Chester W. Brown

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Activin Bioactivity Affects Germ Cell Differentiation in the Postnatal Mouse Testis In Vivo1

M. Matzuk, K. Loveland, S. Mendis, 2010, Biology of reproduction.

Genetic Analysis of the Mammalian Transforming Growth Factor-β Superfamily

M. Matzuk, H. Chang, Chester W. Brown, 2002 .

Genetic analysis of the mammalian transforming growth factor-beta superfamily.

M. Matzuk, Chester W Brown, H. Chang, 2002, Endocrine reviews.

Activins and Inhibins: Roles in Development, Physiology, and Disease.

Maria Namwanje, Chester W. Brown, 2016, Cold Spring Harbor perspectives in biology.

Intraovarian activins are required for female fertility.

Martin M Matzuk, Julio E. Agno, M. Matzuk, 2007, Molecular endocrinology.

Transgenics in Endocrinology

M. Matzuk, T. Kumar, Chester W. Brown, 2001, Contemporary Endocrinology.

Phenotypic expansion of POGZ‐related intellectual disability syndrome (White‐Sutton syndrome)

J. Rosenfeld, J. Lupski, R. Scott, 2019, American journal of medical genetics. Part A.

De Novo Missense Variants in TRAF7 Cause Developmental Delay, Congenital Anomalies, and Dysmorphic Features.

Ellen F. Macnamara, Colleen E. Wahl, J. Rosenfeld, 2018, American journal of human genetics.

Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features.

Juliane Hoyer, Bernt Popp, André Reis, 2017, American journal of human genetics.

Mutations in PURA cause profound neonatal hypotonia, seizures, and encephalopathy in 5q31.3 microdeletion syndrome.

Mahshid S. Azamian, J. Lupski, R. Gibbs, 2014, American journal of human genetics.

The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies

Edwin Cuppen, Claire Redin, Ryan L. Collins, 2016, Nature Genetics.

Mitochondrial dysfunction in obesity.

J. Bournat, Chester W. Brown, 2010, Current opinion in endocrinology, diabetes, and obesity.

Activins are critical modulators of growth and survival.

M. Matzuk, Chester W Brown, Liunan Li, 2003, Molecular endocrinology.

M. Matzuk, R. Habas, M. Shen, 2005, Development.

Absence of heterozygosity due to template switching during replicative rearrangements.

M. Hurles, R. Pfundt, P. Stankiewicz, 2015, American journal of human genetics.

Recurrent HERV‐H‐Mediated 3q13.2–q13.31 Deletions Cause a Syndrome of Hypotonia and Motor, Language, and Cognitive Delays

J. Rosenfeld, L. Shaffer, P. Stankiewicz, 2013, Human mutation.

Phenotypic spectrum and genotype–phenotype correlations of NRXN1 exon deletions

P. Stankiewicz, Ankita Patel, S. Cheung, 2012, European Journal of Human Genetics.

Heterozygous variants in ACTL6A, encoding a component of the BAF complex, are associated with intellectual disability

Alyssa A. Tran, J. Rosenfeld, B. D. de Vries, 2017, Human mutation.

Activin signaling: effects on body composition and mitochondrial energy metabolism.

C. Shaw, B. Graham, Joseph J Shen, 2009, Endocrinology.

Obesity-linked PPARγ S273 phosphorylation promotes insulin resistance through Growth Differentiation Factor 3

Amir I. Mina, Alexander S. Banks, B. Spiegelman, 2020, bioRxiv.

Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure.

Nader Zamani, Chester W. Brown, 2011, Endocrine reviews.

Short title: Activin controls germ cell maturation Summary sentence: Activin modulates germ and Sertoli cell development in the mouse testis in

K. Loveland, S. Mendis, S. Meachem, 2010 .

Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes.

J. Lupski, S. Cheung, N. Katsanis, 2014, American journal of human genetics.

Use of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management

Fan Xia, Pengfei Liu, Xiaoyan Ge, 2017, JAMA pediatrics.

Phenotypic consequences of genetic variation at hemizygous alleles: Sotos syndrome is a contiguous gene syndrome incorporating coagulation factor twelve (FXII) deficiency

J. Lupski, T. Shiihara, Y. Makita, 2005, Genetics in Medicine.

Complex Compound Inheritance of Lethal Lung Developmental Disorders Due to Disruption of the TBX-FGF Pathway.

Justyna A. Karolak, H. Mefford, W. Chung, 2019, American journal of human genetics.

The Collaborative African Genomics Network (CAfGEN): Applying Genomic technologies to probe host factors important to the progression of HIV and HIV-tuberculosis infection in sub-Saharan Africa

G. Mardon, G. Anabwani, N. Hanchard, 2018, AAS open research.

Whole-Exome Sequencing Reveals Uncaptured Variation and Distinct Ancestry in the Southern African Population of Botswana.

