M. Chini

发表

Quantitative NMR-derived interproton distances combined with quantum mechanical calculations of 13C chemical shifts in the stereochemical determination of conicasterol F, a nuclear receptor ligand from Theonella swinhoei.

G. Bifulco, A. Zampella, S. Fiorucci, 2012, The Journal of organic chemistry.

A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry.

Giuseppe Bifulco, Maria Giovanna Chini, Giovanni Sorba, 2010, Journal of medicinal chemistry.

Use of NMR in profiling of cocaine seizures.

Ettore Novellino, Maria Giovanna Chini, Ilaria Lauri, 2013, Forensic science international.

Quantum Mechanical Calculation of NMR Parameters in the Stereostructural Determination of Natural Products

G. Bifulco, R. Riccio, M. G. Chini, 2010 .

Discovery of new molecular entities able to strongly interfere with Hsp90 C-terminal domain

G. Bifulco, R. Riccio, S. Terracciano, 2018, Scientific Reports.

Anti‐inflammatory and analgesic activity of carnosol and carnosic acid in vivo and in vitro and in silico analysis of their target interactions

G. Bifulco, O. Werz, A. Koeberle, 2017, British journal of pharmacology.

In Silico, In Vitro and In Vivo Analysis of Tanshinone IIA and Cryptotanshinone from Salvia miltiorrhiza as Modulators of Cyclooxygenase-2/mPGES-1/Endothelial Prostaglandin EP3 Pathway

G. Bifulco, O. Werz, A. Koeberle, 2022, Biomolecules.

Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach.

G. Bifulco, S. Castellano, C. Milite, 2016, Chemistry.

Discovery of a Secalonic Acid Derivative from Aspergillus aculeatus, an Endophyte of Rosa damascena Mill., Triggers Apoptosis in MDA-MB-231 Triple Negative Breast Cancer Cells

G. Bifulco, A. Chaubey, Shashank K Singh, 2020, ACS omega.

Design, Synthesis, and Biological Activity of Hydroxamic Tertiary Amines as Histone Deacetylase Inhibitors

G. Bifulco, R. Riccio, S. Terracciano, 2012, ChemMedChem.

Guaianolides from Ormenis mixta: Structural Insights and Evaluation of Their Anti-inflammatory Profile

G. Bifulco, N. de Tommasi, A. Kabouche, 2019, Planta Medica.

Carnosol Attenuates LPS-Induced Inflammation of Cardiomyoblasts by Inhibiting NF-κB: A Mechanistic in Vitro and in Silico Study

G. Bifulco, A. Saviano, F. Maione, 2022, Evidence-based complementary and alternative medicine : eCAM.

Pharmacological and molecular docking assessment of cryptotanshinone as natural-derived analgesic compound

G. Bifulco, A. Saviano, S. Laneri, 2020, Biomedicine & Pharmacotherapy.

Down regulation of pro‐inflammatory pathways by tanshinone IIA and cryptotanshinone in a non‐genetic mouse model of Alzheimer's disease

G. Bifulco, A. Calignano, C. Cristiano, 2017, Pharmacological research.

Molecular mechanism of tanshinone IIA and cryptotanshinone in platelet anti-aggregating effects: an integrated study of pharmacology and computational analysis.

G. Bifulco, F. Maione, V. Cantone, 2015, Fitoterapia.

Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors.

G. Bifulco, A. Zampella, S. Fiorucci, 2011, Journal of medicinal chemistry.

Identification of 2,4,5-trisubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one-based small molecules as selective BRD9 binders.

G. Bifulco, S. Terracciano, I. Bruno, 2022, European journal of medicinal chemistry.

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

G. Bifulco, F. Baldelli, E. Distrutti, 2011, PloS one.

Targeting mPGES-1 by a Combinatorial Approach: Identification of the Aminobenzothiazole Scaffold to Suppress PGE2 Levels.

G. Bifulco, O. Werz, A. Koeberle, 2020, ACS medicinal chemistry letters.

Quantum Chemical Calculation of Chemical Shifts in the Stereochemical Determination of Organic Compounds: A Practical Approach

G. Bifulco, R. Riccio, S. D. Micco, 2012 .

Structural basis for the design and synthesis of selective HDAC inhibitors.

G. Bifulco, R. Riccio, S. Terracciano, 2013, Bioorganic & medicinal chemistry.

Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors.

G. Bifulco, R. Riccio, S. Terracciano, 2013, European journal of medicinal chemistry.

Synthesis of new mono and bis amides projected as potential histone deacetylase (HDAC) inhibitors

G. Bifulco, R. Riccio, S. Terracciano, 2010 .

Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases.

G. Bifulco, P. Canonico, G. Tron, 2009, Journal of medicinal chemistry.

Insights into the Ligand Binding to Bromodomain-Containing Protein 9 (BRD9): A Guide to the Selection of Potential Binders by Computational Methods

G. Bifulco, G. Lauro, Simona De Vita, 2021, Molecules.

Identification of the key structural elements of a dihydropyrimidinone core driving toward more potent Hsp90 C-terminal inhibitors.

