thomas Quertermous, 2016, Developmental cell.

Behavior of complex knots in single DNA molecules.

Stephen R Quake, S. Quake, Heun‐Jin Lee, 2003, Physical review letters.

High-throughput multi-antigen microfluidic fluorescence immunoassays.

Axel Scherer, Clive R Taylor, Stephen R Quake, 2006, BioTechniques.

Microfluidic device reads up to four consecutive base pairs in DNA sequencing-by-synthesis.

Stephen R Quake, Emil P Kartalov, S. Quake, 2004, Nucleic acids research.

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR

David Bryder, Stephen R Quake, Irving L Weissman, 2006, Proceedings of the National Academy of Sciences.

Dissecting noncoding and pathogen RNA–protein interactomes

Howard Y. Chang, Stephen R Quake, Kun Qu, 2015, RNA.

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq.

Stephen R Quake, Patrick E. Rothwell, N. Neff, 2016, Cell reports.

Tip-enhanced fluorescence microscopy at 10 nanometer resolution.

Stephen R Quake, Guillaume A Lessard, Lawrence A Wade, 2004, Physical review letters.

Solvent resistant microfluidic DNA synthesizer.

Stephen R Quake, Piero Castrataro, S. Quake, 2007, Lab on a chip.

Noninvasive Prenatal Diagnosis of Single-Gene Disorders by Use of Droplet Digital PCR.

Hojae Lee, Stephen R Quake, S. Quake, 2018, Clinical chemistry.

Single-cell multimodal profiling reveals cellular epigenetic heterogeneity

Stephen R Quake, Lih Feng Cheow, Rui Zhen Tan, 2016, Nature Methods.

A nanoliter-scale nucleic acid processor with parallel architecture

Vincent Studer, Stephen R Quake, S. Quake, 2004, Nature Biotechnology.

Fluorescence near-field microscopy of DNA at sub-10 nm resolution.

Ziyang Ma, Stephen R Quake, Lawrence A Wade, 2006, Physical review letters.

Digital PCR provides absolute quantitation of viral load for an occult RNA virus.

Stephen R Quake, R. White, S. Quake, 2012, Journal of virological methods.

Experimentally validated quantitative linear model for the device physics of elastomeric microfluidic valves.

Axel Scherer, Clive R Taylor, Stephen R Quake, 2007, Journal of applied physics.

Solving the "world-to-chip" interface problem with a microfluidic matrix.

Stephen R Quake, S. Quake, C. Hansen, 2003, Analytical chemistry.

Experimental determination of the evolvability of a transcription factor

Stephen R Quake, Sebastian J Maerkl, S. Quake, 2009, Proceedings of the National Academy of Sciences.

Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching

Cornelia L Dekker, Mark M Davis, Stephen R Quake, 2016, eLife.

Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB)

Stephen R Quake, Paul C Blainey, S. Quake, 2012, Genome research.

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages

Yan Zhang, Bin Liu, Stephen R Quake, 2017, Cell Research.

DNA Sequencing: Clinical Applications of New DNA Sequencing Technologies

Euan A Ashley, Stephen R Quake, Frederick E Dewey, 2012, Circulation.

High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation.

Howard Y. Chang, Stephen R Quake, Angela R Wu, 2012, Lab on a chip.

Anomalous vibrational dispersion in holographically trapped colloidal arrays.

Stephen R Quake, David G Grier, S. Quake, 2006, Physical review letters.

Proteome-wide protein interaction measurements of bacterial proteins of unknown function

Stephen R Quake, Matthias Meier, S. Quake, 2012, Proceedings of the National Academy of Sciences.

Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons

Spyros Darmanis, Stephen R Quake, S. Quake, 2016, Proceedings of the National Academy of Sciences.

Optofluidic cell selection from complex microbial communities for single-genome analysis.

Stephen R Quake, Paul C Blainey, S. Quake, 2013, Methods in enzymology.

BAsE-Seq: a method for obtaining long viral haplotypes from short sequence reads

Niranjan Nagarajan, Andreas Wilm, Stephen R Quake, 2014, Genome Biology.

Dissecting genomic diversity, one cell at a time

Stephen R Quake, Paul C Blainey, S. Quake, 2013, Nature Methods.

Parallel picoliter rt-PCR assays using microfluidics.

Stephen R Quake, S. Quake, W. F. Anderson, 2006, Analytical chemistry.

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination

Baoshan Zhang, Edward M Marcotte, Cornelia L Dekker, 2016, Nature Medicine.

Velocity‐independent microfluidic flow cytometry

Stephen R Quake, S. Quake, Shulamit Eyal, 2002, Electrophoresis.

An in vitro microfluidic approach to generating protein-interaction networks

Stephen R Quake, Doron Gerber, Sebastian J Maerkl, 2009, Nature Methods.

Detection of aneuploidy with digital polymerase chain reaction.

Stephen R Quake, H Christina Fan, H. C. Fan, 2007, Analytical chemistry.

Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

Qingming Luo, Anan Li, Minmin Luo, 2019, eLife.

A microfluidic rectifier: anisotropic flow resistance at low Reynolds numbers.

Alex Groisman, Stephen R Quake, S. Quake, 2004, Physical review letters.

A microfluidic device for kinetic optimization of protein crystallization and in situ structure determination.

Stephen R Quake, Carl L Hansen, S. Quake, 2006, Journal of the American Chemical Society.

Single-Cell DNA-Methylation Analysis Reveals Epigenetic Chimerism in Preimplantation Embryos

Stephen R Quake, Lih Feng Cheow, S. Quake, 2013, Science.

Colloidal lenses allow high-temperature single-molecule imaging and improve fluorophore photostability.

Stephen R Quake, Stavros Stavrakis, S. Quake, 2010, Nature nanotechnology.

Simultaneously Monitoring Immune Response and Microbial Infections during Pregnancy through Plasma cfRNA Sequencing.

Ronald J Wong, Gary M Shaw, Stephen R Quake, 2017, Clinical chemistry.

Phase knowledge enables rational screens for protein crystallization

Stephen R Quake, Carl L Hansen, S. Quake, 2006, Proceedings of the National Academy of Sciences.

Microfluidic single-cell mRNA isolation and analysis.

Stephen R Quake, S. Quake, W. F. Anderson, 2006, Analytical chemistry.

Risky Business: Meeting the Structural Needs of Transdisciplinary Science.

Atul J Butte, George Macones, Gary M Shaw, 2017, The Journal of pediatrics.

A microfluidic processor for gene expression profiling of single human embryonic stem cells.

Axel Scherer, Clive R Taylor, Stephen R Quake, 2008, Lab on a chip.

Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress

Megan N. McClean, Christina Kendziorski, Stephen R Quake, 2017, PLoS biology.

Early somatic mosaicism is a rare cause of long-QT syndrome

Euan A Ashley, Thomas O'Hara, Charles Gawad, 2016, Proceedings of the National Academy of Sciences.

In vitro embryo culture in defined, sub‐microliter volumes

Jessica Melin, Stephen R Quake, S. Quake, 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

Genomic analysis at the single-cell level.

Stephen R Quake, Tomer Kalisky, Paul Blainey, 2011, Annual review of genetics.