J. Larner,

发表

Generation by insulin of a chemical mediator that controls protein phosphorylation and dephosphorylation.

K. Cheng, A. Depaoli-Roach, L. Huang, 1979, Science.

Effects of insulin treatment on muscle 3′,5′-cyclic adenylate levels in vivo and in vitro

J. Larner, C. Villar-Palasi, N. D. Goldberg, 1967 .

Hormonal regulation of glycogen synthase: insulin decreases protein kinase sensitivity to cyclic AMP.

J. Larner, R. Walkenbach, R. Hazen, 1980, Biochimica et biophysica acta.

Muscle glycogen synthase in vivo state:

P. Roach, J. Larner, M. Rosell-Perez, 1977, FEBS letters.

A novel mechanism for the insulin-like effect of vanadate on glycogen synthase in rat adipocytes.

S. Tamura, T. A. Brown, K. Cheng, 1984, The Journal of biological chemistry.

The action of branching enzymes on outer chains of glycogen.

J. Larner,, 1953, Journal of Biological Chemistry.

Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators.

E. Hewlett, A. Rogol, L. Luttrell, 1988, Science.

Inositol, Glycogen, Insulin, and Six Nobelists

J. Larner, J. Larner,, 2013, The Journal of Biological Chemistry.

Joseph Larner Inositol , Glycogen , Insulin , and Six Nobelists

J. Larner, J. Larner,, 2013 .

D-Chiro-Inositol Glycans in Insulin Signaling and Insulin Resistance

D. Brautigan, M. Thorner, J. Larner,, 2010, Molecular medicine.

Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.

A. Gow, J. Larner, M. Brownlee, 2006, Proceedings of the National Academy of Sciences of the United States of America.

A model phosphatase 2C --> phosphatase 1 activation cascade via dual control of inhibitor-1 (INH-1) and DARPP-32 dephosphorylation by two inositol glycan putative insulin mediators from beef liver.

J. Larner, R. Nolan, L. Huang, 1999, Biochemical and biophysical research communications.

Dephosphorylation of PDH by phosphoprotein phosphatases and its allosteric regulation by inositol glycans

J. Larner, L. Huang, S. Abe, 1996 .

Characterization of a Nucleotide Stimulated Aspartic Proteinase in Rat Liver Plasma Membranes

J. Larner, C. Paule, J. Larner,, 1996, Journal of basic and clinical physiology and pharmacology.

Circulating factors and insulin resistance. I. A novel myoinositol 1,2-cyclic phosphate phosphoglycan insulin antagonist from human plasma is elevated in noninsulin-dependent diabetes mellitus.

N. Hooper, J. Larner, A. Turner, 1995, The Journal of clinical endocrinology and metabolism.

Insulin mediators and the mechanism of insulin action.

J. Larner, G. Romero, J. Larner,, 1993, Advances in pharmacology.

The generation of inositolglycan mediators from rat liver plasma membranes: the role of guanine nucleotide binding proteins.

E. Kilgour, G. Romero, J. Larner,, 1992, Biochemical and biophysical research communications.

Identification and characterization of chiroinositol-containing phospholipids from bovine liver.

J. Larner,, Y. Pak, 1992, Biochemical and biophysical research communications.

Insulin and the stimulation of glycogen synthesis. The road from glycogen structure to glycogen synthase to cyclic AMP-dependent protein kinase to insulin mediators.

J. Larner, J. Larner,, 2006, Advances in enzymology and related areas of molecular biology.

Effects of Insulin on Glycogen Metabolism

J. Larner, J. Larner,, 1990 .

Insulin Mediators and the Control of Pyruvate Dehydrogenase Complex a

L. Luttrell, L. Huang, A. Kennington, 1989, Annals of the New York Academy of Sciences.

ATP-Mn2+ stimulates the generation of a putative mediator of insulin action.

C. Villar-Palasi, S. Suzuki, T. Toyota, 1987, Journal of Biological Chemistry.

Selective inhibition of the insulin-stimulated phosphorylation of the 95,000 dalton subunit of the insulin receptor by TAME or BAEE.

J. Larner, Y. Fujita-Yamaguchi, S. Tamura, 1984, Biochemical and biophysical research communications.

Phosphoinositol Glycan Derived Mediators and Insulin Resistance. Prospects for Diagnosis and Therapy

G. Allan, R. Gunn, L‐C. Huang, 1998, Journal of Basic and Clinical Physiology and Pharmacology.

Insulin-Signaling Mechanisms: Lessons From the Old Testament of Glycogen Metabolism and the New Testament of Molecular Biology

J. Larner, J. Larner,, 1988, Diabetes.

An investigation of the properties of rabbit muscle oligo-1,4--1,4-glucantransferase.

T. Nelson, J. Larner,, D. Palmer, 1970, Biochimica et biophysica acta.

Studies on amylo-1, 6-glucosidase.

J. Larner, L. Schliselfeld, J. Larner,, 1956, Biochimica et biophysica acta.

[27] Branching enzyme from liver: Amylo-1,4 → 1,6-transglucosidase

J. Larner,, 1955 .

The action of crystalline muscle phosphorylase on outer chains of glycogen and amylopectin.