G. Bifulco, R. Riccio, C. Saturnino, 2016, Chemical communications.

Long-Lasting Anti-Inflammatory and Antinociceptive Effects of Acute Ammonium Glycyrrhizinate Administration: Pharmacological, Biochemical, and Docking Studies

G. Bifulco, F. Maione, N. Mascolo, 2019, Molecules.

Phytochemical Analysis of the Methanolic Extract and Essential Oil from Leaves of Industrial Hemp Futura 75 Cultivar: Isolation of a New Cannabinoid Derivative and Biological Profile Using Computational Approaches

G. Bifulco, C. Finamore, G. Saviano, 2022, Plants.

The Inactivation Mechanism of Human Group IIA Phospholipase A2 by Scalaradial

G. Bifulco, R. Riccio, A. Tosco, 2012, Chembiochem : a European journal of chemical biology.

Diterpenoid Constituents of Psiadiapunctulata and Evaluation of Their Antimicrobial Activity

G. Bifulco, A. Bisio, G. Donadio, 2022, Journal of natural products.

4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity

G. Bifulco, A. Zampella, S. Fiorucci, 2012, Steroids.

The Binding Mode of Cladocoran A to the Human Group IIA Phospholipase A2

G. Bifulco, R. Riccio, L. Margarucci, 2011, Chembiochem : a European journal of chemical biology.

The molecular mechanism of human group IIA phospholipase A2 inactivation by bolinaquinone

G. Bifulco, R. Riccio, A. Tosco, 2009, Journal of molecular recognition : JMR.

Correction: The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

G. Bifulco, F. Baldelli, E. Distrutti, 2013, PLoS ONE.

Elucidating new structural features of the triazole scaffold for the development of mPGES-1 inhibitors

G. Bifulco, O. Werz, P. Dambruoso, 2015 .

Structure-based discovery of inhibitors of microsomal prostaglandin E2 synthase-1, 5-lipoxygenase and 5-lipoxygenase-activating protein: promising hits for the development of new anti-inflammatory agents.

G. Bifulco, O. Werz, R. Riccio, 2011, Journal of medicinal chemistry.

Identification of 2-Aminoacyl-1,3,4-thiadiazoles as Prostaglandin E2 and Leukotriene Biosynthesis Inhibitors

G. Bifulco, O. Werz, S. Terracciano, 2022, ACS medicinal chemistry letters.

Computational NMR Methods in the Stereochemical Analysis of Organic Compounds: Are Proton or Carbon NMR Chemical Shift Data More Discriminating?

G. Bifulco, R. Riccio, M. G. Chini, 2015 .

From Natural Compounds to Bioactive Molecules through NMR and In Silico Methodologies

S. Terracciano, I. Bruno, Simona De Vita, 2020 .

DFT/NMR integrated approach: a valid support to the total synthesis of chiral molecules

G. Bifulco, R. Riccio, M. Chini, 2008, Magnetic resonance in chemistry : MRC.

Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways.

G. Bifulco, O. Werz, Carmen Festa, 2021, European journal of medicinal chemistry.

Repositioning of Quinazolinedione-Based Compounds on Soluble Epoxide Hydrolase (sEH) through 3D Structure-Based Pharmacophore Model-Driven Investigation

Maria T. Potenza, G. Bifulco, O. Werz, 2022, Molecules.

Natural Iminosugar (+)-Lentiginosine Inhibits ATPase and Chaperone Activity of Hsp90

G. Bifulco, C. Pisano, F. Dal Piaz, 2012, PloS one.

Thiazolidin-4-one-based compounds interfere with the eicosanoid biosynthesis pathways by mPGES-1/sEH/5-LO multi-target inhibition

G. Bifulco, O. Werz, V. Sepe, 2022, European Journal of Medicinal Chemistry Reports.

Glucopyranosylbianthrones from the Algerian Asphodelus tenuifolius: Structural Insights and Biological Evaluation on Melanoma Cancer Cells.

G. Bifulco, S. Terracciano, I. Bruno, 2018, Journal of natural products.

Fibril aggregation inhibitory activity of the β‐sheet breaker peptides: a molecular docking approach

G. Bifulco, M. Scrima, A. D'Ursi, 2009, Journal of peptide science : an official publication of the European Peptide Society.

Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators.

G. Bifulco, N. de Tommasi, M. G. Chini, 2021, Phytochemistry.

Fusicoccane Diterpenes from Hypoestes forsskaolii as Heat Shock Protein 90 (Hsp90) Modulators.

G. Bifulco, R. Cotugno, F. Dal Piaz, 2019, Journal of natural products.

New dihydropyrimidin-2(1H)-one based Hsp90 C-terminal inhibitors

G. Bifulco, R. Riccio, C. Saturnino, 2016 .

Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold.

