M. I. Rodríguez-Franco

发表

Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.

M. de la Fuente Revenga, M. Rodríguez-Franco, D. Caignard, 2015, Journal of medicinal chemistry.

Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase.

C. Pérez, Ana Martínez, M. I. Fernández-Bachiller, 2005, Bioorganic & medicinal chemistry.

Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.

C. Pérez, Manuela G. López, M. Villarroya, 2010, European journal of medicinal chemistry.

Benzothiazepine CGP37157 and its isosteric 2'-methyl analogue provide neuroprotection and block cell calcium entry.

C. Pérez, R. León, Manuela G. López, 2012, ACS chemical neuroscience.

A mild and efficient method for the regioselective iodination of pyrazoles

I. Dorronsoro, M. I. Rodríguez-Franco, Ana I. Hernandez-Higueras, 2001 .

Identification of tetracyclic lactams as NMDA receptor antagonists with potential application in neurological disorders.

Maria M. M. Santos, E. Molins, Lídia M D Gonçalves, 2020, European journal of medicinal chemistry.

The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

A. Feilding, J. Riba, M. de la Fuente Revenga, 2017, Scientific Reports.

N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.

C. Pérez, R. León, Manuela G. López, 2011, European journal of medicinal chemistry.

SELECTIVE DOPAMINE RECEPTORS : SYNTHESIS, COMPLEXING PROPERTIES, AND MOLECULAR MODELLING STUDIES OF NEW PODANDS DERIVED FROM 4-HYDROXY-1H-PYRAZOLE

Ana Martínez, M. Rodríguez-Franco, P. Navarro, 1999 .

Recent Advances in Neurogenic Small Molecules as Innovative Treatments for Neurodegenerative Diseases

M. de la Fuente Revenga, Martín Estrada, Olaia Martí-Marí, 2016, Molecules.

Caesium-Assisted Cyclization of Large Polyether Hexa- and Octaester Pyrazolic Crowns

A. Samat, M. Rodríguez-Franco, P. Navarro, 1987 .

Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups.

C. Pérez, M. de la Fuente Revenga, C. Villalba-Galea, 2020, European journal of medicinal chemistry.

Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.

D. Hadjipavlou-Litina, A. Alcázar, Abdelouahid Samadi, 2012, Journal of medicinal chemistry.

The melatonin-N,N-dibenzyl(N-methyl)amine hybrid ITH91/IQM157 affords neuroprotection in an in vitro Alzheimer's model via hemo-oxygenase-1 induction.

R. León, Manuela G. López, M. Rodríguez-Franco, 2015, ACS chemical neuroscience.

Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.

C. Pérez, M. de la Fuente Revenga, M. Yáñez, 2015, ACS chemical neuroscience.

Regioselective lipase-catalyzed synthesis of l-glutamic α-monoamide derivatives. Effect of the N-blocking group

Ana Martínez, S. Conde, M. Rodríguez-Franco, 1997 .

Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.

C. Pérez, B. Bartolomé, B. Hernández-Ledesma, 2006, Journal of medicinal chemistry.

Discovery of 5-(4-hydroxyphenyl)-3-oxo-pentanoic acid [2-(5-methoxy-1H-indol-3-yl)-ethyl]-amide as a neuroprotectant for Alzheimer's disease by hybridization of curcumin and melatonin.

S. Toldo, Kai Liu, Shijun Zhang, 2014, ACS chemical neuroscience.

Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.

Xavier Barril, F. J. Luque, F Javier Luque, 2009, Journal of medicinal chemistry.

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

E. Laurini, S. Pricl, C. Pérez, 2019, Journal of enzyme inhibition and medicinal chemistry.

New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.

Jörg Rademann, C. Pérez, J. Rademann, 2012, Journal of medicinal chemistry.

PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.

Manuela G. López, Abdelouahid Samadi, J. Marco-Contelles, 2013, ACS chemical neuroscience.

Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.

C. Pérez, Manuela G. López, M. Villarroya, 2009, Journal of medicinal chemistry.

Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole – LH 21

F. Pavón, A. Serrano, A. Cippitelli, 2006, Neuropharmacology.

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

F. J. Luque, F Javier Luque, Vincenza Andrisano, 2009, Journal of medicinal chemistry.

Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates

F. J. Luque, Vincenza Andrisano, Albert Badia, 2010, ChemMedChem.

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

P. Agostinho, C. Pérez, Ignacio Moraleda, 2013, ACS chemical neuroscience.

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

C. Pérez, Manuela G. López, M. Villarroya, 2010, Journal of medicinal chemistry.

Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

M. Loza, J. Brea, F. Feixas, 2022, Journal of medicinal chemistry.

From the Design to the In Vivo Evaluation of Benzohomoadamantane-Derived Soluble Epoxide Hydrolase Inhibitors for the Treatment of Acute Pancreatitis

M. Loza, J. Brea, F. Feixas, 2021, Journal of medicinal chemistry.

Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: Involvement in hippocampal neuronal loss in Alzheimer's disease

I. Ferrer, E. Carro, D. Antequera, 2012, Neurobiology of Disease.

Novel Tacrine‐Grafted Ugi Adducts as Multipotent Anti‐Alzheimer Drugs: A Synthetic Renewal in Tacrine–Ferulic Acid Hybrids

V. Andrisano, M. Bartolini, M. Bolognesi, 2015, ChemMedChem.

Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.

E. Uriarte, P. Oliveira, C. Pérez, 2018, European journal of medicinal chemistry.

New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.