J. Larner,, 1955, The Journal of biological chemistry.

Allosteric activation of protein phosphatase 2C by D-chiro-inositol-galactosamine, a putative mediator mimetic of insulin action.

J. Bushweller, D. Brautigan, S. Lukasik, 2005, Biochemistry.

CHAPTER 2 – Hormonal and Metabolic Control of Phosphoprotein Phosphatase

J. Larner, R. Curnow, J. Larner,, 1979 .

Contrasting interactions between phorbol ester and insulin on the regulation of glycogen synthase activity and p33 mRNA accumulation in rat hepatoma cells.

A. Larner, T. Sato, T. Ye, 1988, Archives of biochemistry and biophysics.

Structure of glycogens and amylopectins. I. Enzymatic determination of chain length.

G. T. Cori, B. Illingworth, J. Larner,, 1952, The Journal of biological chemistry.

Inositol dehydrogenase from Aerobacter aerogenes.

J. Stamer, W. T. Jackson, J. Larner,, 1956, Archives of biochemistry and biophysics.

STUDIES ON UDPG: ALPHA-1,4-GLUCAN ALPHA-4-GLUCOSYLTRANSFERASE. VII. CONVERSION OF THE ENZYME FROM GLUCOSE-6-PHOSPHATE-DEPENDENT TO INDEPENDENT FORM IN LIVER.

S. Hizukuri, J. Larner, J. Larner,, 1964, Biochemistry.

Insulin-like effect of vanadate on adipocyte glycogen synthase and on phosphorylation of 95,000 dalton subunit of insulin receptor.

J. Larner, S. Tamura, T. A. Brown, 1983, Biochemical and biophysical research communications.

‘Insulin-like’ effects of lithium ion on isolated rat adipocytes II. Specific activation of glycogen synthase

J. Larner, K. Cheng, S. Creacy, 2004, Molecular and Cellular Biochemistry.

[73] Glycogen synthetase (synthase) from skeletal muscle: D and I forms☆

J. Larner, C. Villar-Palasi, K. K. Schlender, 1972 .

Rat liver insulin mediator which stimulates pyruvate dehydrogenase phosphate contains galactosamine and D-chiroinositol.

M. Kinter, T. Shen, L. Huang, 1988, Biochemical and biophysical research communications.

A pertussis toxin-sensitive G-protein mediates some aspects of insulin action in BC3H-1 murine myocytes.

L. Luttrell, E. Kilgour, G. Romero, 1990, The Journal of biological chemistry.

D-chiro-inositol glycan stimulates insulin secretion in pancreatic β cells

D. Bayliss, J. Larner, R. Lazarenko, 2014, Molecular and Cellular Endocrinology.

Protection against the synaptic targeting and toxicity of Alzheimer's‐associated Aβ oligomers by insulin mimetic chiro‐inositols

W. Klein, D. Brautigan, M. Thorner, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha.

J. Larner, A. Martín-Montalvo, D. Brautigan, 2010, Bioorganic & medicinal chemistry.

Isolation, structure, synthesis, and bioactivity of a novel putative insulin mediator. A galactosamine chiro-inositol pseudo-disaccharide Mn2+ chelate with insulin-like activity.

J. Larner, M. Fonteles, G. Rule, 2003, Journal of medicinal chemistry.

G(q/11) is involved in insulin-stimulated inositol phosphoglycan putative mediator generation in rat liver membranes: co-localization of G(q/11) with the insulin receptor in membrane vesicles.

B. Wilson, J. Larner, S. Sleight, 2002, Biochemical and biophysical research communications.

Both myo-inositol to chiro-inositol epimerase activities and chiro-inositol to myo-inositol ratios are decreased in tissues of GK type 2 diabetic rats compared to Wistar controls.

J. Nadler, T. Sun, D. Heimark, 2002, Biochemical and biophysical research communications.

In vivo chiro-inositol metabolism in the rat: a defect in chiro-inositol synthesis from myo-inositol and an increased incorporation of chiro-[3H]inositol into phospholipid in the Goto-Kakizaki (G.K) rat.

R. Farese, Y. Hong, T. Piccariello, 1998, Molecules and cells.

Urinary myo-Inositol-to-chiro-Inositol Ratios and Insulin Resistance

J. Larner, J. Craig, J. Larner,, 1996, Diabetes Care.

Urinary chiro-Inositol Excretion is an Index Marker of Insulin Sensitivity in Japanese Type II Diabetes

Y. Hinokio, M. Hirai, T. Toyota, 1994, Diabetes Care.

chiro-inositol deficiency and insulin resistance: a comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjects.

I. Asplin, G. Galasko, J. Larner,, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Chiroinositol deficiency and insulin resistance. I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneously diabetic rhesus monkeys.

B. Hansen, N. Bodkin, H. Ortmeyer, 1993, Endocrinology.

Chiroinositol deficiency and insulin resistance. III. Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo.

M. Fonteles, D. B. Houston, L. Huang, 1993, Endocrinology.

In vivo conversion of [3H]myoinositol to [3H]chiroinositol in rat tissues.