G. Bifulco, R. Riccio, S. Terracciano, 2015, Chemical communications.

Design and synthesis of a second series of triazole-based compounds as potent dual mPGES-1 and 5-lipoxygenase inhibitors.

G. Bifulco, O. Werz, R. Riccio, 2012, European journal of medicinal chemistry.

Identification and mechanism of action analysis of the new PARP-1 inhibitor 2″-hydroxygenkwanol A.

G. Bifulco, A. Tosco, F. Dal Piaz, 2015, Biochimica et biophysica acta.

Preliminary Structure-Activity Relationship on Theonellasterol, a New Chemotype of FXR Antagonist, from the Marine Sponge Theonella swinhoei

G. Bifulco, V. Sepe, A. Zampella, 2012, Marine drugs.

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Simona De Vita, Gianluigi Lauro, Maria Giovanna Chini, 2020, RSC advances.

Exploring the Anticancer Potential of Premna resinosa (Hochst.) Leaf Surface Extract: Discovering New Diterpenes as Heat Shock Protein 70 (Hsp70) Binding Agents

G. Bifulco, A. Bisio, I. Faraone, 2023, Plants.

A chemical-biological study reveals C9-type iridoids as novel heat shock protein 90 (Hsp90) inhibitors.

G. Bifulco, R. Cotugno, C. Pisano, 2013, Journal of medicinal chemistry.

Limonoids from Guarea guidonia and Cedrela odorata: Heat Shock Protein 90 (Hsp90) Modulator Properties of Chisomicine D

G. Bifulco, F. Dal Piaz, N. de Tommasi, 2021, Journal of natural products.

Introducing structure-based three-dimensional pharmacophore models for accelerating the discovery of selective BRD9 binders.

G. Bifulco, S. Terracciano, I. Bruno, 2021, Bioorganic chemistry.

Cytotoxic Sesquiterpenoids from Ammoides atlantica Aerial Parts

G. Bifulco, M. De Leo, N. de Tommasi, 2022, Journal of natural products.

Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.

G. Bifulco, V. Sepe, A. Zampella, 2012, Journal of medicinal chemistry.

Can Small Chemical Modifications of Natural Pan-inhibitors Modulate the Biological Selectivity? The Case of Curcumin Prenylated Derivatives Acting as HDAC or mPGES-1 Inhibitors.

G. Bifulco, O. Werz, A. Koeberle, 2015, Journal of natural products.

Discovery of new molecular entities able to strongly interfere with Hsp90 C-terminal domain

G. Bifulco, R. Riccio, S. Terracciano, 2018, Scientific Reports.

Discovery That Theonellasterol a Marine Sponge Sterol Is a Highly Selective FXR Antagonist That Protects against Liver Injury in Cholestasis

G. Bifulco, V. Sepe, A. Zampella, 2012, PloS one.

The molecular mechanism of human group IIA phospholipase A2 inactivation by bolinaquinone

G. Bifulco, R. Riccio, A. Tosco, 2009, Journal of molecular recognition : JMR.

Molecular insights into azumamide e histone deacetylases inhibitory activity.

G. Bifulco, R. Riccio, I. Izzo, 2007, Journal of the American Chemical Society.

NMR Metabolomics and Chemometrics of Commercial Varieties of Phaseolus vulgaris L. Seeds from Italy and In Vitro Antioxidant and Antifungal Activity

A. Casapullo, G. Lauro, F. Fantasma, 2024, Plants.

Pharmacological and molecular docking assessment of cryptotanshinone as natural-derived analgesic compound.

S. Laneri, A. Sacchi, A. Calignano, 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Biological Profile of Two Gentiana lutea L. Metabolites Using Computational Approaches and In Vitro Tests

G. Bifulco, C. Finamore, G. Saviano, 2021, Biomolecules.

Exploring the chemical space of functionalized [1,2,4]triazolo[4,3-a]quinoxaline-based compounds targeting the bromodomain of BRD9.

G. Bifulco, S. Terracciano, I. Bruno, 2023, Bioorganic chemistry.

Identification and Development of BRD9 Chemical Probes

G. Lauro, Ester Colarusso, M. Chini, 2024, Pharmaceuticals.

Nutraceutical Aspects of Selected Wild Edible Plants of the Italian Central Apennines

F. Fantasma, M. Iorizzi, M. Chini, 2024, Nutraceuticals.

DFT/NMR integrated approach: a valid support to the total synthesis of chiral molecules

G. Bifulco, R. Riccio, M. Chini, 2008, Magnetic resonance in chemistry : MRC.

Guaianolides from Ormenis mixta: Structural Insights and Evaluation of Their Anti-inflammatory Profile

G. Bifulco, N. de Tommasi, A. Kabouche, 2019, Planta Medica.