E. Laurini, S. Pricl, C. Pérez, 2016, Future medicinal chemistry.

The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

A. Feilding, J. Riba, M. de la Fuente Revenga, 2017, Scientific Reports.

Optimization of Bicyclic Lactam Derivatives as NMDA Receptor Antagonists

Maria M. M. Santos, Lídia M D Gonçalves, M. Rodríguez-Franco, 2017, ChemMedChem.

2-Oxaadamant-1-yl ureas as soluble epoxide hydrolase inhibitors: in vivo evaluation in a murine model of acute pancreatitis.

M. Loza, J. Brea, J. Oyarzábal, 2020, Journal of medicinal chemistry.

Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.

A. Cuadrado, F. Gago, C. Pérez, 2020, European journal of medicinal chemistry.

Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia

P. Negredo, R. León, Manuela G. López, 2013, Neuropharmacology.

The Melatonin Analog IQM316 May Induce Adult Hippocampal Neurogenesis and Preserve Recognition Memories in Mice

D. Acuña-Castroviejo, E. Carro, M. de la Fuente Revenga, 2018, Cell transplantation.

New coumarin-based fluorescent melatonin ligands. Design, synthesis and pharmacological characterization.

D. Sugden, M. de la Fuente Revenga, M. Rodríguez-Franco, 2015, European journal of medicinal chemistry.

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.

C. Pérez, M. Rodríguez-Franco, D. Viña, 2016, European journal of medicinal chemistry.

N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.

Stefano Alcaro, Katarina Nikolic, Francesco Ortuso, 2014, Journal of medicinal chemistry.

An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver

J. Encinar, A. I. Rojo, A. Cuadrado, 2022, Redox biology.

Corrigendum to “An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver” [Redox Biol. 55 (2022) 102396/PMID: 35839629]

J. Encinar, A. I. Rojo, A. Cuadrado, 2022, Redox biology.

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.

E. Laurini, S. Pricl, C. Pérez, 2018, European journal of medicinal chemistry.

Multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis in vitro.

C. Pérez, Irene Bolea, Abdelouahid Samadi, 2013, Current Alzheimer research.

Selective carriers of ammonium ions. I. Synthesis and template effect of cesium chloride and x-ray structure and ionophoric properties of polyether crowns containing 1-methyl-3,5-bis(methylene)-1H-pyrazole units

A. Samat, C. Foces-Foces, F. H. Cano, 1989 .

Synthesis and muscarinic activities of O-[(benzyl- or benzoyl-pyrazolyl)propynyl]-oximes of N-methylpiperidinone, 3-tropinone, and 3-quinuclidinone.

J. Baños, A. Badía, Ana Martínez, 2002, Bioorganic & medicinal chemistry.

Potent and selective MAO-B inhibitory activity: amino- versus nitro-3-arylcoumarin derivatives.

S. Vilar, L. Santana, E. Uriarte, 2015, Bioorganic & medicinal chemistry letters.

Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.

F. J. Luque, V. Andrisano, M. Bartolini, 2012, Journal of medicinal chemistry.

Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.

C. Pérez, R. León, Manuela G. López, 2017, European journal of medicinal chemistry.

Non-cholinergic pharmacotherapy approaches to the future treatment of Alzheimer's disease.

Ana Martínez, S. Conde, M. Rodríguez-Franco, 2002, Mini reviews in medicinal chemistry.

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

A. Cuadrado, R. León, Manuela G. López, 2022, Medicinal research reviews.

Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.

C. Pérez, M. de la Fuente Revenga, Ignacio Moraleda, 2013, European journal of medicinal chemistry.

Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.

C. Pérez, Ignacio Moraleda, I. Iriepa, 2012, European journal of medicinal chemistry.

Multi-target novel neuroprotective compound ITH33/IQM9.21 inhibits calcium entry, calcium signals and exocytosis.

A. Caricati‐Neto, M. Yáñez, S. Conde, 2011, Cell calcium.

Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades

C. Pérez, R. León, Manuela G. López, 2022, Journal of medicinal chemistry.

New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.

C. Pérez, Manuela G. López, M. Villarroya, 2014, Journal of medicinal chemistry.

Tacrine–Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

C. Pérez, N. Campillo, Manuela G. López, 2009, ChemMedChem.

Antinociceptive and modulatory effect of pathoplastic changes in spinal glia of a TLR4/CD14 blocking molecule in two models of pain in rat.

M. Rodríguez-Franco, C. Goicoechea, J. Uranga, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

3‐Amidocoumarins as Potential Multifunctional Agents against Neurodegenerative Diseases

L. Santana, E. Uriarte, M. Rodríguez-Franco, 2015, ChemMedChem.

Selective carriers of norepinephrine and ammonium ions: ionophoric properties and molecular modelling studies of diester crown compounds containing a 1,3-bis(1H-pyrazol-1-yl)propane unit.

S. Conde, P. Navarro, A. Martínez, 1997, Bioorganic & medicinal chemistry.

8-Amide and 8-carbamate substitution patterns as modulators of 7-hydroxy-4-methylcoumarin's antidepressant profile: Synthesis, biological evaluation and docking studies.

E. Uriarte, Cristina Val, M. Loza, 2023, European journal of medicinal chemistry.

Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.

C. Pérez, Manuela G. López, M. Villarroya, 2010, Journal of medicinal chemistry.

Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.

V. Andrisano, M. Bartolini, F. Mancini, 2009, Journal of medicinal chemistry.

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.