L. Huang, K. Lilley, J. Larner,, 1992, The Journal of biological chemistry.

Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus.

C. Bogardus, J. Larner, B. Hansen, 1990, The New England journal of medicine.

Duality in the mechanism of action of insulin.

E. Kilgour, D. B. Houston, L. Huang, 1990, Advances in second messenger and phosphoprotein research.

Insulin mediators: structure and formation.

L. Huang, G. Romero, C. Schwartz, 1988, Cold Spring Harbor symposia on quantitative biology.

A proteolytic mechanism for the action of insulin via oligopeptide mediator formation.

J. Larner, S. Tamura, K. Kikuchi, 1982, Federation proceedings.

Udpglucose: α-1,4-glucan α-4-glucosyltransferase in heart regulation of the activity of the transferase in vivo and in vitro in rat. A dissociation in the action of isulin on transport and on transferase conversion

F. Nuttall, J. Larner, C. Villar-Palasi, 1969 .

UDPglucose: alpha-I,4-glucan alpha-4-glucosyltransferase in heart regulation of the activity of the transferase in vivo and in vitro in rat. A dissociation in the action of insulin on transport and on transferase conversion.

F. Nuttall, C. Villar-Palasi, F. Huijing, 1969, Biochimica et biophysica acta.

Intracellular mediators of insulin action.

J. Larner, K. Cheng, J. Larner,, 1985, Annual review of physiology.

D-Chiro-Inositol – Its Functional Role in Insulin Action and its Deficit in Insulin Resistance

J. Larner, J. Larner,, 2002, International journal of experimental diabetes research.

A putative mediator of insulin action which inhibits adenylate cyclase and adenosine 3',5'-monophosphate-dependent protein kinase: partial purification from rat liver: site and kinetic mechanism of action.

E. Hewlett, C. Malchoff, K. Cheng, 1987, Endocrinology.

Insulin mediators are the signal transduction system responsible for insulin's actions on human placental steroidogenesis.

J. Larner, J. Nestler, L. Huang, 1991, Endocrinology.

Insulin mediator stimulation of pyruvate dehydrogenase phosphatases.

C. Villar-Palasi, L. Huang, K. Lilley, 1992, Archives of biochemistry and biophysics.

Insulin and a putative insulin metabolic mediator fraction from liver and muscle stimulate p33 messenger ribonucleic acid accumulation by apparently different mechanisms.

J. Larner, A. Larner, L. Huang, 1988, Endocrinology.

Isolation and characterization of bovine lactate dehydrogenase X.

J. Larner, G. Fleisher, E. Kolb, 1970, Biochemistry.

Hormonal control of glycogen metabolism.

F. Murad, G. Brooker, P. Roach, 1979, Advances in experimental medicine and biology.

Synergistic Effects of d-Chiro-Inositol and Manganese on Blood Glucose and Body Weight of Streptozotocin-Induced Diabetic Rats

D. Heimark, G. Gluck, T. Anguelova, 2010 .

Fasting Decreases the Content of D-Chiroinositol in Human Skeletal Muscle

J. Larner, P. Shashkin, A. Katz, 2002, International journal of experimental diabetes research.

D-chiro-inositol Improves Insulin and Glucose Profiles in Human Subjects with Impaired Glucose Tolerance

G. Allan, C. Kessler, J. Larner,, 1998 .

In vivo D-chiroinositol activates skeletal muscle glycogen synthase and inactivates glycogen phosphorylase in rhesus monkeys

J. Larner, B. Hansen, N. Bodkin, 1995 .

Chiroinositol deficiency and insulin resistance. II. Acute effects of D-chiroinositol administration in streptozotocin-diabetic rats, normal rats given a glucose load, and spontaneously insulin-resistant rhesus monkeys.

B. Hansen, L. Huang, H. Ortmeyer, 1993, Endocrinology.

Insulin-like and Insulin-enhancing Effects of the Sulfonylurea Glyburide on Rat Adipose Glycogen Synthase

J. Larner, N. Altan, V. Altan, 1985, Diabetes.

Effects of insulin, methoxamine, and calcium on glycogen synthase in rat adipocytes.

J. Lawrence, J. Larner,, 1978, Molecular pharmacology.

Evidence for alpha adrenergic activation of phosphorylase and inactivation of glycogen synthase in rat adipocytes. Effects of alpha and beta adrenergic agonists and antagonists on glycogen synthase and phosphorylase.

J. Larner, J. Lawrence, J. Larner,, 1977, Molecular pharmacology.

The metabolism in the rat of photosynthetically prepared myo-inositol-C14☆

E. A. Moscatelli, J. Larner,, 1959 .

Alpha adrenergic and cholinergic-muscarinic regulation of adenosine cyclic 3',5'-monophosphate levels in the rat parotid.

Y. Oron, J. Kellogg, J. Larner,, 1978, Molecular pharmacology.

Molecular cloning of rat type 2C (IA) protein phosphatase mRNA.

A. Yasui, J. Larner, K. Kikuchi, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Rabbit skeletal muscle phosphorylase kinase. Comparison of glycogen synthase and phosphorylase as substrates.