G. Mardon, F. Yu, S. Swaminathan, 2018, American journal of human genetics.

The collaborative African genomics network training program: a trainee perspective on training the next generation of African scientists

G. Mardon, G. Anabwani, N. Hanchard, 2017, Genetics in Medicine.

Enabling Genomic Revolution in Africa

Faisal M. Fadlelmola, Dan J Stein, Ebony B Madden, 2019, The Genetics of African Populations in Health and Disease.

Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures

G. Cooper, S. Papuc, J. Schreiber, 2019, European Journal of Human Genetics.

Further delineation of the clinical spectrum of KAT6B disorders and allelic series of pathogenic variants

E. Zackai, J. Lupski, R. Gibbs, 2020, Genetics in Medicine.

Mosaicism for r(X) and der(X)del(X)(p11.23)dup(X)(p11.21p11.22) provides insight into the possible mechanism of rearrangement

Z. Ou, P. Stankiewicz, M. L. Cooper, 2008, Molecular Cytogenetics.

Exome Sequencing Reveals a Putative Role for HLA-C*03:02 in Control of HIV-1 in African Pediatric Populations

G. Mardon, G. Anabwani, N. Hanchard, 2021, Frontiers in Genetics.

Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis in the aged

J. Schultze, J. Elsworth, V. Dixit, 2017, Nature.

Unmapped exome reads implicate a role for Anelloviridae in childhood HIV-1 long-term non-progression

G. Mardon, G. Anabwani, H. Noyes, 2021, NPJ genomic medicine.

Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration.

Attila Horvath, E. Pintye, L. Nagy, 2016, Immunity.

Identifying Gene Disruptions in Novel Balanced de novo Constitutional Translocations in Childhood Cancer Patients by Whole Genome Sequencing

Caleb F. Davis, R. Gibbs, D. Wheeler, 2014, Genetics in Medicine.

Mutations in LTBP4 cause a syndrome of impaired pulmonary, gastrointestinal, genitourinary, musculoskeletal, and dermal development.

K. Holland, D. Rifkin, M. Marble, 2009, American journal of human genetics.

Recurrent microdeletions of 15q25.2 are associated with increased risk of congenital diaphragmatic hernia, cognitive deficits and possibly Diamond–Blackfan anaemia

P. Stankiewicz, E. Roeder, V. Enciso, 2010, Journal of Medical Genetics.

Immunity Macrophage PPARγ , a lipid activated transcription factor controls a growth factor GDF 3 and skeletal muscle regeneration

E. Pintye, L. Nagy, P. Tontonoz, 2016 .

Macrophage PPAR g , a Lip id Activated Transcription Factor Controls the Growth Factor GDF 3 and Skeletal Muscle Regeneration Graphical

Attila Horvath, E. Pintye, L. Nagy, 2016 .

Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions

M. Matzuk, T. Woodruff, Chester W Brown, 2000, Nature Genetics.

Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose.

M. Matzuk, Joseph J Shen, Lihua Huang, 2009, Molecular endocrinology.

Case Report: An Infant With Kabuki Syndrome, Alobar Holoprosencephaly and Truncus Arteriosus: A Case for Whole Exome Sequencing in Neonates With Congenital Anomalies

E. Pivnick, Shannon Holtrop, P. Zaveri, 2021, Frontiers in Genetics.

Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes

M. Matzuk, M. Griswold, Ankur K Nagaraja, 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

Molecular characterization of co‐occurring Duchenne muscular dystrophy and X‐linked oculo‐facio‐cardio‐dental syndrome in a girl

L. Biesecker, J. Johnston, Yong-hui Jiang, 2009, American journal of medical genetics. Part A.

Insulin Regulates Lipolysis and Fat Mass by Upregulating Growth/Differentiation Factor 3 in Adipose Tissue Macrophages

T. Izumi, K. Mizuno, Yun Bu, 2018, Diabetes.

Identification of novel candidate disease genes from de novo exonic copy number variants

J. Rosenfeld, P. Stankiewicz, A. Breman, 2017, Genome Medicine.

Combinatorial actions of Tgf&bgr; and Activin ligands promote oligodendrocyte development and CNS myelination

F. Hayot, E. Bottinger, N. Mitiku, 2014, Journal of Cell Science.

Combinatorial actions of Tgfβ and Activin ligands promote oligodendrocyte development and CNS myelination

F. Hayot, E. Bottinger, John N. Mariani, 2014, Development.

A novel GJB2 (connexin 26) mutation, F142L, in a patient with unusual mucocutaneous findings and deafness.

G. Richard, C. Flaitz, P. Fang, 2003, The Journal of investigative dermatology.

SMAD2 and SMAD3 differentially regulate adiposity and the growth of subcutaneous white adipose tissue

Tamekia Jones, M. Puchowicz, J. Pierre, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

De novo terminal 22q12.3q13.3 duplication with pituitary hypoplasia

Ankita Patel, R. Rauch, R. Heptulla, 2009, American Journal of Medical Genetics. Part A.

Isolation and Manipulation of Adipogenic Cells to Assess TGF-β Superfamily Functions.

J. Bournat, Chester W Brown, Maria Namwanje, 2016, Methods in molecular biology.