A. Depaoli-Roach, P. Roach, J. Larner, 1979, The Journal of biological chemistry.

Insulin-like effect of trypsin on the phosphorylation of rat adipocyte insulin receptor.

J. Larner, Y. Fujita-Yamaguchi, S. Tamura, 1983, The Journal of biological chemistry.

Mechanisms subserving insulin action in the gonad: evidence that insulin induces specific phosphorylation of its immunoprecipitable receptor on ovarian cells.

R. Furlanetto, J. Veldhuis, S. Tamura, 1984, Biochemical and biophysical research communications.

Long-term effects of insulin on the enzyme activity and messenger RNA of glycogen synthase in rat hepatoma H4 cells: an effect of insulin on glycogen synthase mRNA stability.

J. Larner, C. Villar-Palasi, Y. Nagasaka, 1991, Archives of biochemistry and biophysics.

Glycogen Synthase and Its Control

J. Larner, C. Villar-Palasi, J. Larner,, 1971 .

Correlation between structure and glycogen content of livers from rats on a controlled feeding schedule

J. Larner, R. Cardell, M. B. Babcock, 1973, The Anatomical record.

Glucose kinetics in leprechaunism: accelerated fasting due to insulin resistance.

J. Olefsky, J. Larner, D. Bier, 1980, The Journal of clinical endocrinology and metabolism.

A uridine coenzyme-linked pathway of glycogen synthesis in muscle.

C. Villar-Palasi, J. Larner,, 1958, Biochimica et biophysica acta.

Action of amylo-1,6-glucosidase and phosphorylase on glycogen and amylopectin.

J. Larner, G. T. Cori, J. Larner,, 1951, Journal of Biological Chemistry.

STUDIES ON UDPG-ALPHA-GLUCAN TRANSGLUCOSYLASE. III. INTERCONVERSION OF TWO FORMS OF MUSCLE UDPG-ALPHA-GLUCAN TRANSGLUCOSYLASE BY A PHOSPHORYLATION-DEPHOSPHORYLATION REACTION SEQUENCE.

J. Larner, D. Friedman, J. Larner,, 1963, Biochemistry.

Activation of liver guanylate cyclase by bile salts and contaminants in crude secretin and pancreozymin preparations.

F. Murad, H. Kimura, K. Ichihara, 1977, Biochimica et biophysica acta.

Chronic treatment with d‐chiro‐inositol prevents autonomic and somatic neuropathy in STZ‐induced diabetic mice

M. Fonteles, A. Tomé, V. X. Farias, 2011, Diabetes, obesity & metabolism.

An absolute requirement for insulin in the control of hepatic glycogenesis by glucose.

T. B. Miller, J. Larner, R. Hazen, 1973, Biochemical and biophysical research communications.

Insulin Stimulation of Glycogen Synthase in Cultured Human Diploid Fibroblasts

B. Howard, P. Bennett, J. Larner, 1980, Diabetes.

Pattern of Action of Crystalline Muscle Phosphorylase on Glycogen as Determined from Molecular Size Distribution Studies

B. Ray, J. Larner,, H. Crandall, 1956 .

Selective transcription of an insulin-regulated gene in nuclear extracts of rat hepatoma cells.

A. Larner, T. Sato, J. Larner,, 1988, Biochemical and biophysical research communications.

Insulin mediators and their control of metabolism through protein phosphorylation.

J. Larner, S. Tamura, K. Kikuchi, 1982, Recent progress in hormone research.

Effects of D-chiroinositol added to a meal on plasma glucose and insulin in hyperinsulinemic rhesus monkeys.

B. Hansen, H. Ortmeyer, J. Larner,, 1995, Obesity research.

Insulin action in intact mouse diaphragm II.

Y. Oron, J. Larner, G. Galasko, 1980, Molecular and Cellular Biochemistry.

Effects of insulin alone on the accumulation of a specific mRNA in rat hepatoma cells.

J. L. Messina, J. Hamlin, J. Larner,, 1985, The Journal of biological chemistry.

Chemical mechanism of insulin action via proteolytic formation of mediator peptides

S. Tamura, K. Kikuchi, K. Cheng, 1981, Molecular and Cellular Biochemistry.

Rabbit skeletal muscle glycogen synthase. II. Enzyme phosphorylation state and effector concentrations as interacting control parameters.

P. Roach, J. Larner,, 1976, The Journal of biological chemistry.

Mediators of postreceptor action of insulin.

J. Larner, J. Larner,, 1983, The American journal of medicine.

On the mechanism of action of adenosine 3',5' cyclophosphate.

J. Larner, F. Huijing, J. Larner,, 1966, Proceedings of the National Academy of Sciences of the United States of America.

On the effect of adenosine 3′,5′ cyclophosphate on the kinase of UDPG: α-1,4-glucan α-4 glucosyl transferase

J. Larner, F. Huijing, J. Larner,, 1966 .

‘Insulin-like’ effects of lithium ion on isolated rat adipocytes I. Stimulation of glycogenesis beyond glucose transport

J. Larner, K. Cheng, S. Creacy, 2004, Molecular and Cellular Biochemistry.

Rapid activation-inactivation of liver uridine diphosphate glucose-glycogen transferase and phosphorylase by insulin and glucagon in vivo.

J. Larner, J. Bishop, J. Larner,, 1967, The Journal of biological chemistry.

Insulin-mediated effect on the activity of UDPG-glycogen transglucosylase of muscle.

J. Larner, C. Villar-Palasi, J. Larner,, 1960, Biochimica et biophysica acta.

Structure of glycogens and amylopectins. II. Analysis by stepwise enzymatic degradation.

C. Cori, G. T. Cori, B. Illingworth, 1952, The Journal of biological chemistry.

Insulin-mimetic actions of wheat germ agglutinin and concanavalin A on specific mRNA levels.

J. L. Messina, J. Hamlin, J. Larner,, 1987, Archives of biochemistry and biophysics.

Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma

J. Mi, J. Larner, X. Kong, 2011, Cell Death and Disease.

Methods in diabetes research

W. Clarke, J. Larner, S. Pohl, 1984 .

Four questions times two: a dialogue on the mechanism of insulin action dedicated to Earl W. Sutherland.

J. Larner, J. Larner,, 1975, Metabolism: clinical and experimental.

Insulin Mediators and Their Control of Covalent Phosphorylation

Y. Oron, J. Larner, R. Cabelli, 1981 .

Gastrointestinal digestion of starch. III. Intestinal carbohydrase activities in germ-free and non-germ-free animals.

R. Gillespie, J. Larner,, 1957, The Journal of biological chemistry.

Gastrointestinal digestion of starch. II. Properties of the intestinal carbohydrases.

J. Larner, R. Gillespie, J. Larner,, 1956, The Journal of biological chemistry.

ACTION OF INTESTINAL EXTRACTS ON “BRANCHED” OLIGOSACCHARIDES1

J. Larner,, C. M. McNickle, 1954 .

ENZYMES IN A GLYCOGEN STORAGE MYOPATHY.

C. Villar-Palasi, J. Larner,, 1959, Proceedings of the National Academy of Sciences of the United States of America.

A rapid filter paper assay for UDPglucose-glycogen glucosyltransferase, including an improved biosynthesis of UDP-14C-glucose.

J. A. Thomas, J. Larner, K. K. Schlender, 1968, Analytical biochemistry.

Glycogen Storage Disease, Type V

W. Whelan, M. Cameron, J. Larner,, 2008 .

INSULIN‐STIMULATED GLYCOGEN FORMATION IN RAT DIAPHRAGM *

J. Larner, C. V. Palasi, D. Richman, 1959, Annals of the New York Academy of Sciences.

Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls.

J. Larner, J. McAllister, D. Heimark, 2014, Endocrine journal.

Insulin and the Control of UDPG‐α‐Glucan Transglucosylase Activity

D. Friedman, J. Craig, M. Cameron, 2008 .

Hormonal and nonhormonal control of glycogen metabolism.

J. Larner, J. Larner,, 1966, Transactions of the New York Academy of Sciences.

Insulin treatment and increased UDPG-glycogen transglucosylase activity in muscle.

J. Larner, C. Villar-Palasi, J. Larner,, 1961, Archives of biochemistry and biophysics.

Insulin-stimulated glycogen formation in rat diaphragm. Levels of tissue intermediates in short-time experiments.

C. Villar-Palasi, D. Richman, J. Larner,, 1960, Archives of biochemistry and biophysics.

STUDIES ON UDPG-ALPHA-GLUCAN TRANSGLUCOSYLASE. V. TWO FORMS OF THE ENZYME IN DOG SKELETAL MUSCLE AND THEIR INTERCONVERSION.

J. Larner, M. Rosell-Perez, J. Larner,, 1964, Biochemistry.

Substrate cleavage points of α- and β-amylases☆

J. Larner, F. C. Mayer, J. Larner,, 1958 .

Human Pharmacology: Molecular To Clinical

Theodore M. Brody, J. Larner, K. Minneman, 1991 .

Enzymic analysis of cyclic 3', 5'-AMP in mammalian tissues and urine.

J. Larner, A. O'toole, N. D. Goldberg, 1969, Analytical biochemistry.

Regulation of glycogen synthase: a relation of enzymic properties with biological function

P. Roach, J. Larner, J. Larner,, 1976 .

Ca2+-stimulated phosphorylation of muscle glycogen synthase by phosphorylase b kinase.

A. Depaoli-Roach, P. Roach, J. Larner,, 1978, Journal of cyclic nucleotide research.

Inhibition of insulin receptor phosphorylation by indomethacin

J. Larner, J. L. Messina, S. Tamura, 1985, Molecular and Cellular Biochemistry.

Inactivation of glycogen synthase by the tumor inhibitor vernolepin.

J. Larner, S. M. Kupchan, C. Smith, 1972, Biochimica et biophysica acta.

Substrate Cleavage Point of the α- and β-Amylases1

F. C. Mayer, J. Larner,, 1959 .

Insulin stimulation of glycogen synthase activity in cultured human fibroblasts from diabetic and control subjects

J. Larner, L. Huang, J. Craig, 2004, Diabetologia.

Rabbit skeletal muscle glycogen synthase. I. Relationship between phosphorylation state and kinetic properties.

P. Roach, J. Larner, Y. Takeda, 1976, The Journal of biological chemistry.

Activation of rat adipocyte glycogen synthase by insulins.

J. Larner, J. Lawrence, J. Guinovart, 1977, The Journal of biological chemistry.

Participation of histidine in catalytic activity of intestinal carbohydrases.

R. Gillespie, J. Larner,, 1955, Archives of biochemistry and biophysics.

Hormonal and non-hormonal control of glycogen synthesis-control of transferase phosphatase and transferase I kinase.

J. Larner, C. Villar-Palasi, F. Huijing, 1968, Advances in enzyme regulation.

GLYCOGEN METABOLISM AND THE MECHANISM OF ACTION OF CYCLIC AMP

J. Larner, C. Villar-Palasi, L. Shen, 1971, Annals of the New York Academy of Sciences.

Covalent phosphorylation in the regulation of glycogen synthase activity

P. Roach, J. Larner, J. Larner,, 1977, Molecular and Cellular Biochemistry.

Influence Of Epinephrine and Insulin on Uridine Diphosphate Glucose-α-Glucan Transferase and Phosphorylase in Muscle

J. Larner, J. Craig, J. Larner,, 1964, Nature.

Molecular characteristics of the totally dependent and independent forms of glycogen synthase of rabbit skeletal muscle. I. Preparation and characteristics of the totally glucose 6-phosphate dependent form.

J. Larner, N. E. Brown, J. Larner,, 1971, Biochimica et biophysica acta.

COVALENT AND NONCOVALENT CONTROL OF GLYCOGEN SYNTHESIS *

J. Larner,, 1973, Annals of the New York Academy of Sciences.

Insulin and Glycogen Synthase

J. Larner, J. Larner,, 1972, Diabetes.

Studies on UDPG-glycogen transglucosylase. I. Preparation and differentiation of two activities of UDPG-glycogen transglucosylase from rat skeletal muscle.

J. Larner, C. Villar-Palasi, M. Rosell-Perez, 1962, Biochemistry.

Concanavalin A-stimulated Ca2+ uptake in rat splenocytes

Y. Oron, L. Rebhun, A. Larner, 1980, Molecular and Cellular Biochemistry.

A rapid micro assay method for amylo-1,6-glucosidase.

J. Larner, T. Nelson, J. Larner,, 1970, Analytical biochemistry.

Purification and properties of rabbit muscle amylo-1,6-glucosidase-oligo-1,4-1,4-transferase.

T. Nelson, E. Kolb, J. Larner,, 1969, Biochemistry.

HYDROLYSIS OF NIGEROSE BY INTESTINAL EXTRACTS1

R. Gillespie, J. Larner,, 1956 .

Activation of glycogen synthase in rat adipocytes by insulin and glucose involves increased glucose transport and phosphorylation.

J. Larner, J. Lawrence, J. Larner,, 1978, The Journal of biological chemistry.

Antihyperglycemic effects of 3-O-methyl-D-chiro-inositol and D-chiro-inositol associated with manganese in streptozotocin diabetic rats.

M. Fonteles, J. Larner,, M. Q. Almeida, 2000, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Mechanisms of insulin resistance in cultured fibroblasts from a patient with leprechaunism: impaired post-binding actions of insulin and multiplication-stimulating activity.

J. Larner, M. Elders, J. Craig, 1984, Metabolism: clinical and experimental.

Uridinediphosphate glucose pyrophosphorylase from skeletal muscle.

J. Larner, C. Villar-Palasi, J. Larner,, 1960, Archives of biochemistry and biophysics.

Mechanism of control of hepatic glycogenesis by insulin.

T. B. Miller, J. Larner, J. Larner,, 1973, The Journal of biological chemistry.

[64] Muscle and liver UDP-glucose: α-1,4-glucan α-4-glucosyltransferase (glycogen synthetase)

S. Hizukuri, J. Larner, C. Villar-Palasi, 1966 .

Molecular characteristics of the totally dependent and independent forms of glycogen synthase of rabbit skeletal muscle. II. Some chemical characteristics of the enzyme protein and of its change on interconversion.

J. Larner, C. Smith, N. E. Brown, 1971, Biochimica et biophysica acta.

STUDIES ON UDPG: ALPHA-1.4-GLUCAN ALPHA-4-GLUCOSYLTRANSFERASE. VI. SPECIFICITY AND STRUCTURAL REQUIREMENTS FOR THE ACTIVATOR OF THE D FORM OF THE DOG MUSCLE ENZYME.

J. Larner, M. Rosell-Perez, J. Larner,, 1964, Biochemistry.

Infusion of pH 2.0 d-chiro-inositol glycan insulin putative mediator normalizes plasma glucose in streptozotocin diabetic rats at a dose equivalent to insulin without inducing hypoglycaemia

M. Fonteles, L. Huang, J. Larner,, 1996, Diabetologia.

Glycogen metabolism and glycolytic enzymes.

C. Villar-Palasi, J. Larner,, 1970, Annual review of biochemistry.

Characterization of skeletal muscle insulin receptor.

J. Larner, J. H. Whipple, R. Dubler, 1985, Archives of biochemistry and biophysics.

SYMPTOMATIC HYPOGLYCEMIA, VISCERAL FATTY METAMORPHOSIS, AND AGLYCOGENOSIS IN AN INFANT LACKING GLYCOGEN SYNTHETASE AND PHOSPHORYLAS.

J. Larner, T. Teree, J. Parr, 1965, Pediatrics.

Purification and partial characterization of a putative mediator of insulin action on cyclic AMP-dependent protein kinase

D. Kilpatrick, J. Larner,, M. Thompson, 1984, Molecular and Cellular Biochemistry.

Long term regulation of glycogen metabolizing enzymes by insulin in H4 hepatoma cells

J. Larner, M. Goheer, R. Curnow, 1987, Molecular and Cellular Biochemistry.

Mechanisms of insulin resistance in cultured fibroblasts from a patient with leprechaunism: resistance to proteolytic activation of glycogen synthase by trypsin

J. Larner, M. Elders, J. Craig, 1985, Molecular and Cellular Biochemistry.

Multiple phosphorylation of rabbit skeletal muscle glycogen synthase. Comparison of the actions of different protein kinases capable of catalyzing phosphorylation in vitro.

A. Depaoli-Roach, P. Roach, J. Larner, 1979, The Journal of biological chemistry.

Glycogen synthase can use glucose as an acceptor.

E. Salsas, J. Larner,, 1975, The Journal of biological chemistry.

Brody's human pharmacology : molecular to clinical

K. Minneman, T. Brody, J. Larner,, 2005 .

Calcium control of glycogen synthase activities in mouse diaphragms, rat adipocytes and rat hepatocytes.

Y. Oron, J. Larner, J. Garrison, 1984, Cell calcium.

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells

J. Mi, J. Larner, P. Sun, 2013, Cell Death and Disease.

D-chiro-inositol and Insulin Resistance: An Allosteric Point of View

J. Larner, J. Larner,, 2002 .

Circulating factors and insulin resistance. II. The action of the novel myo-inositol cyclic 1,2-inositol phosphate phosphoglycan insulin antagonist from human plasma in regulating pyruvate dehydrogenase phosphatase.

J. Larner, G. Galasko, S. Abe, 1996, The Journal of clinical endocrinology and metabolism.

A NEW NOMENCLATURE FOR KINASE PHOSPHATASE CATALYZED INTERCONVERTIBLE ENZYMES *

J. Larner,, 1971, Annals of the New York Academy of Sciences.

ENZYMATIC REGULATION OF GLYCOGEN SYNTHESIS: PHOSPHORYLATION OF GLYCOGEN SYNTHASE BY CYCLIC AMP-DEPENDENT PROTEIN KINASE, CYCLIC AMP-INDEPENDENT SYNTHASE KINASE AND PHOSPHORYLASE KINASE1

A. Depaoli-Roach, P. Roach, J. Larner, 1980 .

Stimulation of maximal intracellular insulin action on glycogen synthase by preincubation of adipocytes with adenosine 5'-triphosphate.

J. Larner, S. Tamura, R. Dubler, 1983, The Journal of biological chemistry.

Effect of temperature on insulin binding and action in cultured human fibroblasts.

J. Larner, H. Hidaka, B. Howard, 1983, Life sciences.

Gastrointestinal digestion of starch. I. The action of oligo-1,6-glucosidase on branched saccharides.

J. Larner,, C. M. McNickle, 1955, The Journal of biological chemistry.

Positive interaction between insulin and phorbol esters on the regulation of a specific messenger ribonucleic acid in rat hepatoma cells.

J. Larner, J. L. Messina, J. Hamlin, 1987, Endocrinology.

The influence of insulin and epinephrine on adenosine 3',5'-phosphate and glycogen transferase in muscle.

T. Rall, J. Craig, J. Larner,, 1969, Biochimica et biophysica acta.

Insulin Activity: The Solid Matrix

J. Roth, G. Marinetti, I. Goldfine, 1973, Science.

Autoantibodies to the insulin receptor activate glycogen synthase in rat adipocytes

C. Kahn, J. Larner, J. Lawrence, 1978, Molecular and Cellular Biochemistry.

Specificity of activation of glycogen synthase I from skeletal muscle and heart.

J. A. Thomas, J. Larner, K. K. Schlender, 1973, Biochimica et biophysica acta.

Interconversion of two forms of muscle UDPG-alpha-glucan transglucosylase by a phosphorylation-dephosphorylation reaction sequence.

J. Larner, D. Friedman, J. Larner,, 1962, Biochimica et biophysica acta.

Structural studies on rabbit muscle glycogen synthase. II. Limited proteolysis.

J. Larner, Y. Takeda, J. Larner,, 1975, The Journal of biological chemistry.

Studies on the Insulin Mediator: II. Separation of Two Antagonistic Biologically Active Materials from Fraction II

J. Larner, L. Huang, K. Cheng, 1980, Diabetes.

Effect of pH and 3-Hydroxybutyrate on Insulin Binding and Action in Cultured Human Fibroblasts

P. Bennett, J. Larner, H. Hidaka, 1981, Diabetes.

Multiple Intracellular Peptide Mediators of Insulin Action

S. Tamura, C. Malchoff, K. Cheng, 1985 .

Stable cholinergic‐muscarinic inhibition of rat parotid adenylate cyclase

Y. Oron, J. Kellogg, J. Larner,, 1978, FEBS letters.

Epinephrine effects on cyclic AMP-dependent protein kinases from rat diaphragms.

J. Larner, J. Guinovart, J. Larner,, 1980, Biochimica et biophysica acta.

Reversible inhibition of cyclic AMP-dependent protein kinase by insulin

J. Larner, R. Walkenbach, R. Hazen, 1978, Molecular and Cellular Biochemistry.

Hormonal effects on fat cell adenosine 3',5'-monophosphate dependent protein kinase.

J. Larner, J. Lawrence, J. Guinovart, 1978, Biochimica et biophysica acta.

"Stable" effects of insulin and isoproterenol on adipocyte pyruvate dehydrogenase.

J. Larner, K. Cheng, J. Larner,, 1987, Archives of biochemistry and biophysics.

Studies on glycogen synthetase interconverting enzymes in in vitro perfused compared to non-perfused rat hearts.

F. Nuttall, J. Larner, J. Larner,, 1971, Biochimica et biophysica acta.

Presence in liver of a 3':5'-cyclic AMP stimulated kinase for the I form of UDPG-glycogen glucosyltransferase.

J. Larner, J. Bishop, J. Larner,, 1969, Biochimica et biophysica acta.

STUDIES ON UDPG-ALPHA-GLUCAN TRANSGLUCOSYLASE. IV. PURIFICATION AND CHARACTERIZATION OF TWO FORMS FROM RABBIT SKELETAL MUSCLE.

J. Larner, M. Rosell-Perez, J. Larner,, 1964, Biochemistry.

Studies on UDPG-glycogen transglucosylase. II. Species variation of glucose-6-phosphate sensitivity of UDPG-glycogen transglucosylase.

M. Rosell-Perez, J. Larner,, 1962, Biochemistry.

Purification and properties of glycogen synthase I from skeletal muscle: two kinetic forms.

J. Larner, K. K. Schlender, J. Larner,, 1973, Biochimica et biophysica acta.

Uridine diphosphate glucose: α-1,4-glucan α-4-glucosyltrans ferase in heart: Two forms of the enzyme, interconversion reactions and properties

J. Larner, C. Villar-Palasi, N. E. Brown, 1969 .

Proof of phosphorylation and evidence for different primary structure of phosphorylated sites of glycogen synthases from rabbit and frog tissues

J. Larner, A. M. Rosenkrans, Addison M. Rosenkrans, 1973 .

Letter: Insulin activity: the solid matrix.

C. Kahn, R. Lefkowitz, J. Roth, 1973, Science.

Levels of activity of the enzymes of the glycogen cycle in rat tissues.

J. Larner, C. Villar-Palasi, J. Larner,, 1960, Archives of biochemistry and biophysics.

Synthesis of C-glycoside analogues of beta-galactosamine-(1-->4)-3-O-methyl-D-chiro-inositol and assay as activator of protein phosphatases PDHP and PP2Calpha.

D. Brautigan, Milton L. Brown, F. Camara, 2010, Bioorganic & Medicinal Chemistry.

Insulin stimulates the biosynthesis of chiro-inositol-containing phospholipids in a rat fibroblast line expressing the human insulin receptor.

C. Paule, L. Huang, Y. Bao, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The amino acid sequence of the phosphorylation site of muscle uridine diphosphoglucose α-1,4-glucan α-4-glucosyl transferase

F. Sanger, J. Larner, J. Larner,, 1965 .

Studies on Uridine Diphosphate Glucose:α-1,4-Glucan α-4-Glucosyltransferase. VIII. Catalysis of the Phosphorylation of Muscle Phosphorylase and Transferase by Separate Enzymes*

J. Larner, D. Friedman, J. Larner,, 1965 .

The inhibition of UDPG-glycogen synthase activity in vivo and in vitro by cinchona alkaloids

J. Larner, L. Rossini, J. Larner,, 1971 .

Studies on the action of amylo-I,6-glucosidase.

T. Nelson, J. Larner,, 1970, Biochimica et biophysica acta.

Mechanism of control of hepatic glycogenesis by insulin.

T. B. Miller, J. Larner,, 1973, The Journal of biological chemistry.

The influence of chain size and molecular weight on the kinetic constants for the span glucose to polysaccharide for rabbit muscle glycogen synthase

S. Hizukuri, Y. Takeda, J. Larner,, 1976, Molecular and Cellular Biochemistry.

D‐Chiro‐Inositol in Insulin Action and Insulin Resistance ‐ Old‐Fashioned Biochemistry Still at Work

J. Larner,, 2001, IUBMB life.

Glycogen Storage Disease Type V

W. Whelan, M. Cameron, J. Larner,, 2008, Definitions.

A modified rapid filtration assay of glycogen synthase.

Y. Oron, J. Larner, J. Larner,, 1979, Analytical biochemistry.